Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000018 · All tissues

Acute appendicitis, no complications: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Acute appendicitis

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	pericyte	7.76	Significant	3.32e-09	1.17	Specific	128	517
2	fibroblast	5.36	Nominal	2.44e-15	1.14	Other	184	826
3	hepatocyte	4.82	Nominal	5.68e-12	1.11	Other	1,515	3,822
4	muscle_stem_cell	4.44	Nominal	0.75	1.06	Other	7	27
5	adipose_stem_and_progenitor_cell	4.31	Nominal	3.56e-12	1.11	Other	327	954
6	smooth_muscle_cell	3.69	Nominal	0.75	1.04	Other	27	139
7	monocyte	3.29	Nominal	6.63e-22	1.11	Other	2,176	3,871
8	adipocyte	3.25	Nominal	1.00	0.99	Other	33	111
9	endothelial_cell	0.81	Nonsignificant	1.00	0.90	Other	373	974
10	induced_pluripotent_stem_cell	0.81	Nonsignificant	1.00	0.98	Other	0	0
11	epithelial_cell	0.70	Nonsignificant	1.00	0.94	Other	24	47
12	granulocyte	0.54	Nonsignificant	1.00	0.79	Other	5	6
13	dendritic_cell	0.45	Nonsignificant	1.00	0.88	Other	496	724
14	mesothelial_cell	0.44	Nonsignificant	1.00	0.80	Other	6	36
15	macrophage	0.36	Nonsignificant	1.00	0.86	Other	813	1,732
16	schwann_cell	0.29	Nonsignificant	1.00	0.76	Other	10	57
17	plasma_cell	0.18	Nonsignificant	1.00	0.80	Other	17	24
18	astrocyte	0.10	Nonsignificant	1.00	0.76	Other	256	1,203
19	granulosa_cell	0.04	Nonsignificant	1.00	0.83	Other	293	670
20	neuron	0.04	Nonsignificant	1.00	0.71	Other	330	1,328
21	chondrocyte	0.03	Nonsignificant	1.00	0.66	Other	548	1,069
22	microglia	0.03	Nonsignificant	1.00	0.63	Other	61	129
23	B_cell	0.02	Nonsignificant	1.00	0.68	Other	356	694
24	haematopoietic_progenitor_cell	0.02	Nonsignificant	1.00	0.69	Other	262	502
25	oligodendrocyte	0.01	Nonsignificant	1.00	0.65	Other	385	1,507
26	melanocyte	0.01	Nonsignificant	1.00	0.60	Other	97	309
27	platelet	8.64e-03	Nonsignificant	—	0.00	Other	85	104
28	thymocyte	4.62e-03	Nonsignificant	1.00	0.56	Other	168	512
29	innate_lymphoid_cell_2	3.75e-03	Nonsignificant	1.00	0.52	Other	3	8
30	T_cell	3.21e-03	Nonsignificant	1.00	0.37	Other	470	959
31	oligodendrocyte_precursor_cell	3.02e-03	Nonsignificant	1.00	0.47	Other	461	1,454
32	cardiomyocyte	2.02e-03	Nonsignificant	1.00	0.64	Other	533	2,045
33	skeletal_muscle_cell	1.93e-03	Nonsignificant	1.00	0.48	Other	944	2,600
34	natural_killer_cell	5.35e-04	Nonsignificant	1.00	0.38	Other	1,204	2,052

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	HEP.acute_phase	12.93	Significant	1.66e-37	1.83	Specific	1,441	3,641
2	EC.liver_sinusoidal	9.81	Significant	2.92e-11	1.56	Specific	1,083	1,925
3	PERI.pericyte	7.76	Significant	—	—	—	117	0
4	FIB.interstitial	6.86	Significant	2.57e-09	1.98	Specific	288	940
5	EPI.intrahepatic_cholangiocyte_defense	6.69	Significant	—	2.26	Relevant	8	13
6	FIB.barrier_secretory	6.65	Significant	0.41	1.57	Other	81	228
7	FIB.suburothelial	5.35	Nominal	1.00	0.77	Other	122	432
8	FIB.neurolectin_mucosa	5.07	Nominal	1