Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000019 · All tissues

Acute appendicitis, with complications: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Acute appendicitis

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	monocyte	17.56	Significant	3.30e-49	1.33	Specific	2,176	3,871
2	thymocyte	12.78	Significant	9.00e-08	1.18	Specific	168	512
3	dendritic_cell	11.24	Significant	9.00e-08	1.20	Specific	496	724
4	macrophage	7.36	Significant	7.80e-10	1.12	Specific	813	1,732
5	haematopoietic_progenitor_cell	5.49	Nominal	1.00	1.04	Other	262	502
6	granulocyte	4.22	Nominal	1.00	1.07	Other	5	6
7	innate_lymphoid_cell_2	4.21	Nominal	1.00	1.07	Other	3	8
8	platelet	4.11	Nominal	—	0.96	Other	85	104
9	B_cell	3.54	Nominal	4.72e-05	1.08	Other	356	694
10	adipose_stem_and_progenitor_cell	2.57	Nonsignificant	1.00	0.96	Other	327	954
11	fibroblast	1.19	Nonsignificant	1.00	0.89	Other	184	826
12	microglia	1.05	Nonsignificant	1.00	0.77	Other	61	129
13	smooth_muscle_cell	0.91	Nonsignificant	1.00	0.76	Other	27	139
14	pericyte	0.58	Nonsignificant	1.00	0.69	Other	128	517
15	T_cell	0.49	Nonsignificant	1.00	0.62	Other	470	959
16	muscle_stem_cell	0.39	Nonsignificant	1.00	0.65	Other	7	27
17	natural_killer_cell	0.38	Nonsignificant	1.00	0.58	Other	1,204	2,052
18	oligodendrocyte	0.33	Nonsignificant	1.00	0.58	Other	385	1,507
19	plasma_cell	0.28	Nonsignificant	1.00	0.52	Other	17	24
20	epithelial_cell	0.17	Nonsignificant	1.00	0.55	Other	24	47
21	induced_pluripotent_stem_cell	0.15	Nonsignificant	1.00	0.49	Other	0	0
22	schwann_cell	0.10	Nonsignificant	1.00	0.69	Other	10	57
23	chondrocyte	0.09	Nonsignificant	1.00	0.40	Other	548	1,069
24	neuron	0.04	Nonsignificant	1.00	0.46	Other	330	1,328
25	adipocyte	0.04	Nonsignificant	1.00	0.42	Other	33	111
26	melanocyte	0.02	Nonsignificant	1.00	0.55	Other	97	309
27	endothelial_cell	0.02	Nonsignificant	1.00	0.31	Other	373	974
28	mesothelial_cell	0.01	Nonsignificant	1.00	0.35	Other	6	36
29	granulosa_cell	6.93e-03	Nonsignificant	1.00	0.65	Other	293	670
30	cardiomyocyte	5.39e-03	Nonsignificant	1.00	0.37	Other	533	2,045
31	hepatocyte	1.34e-03	Nonsignificant	1.00	0.28	Other	1,515	3,822
32	oligodendrocyte_precursor_cell	3.21e-05	Nonsignificant	1.00	0.22	Other	461	1,454
33	skeletal_muscle_cell	1.82e-06	Nonsignificant	1.00	0.18	Other	944	2,600
34	astrocyte	1.52e-06	Nonsignificant	1.00	0.16	Other	256	1,203

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	MONO.CD14	17.82	Significant	6.45e-05	1.87	Specific	2,294	4,139
2	MONO.CD16	16.22	Significant	0.87	0.80	Specific	1,304	1,835
3	DC.cDC1	15.27	Significant	0.63	1.06	Relevant	55	112
4	DC.cDC2	13.45	Significant	9.09e-04	1.75	Specific	1,189	1,793
5	THYMO.thymocyte	12.78	Significant	—	—	Specific	163	495
6	MAC.LAM	11.08	Significant	1.62e-11	1.87	Specific	914	2,064
7	DC.mig	10.27	Significant	—	0.00	Relevant	89	156
8	MAC.MDM	10.06	Significant	0.03	1.41	Specific	623	986
9	T.CD4_Th2	10.01	Significant	—	2.36	Specific	1	2
10	MAC.proliferating	9.24	Significant	0.02	1.66	Specific	87	253
11	MAC.resident_cardiac	7.11	Significant	0.57	1.10	Specific	485	1,074
12	MAC.microglia_like	6.81	Significant	1.00	0.70	Relevant	124	179
13	HPC.haematopoietic_progenitor_cell	5.49	Nominal	—	—	Other	211	370
14	FIB.barrier_secretory	5.38	Nominal	0.29	1.28	Other	81	228
15	B.germinal_center	5.31	Nominal	0.01	2.00	Other	233	655
16	GRANU.MAST	5.09	Nominal	5.96e-03	2.29	Other	5	6
17	B.memory	4.41	Nominal	4.43e-23	2.79	Other	442	882
18	MAC.resident_iron	4.34	Nominal	1.00	0.39	Other	16	21
19	ILC2.innate_lymphoid_cell_2	4.21	Nominal	—	—	Other	2	0
20	MAC.resident_repair	4.16	Nominal	1.00	0.31	Other	796	1,426
21	PLAT.platelet	4.11	Nominal	—	0.00	Other	38	53
22	B.age_associated	3.51	Nominal	0.19	1.39	Other	207	350
23	FIB.lung_alveolar	2.95	Nonsignificant	—	1.07	Other	6	15
24	FIB.interstitial	2.84	Nonsignificant	2.70e-16	1.42	Other	288	940
25	B.naive	2.79	Nonsignificant	1.00	0.14	Other	307	595
26	GRANU.neutrophil	2.71	Nonsignificant	1.00	0.00	Other	1,235	2,649
27	ASPC.adipose_stem_and_progenitor_cell	2.57	Nonsignificant	—	—	Other	324	930
28	T.CD4_Treg	2.47	Nonsignificant	5.59e-13	1.78	Other	244	511
29	FIB.neurolectin_mucosa	2.32	Nonsignificant	0.65	1.09	Other	133	394
30	MAC.kupffer	2.09	Nonsignificant	1.00	0.24	Other	189	530
31	EPI.extrahepatic_cholangiocyte	1.25	Nonsignificant	—	1.29	Other	37	71
32	T.CD4_Tfh	1.07	Nonsignificant	0.11	1.30	Other	47	45
33	EPI.hepatic_ductular_cholangiocyte	1.06	Nonsignificant	0.39	1.16	Other	83	243
34	MG.microglia	1.05	Nonsignificant	—	—	Other	49	0
35	T.CD8_Tcm	1.05	Nonsignificant	0.02	1.36	Other	460	926
36	EPI.bile_duct_cholangiocyte	1.04	Nonsignificant	1.00	1.07	Other	37	60
37	EPI.alveolar_type_1	1.01	Nonsignificant	0.39	1.18	Other	26	101
38	FIB.skin_neurosecretory	0.98	Nonsignificant	—	0.44	Other	0	0
39	EPI.colonocyte	0.91	Nonsignificant	2.53e-03	1.19	Other	294	815
40	SMC.smooth_muscle_cell	0.91	Nonsignificant	—	—	Other	20	101
41	EPI.ileal_bile_transport	0.89	Nonsignificant	0.39	1.19	Other	61	93
42	T.CD4_Trm	0.85	Nonsignificant	0.01	1.28	Other	176	363
43	EPI.intrahepatic_cholangiocyte_defense	0.82	Nonsignificant	—	1.52	Other	8	13
44	T.CD8_Trm	0.81	Nonsignificant	3.84e-04	1.37	Other	211	346
45	EPI.cervical_suprabasal	0.79	Nonsignificant	—	1.48	Other	14	50
46	EPI.renal_proximal_tubule	0.79	Nonsignificant	0.39	1.15	Other	525	806
47	T.CD4_transitional	0.74	Nonsignificant	0.11	1.24	Other	48	110
48	FIB.tracheal_subepithelial	0.67	Nonsignificant	—	0.34	Other	0	0
49	FIB.reticular	0.65	Nonsignificant	1.00	0.79	Other	19	87
50	FIB.transitioning	0.62	Nonsignificant	1.00	0.72	Other	172	497
51	PERI.pericyte	0.58	Nonsignificant	—	—	Other	117	0
52	T.CD8_naive	0.57	Nonsignificant	0.14	1.10	Other	317	708
53	FIB.skin_tenogenic	0.56	Nonsignificant	—	0.29	Other	108	227
54	MAC.alveolar	0.52	Nonsignificant	1.00	0.01	Other	1,432	3,122
55	T.CD4_Tem	0.48	Nonsignificant	1.00	0.96	Other	365	697
56	NEU.INH_LAMP5	0.48	Nonsignificant	0.31	1.14	Other	263	532
57	EPI.ectocervical_granular	0.44	Nonsignificant	—	1.10	Other	11	23
58	T.CD4_Tcm	0.42	Nonsignificant	1.00	0.88	Other	494	988
59	EPI.ileal_enterocyte_absorptive	0.42	Nonsignificant	0.39	1.12	Other	118	338
60	MUSC.muscle_stem_cell	0.39	Nonsignificant	—	—	Other	4	18
61	EPI.renal_distal_tubule	0.39	Nonsignificant	1.00	0.99	Other	133	361
62	FIB.skin_sheath	0.38	Nonsignificant	1.00	0.70	Other	49	118
63	NK.natural_killer_cell	0.38	Nonsignificant	—	—	Other	1,204	2,045
64	EPI.alveolar_type_2	0.35	Nonsignificant	1.00	0.98	Other	813	1,853
65	T.CD4_Th17	0.33	Nonsignificant	1.00	0.70	Other	421	794
66	OLG.oligodendrocyte	0.33	Nonsignificant	—	—	Other	384	1,397
67	PC.IgG_systemic	0.32	Nonsignificant	0.74	0.90	Other	41	60
68	FIB.skin_papillary	0.29	Nonsignificant	—	0.05	Other	0	0
69	EPI.colonic_tuft	0.29	Nonsignificant	—	0.95	Other	7	24
70	T.CD8_transitional	0.28	Nonsignificant	1.00	0.68	Other	497	932
71	PC.IgA_muocsal	0.28	Nonsignificant	0.74	0.87	Other	18	31
72	T.CD4_naive	0.26	Nonsignificant	1.00	0.47	Other	399	866
73	FIB.suburothelial	0.24	Nonsignificant	1.00	0.67	Other	122	432
74	T.gamma_delta	0.24	Nonsignificant	1.00	0.51	Other	588	1,078
75	FIB.perivascular_interface	0.23	Nonsignificant	1.00	0.64	Other	0	0
76	EPI.intrahepatic_cholangiocyte_transport	0.22	Nonsignificant	—	0.84	Other	12	42
77	T.CD8_Tem	0.21	Nonsignificant	1.00	0.36	Other	1,083	1,857
78	T.MAIT	0.21	Nonsignificant	1.00	0.45	Other	469	855
79	T.CD4_cytotoxic	0.21	Nonsignificant	1.00	0.46	Other	855	1,493
80	EPI.renal_principal_cell	0.17	Nonsignificant	1.00	0.87	Other	207	403
81	HEP.pericentral_lipoprotein	0.16	Nonsignificant	—	2.90	Other	0	0
82	IPSC.induced_pluripotent_stem_cell	0.15	Nonsignificant	—	—	Other	0	0
83	EPI.skin_follicular_keratinizing	0.15	Nonsignificant	1.00	0.87	Other	30	81
84	EPI.esophageal_suprabasal	0.15	Nonsignificant	1.00	0.96	Other	158	404
85	EPI.ileal_enterocyte_crypt	0.11	Nonsignificant	1.00	0.88	Other	67	113
86	SCHWN.schwann_cell	0.10	Nonsignificant	—	—	Other	7	33
87	NEU.INH_PVALB	0.10	Nonsignificant	0.33	1.05	Other	193	183
88	EPI.renal_intercalated_cell_type_B	0.09	Nonsignificant	—	0.59	Other	6	7
89	CHOND.chondrocyte	0.09	Nonsignificant	—	—	Other	519	730
90	EPI.gastric_foveolar	0.08	Nonsignificant	—	0.60	Other	0	0
91	FIB.adventitial	0.08	Nonsignificant	1.00	0.01	Other	268	1,447
92	FIB.barrier_purinergic	0.08	Nonsignificant	—	0.00	Other	1	3
93	DC.pDC	0.07	Nonsignificant	1.00	0.00	Other	496	1,028
94	EPI.esophageal_basal	0.07	Nonsignificant	1.00	0.82	Other	4	10
95	EPI.pancreatic_islet	0.07	Nonsignificant	1.00	1.07	Other	52	132
96	EPI.skin_interfollicular_spinous	0.07	Nonsignificant	1.00	0.81	Other	260	563
97	EPI.ileal_goblet	0.06	Nonsignificant	1.00	0.84	Other	181	432
98	EC.capillary	0.06	Nonsignificant	0.15	1.09	Other	514	1,635
99	EPI.tracheal_basal	0.05	Nonsignificant	1.00	0.77	Other	398	1,120
100	EPI.lung_club_secretory	0.05	Nonsignificant	1.00	0.82	Other	5	14
101	NEU.EXC_SYT2	0.04	Nonsignificant	—	0.86	Other	40	77
102	ADIPO.adipocyte	0.04	Nonsignificant	—	—	Other	20	62
103	EPI.pancreatic_ductal_bicarbonate	0.03	Nonsignificant	1.00	0.89	Other	131	548
104	MEL.melanocyte	0.02	Nonsignificant	—	—	Other	79	242
105	EPI.renal_intercalated_cell_type_A	0.02	Nonsignificant	1.00	0.72	Other	67	142
106	EPI.renal_immature_ureteric_bud	0.02	Nonsignificant	1.00	0.73	Other	217	569
107	EPI.skin_sweat_duct_keratinocyte	0.02	Nonsignificant	1.00	1.07	Other	146	301
108	FIB.hepatic_stellate_cell	0.02	Nonsignificant	—	0.00	Other	64	252
109	EPI.colonic_enteroendocrine	0.01	Nonsignificant	—	0.23	Other	1	1
110	NEU.INH_VIP	0.01	Nonsignificant	0.97	0.91	Other	241	366
111	EPI.tracheal_submucosal_gland	0.01	Nonsignificant	—	0.11	Other	0	0
112	EPI.lung_multiciliated	0.01	Nonsignificant	1.00	0.69	Other	16	49
113	EC.lymphatic	0.01	Nonsignificant	0.97	0.94	Other	630	998
114	MESO.mesothelial_cell	0.01	Nonsignificant	—	—	Other	2	18
115	EPI.skin_keratinocyte_progenitor	0.01	Nonsignificant	—	0.07	Other	0	3
116	EPI.skin_hair_follicle_companion	9.64e-03	Nonsignificant	—	0.02	Other	8	12
117	EC.venous	9.15e-03	Nonsignificant	0.97	0.88	Other	516	1,387
118	EC.arterial	8.88e-03	Nonsignificant	0.97	0.94	Other	356	885
119	EPI.salivary_myoepithelial	8.74e-03	Nonsignificant	1.00	0.70	Other	191	714
120	EPI.renal_thick_ascending_limb	8.29e-03	Nonsignificant	1.00	0.68	Other	453	1,153
121	GRNLSA.granulosa_cell	6.93e-03	Nonsignificant	—	—	Other	257	0
122	CM.cardiomyocyte	5.39e-03	Nonsignificant	—	—	Other	524	2,032
123	NEU.EXC_CT	4.64e-03	Nonsignificant	0.97	0.91	Other	362	384
124	EPI.skin_keratinocyte_proliferating	4.45e-03	Nonsignificant	1.00	0.66	Other	47	76
125	EPI.salivary_duct_ion_transport	2.34e-03	Nonsignificant	1.00	0.60	Other	5	11
126	EC.heart_remodeling	2.07e-03	Nonsignificant	0.97	0.90	Other	569	1,594
127	NEU.EXC_IT	1.66e-03	Nonsignificant	0.33	1.05	Other	411	192
128	EPI.tracheal_suprabasal	1.44e-03	Nonsignificant	1.00	0.61	Other	29	56
129	HEP.canalicular_transport	1.41e-03	Nonsignificant	0.97	1.01	Other	1,290	3,434
130	EPI.skin_appendage_keratinocyte	1.40e-03	Nonsignificant	1.00	0.77	Other	87	222
131	EPI.thymic_medullary	1.38e-03	Nonsignificant	1.00	0.59	Other	26	133
132	EC.liver_sinusoidal	1.20e-03	Nonsignificant	0.97	0.79	Other	1,083	1,925
133	EPI.skin_sebaceous_duct_luminal	5.58e-04	Nonsignificant	1.00	0.68	Other	100	249
134	HEP.periportal_metabolic	5.24e-04	Nonsignificant	0.97	0.99	Other	1,750	4,427
135	EPI.pancreatic_ductal_mucinous	2.69e-04	Nonsignificant	1.00	0.59	Other	219	430
136	EPI.pancreatic_ductal_perivascular	2.42e-04	Nonsignificant	1.00	0.55	Other	4	30
137	EPI.skin_hair_follicle_bulge	1.31e-04	Nonsignificant	1.00	0.49	Other	51	178
138	EPI.endocervical_secretory	7.98e-05	Nonsignificant	—	0.00	Other	0	0
139	EPI.salivary_mucous_acinar	7.65e-05	Nonsignificant	1.00	0.44	Other	639	1,189
140	EPI.salivary_intercalated_defense	7.56e-05	Nonsignificant	1.00	0.53	Other	81	161
141	HEP.acute_phase	6.39e-05	Nonsignificant	0.97	0.92	Other	1,441	3,641
142	OPC.oligodendrocyte_precursor_cell	3.21e-05	Nonsignificant	—	—	Other	413	1,269
143	EPI.pancreatic_acinar	2.85e-05	Nonsignificant	1.00	0.52	Other	429	1,475
144	EPI.thymic_cortical	1.61e-05	Nonsignificant	1.00	0.57	Other	442	824
145	EPI.salivary_serous_acinar	1.39e-05	Nonsignificant	1.00	0.60	Other	233	531
146	EPI.salivary_duct_excretory	1.09e-05	Nonsignificant	1.00	0.41	Other	85	180
147	EPI.skin_keratinocyte_basal	1.05e-05	Nonsignificant	—	0.00	Other	13	26
148	EPI.pancreatic_ductal_progenitor	9.10e-06	Nonsignificant	1.00	0.40	Other	234	873
149	SKM.type_2_fast	3.18e-06	Nonsignificant	3.68e-06	1.06	Other	972	2,639
150	ASTRO.astrocyte	1.52e-06	Nonsignificant	—	—	Other	228	1,111
151	NEU.EXC_NTNG1	6.50e-12	Nonsignificant	—	0.00	Other	0	0
152	SKM.type_1_slow	5.08e-12	Nonsignificant	1.00	0.65	Other	923	2,478

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	DC.cDC1.homeostatic_inhibitory	29.95	Significant	—	1.21	Relevant	0	0
2	MONO.CD14.APC_like	23.60	Significant	6.60e-14	3.09	Specific	1,686	2,493
3	MONO.CD16.inflammatory	21.59	Significant	3.54e-09	2.77	—	1,640	168
4	T.CD4_Th2.tissue_adapted	21.59	Significant	—	0.97	—	0	0
5	MONO.CD14.remodeling	20.74	Significant	8.08e-07	2.08	—	2,373	295
6	DC.cDC2.monocyte_like	20.62	Significant	8.78e-03	1.94	—	1,285	791
7	THYMO.DP_early	19.15	Significant	5.67e-11	2.35	—	326	313
8	DC.cDC2.migratory	18.58	Significant	0.01	1.84	—	185	39
9	MAC.LAM.lipid_phagocytosis	17.83	Significant	1.96e-04	2.23	—	369	328
10	MONO.CD16.hepatic_mac_like	17.62	Significant	0.42	1.32	—	803	117
11	THYMO.SP_CD4_naive	17.44	Significant	0.78	1.11	—	65	75
12	MONO.CD14.baseline	17.32	Significant	1.00	0.82	—	2,268	76
13	HPC.MPP_activated	17.00	Significant	—	1.69	Relevant	0	0
14	MONO.CD14.platelet_bound	15.62	Significant	1.00	0.62	—	964	176
15	MONO.CD14.cord_tolerance	15.57	Significant	1.00	0.45	—	864	753
16	MONO.CD16.platelet_bound	15.49	Significant	0.81	1.02	Relevant	372	508
17	MAC.LAM.perivascular_angiocrine	14.95	Significant	—	0.74	—	53	138
18	DC.cDC1.activated	14.91	Significant	—	0.32	Relevant	0	0
19	MAC.LAM.antimicrobial	14.72	Significant	1.96e-04	2.15	—	389	93
20	THYMO.SP_CD8_naive	14.38	Significant	0.09	1.39	—	297	177
21	MONO.CD16.baseline	13.77	Significant	1.00	0.34	—	50	1
22	DC.cDC2.adhesion_signaling	13.43	Significant	0.94	1.00	—	35	9
23	MONO.CD16.patrolling	12.66	Significant	1.00	0.24	—	797	216
24	MAC.MDM.inflammatory_phagocytic	11.79	Significant	0.44	1.43	—	199	52
25	DC.cDC1.cross_presenting	11.70	Significant	—	0.00	—	0	0
26	DC.cDC2.tolerogenic_regulatory	10.93	Significant	0.94	0.48	—	44	4
27	DC.cDC1.proliferative	10.63	Significant	—	0.00	Relevant	0	0
28	MAC.LAM.anti_inflammatory	10.51	Significant	1.00	0.90	Relevant	86	132
29	DC.mig.baseline	10.27	Significant	—	0.00	—	1	0
30	MAC.proliferating.stress	10.14	Significant	—	0.24	Relevant	87	136
31	DC.cDC2.pro_inflammatory	10.11	Significant	0.94	0.47	—	3	5
32	DC.cDC2.antiviral	9.98	Significant	0.94	0.57	—	100	37
33	MAC.MDM.APC_dendritic	9.95	Significant	0.94	1.01	—	48	15
34	MAC.MDM.complement_resolving	9.59	Significant	0.94	0.75	Relevant	440	860
35	THYMO.SP_CD8_naive_stress	9.51	Significant	1.00	0.57	—	1	1
36	THYMO.proliferative_G2M	9.39	Significant	—	0.00	—	164	413
37	MAC.LAM.inflammatory_APC	9.10	Significant	1.00	0.13	—	872	165
38	ASPC.stem_like_progenitor	9.03	Significant	6.98e-07	1.96	Specific	300	842
39	MAC.proliferating.DNA_replication	8.81	Significant	0.42	1.11	Relevant	3	6
40	DC.cDC2.proliferative	8.69	Significant	—	0.00	Relevant	39	71
41	THYMO.CD8aa_IELp	8.34	Significant	—	0.00	—	1	7
42	MAC.microglia_like.phagocytic_redox	8.07	Significant	—	0.52	—	0	0
43	MAC.microglia_like.inflammatory_chemokine	7.62	Significant	—	0.00	Relevant	20	32
44	MAC.LAM.lipid_opsonization	7.53	Significant	1.00	0.61	—	45	14
45	MAC.resident_cardiac.phagocytic_homeostasis	7.31	Significant	0.08	1.88	Specific	564	1,221
46	MAC.MDM.LAM_like	7.03	Significant	0.94	0.36	Relevant	12	14
47	MAC.resident_cardiac.antigen_presenting	7.00	Significant	0.88	0.69	—	52	27
48	HPC.CLP_B_primed	6.58	Significant	—	0.69	Relevant	0	0
49	PLAT.megakaryocytic	6.51	Significant	—	0.97	Relevant	0	0
50	MAC.resident_repair.lipid_phagocytic	6.34	Significant	0.43	1.53	Other	228	604
51	FIB.barrier_secretory.remodeling	6.26	Significant	—	0.38	Relevant	0	0
52	MAC.resident_iron.redox_metabolic	6.21	Significant	0.32	1.34	Other	4	4
53	B.germinal_center.DZ_M_phase	6.13	Significant	—	1.47	Relevant	0	0
54	HPC.MEP	6.05	Significant	0.77	1.15	Other	599	1,195
55	B.memory.pDC_imprint	5.99	Significant	2.15e-03	2.20	Specific	157	103
56	DC.cDC1.baseline	5.93	Significant	—	0.00	Relevant	0	0
57	GRANU.MAST.activated_repair	5.93	Significant	—	0.47	Relevant	0	1
58	MAC.resident_cardiac.inflammatory_reparative	5.85	Significant	0.88	0.49	Relevant	31	96
59	B.germinal_center.LZ_survival	5.81	Significant	—	0.37	Relevant	0	0
60	ILC2.migratory	5.64	Significant	—	1.03	Relevant	0	0
61	B.germinal_center.DZ_S_phase	5.61	Significant	—	0.21	Relevant	0	0
62	B.germinal_center.LZ_memory_precursor	5.56	Significant	—	0.00	Relevant	0	0
63	HPC.GMP_inflammatory	5.33	Nominal	0.77	0.94	Other	20	10
64	MAC.resident_iron.heme_catabolism	5.12	Nominal	0.32	1.38	Other	30	51
65	GRANU.MAST.activated_acute	4.99	Nominal	—	0.00	Relevant	0	0
66	FIB.interstitial.lipid_matrix	4.99	Nominal	9.32e-04	1.68	Other	258	191
67	HPC.LMPP	4.95	Nominal	0.77	0.98	Other	65	31
68	MAC.resident_repair.chemokine_angiocrine	4.94	Nominal	0.43	1.27	Other	87	138
69	FIB.barrier_secretory.homeostasis	4.75	Nominal	—	0.00	Other	0	0
70	B.memory.migratory	4.66	Nominal	0.77	0.90	Other	123	208
71	ILC2.activated	4.64	Nominal	—	6.94e-17	Other	0	0
72	B.memory.baseline	4.63	Nominal	0.38	1.26	Other	472	99
73	MAC.microglia_like.patrolling_adhesive	4.40	Nominal	—	0.00	Other	0	0
74	THYMO.DP_early_stress	4.39	Nominal	—	0.00	Other	0	0
75	B.memory.preactivated	4.34	Nominal	0.53	1.15	Other	173	174
76	FIB.interstitial.stress_secretory	4.32	Nominal	0.38	1.33	Other	92	56
77	T.CD4_Treg.Tr1_like	4.22	Nominal	—	1.22	Other	8	8
78	MAC.resident_iron.APC_iron_sensing	4.12	Nominal	0.58	0.93	Other	211	114
79	B.germinal_center.LZ_selection	4.09	Nominal	—	0.00	Other	0	0
80	ASPC.inflammatory	3.89	Nominal	0.63	1.26	Other	21	61
81	GRANU.MAST.resting_granule	3.85	Nominal	—	0.00	Other	0	0
82	MAC.kupffer.metabolic	3.81	Nominal	—	1.04	Other	25	36
83	B.age_associated.naive_transitional	3.69	Nominal	—	0.25	Other	0	0
84	THYMO.SP_CD8_transitional	3.64	Nominal	1.00	0.44	Other	32	75
85	MAC.resident_repair.ECM_stromal_crosstalk	3.56	Nominal	0.87	0.79	Other	95	158
86	B.age_associated.migratory	3.50	Nominal	0.59	0.80	Other	2	2
87	MAC.resident_repair.antigen_presenting	3.49	Nominal	0.87	0.64	Other	244	113
88	B.age_associated.activated	3.42	Nominal	—	0.00	Other	18	22
89	ASPC.baseline	3.21	Nominal	2.76e-04	1.44	Other	363	170
90	FIB.lung_alveolar.mito_secretory	3.20	Nominal	—	0.48	Other	0	0
91	GRANU.neutrophil.tissue_patrolling	3.17	Nominal	—	1.28	Other	0	0
92	MAC.resident_iron.heme_recycling	3.15	Nominal	—	0.00	Other	30	37
93	MONO.CD14.repair_M2_like	3.11	Nominal	1.00	0.00	Other	550	1,495
94	B.naive.purinergic	3.00	Nominal	0.27	1.58	Other	384	820
95	B.naive.proteostasis	2.96	Nonsignificant	0.48	1.45	Other	49	69
96	B.memory.activated	2.96	Nonsignificant	1.00	0.11	Other	105	29
97	MAC.resident_repair.stress_iron	2.96	Nonsignificant	0.87	0.80	Other	48	97
98	B.naive.remodeling	2.95	Nonsignificant	1.00	1.02	Other	135	230
99	B.naive.restrained	2.93	Nonsignificant	1.00	1.10	Other	183	353
100	HPC.GMP_granulocytic	2.85	Nonsignificant	—	0.00	Other	3	3
101	T.CD8_Tcm.NK_like	2.82	Nonsignificant	7.13e-03	1.77	Other	334	581
102	T.CD4_Treg.APC_interactive	2.79	Nonsignificant	0.09	1.50	Other	118	28
103	EPI.colonocyte.ionocyte_BEST4	2.76	Nonsignificant	5.31e-05	2.24	Other	103	188
104	B.naive.antigen_presenting_ready	2.75	Nonsignificant	1.00	0.71	Other	48	73
105	FIB.interstitial.mesenchymal_APC	2.72	Nonsignificant	1.00	0.77	Other	81	33
106	GRANU.neutrophil.antiviral_endotoxin	2.72	Nonsignificant	—	0.26	Other	0	0
107	ASPC.niche_keeping_progenitor	2.72	Nonsignificant	0.96	1.08	Other	52	219
108	PLAT.adhesion	2.72	Nonsignificant	—	0.00	Other	0	0
109	FIB.neurolectin_mucosa.inflammatory	2.71	Nonsignificant	0.24	1.56	Other	52	110
110	MAC.kupffer.monocyte_like	2.66	Nonsignificant	—	0.58	Other	0	0
111	B.naive.activated	2.64	Nonsignificant	1.00	0.63	Other	77	127
112	B.naive.receptor_recycle	2.61	Nonsignificant	1.00	0.58	Other	51	0
113	FIB.neurolectin_mucosa.axon_responsive	2.61	Nonsignificant	0.27	1.31	Other	10	10
114	FIB.lung_alveolar.stress_interacting	2.60	Nonsignificant	—	0.00	Other	0	0
115	ILC2.quiescent	2.58	Nonsignificant	—	0.00	Other	0	0
116	THYMO.proliferative_S	2.58	Nonsignificant	1.00	0.04	Other	163	418
117	EPI.extrahepatic_cholangiocyte.barrier_interface	2.52	Nonsignificant	—	0.73	Other	0	0
118	MONO.CD14.inflammatory	2.50	Nonsignificant	1.00	0.04	Other	92	134
119	HPC.MPP_IEG	2.49	Nonsignificant	0.97	0.23	Other	45	46
120	T.CD4_Th2.precursor	2.35	Nonsignificant	—	0.00	Other	0	0
121	GRANU.neutrophil.primed_degranulation	2.30	Nonsignificant	—	0.00	Other	0	0
122	FIB.interstitial.immune_interact	2.26	Nonsignificant	1.00	0.78	Other	12	1
123	EPI.alveolar_type_1.activated	2.25	Nonsignificant	—	1.64	Other	0	0
124	B.naive.metabolic	2.24	Nonsignificant	1.00	0.18	Other	50	79
125	MAC.kupffer.stress	2.19	Nonsignificant	0.56	0.95	Other	9	3
126	T.CD4_naive.gut_prone	2.11	Nonsignificant	8.59e-03	1.73	Other	35	70
127	ASPC.proliferative	2.10	Nonsignificant	1.00	0.87	Other	33	85
128	B.naive.baseline	2.04	Nonsignificant	1.00	0.17	Other	10	13
129	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	2.01	Nonsignificant	—	1.59	Other	0	0
130	FIB.neurolectin_mucosa.remodeling_repair	1.97	Nonsignificant	—	0.00	Other	4	2
131	ASPC.secretory	1.96	Nonsignificant	1.00	0.68	Other	76	5
132	MAC.resident_iron.stress_tolerogenic	1.92	Nonsignificant	—	0.00	Other	0	0
133	T.CD4_Treg.central_naive_like	1.89	Nonsignificant	0.99	0.35	Other	333	45
134	FIB.neurolectin_mucosa.nerve_interface	1.88	Nonsignificant	—	0.00	Other	4	0
135	FIB.interstitial.mesenchymal_regulator	1.84	Nonsignificant	1.00	0.83	Other	4	4
136	DC.cDC2.lipid_metabolic	1.83	Nonsignificant	—	0.00	Other	0	0
137	NK.cytokine_tissue_resident	1.80	Nonsignificant	6.33e-03	1.86	Other	74	82
138	MAC.kupffer.inflammatory	1.71	Nonsignificant	—	0.00	Other	7	4
139	T.CD4_Tfh.effector_migratory	1.70	Nonsignificant	3.57e-03	1.80	Other	122	57
140	ASPC.preadipocyte_lipid_primed	1.70	Nonsignificant	1.00	0.40	Other	331	129
141	EPI.colonocyte.distal_absorptive	1.68	Nonsignificant	—	1.32	Other	0	0
142	EPI.bile_duct_cholangiocyte.inflammatory_APC	1.64	Nonsignificant	—	0.76	Other	2	0
143	MG.expanding	1.62	Nonsignificant	0.20	1.43	Other	2	1
144	EPI.hepatic_ductular_cholangiocyte.ion_transport	1.60	Nonsignificant	—	1.01	Other	0	0
145	ASPC.remodeling	1.60	Nonsignificant	1.00	0.44	Other	106	354
146	T.CD4_Treg.tissue_effector	1.57	Nonsignificant	0.99	0.38	Other	16	13
147	T.CD4_transitional.APC_interacting	1.49	Nonsignificant	0.26	1.51	Other	10	14
148	T.CD8_Trm.dendritic_recruiter	1.44	Nonsignificant	0.19	1.42	Other	47	85
149	T.CD4_Tfh.suppression_exhaustion	1.39	Nonsignificant	0.99	1.02	Other	0	2
150	MAC.kupffer.tolerogenic	1.31	Nonsignificant	—	0.00	Other	45	49
151	T.CD8_Tcm.baseline	1.30	Nonsignificant	0.14	1.35	Other	90	89
152	T.CD4_Trm.stress_adaptive	1.28	Nonsignificant	0.32	1.44	Other	8	22
153	FIB.interstitial.remodeling	1.23	Nonsignificant	1.00	0.09	Other	31	9
154	MG.phagocytic_APC	1.23	Nonsignificant	0.20	1.45	Other	25	8
155	T.CD4_Trm.metal_stress	1.22	Nonsignificant	0.63	1.19	Other	34	58
156	EPI.renal_distal_tubule.ion_transport	1.20	Nonsignificant	—	0.49	Other	0	0
157	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	1.20	Nonsignificant	—	0.73	Other	0	0
158	NK.cytokine_lung_immediate_early	1.16	Nonsignificant	1.30e-04	1.97	Other	424	274
159	NK.cytokine_tissue_activation	1.15	Nonsignificant	0.02	1.75	Other	267	450
160	T.CD4_Tcm.APC_mimicry	1.14	Nonsignificant	1.40e-03	1.83	Other	54	43
161	EPI.ectocervical_granular.inflammatory	1.13	Nonsignificant	—	1.15	Other	0	0
162	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	1.12	Nonsignificant	—	0.07	Other	5	3
163	SMC.contractile	1.12	Nonsignificant	0.35	1.33	Other	80	588
164	ASPC.adipocyte_capillary_interface	1.12	Nonsignificant	1.00	0.31	Other	21	54
165	T.CD4_Trm.activated	1.07	Nonsignificant	0.63	1.15	Other	32	26
166	THYMO.DN_preTCR	1.06	Nonsignificant	1.00	0.02	Other	41	71
167	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	1.06	Nonsignificant	—	0.15	Other	6	9
168	ASPC.activated	1.03	Nonsignificant	1.00	0.28	Other	164	162
169	SMC.activated	1.02	Nonsignificant	0.37	1.18	Other	2	5
170	EPI.hepatic_ductular_cholangiocyte.secretory_transport	1.00	Nonsignificant	—	0.00	Other	0	0
171	T.CD4_transitional.tissue_enagement	0.99	Nonsignificant	0.86	0.99	Other	5	11
172	EPI.ileal_bile_transport.detox_transcytosis	0.99	Nonsignificant	—	0.45	Other	0	1
173	PERI.inflammatory	0.98	Nonsignificant	7.39e-04	1.86	Other	40	77
174	FIB.skin_neurosecretory.baseline	0.98	Nonsignificant	—	0.00	Other	0	0
175	T.CD8_Trm.inflammatory	0.97	Nonsignificant	0.70	1.09	Other	124	176
176	EPI.cervical_suprabasal.secretory_vesicle	0.95	Nonsignificant	—	0.42	Other	0	0
177	EPI.renal_proximal_tubule.detox_antioxidant	0.94	Nonsignificant	2.88e-05	3.08	Other	394	77
178	EPI.ectocervical_granular.secretory_apocrine	0.94	Nonsignificant	—	0.32	Other	0	0
179	T.CD8_Trm.homeostatic	0.94	Nonsignificant	0.70	1.03	Other	42	5
180	T.CD4_Trm.cytotoxic_effector	0.93	Nonsignificant	0.32	1.30	Other	118	77
181	EPI.colonocyte.crypt_progenitor	0.91	Nonsignificant	0.88	1.11	Other	115	265
182	FIB.reticular.ECM_builder	0.89	Nonsignificant	—	0.37	Other	0	0
183	MAC.kupffer.fibrogenic	0.88	Nonsignificant	—	0.00	Other	0	0
184	T.CD4_transitional.primed_helper_effector	0.87	Nonsignificant	0.74	1.15	Other	19	43
185	EPI.ileal_bile_transport.absorptive_xenobiotic	0.86	Nonsignificant	0.78	0.60	Other	11	12
186	EPI.hepatic_ductular_cholangiocyte.stress	0.85	Nonsignificant	—	0.00	Other	0	0
187	T.CD4_Trm.baseline	0.85	Nonsignificant	0.99	0.86	Other	31	21
188	FIB.transitioning.motility_remodelling	0.85	Nonsignificant	—	0.47	Other	0	0
189	T.CD8_Tcm.helper_like	0.84	Nonsignificant	0.90	0.89	Other	81	159
190	T.CD8_Tcm.effector_bias	0.84	Nonsignificant	0.90	0.87	Other	199	329
191	ASPC.mesothelial_like	0.84	Nonsignificant	1.00	1.04	Other	143	486
192	T.CD8_naive.effector_transition	0.82	Nonsignificant	0.32	1.25	Other	35	62
193	EPI.alveolar_type_1.baseline	0.82	Nonsignificant	1.00	0.00	Other	8	0
194	NK.immature_bridge	0.81	Nonsignificant	1.73e-04	1.75	Other	117	122
195	T.CD4_Tem.transitional_CM	0.78	Nonsignificant	0.21	1.21	Other	31	20
196	MG.baseline	0.77	Nonsignificant	1.00	0.19	Other	16	5
197	T.CD8_naive.lipid_synthesis	0.77	Nonsignificant	0.32	1.39	Other	6	4
198	EC.capillary.angiogenic_tip	0.77	Nonsignificant	0.07	1.34	Other	186	218
199	FIB.reticular.stress_metallothionein	0.75	Nonsignificant	—	0.60	Other	3	32
200	EPI.hepatic_ductular_cholangiocyte.polarity	0.74	Nonsignificant	—	0.00	Other	0	0
201	T.CD4_Tfh.precursor_migratory	0.72	Nonsignificant	0.99	0.65	Other	72	27
202	OLG.reactive_repair	0.71	Nonsignificant	0.02	1.41	Other	385	385
203	FIB.transitioning.ISG_primed_interface	0.71	Nonsignificant	—	0.00	Other	17	80
204	NEU.INH_LAMP5.glial_interface	0.71	Nonsignificant	—	1.02	Other	0	0
205	EPI.colonocyte.junction_remodeling	0.71	Nonsignificant	1.00	0.58	Other	218	305
206	T.CD4_naive.proteostasis	0.68	Nonsignificant	0.21	1.41	Other	14	9
207	CHOND.angiogenic	0.68	Nonsignificant	—	2.48	Other	0	0
208	FIB.tracheal_subepithelial.baseline	0.67	Nonsignificant	—	0.00	Other	0	0
209	T.CD8_naive.splicing_enriched	0.66	Nonsignificant	0.27	1.32	Other	120	16
210	T.CD8_naive.vesicle_secretory	0.66	Nonsignificant	0.48	1.17	Other	42	0
211	EPI.colonocyte.proximal_transport	0.65	Nonsignificant	1.00	0.47	Other	24	12
212	EPI.cervical_suprabasal.inflammatory_repair	0.63	Nonsignificant	—	0.00	Other	0	0
213	MAC.alveolar.stress_metabolic	0.63	Nonsignificant	0.15	1.74	Other	116	148
214	NEU.INH_LAMP5.projecting	0.62	Nonsignificant	—	0.58	Other	0	0
215	T.CD4_Trm.central_like	0.62	Nonsignificant	0.99	0.63	Other	38	31
216	FIB.reticular.immune_interface	0.62	Nonsignificant	—	0.00	Other	1	6
217	PERI.baseline	0.61	Nonsignificant	0.01	1.63	Other	39	66
218	SMC.metabolic	0.61	Nonsignificant	1.00	0.26	Other	14	40
219	MAC.alveolar.scavenging_endocytic	0.61	Nonsignificant	—	0.51	Other	140	283
220	T.CD4_naive.Treg_like	0.60	Nonsignificant	0.25	1.48	Other	121	72
221	T.CD4_Tcm.migratory_cilium	0.59	Nonsignificant	0.44	1.38	Other	5	10
222	T.CD4_transitional.baseline	0.58	Nonsignificant	0.97	0.57	Other	59	97
223	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.58	Nonsignificant	1.00	0.00	Other	58	89
224	EPI.ectocervical_granular.immune_interact	0.57	Nonsignificant	—	0.00	Other	0	0
225	FIB.reticular.stromal_niche	0.56	Nonsignificant	0.90	0.48	Other	0	0
226	FIB.skin_tenogenic.baseline	0.56	Nonsignificant	—	0.00	Other	0	2
227	PC.IgA_muocsal.plasmablast	0.56	Nonsignificant	0.04	1.50	Other	5	4
228	FIB.transitioning.matrix_stress	0.55	Nonsignificant	—	0.19	Other	47	138
229	T.CD4_Tfh.canonical_GC_helper	0.55	Nonsignificant	0.99	0.13	Other	1	2
230	MAC.alveolar.inflammatory	0.55	Nonsignificant	0.82	1.07	Other	208	312
231	NEU.INH_LAMP5.rosehip	0.55	Nonsignificant	—	0.27	Other	0	0
232	T.CD4_Tem.inflammatory	0.54	Nonsignificant	0.21	1.19	Other	28	6
233	T.CD8_Trm.cytotoxic	0.54	Nonsignificant	1.00	0.77	Other	165	85
234	T.CD4_Tcm.Tfh_like	0.54	Nonsignificant	1.00	1.07	Other	102	214
235	OLG.myelinating_stress	0.52	Nonsignificant	0.13	1.19	Other	232	62
236	T.CD4_naive.proteostasis_mitoprot	0.52	Nonsignificant	0.32	1.30	Other	15	37
237	EPI.alveolar_type_2.baseline_surfactant	0.52	Nonsignificant	0.45	1.28	Other	64	9
238	T.CD4_Tem.cytotoxic_effector	0.52	Nonsignificant	0.21	1.27	Other	225	398
239	T.CD8_naive.baseline	0.51	Nonsignificant	0.91	0.91	Other	142	2
240	NK.adaptive_immature_precursor	0.50	Nonsignificant	0.09	1.48	Other	358	111
241	EPI.renal_principal_cell.canonical_vasopressin	0.49	Nonsignificant	0.48	1.40	Other	2	0
242	T.CD4_Th17.migratory	0.49	Nonsignificant	0.31	1.34	Other	13	23
243	EPI.ileal_enterocyte_absorptive.villus_tip	0.49	Nonsignificant	5.72e-07	3.45	Other	4	3
244	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.49	Nonsignificant	—	0.00	Other	0	0
245	T.CD4_Tcm.baseline	0.49	Nonsignificant	0.90	1.18	Other	61	31
246	MAC.alveolar.capillary_interacting	0.49	Nonsignificant	0.82	0.81	Other	113	181
247	T.CD4_Tcm.DC_interact	0.48	Nonsignificant	0.90	1.19	Other	72	32
248	T.CD4_transitional.primed_cytotoxic	0.48	Nonsignificant	0.97	0.48	Other	28	30
249	PERI.angiocrine	0.48	Nonsignificant	1.00	0.65	Other	93	102
250	T.CD8_naive.cytokine_dampened	0.48	Nonsignificant	0.91	0.84	Other	71	4
251	T.CD4_Tcm.synapse_dynamics	0.48	Nonsignificant	1.00	1.00	Other	15	10
252	MAC.alveolar.biosynthetic_sterol_heme	0.47	Nonsignificant	0.82	0.62	Other	347	40
253	EPI.renal_distal_tubule.ciliated_remodelling	0.47	Nonsignificant	—	0.67	Other	0	0
254	MUSC.baseline	0.45	Nonsignificant	0.92	1.22	Other	0	0
255	T.CD4_Trm.helper_like	0.44	Nonsignificant	0.99	0.29	Other	84	147
256	OLG.myelinating_mature	0.43	Nonsignificant	0.02	1.20	Other	363	94
257	T.CD8_naive.innate_like	0.42	Nonsignificant	0.86	0.96	Other	10	1
258	MUSC.activated_migratory	0.42	Nonsignificant	0.92	0.92	Other	6	7
259	OLG.vesicle_trafficking	0.42	Nonsignificant	0.13	1.22	Other	124	10
260	MUSC.early_activation	0.41	Nonsignificant	0.92	0.80	Other	4	32
261	PC.IgG_systemic.metabolic	0.41	Nonsignificant	0.28	1.30	Other	46	63
262	EPI.bile_duct_cholangiocyte.secretory_mucin	0.41	Nonsignificant	—	0.00	Other	7	12
263	PERI.cardiac_skeletal	0.41	Nonsignificant	1.00	0.27	Other	313	630
264	IPSC.endoderm_primed	0.41	Nonsignificant	0.90	1.01	Other	0	0
265	T.CD8_naive.nfkb_related	0.40	Nonsignificant	0.91	0.64	Other	1	0
266	FIB.skin_sheath.neuro_vascular_interface	0.39	Nonsignificant	—	6.94e-17	Other	0	0
267	T.MAIT.migratory	0.39	Nonsignificant	0.03	1.86	Other	10	1
268	FIB.skin_sheath.ECM_immune	0.38	Nonsignificant	—	0.35	Other	0	0
269	ASPC.signal_integrator	0.38	Nonsignificant	—	0.00	Other	0	0
270	EPI.renal_distal_tubule.immune_modulatory	0.38	Nonsignificant	—	0.71	Other	0	0
271	T.CD4_cytotoxic.NK_adapted	0.38	Nonsignificant	0.10	1.50	Other	82	33
272	FIB.skin_sheath.stress_chaperone	0.38	Nonsignificant	—	0.00	Other	0	0
273	T.CD4_Tcm.effector_like	0.38	Nonsignificant	0.90	1.14	Other	293	533
274	MAC.alveolar.lipid_autophagy	0.37	Nonsignificant	—	0.00	Other	35	44
275	IPSC.proliferative	0.37	Nonsignificant	3.60e-07	1.26	Other	0	0
276	T.CD8_naive.mito_proteostasis	0.36	Nonsignificant	0.57	1.13	Other	428	100
277	SCHWN.reactive_inflammatory	0.36	Nonsignificant	—	1.14	Other	0	0
278	T.CD4_naive.resist_bystander	0.35	Nonsignificant	0.36	1.22	Other	40	25
279	T.CD8_transitional.effector_primed	0.35	Nonsignificant	0.11	1.19	Other	435	151
280	T.CD4_Tcm.tissue_homing	0.35	Nonsignificant	1.00	0.64	Other	78	46
281	EPI.ileal_enterocyte_absorptive.brush_border	0.35	Nonsignificant	1.00	0.00	Other	580	1,717
282	T.CD8_transitional.early	0.35	Nonsignificant	0.11	1.18	Other	327	55
283	NK.cytokine_axis_baseline	0.35	Nonsignificant	1.00	0.79	Other	1,172	116
284	T.CD8_Trm.muscosal_Tc17	0.35	Nonsignificant	1.00	0.28	Other	19	38
285	FIB.transitioning.secretory_procollagen	0.34	Nonsignificant	—	0.00	Other	0	0
286	T.CD4_Tcm.Th2_like	0.34	Nonsignificant	1.00	0.68	Other	23	55
287	FIB.suburothelial.contractile_myofibroblast	0.33	Nonsignificant	—	0.83	Other	9	0
288	PC.IgG_systemic.secretory	0.33	Nonsignificant	0.59	0.94	Other	0	0
289	NK.adaptive_adipose_stress	0.32	Nonsignificant	1.00	0.86	Other	374	39
290	EPI.alveolar_type_2.stress_response	0.32	Nonsignificant	0.74	0.87	Other	675	1,562
291	T.CD4_Tcm.crosstalk_myeloid	0.32	Nonsignificant	1.00	0.69	Other	5	4
292	OLG.stress	0.32	Nonsignificant	1.00	0.86	Other	232	8
293	EPI.colonic_tuft.activated	0.31	Nonsignificant	—	0.00	Other	0	0
294	T.CD4_Tcm.imprinted_splicing	0.31	Nonsignificant	1.00	0.98	Other	6	17
295	PC.IgG_systemic.interacting	0.31	Nonsignificant	0.28	1.40	Other	0	0
296	EPI.skin_interfollicular_spinous.upper_lipid	0.30	Nonsignificant	—	1.49	Other	6	6
297	NK.adaptive_axis_baseline	0.30	Nonsignificant	1.00	0.87	Other	1,008	153
298	T.gamma_delta.early_effector	0.30	Nonsignificant	0.22	1.31	Other	89	0
299	FIB.perivascular_interface.vascular_BM_remodelling	0.30	Nonsignificant	—	0.97	Other	0	0
300	T.CD4_Tcm.RNA_control	0.30	Nonsignificant	1.00	0.59	Other	96	4
301	FIB.suburothelial.inflammatory_prostanoid	0.29	Nonsignificant	—	0.33	Other	0	0
302	FIB.skin_papillary.baseline	0.29	Nonsignificant	—	0.00	Other	0	0
303	T.CD4_Th17.baseline	0.29	Nonsignificant	0.88	0.78	Other	51	5
304	MUSC.quiescent_reservoir	0.29	Nonsignificant	0.97	0.26	Other	2	8
305	EPI.alveolar_type_2.injury_primed	0.29	Nonsignificant	0.74	0.91	Other	434	245
306	PC.IgA_muocsal.baseline	0.29	Nonsignificant	0.52	1.05	Other	3	5
307	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	0.29	Nonsignificant	—	0.42	Other	0	0
308	T.CD4_Tcm.secretory	0.29	Nonsignificant	1.00	0.81	Other	20	11
309	T.CD8_transitional.Trm_primed	0.28	Nonsignificant	0.72	0.99	Other	108	15
310	T.CD4_naive.survival_neddylation	0.28	Nonsignificant	1.00	1.00	Other	26	38
311	NK.cytokine_biosynthetic_primed	0.28	Nonsignificant	1.00	0.57	Other	360	21
312	T.CD4_cytotoxic.activated	0.28	Nonsignificant	0.43	1.28	Other	3	1
313	T.CD8_transitional.stress	0.27	Nonsignificant	—	0.48	Other	24	34
314	EPI.colonic_tuft.homeostatic	0.27	Nonsignificant	—	0.00	Other	0	0
315	FIB.suburothelial.homeostasis_matrix	0.27	Nonsignificant	0.58	1.26	Other	258	921
316	FIB.adventitial.inflammatory_activated	0.27	Nonsignificant	0.24	1.08	Other	100	473
317	T.CD4_naive.neddylation	0.27	Nonsignificant	0.95	1.05	Other	104	222
318	T.CD4_Th17.cytotoxic	0.26	Nonsignificant	0.88	0.68	Other	332	123
319	NEU.INH_LAMP5.exc_inh_balance	0.26	Nonsignificant	—	0.00	Other	46	2
320	NK.cytokine_vascular_patrolling	0.26	Nonsignificant	1.00	0.49	Other	863	94
321	EPI.colonocyte.secretory_boost	0.26	Nonsignificant	1.00	0.04	Other	98	91
322	PC.IgA_muocsal.activated	0.26	Nonsignificant	0.93	0.77	Other	17	8
323	T.CD8_Tcm.gut_homing	0.25	Nonsignificant	1.00	0.02	Other	380	112
324	NK.cytokine_quiescent	0.25	Nonsignificant	1.00	0.62	Other	623	1,062
325	NK.adaptive_HLAE_tuned	0.25	Nonsignificant	1.00	0.59	Other	1,124	189
326	EPI.renal_principal_cell.inflammatory	0.25	Nonsignificant	0.48	1.35	Other	74	157
327	T.CD8_Tem.early_helper_like	0.25	Nonsignificant	0.16	1.33	Other	445	755
328	EPI.ileal_enterocyte_crypt.villus_transition	0.24	Nonsignificant	—	0.89	Other	7	10
329	PC.IgA_muocsal.migratory	0.24	Nonsignificant	0.49	1.10	Other	4	1
330	NK.cytokine_repair_primed	0.24	Nonsignificant	1.00	0.48	Other	266	11
331	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	0.23	Nonsignificant	—	0.32	Other	0	0
332	T.MAIT.MAPK_brake	0.23	Nonsignificant	0.85	1.23	Other	44	66
333	NK.adaptive_biosynthetic_primed	0.23	Nonsignificant	1.00	0.58	Other	244	405
334	EPI.ileal_goblet.immature	0.23	Nonsignificant	—	1.22	Other	0	0
335	T.gamma_delta.central_memory	0.23	Nonsignificant	0.78	1.01	Other	460	919
336	T.CD8_Tem.stress_adapted	0.23	Nonsignificant	0.66	0.99	Other	607	520
337	T.CD4_naive.mature	0.23	Nonsignificant	1.00	0.85	Other	211	100
338	DC.pDC.poised_migratory	0.23	Nonsignificant	0.13	1.21	Other	54	95
339	T.CD4_naive.purinergic	0.22	Nonsignificant	1.00	0.81	Other	49	1
340	T.CD4_naive.neddylation_mitoprot	0.22	Nonsignificant	1.00	0.90	Other	93	56
341	T.CD8_Tem.baseline	0.22	Nonsignificant	0.66	1.01	Other	458	356
342	NK.adaptive_classII_inhibitory	0.21	Nonsignificant	1.00	0.38	Other	880	154
343	T.CD4_Tcm.regulatory_poised	0.21	Nonsignificant	1.00	0.71	Other	2	3
344	EC.capillary.activated	0.21	Nonsignificant	0.76	1.26	Other	2	5
345	T.CD4_naive.mature_mitoprot	0.20	Nonsignificant	1.00	0.80	Other	212	476
346	FIB.perivascular_interface.vasomotor_tone	0.20	Nonsignificant	—	0.00	Other	0	0
347	T.CD8_Tem.TEMRA	0.20	Nonsignificant	0.63	1.08	Other	920	1,088
348	EPI.colonocyte.goblet_interface	0.20	Nonsignificant	—	0.00	Other	11	21
349	T.CD4_Tem.long_term_memory	0.19	Nonsignificant	1.00	0.27	Other	314	587
350	T.CD8_Tem.signaling_turnover	0.19	Nonsignificant	0.63	1.17	Other	425	683
351	FIB.perivascular_interface.lipid_shuttle	0.19	Nonsignificant	—	0.00	Other	51	170
352	EPI.esophageal_suprabasal.proliferative_S	0.19	Nonsignificant	—	0.41	Other	26	41
353	T.gamma_delta.cytotoxic_effector	0.18	Nonsignificant	0.83	0.78	Other	349	109
354	MEL.neurotrophic_migratory	0.18	Nonsignificant	—	1.55	Other	0	0
355	EPI.esophageal_suprabasal.proliferative_G2M	0.18	Nonsignificant	—	0.51	Other	0	0
356	FIB.adventitial.PI16_matrix	0.18	Nonsignificant	0.24	1.09	Other	70	90
357	T.CD4_Tcm.retro_ZNF117	0.18	Nonsignificant	1.00	0.26	Other	5	9
358	EPI.ileal_enterocyte_crypt.bile_transport	0.18	Nonsignificant	0.49	1.03	Other	2	0
359	HEP.pericentral_lipoprotein.UPR_redox	0.17	Nonsignificant	—	0.67	Other	0	0
360	T.MAIT.vesicle	0.17	Nonsignificant	0.96	0.56	Other	37	65
361	IPSC.mesendo_primed	0.17	Nonsignificant	0.81	1.03	Other	0	0
362	IPSC.axial_identity_primed	0.17	Nonsignificant	0.99	0.98	Other	0	0
363	T.MAIT.early_activation	0.17	Nonsignificant	0.96	0.67	Other	57	4
364	T.CD4_naive.homeostatic	0.17	Nonsignificant	1.00	0.70	Other	215	108
365	T.CD4_naive.survival	0.17	Nonsignificant	1.00	0.71	Other	12	17
366	IPSC.canonical_pluripotent	0.16	Nonsignificant	0.85	1.01	Other	0	0
367	T.MAIT.quiescent	0.16	Nonsignificant	0.96	0.38	Other	100	5
368	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.16	Nonsignificant	0.45	1.25	Other	14	32
369	EPI.skin_follicular_keratinizing.transit_amplifying	0.16	Nonsignificant	—	0.00	Other	21	49
370	FIB.suburothelial.urothelial_interface	0.16	Nonsignificant	0.93	0.28	Other	9	8
371	NEU.INH_PVALB.metabotropic	0.16	Nonsignificant	—	0.84	Other	0	0
372	EPI.esophageal_suprabasal.differentiating_keratin	0.15	Nonsignificant	0.78	0.97	Other	131	61
373	T.MAIT.cytotoxic	0.15	Nonsignificant	0.96	0.56	Other	52	15
374	HEP.pericentral_lipoprotein.ApoB_coagulation	0.15	Nonsignificant	—	0.00	Other	0	0
375	EPI.skin_follicular_keratinizing.upper_infundibulum	0.15	Nonsignificant	—	0.31	Other	8	2
376	EPI.skin_sweat_duct_keratinocyte.barrier	0.15	Nonsignificant	—	1.52	Other	0	0
377	EPI.renal_distal_tubule.stress	0.14	Nonsignificant	—	0.00	Other	0	0
378	T.CD8_Tem.motility_primed	0.14	Nonsignificant	0.84	0.77	Other	269	4
379	T.CD4_naive.activated_stress	0.14	Nonsignificant	1.00	0.61	Other	339	429
380	SCHWN.translation_boost	0.14	Nonsignificant	—	0.38	Other	8	1
381	EPI.pancreatic_islet.beta	0.14	Nonsignificant	0.13	1.20	Other	42	57
382	T.CD4_cytotoxic.baseline	0.13	Nonsignificant	0.97	0.58	Other	0	0
383	NEU.INH_PVALB.fastspike	0.13	Nonsignificant	—	0.51	Other	24	22
384	T.CD4_cytotoxic.terminal_effector	0.13	Nonsignificant	0.97	0.54	Other	286	21
385	NK.adaptive_terminal_cytotoxic	0.13	Nonsignificant	1.00	0.02	Other	485	802
386	EPI.skin_follicular_keratinizing.root_infundibulum	0.13	Nonsignificant	—	0.00	Other	0	0
387	T.CD4_cytotoxic.precursor	0.13	Nonsignificant	0.87	1.02	Other	156	67
388	T.MAIT.stress	0.12	Nonsignificant	—	0.00	Other	0	0
389	NEU.INH_VIP.LAMP5_hybrid	0.12	Nonsignificant	—	1.75	Other	1	9
390	T.CD4_naive.survival_mitoprot	0.12	Nonsignificant	1.00	0.59	Other	13	7
391	EPI.renal_principal_cell.activated_acute	0.11	Nonsignificant	1.00	0.88	Other	29	59
392	T.CD8_transitional.APC_like	0.11	Nonsignificant	1.00	0.38	Other	205	62
393	CM.contractile_oxphos	0.11	Nonsignificant	0.72	1.11	Other	6	19
394	EPI.lung_club_secretory.ciliogenesis_primed	0.11	Nonsignificant	—	0.79	Other	0	0
395	NEU.INH_PVALB.serotonergic	0.11	Nonsignificant	—	0.29	Other	0	0
396	CHOND.activated_fibro_like	0.11	Nonsignificant	0.01	1.33	Other	531	188
397	T.CD4_Tcm.stress	0.10	Nonsignificant	1.00	0.05	Other	5	11
398	EPI.esophageal_suprabasal.basal_transitional	0.10	Nonsignificant	0.78	0.69	Other	44	67
399	FIB.barrier_purinergic.stress_GF_binding	0.10	Nonsignificant	—	0.97	Other	0	0
400	NEU.INH_PVALB.nuclear_reg	0.10	Nonsignificant	1.00	1.00	Other	25	12
401	EPI.lung_club_secretory.ciliogenesis_axoneme	0.10	Nonsignificant	—	0.92	Other	0	0
402	EPI.ileal_enterocyte_crypt.baseline	0.09	Nonsignificant	0.49	1.08	Other	11	6
403	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	0.09	Nonsignificant	—	0.00	Other	0	0
404	EPI.ileal_enterocyte_crypt.secretory_precursor	0.09	Nonsignificant	—	0.44	Other	0	0
405	EPI.renal_intercalated_cell_type_B.baseline	0.09	Nonsignificant	—	0.00	Other	3	1
406	PC.IgG_systemic.stress	0.09	Nonsignificant	—	0.00	Other	1	5
407	EPI.renal_distal_tubule.repair	0.08	Nonsignificant	—	0.00	Other	34	102
408	EPI.gastric_foveolar.baseline	0.08	Nonsignificant	—	0.00	Other	0	0
409	EPI.pancreatic_ductal_bicarbonate.stress	0.08	Nonsignificant	—	0.58	Other	12	33
410	CHOND.pro_inflammatory	0.08	Nonsignificant	1.00	0.91	Other	181	351
411	NEU.EXC_SYT2.nuclear_reg	0.08	Nonsignificant	—	0.97	Other	0	0
412	EPI.esophageal_basal.junctional_barrier	0.07	Nonsignificant	—	0.32	Other	0	0
413	EPI.tracheal_basal.activated_stress	0.07	Nonsignificant	0.12	1.51	Other	32	0
414	EPI.skin_interfollicular_spinous.baseline	0.07	Nonsignificant	0.88	1.07	Other	35	3
415	EPI.esophageal_basal.activated_progenitor	0.07	Nonsignificant	0.37	1.16	Other	1	0
416	EPI.skin_interfollicular_spinous.early_differentiation	0.06	Nonsignificant	0.88	0.98	Other	89	19
417	FIB.barrier_purinergic.lipid_secretory	0.06	Nonsignificant	—	0.00	Other	0	0
418	NEU.INH_PVALB.neuromodulatory	0.06	Nonsignificant	—	0.00	Other	0	0
419	ADIPO.immature	0.06	Nonsignificant	—	0.61	Other	24	40
420	MESO.activated_migratory	0.06	Nonsignificant	—	0.44	Other	0	0
421	NEU.INH_VIP.develop_niche	0.06	Nonsignificant	—	1.23	Other	0	0
422	OLG.regulatory	0.06	Nonsignificant	1.00	0.54	Other	353	73
423	EPI.renal_principal_cell.injury_repair	0.06	Nonsignificant	1.00	0.38	Other	26	9
424	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.06	Nonsignificant	—	0.00	Other	0	0
425	GRNLSA.chemokine_mechanosensory	0.05	Nonsignificant	0.52	1.22	Other	1	0
426	EPI.ileal_enterocyte_crypt.proliferative_S	0.05	Nonsignificant	0.49	1.07	Other	4	2
427	ADIPO.hypoxia_remodelling	0.05	Nonsignificant	—	0.00	Other	29	105
428	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.05	Nonsignificant	—	1.13	Other	0	0
429	EPI.esophageal_suprabasal.proliferative_exit	0.05	Nonsignificant	—	0.00	Other	0	0
430	EPI.ileal_goblet.baseline	0.05	Nonsignificant	0.85	0.96	Other	16	2
431	NEU.INH_PVALB.chandelier	0.05	Nonsignificant	1.00	8.08e-03	Other	19	16
432	EPI.tracheal_basal.homeostatic_progenitor	0.04	Nonsignificant	0.96	0.39	Other	285	74
433	EPI.ileal_goblet.inflammatory_mucin	0.04	Nonsignificant	0.85	0.36	Other	6	9
434	EPI.skin_interfollicular_spinous.stress_UPR	0.04	Nonsignificant	—	0.12	Other	0	0
435	EC.arterial.homeostatic	0.04	Nonsignificant	0.21	1.15	Other	24	3
436	CHOND.articular_collagen	0.04	Nonsignificant	1.00	0.55	Other	551	266
437	EPI.lung_club_secretory.canonical_surfactant	0.04	Nonsignificant	—	0.00	Other	74	104
438	CHOND.remodeling	0.04	Nonsignificant	—	0.00	Other	5	0
439	EPI.ileal_goblet.stress_metallothionein	0.03	Nonsignificant	—	0.00	Other	4	11
440	EPI.renal_thick_ascending_limb.barrier_repair	0.03	Nonsignificant	0.27	1.17	Other	141	284
441	FIB.hepatic_stellate_cell.fibrogenic	0.03	Nonsignificant	—	0.42	Other	0	0
442	FIB.adventitial.adhesion_lipid	0.03	Nonsignificant	1.00	0.90	Other	58	209
443	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.03	Nonsignificant	—	0.97	Other	0	0
444	NEU.EXC_CT.Ca2_sensor	0.03	Nonsignificant	—	1.32	Other	0	0
445	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.03	Nonsignificant	—	0.00	Other	0	0
446	EC.venous.quiescent_homeostatic	0.03	Nonsignificant	0.54	1.14	Other	456	360
447	OLG.regulatory_activated	0.03	Nonsignificant	1.00	0.29	Other	196	614
448	EPI.renal_intercalated_cell_type_A.PC_transitional	0.03	Nonsignificant	—	0.00	Other	203	407
449	MEL.secretory_quiescent	0.02	Nonsignificant	0.79	1.10	Other	19	13
450	EPI.colonic_enteroendocrine.progenitor	0.02	Nonsignificant	—	0.97	Other	0	0
451	NEU.EXC_SYT2.synaptic	0.02	Nonsignificant	—	0.00	Other	0	0
452	EC.lymphatic.activated	0.02	Nonsignificant	0.62	1.10	Other	47	73
453	EC.lymphatic.tip_migratory	0.02	Nonsignificant	0.62	1.16	Other	23	37
454	EPI.tracheal_submucosal_gland.acinar_serous	0.02	Nonsignificant	—	0.73	Other	0	0
455	IPSC.mesenchymal_primed	0.02	Nonsignificant	7.33e-13	1.40	Other	0	0
456	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.02	Nonsignificant	—	0.00	Other	19	54
457	EPI.renal_immature_ureteric_bud.osmoprotective	0.02	Nonsignificant	0.38	1.07	Other	126	44
458	EPI.lung_multiciliated.stress	0.02	Nonsignificant	—	0.61	Other	67	165
459	MEL.dedifferentiated_migratory	0.02	Nonsignificant	—	0.75	Other	0	0
460	EPI.skin_interfollicular_spinous.stress_oxidative	0.02	Nonsignificant	—	0.00	Other	0	0
461	FIB.adventitial.mechano_chemo_sensing	0.02	Nonsignificant	0.09	1.13	Other	135	524
462	EC.capillary.inflammatory	0.02	Nonsignificant	1.00	0.93	Other	27	51
463	EPI.skin_keratinocyte_progenitor.activated_stress	0.02	Nonsignificant	—	0.38	Other	0	0
464	EPI.renal_intercalated_cell_type_A.acid_secretion	0.02	Nonsignificant	0.43	1.09	Other	12	6
465	IPSC.stromal_primed	0.02	Nonsignificant	1.00	0.65	Other	0	0
466	EPI.renal_immature_ureteric_bud.defense_secretory	0.02	Nonsignificant	0.38	1.10	Other	45	76
467	CM.inflammatory	0.01	Nonsignificant	—	1.69	Other	0	0
468	EC.capillary.stress	0.01	Nonsignificant	1.00	0.80	Other	44	36
469	EPI.pancreatic_ductal_bicarbonate.baseline	0.01	Nonsignificant	0.80	1.05	Other	11	42
470	EC.capillary.postcap_venule	0.01	Nonsignificant	1.00	0.87	Other	355	261
471	EC.venous.cardiac_structural	0.01	Nonsignificant	0.45	1.30	Other	102	229
472	EPI.skin_interfollicular_spinous.inflammatory	0.01	Nonsignificant	—	0.00	Other	0	0
473	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.01	Nonsignificant	—	1.13	Other	0	0
474	EPI.salivary_myoepithelial.activated	0.01	Nonsignificant	0.09	1.48	Other	85	281
475	EC.capillary.baseline	0.01	Nonsignificant	1.00	0.77	Other	246	560
476	DC.pDC.immature_metabolic	0.01	Nonsignificant	0.96	0.83	Other	78	124
477	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.01	Nonsignificant	—	1.26	Other	39	82
478	IPSC.stress	0.01	Nonsignificant	0.47	1.12	Other	0	0
479	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.01	Nonsignificant	—	0.00	Other	0	0
480	EPI.salivary_myoepithelial.baseline	9.93e-03	Nonsignificant	0.65	1.05	Other	42	141
481	EC.arterial.elastic	9.28e-03	Nonsignificant	0.97	1.07	Other	22	45
482	EPI.renal_principal_cell.intercalated_like	9.13e-03	Nonsignificant	1.00	0.22	Other	63	66
483	EC.capillary.angiocrine	9.01e-03	Nonsignificant	1.00	0.77	Other	250	630
484	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	8.93e-03	Nonsignificant	0.80	1.05	Other	219	533
485	EC.heart_remodeling.translation_boost	8.81e-03	Nonsignificant	—	0.46	Other	0	0
486	NEU.EXC_IT.structural	8.49e-03	Nonsignificant	0.31	1.10	Other	171	41
487	EC.liver_sinusoidal.prostanoid	8.44e-03	Nonsignificant	—	0.47	Other	11	64
488	EPI.lung_multiciliated.baseline	8.35e-03	Nonsignificant	—	0.00	Other	0	7
489	EC.venous.baseline	8.21e-03	Nonsignificant	0.94	0.97	Other	346	807
490	EC.venous.activated	8.16e-03	Nonsignificant	0.85	1.04	Other	247	752
491	NEU.INH_VIP.matrix	7.85e-03	Nonsignificant	—	0.92	Other	24	77
492	HEP.canalicular_transport.sterol_lipid_biosynthesis	7.34e-03	Nonsignificant	—	1.50	Other	10	20
493	ADIPO.thermogenic	6.52e-03	Nonsignificant	—	0.00	Other	0	0
494	HEP.canalicular_transport.injury_stress	6.15e-03	Nonsignificant	0.68	1.10	Other	289	24
495	EPI.renal_thick_ascending_limb.salt_sensing	6.15e-03	Nonsignificant	1.00	0.94	Other	73	103
496	FIB.hepatic_stellate_cell.contractile	6.11e-03	Nonsignificant	—	0.32	Other	0	0
497	CM.baseline	6.09e-03	Nonsignificant	0.91	1.00	Other	393	0
498	EC.lymphatic.baseline	5.94e-03	Nonsignificant	1.00	0.88	Other	38	72
499	EC.arterial.inflammatory	5.93e-03	Nonsignificant	0.97	0.93	Other	63	50
500	EPI.colonic_enteroendocrine.Lcell_peptide	5.91e-03	Nonsignificant	—	0.00	Other	0	0
501	EPI.tracheal_submucosal_gland.ductal_luminal	5.14e-03	Nonsignificant	—	0.00	Other	0	0
502	HEP.periportal_metabolic.apolipoprotein_secretory	4.99e-03	Nonsignificant	0.55	1.20	Other	43	110
503	EPI.renal_thick_ascending_limb.remodeling	4.52e-03	Nonsignificant	0.68	1.07	Other	152	92
504	EPI.skin_interfollicular_spinous.transition_basal	4.41e-03	Nonsignificant	1.00	0.27	Other	100	127
505	FIB.adventitial.complement_angiocrine	4.38e-03	Nonsignificant	1.00	0.66	Other	153	684
506	NEU.EXC_CT.remodeling	4.17e-03	Nonsignificant	—	0.59	Other	23	1
507	MESO.activated_stress	3.96e-03	Nonsignificant	—	0.00	Other	0	0
508	EPI.salivary_myoepithelial.contractile_repair	3.89e-03	Nonsignificant	—	0.00	Other	3	9
509	EC.arterial.arteriole_interface	3.88e-03	Nonsignificant	0.97	0.91	Other	31	12
510	EC.heart_remodeling.angiocrine	3.60e-03	Nonsignificant	0.96	1.04	Other	182	525
511	HEP.periportal_metabolic.stress_checkpoint	3.56e-03	Nonsignificant	0.55	1.09	Other	234	786
512	FIB.hepatic_stellate_cell.inflammatory	3.38e-03	Nonsignificant	—	0.00	Other	0	0
513	NEU.INH_VIP.cannabinoid	3.17e-03	Nonsignificant	—	0.60	Other	0	0
514	EC.capillary.migratory	2.75e-03	Nonsignificant	1.00	0.44	Other	181	509
515	EC.heart_remodeling.remodeling_secretory	2.73e-03	Nonsignificant	0.96	1.00	Other	605	1,341
516	EC.arterial.arteriole_gas_exchange	2.63e-03	Nonsignificant	0.97	0.95	Other	238	131
517	MESO.secretory_structural	2.53e-03	Nonsignificant	—	0.23	Other	0	0
518	DC.pDC.baseline	2.40e-03	Nonsignificant	0.96	0.68	Other	88	123
519	EC.arterial.angiogenic_tip	2.37e-03	Nonsignificant	—	0.00	Other	30	37
520	EPI.salivary_duct_ion_transport.baseline	2.34e-03	Nonsignificant	—	—	Other	0	0
521	EC.lymphatic.valve	2.16e-03	Nonsignificant	—	0.04	Other	0	0
522	ADIPO.inflammatory	2.16e-03	Nonsignificant	—	0.00	Other	0	0
523	EC.venous.remodeling_stalk	2.15e-03	Nonsignificant	0.94	0.83	Other	559	566
524	GRNLSA.cholesterol_mevalonate	2.03e-03	Nonsignificant	0.58	1.18	Other	9	4
525	EPI.thymic_medullary.canonical_alarmin	1.98e-03	Nonsignificant	0.25	1.23	Other	8	17
526	EPI.salivary_myoepithelial.junctional_transport	1.95e-03	Nonsignificant	1.00	0.07	Other	66	121
527	EC.heart_remodeling.capillary_metabolic	1.92e-03	Nonsignificant	0.96	1.12	Other	54	414
528	EPI.tracheal_suprabasal.secretory_immune	1.68e-03	Nonsignificant	—	0.26	Other	0	0
529	EPI.lung_multiciliated.mature_motile_cilia	1.65e-03	Nonsignificant	—	0.00	Other	0	0
530	EPI.thymic_medullary.stress_APC	1.55e-03	Nonsignificant	0.25	1.29	Other	2	4
531	GRNLSA.lipid_hypoxia	1.54e-03	Nonsignificant	0.62	1.09	Other	28	0
532	EPI.renal_thick_ascending_limb.cation_flux	1.48e-03	Nonsignificant	1.00	0.89	Other	57	95
533	EC.venous.adipose_lipid	1.45e-03	Nonsignificant	0.94	0.72	Other	254	476
534	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	1.43e-03	Nonsignificant	0.64	1.27	Other	2	9
535	HEP.acute_phase.stress_secretory	1.35e-03	Nonsignificant	0.18	1.24	Other	26	3
536	EC.liver_sinusoidal.secretory_lipoprotein	1.30e-03	Nonsignificant	0.51	1.14	Other	120	70
537	EPI.skin_keratinocyte_proliferating.early_spinous_transition	1.28e-03	Nonsignificant	—	0.00	Other	135	290
538	EPI.tracheal_suprabasal.transitional_wound	1.27e-03	Nonsignificant	—	0.00	Other	16	1
539	EPI.pancreatic_islet.delta	1.23e-03	Nonsignificant	—	0.39	Other	0	0
540	EC.arterial.metabolic	1.18e-03	Nonsignificant	0.97	0.81	Other	195	159
541	MESO.baseline	1.11e-03	Nonsignificant	0.78	0.83	Other	0	6
542	GRNLSA.stress_metabolic	1.01e-03	Nonsignificant	—	0.40	Other	1	2
543	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	9.36e-04	Nonsignificant	—	0.00	Other	0	0
544	CM.osmoprotection	9.36e-04	Nonsignificant	0.91	1.02	Other	34	57
545	HEP.periportal_metabolic.stress_chaperone	8.63e-04	Nonsignificant	—	0.17	Other	66	128
546	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	8.51e-04	Nonsignificant	—	0.29	Other	0	0
547	FIB.adventitial.baseline	7.44e-04	Nonsignificant	1.00	0.46	Other	157	278
548	EPI.thymic_medullary.hormone_xeno_barrier	7.15e-04	Nonsignificant	—	0.00	Other	0	8
549	CM.oxidative_phospho	6.91e-04	Nonsignificant	0.91	0.99	Other	266	792
550	EPI.skin_interfollicular_spinous.proliferative	6.83e-04	Nonsignificant	—	0.00	Other	0	0
551	EC.lymphatic.scavenger	6.35e-04	Nonsignificant	1.00	0.21	Other	203	257
552	HEP.canalicular_transport.inflammatory	6.12e-04	Nonsignificant	1.00	0.96	Other	1,335	194
553	EPI.pancreatic_ductal_perivascular.baseline	3.73e-04	Nonsignificant	0.14	1.22	Other	1	5
554	EPI.pancreatic_acinar.inflammatory_regenerative	2.93e-04	Nonsignificant	0.47	1.20	Other	25	113
555	EPI.lung_club_secretory.inflammatory	2.87e-04	Nonsignificant	—	0.00	Other	0	0
556	EC.arterial.mito_contact	2.70e-04	Nonsignificant	0.97	0.67	Other	14	5
557	IPSC.mesodermal_primed	2.47e-04	Nonsignificant	1.00	0.48	Other	0	0
558	MEL.mature_oxidative_traffic	2.36e-04	Nonsignificant	0.95	0.64	Other	247	285
559	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	2.36e-04	Nonsignificant	0.68	0.95	Other	449	1,034
560	MEL.stress_glucocorticoid	2.34e-04	Nonsignificant	0.95	0.84	Other	11	34
561	EPI.renal_thick_ascending_limb.canonical_salt_transporter	2.08e-04	Nonsignificant	1.00	0.35	Other	322	317
562	EPI.skin_sebaceous_duct_luminal.detox_repair	1.92e-04	Nonsignificant	0.72	0.83	Other	137	94
563	NEU.INH_VIP.enkephalinergic	1.70e-04	Nonsignificant	—	0.45	Other	0	0
564	EC.heart_remodeling.perivascular	1.60e-04	Nonsignificant	0.96	0.92	Other	124	408
565	CM.sarcomere_actin_interface	1.56e-04	Nonsignificant	1.00	0.95	Other	450	78
566	EPI.salivary_intercalated_defense.canonical_antimicrobial	1.53e-04	Nonsignificant	0.09	1.13	Other	11	22
567	CM.mito_proteostasis	1.48e-04	Nonsignificant	0.91	0.99	Other	329	29
568	EPI.skin_hair_follicle_bulge.quiescent	1.46e-04	Nonsignificant	0.23	1.25	Other	56	69
569	CM.translation_boost_RPL	1.32e-04	Nonsignificant	0.91	1.00	Other	129	1
570	CM.translation_boost_RPS	1.31e-04	Nonsignificant	0.91	0.99	Other	69	16
571	GRNLSA.EMT_insulin_signaling	1.29e-04	Nonsignificant	0.67	1.08	Other	47	84
572	NEU.INH_VIP.excitatory_coupled	1.23e-04	Nonsignificant	—	0.00	Other	13	0
573	EPI.endocervical_secretory.secretory_translocon	1.18e-04	Nonsignificant	—	0.67	Other	0	0
574	HEP.canalicular_transport.ductular_like_transition	1.15e-04	Nonsignificant	1.00	0.80	Other	400	87
575	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	1.13e-04	Nonsignificant	0.86	0.80	Other	40	191
576	EPI.skin_hair_follicle_bulge.niche_crosstalk	1.08e-04	Nonsignificant	—	0.00	Other	29	88
577	IPSC.neuroendocrine_primed	1.06e-04	Nonsignificant	—	0.00	Other	0	0
578	MESO.antiviral	1.03e-04	Nonsignificant	—	0.03	Other	3	8
579	EC.liver_sinusoidal.hypoxia_metabolic	1.03e-04	Nonsignificant	0.87	0.86	Other	183	107
580	CM.mechano_activated	1.02e-04	Nonsignificant	0.91	0.97	Other	205	134
581	EPI.skin_sweat_duct_keratinocyte.repair	9.68e-05	Nonsignificant	—	0.60	Other	0	0
582	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	8.54e-05	Nonsignificant	—	1.65	Other	0	0
583	FIB.adventitial.mito_secretory	8.54e-05	Nonsignificant	1.00	0.60	Other	21	7
584	HEP.canalicular_transport.pericentral_like_hypoxia	7.88e-05	Nonsignificant	1.00	0.75	Other	326	8
585	EPI.salivary_mucous_acinar.baseline	7.65e-05	Nonsignificant	—	—	Other	394	683
586	EPI.skin_hair_follicle_bulge.anagen_growth	7.65e-05	Nonsignificant	—	0.46	Other	0	0
587	EC.arterial.ion_pump	7.21e-05	Nonsignificant	0.97	0.56	Other	3	2
588	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	7.20e-05	Nonsignificant	—	0.00	Other	0	0
589	NEU.INH_VIP.nuclear_reg	6.84e-05	Nonsignificant	—	0.18	Other	20	4
590	EPI.thymic_cortical.secretory_remodeling	6.04e-05	Nonsignificant	—	0.69	Other	4	1
591	SCHWN.axon_contact_cardiac	5.77e-05	Nonsignificant	0.99	0.23	Other	18	63
592	OPC.proliferative_immune_interact	5.50e-05	Nonsignificant	0.09	1.15	Other	180	373
593	EC.heart_remodeling.activated_acute	5.14e-05	Nonsignificant	0.96	0.94	Other	102	186
594	EPI.skin_hair_follicle_companion.activated_migratory	4.72e-05	Nonsignificant	—	0.00	Other	0	0
595	EPI.pancreatic_ductal_bicarbonate.activated	4.70e-05	Nonsignificant	0.86	0.75	Other	10	7
596	OPC.premyelinating	4.58e-05	Nonsignificant	0.38	1.06	Other	185	12
597	HEP.canalicular_transport.baseline	4.51e-05	Nonsignificant	1.00	0.86	Other	199	477
598	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	4.32e-05	Nonsignificant	0.96	0.96	Other	7	16
599	EPI.thymic_medullary.proliferative_APC	3.82e-05	Nonsignificant	—	0.00	Other	0	0
600	EPI.pancreatic_acinar.stress	3.70e-05	Nonsignificant	0.50	1.14	Other	28	28
601	EPI.pancreatic_ductal_perivascular.protective_antioxidant	3.65e-05	Nonsignificant	—	0.00	Other	11	69
602	EPI.skin_keratinocyte_basal.transit_amplifying	3.31e-05	Nonsignificant	—	0.97	Other	0	0
603	FIB.adventitial.activated_remodelling	3.11e-05	Nonsignificant	—	0.00	Other	141	319
604	HEP.periportal_metabolic.acute_phase_barrier	3.09e-05	Nonsignificant	0.99	0.92	Other	533	138
605	HEP.acute_phase.baseline	2.68e-05	Nonsignificant	0.82	1.03	Other	946	19
606	NEU.INH_VIP.serotonergic	2.60e-05	Nonsignificant	—	0.00	Other	9	2
607	HEP.periportal_metabolic.inflammatory_activated	1.80e-05	Nonsignificant	0.99	0.90	Other	712	1,610
608	EPI.ectocervical_granular.proliferative_basal	1.77e-05	Nonsignificant	—	0.00	Other	0	0
609	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.73e-05	Nonsignificant	—	0.57	Other	0	0
610	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	1.60e-05	Nonsignificant	—	0.00	Other	0	0
611	EPI.salivary_duct_excretory.baseline	1.53e-05	Nonsignificant	0.45	1.12	Other	23	57
612	EPI.salivary_serous_acinar.secretory_active	1.52e-05	Nonsignificant	0.66	1.01	Other	242	69
613	EC.heart_remodeling.remodeling_stalk	1.52e-05	Nonsignificant	0.96	0.68	Other	33	111
614	HEP.canalicular_transport.secretory_ERAD_UPR	1.37e-05	Nonsignificant	1.00	0.57	Other	232	28
615	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	1.13e-05	Nonsignificant	—	0.00	Other	0	0
616	IPSC.midbrain_primed	1.11e-05	Nonsignificant	1.00	0.40	Other	0	0
617	GRNLSA.secretory_remodeling	1.05e-05	Nonsignificant	0.95	0.90	Other	90	25
618	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	9.74e-06	Nonsignificant	—	0.00	Other	0	0
619	EPI.skin_keratinocyte_basal.spinous_transition	8.64e-06	Nonsignificant	—	0.00	Other	0	0
620	IPSC.neural_primed	7.80e-06	Nonsignificant	1.00	0.42	Other	0	0
621	HEP.periportal_metabolic.urea_onecarbon_secretory	6.71e-06	Nonsignificant	0.99	0.99	Other	1,332	3,053
622	HEP.periportal_metabolic.xenobiotic_detox	6.65e-06	Nonsignificant	0.99	0.88	Other	1,440	139
623	EC.liver_sinusoidal.stress	6.28e-06	Nonsignificant	—	0.00	Other	413	158
624	NEU.INH_VIP.regulatory_remodeling	6.22e-06	Nonsignificant	—	0.00	Other	6	1
625	EPI.skin_appendage_keratinocyte.transit_amplifying	6.10e-06	Nonsignificant	—	0.00	Other	109	358
626	EPI.pancreatic_islet.alpha	5.86e-06	Nonsignificant	—	0.00	Other	152	330
627	EPI.salivary_serous_acinar.seromucous_like	5.68e-06	Nonsignificant	—	1.75	Other	0	0
628	GRNLSA.p53_damage	5.39e-06	Nonsignificant	—	0.00	Other	13	10
629	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	4.96e-06	Nonsignificant	—	0.00	Other	49	237
630	NEU.EXC_CT.projector	4.69e-06	Nonsignificant	0.70	0.90	Other	87	26
631	GRNLSA.proliferative_migratory	4.56e-06	Nonsignificant	0.95	0.66	Other	248	292
632	SKM.type_2_fast.oxidative_IIa	4.09e-06	Nonsignificant	0.44	1.03	Other	946	56
633	ASTRO.homeostatic	3.90e-06	Nonsignificant	0.65	1.07	Other	200	431
634	EPI.skin_keratinocyte_proliferating.detox_repair	3.84e-06	Nonsignificant	—	0.00	Other	0	0
635	OPC.homeostatic	3.64e-06	Nonsignificant	0.71	0.97	Other	394	160
636	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	3.45e-06	Nonsignificant	0.96	0.55	Other	33	34
637	ASTRO.stress_acute	2.40e-06	Nonsignificant	0.65	1.03	Other	60	56
638	EPI.endocervical_secretory.squamous_barrier	1.91e-06	Nonsignificant	—	0.00	Other	0	0
639	ASTRO.A2_reactive	1.87e-06	Nonsignificant	0.65	1.09	Other	10	37
640	HEP.periportal_metabolic.canonical_urea_cycle	1.81e-06	Nonsignificant	0.99	0.80	Other	1,464	269
641	EPI.pancreatic_ductal_progenitor.baseline	1.78e-06	Nonsignificant	0.96	0.74	Other	179	702
642	HEP.acute_phase.proliferative	1.64e-06	Nonsignificant	—	0.70	Other	4	6
643	SKM.type_2_fast.glycolytic_IIx_IIb	1.63e-06	Nonsignificant	0.44	1.02	Other	565	1,482
644	ASTRO.A1_reactive	1.62e-06	Nonsignificant	0.65	1.02	Other	433	394
645	EPI.skin_keratinocyte_basal.basement_anchoring	1.41e-06	Nonsignificant	—	0.00	Other	0	0
646	EPI.pancreatic_ductal_progenitor.ciliated_transport	1.26e-06	Nonsignificant	—	0.00	Other	105	368
647	EPI.salivary_duct_excretory.stress	1.11e-06	Nonsignificant	0.57	1.02	Other	33	68
648	EPI.salivary_serous_acinar.quiescent	8.06e-07	Nonsignificant	0.49	1.09	Other	178	493
649	NEU.INH_VIP.canonical_disinhibitory	7.76e-07	Nonsignificant	0.98	0.45	Other	59	38
650	HEP.acute_phase.hypoxia_lipid	7.62e-07	Nonsignificant	—	1.14	Other	0	0
651	HEP.acute_phase.inflammatory	7.07e-07	Nonsignificant	0.99	0.98	Other	382	649
652	CM.anti_inflammatory	6.78e-07	Nonsignificant	1.00	0.81	Other	424	1,503
653	ASTRO.hypoxia_angiogenic	6.69e-07	Nonsignificant	0.65	1.11	Other	5	18
654	ASTRO.synaptic_interaction	6.54e-07	Nonsignificant	0.41	1.12	Other	76	334
655	EC.liver_sinusoidal.remodeling_lipotoxicity	6.20e-07	Nonsignificant	—	0.00	Other	90	58
656	EC.liver_sinusoidal.inflammatory	5.71e-07	Nonsignificant	—	0.00	Other	223	154
657	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	3.18e-07	Nonsignificant	—	0.00	Other	0	0
658	EPI.pancreatic_acinar.quiet_dedifferentiation	3.01e-07	Nonsignificant	0.90	1.04	Other	142	171
659	EPI.salivary_intercalated_defense.inflammatory	2.47e-07	Nonsignificant	0.99	0.59	Other	152	360
660	HEP.acute_phase.complement_metabolic	2.17e-07	Nonsignificant	0.99	0.81	Other	1,423	3,464
661	EPI.skin_sebaceous_duct_luminal.immune_interface	2.05e-07	Nonsignificant	—	0.00	Other	0	0
662	NEU.EXC_IT.transitional	1.88e-07	Nonsignificant	0.54	1.12	Other	237	142
663	EPI.skin_sweat_duct_keratinocyte.signal_gate	1.46e-07	Nonsignificant	—	0.00	Other	43	26
664	ASTRO.neuromodulatory	1.12e-07	Nonsignificant	0.95	0.87	Other	34	172
665	EPI.pancreatic_acinar.metabolic_onecarbon	1.10e-07	Nonsignificant	0.90	0.98	Other	287	328
666	NEU.EXC_CT.Ca2_signaling	1.07e-07	Nonsignificant	—	0.00	Other	68	17
667	ASTRO.stress_mito	8.75e-08	Nonsignificant	0.65	1.04	Other	47	110
668	NEU.INH_VIP.opioid	7.54e-08	Nonsignificant	—	0.00	Other	50	9
669	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	4.44e-08	Nonsignificant	—	0.00	Other	0	0
670	EPI.pancreatic_ductal_progenitor.ADM_like	3.54e-08	Nonsignificant	—	0.00	Other	0	0
671	EPI.pancreatic_acinar.baseline	3.81e-09	Nonsignificant	0.97	0.76	Other	274	163
672	EPI.pancreatic_acinar.adhesion_remodeling	1.94e-09	Nonsignificant	0.90	0.94	Other	210	784
673	NEU.EXC_IT.neuromodulated	1.02e-09	Nonsignificant	0.54	1.11	Other	176	116
674	HEP.acute_phase.complement_antiviral	5.04e-10	Nonsignificant	0.99	0.62	Other	377	751
675	ASTRO.immature_lipid	4.59e-10	Nonsignificant	1.00	0.36	Other	23	113
676	NEU.EXC_IT.adhesion	1.87e-10	Nonsignificant	0.95	0.99	Other	252	108
677	EPI.skin_sweat_duct_keratinocyte.proliferative_S	1.26e-10	Nonsignificant	—	0.00	Other	0	0
678	SKM.type_1_slow.glycolytic	2.14e-11	Nonsignificant	0.57	1.12	Other	362	647
679	NEU.EXC_NTNG1.synaptic	1.39e-11	Nonsignificant	—	0.67	Other	0	0
680	EPI.salivary_intercalated_defense.basal_EMT	2.91e-12	Nonsignificant	—	0.00	Other	0	0
681	EPI.thymic_cortical.Notch_interface	2.19e-12	Nonsignificant	—	0.56	Other	82	137
682	NEU.EXC_IT.callosal	1.37e-12	Nonsignificant	1.00	0.75	Other	286	119
683	SKM.type_1_slow.oxidative	7.53e-13	Nonsignificant	0.98	0.95	Other	802	251
684	EPI.thymic_cortical.baseline	6.91e-14	Nonsignificant	0.99	0.15	Other	185	386
685	SKM.type_1_slow.contractile	5.38e-14	Nonsignificant	0.98	0.78	Other	596	8
686	NEU.EXC_IT.guidance	5.01e-14	Nonsignificant	1.00	0.39	Other	274	63
687	NEU.EXC_NTNG1.nuclear_reg	1.74e-15	Nonsignificant	—	0.00	Other	0	0
688	GRNLSA.angiocrine_mechanosensory	0.00	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

25 unique genes. Showing 1–25. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
HLX	01-High	0.55	7.91	G1	C1	—	DC.cDC1.activated (Tier: relevant) HPC.CLP_B_primed (Tier: relevant)	36 cells — complete matches	73	243
HLX-AS1	02-Medium	0.71	10.58	G1	C2	—	DC.cDC2 (Tier: specific) DC.cDC1.activated (Tier: relevant) DC.cDC1.baseline (Tier: relevant) MAC.proliferating.DNA_replication (Tier: relevant)	29 cells — complete matches	72	241
LTBR	02-Medium	0.70	9.94	G1	C2	—	monocyte (Tier: specific) MONO.CD16 (Tier: specific) MONO.CD14.APC_like (Tier: specific)	9 cells — complete matches	21	43
ENSG00000256433	02-Medium	0.59	9.28	G1	C2	—	—	—	14	28
ENSG00000296435	02-Medium	0.58	9.72	G1	C2	—	—	—	38	96
ENSG00000305986	02-Medium	0.56	9.12	G1	C2	—	—	—	43	107
SCNN1A	02-Medium	0.55	9.90	G1	C2	EPI.renal_principal_cell (L1S), EPI.hepatic_ductular_cholangiocyte.ion_transport (L2)	—	33 cells — complete matches	15	33
ENSG00000296502	02-Medium	0.52	7.84	G1	C2	—	—	—	45	107
LINC02817	02-Medium	0.51	7.76	G1	C2	—	—	—	26	87
TNFRSF1A	02-Medium	0.48	7.83	G1	C2	EPI.ileal_enterocyte_absorptive.brush_border (L2)	T.CD4_Th2 (Tier: specific)	17 cells — complete matches	22	43
PITX2	02-Medium	0.46	8.46	G2	C2	—	—	31 cells — complete matches	0	0
ENSG00000294570	02-Medium	0.45	4.74	G1	C2	—	—	—	11	63
MTARC1	02-Medium	0.44	4.04	G1	C2	—	—	—	56	174
PLEKHG6	02-Medium	0.44	5.88	G1	C2	—	DC.mig (Tier: relevant) DC.cDC2.proliferative (Tier: relevant)	38 cells — complete matches	13	33
ENSG00000286231	02-Medium	0.42	3.20	G1	C2	—	—	—	45	124
MTARC2	02-Medium	0.38	2.24	G1	C2	—	—	—	39	108
CD27	02-Medium	0.38	3.27	G1	C2	B.memory (L1S), B.memory.baseline (L2), NK.adaptive_immature_precursor (L2), T.CD4_cytotoxic.precursor (L2), T.CD4_transitional.primed_helper_effector (L2), T.CD8_Tem.early_helper_like (L2), T.CD8_transitional.APC_like (L2), T.gamma_delta.central_memory (L2), THYMO.CD8aa_IELp (L2), THYMO.SP_CD4_naive (L2)	B.memory.pDC_imprint (Tier: specific) B.germinal_center.LZ_survival (Tier: relevant)	124 cells — complete matches	20	36
CD27-AS1	02-Medium	0.37	3.10	G1	C2	—	—	—	12	30
VAMP1-AS1	02-Medium	0.37	3.04	G1	C2	—	—	—	10	24
TAPBPL	02-Medium	0.36	2.83	G1	C2	—	—	EPI.cervical_suprabasal.secretory_vesicle (L2)	17	36
C1orf115	02-Medium	0.36	1.14	G1	C2	—	B.memory.pDC_imprint (Tier: specific) DC.cDC1 (Tier: relevant) B.germinal_center.DZ_S_phase (Tier: relevant) DC.cDC1.homeostatic_inhibitory (Tier: relevant)	33 cells — complete matches	42	112
VAMP1	02-Medium	0.34	1.74	G1	C2	—	T.CD4_Th2 (Tier: specific) B.memory.pDC_imprint (Tier: specific)	27 cells — complete matches	12	49
ENSG00000295022	02-Medium	0.32	1.07	G1	C2	—	—	—	13	30
CD9	02-Medium	0.32	1.74	G1	C2	EC.capillary.angiogenic_tip (L2), FIB.neurolectin_mucosa.nerve_interface (L2), FIB.reticular.ECM_builder (L2), HPC.GMP_inflammatory (L2), MAC.MDM.LAM_like (L2), MAC.kupffer.metabolic (L2), MAC.resident_iron.heme_catabolism (L2), MAC.resident_repair.lipid_phagocytic (L2), OLG.myelinating_mature (L2), PLAT.adhesion (L2), T.CD8_transitional.Trm_primed (L2), THYMO.SP_CD8_naive (L2)	macrophage (Tier: specific) MAC.LAM (Tier: specific) MAC.LAM.anti_inflammatory (Tier: relevant) MAC.MDM.LAM_like (Tier: relevant) MAC.resident_cardiac.inflammatory_reparative (Tier: relevant) MONO.CD16.platelet_bound (Tier: relevant)	122 cells — complete matches	2	6
ENSG00000305396	02-Medium	0.32	0.99	G1	C2	—	—	—	14	32

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.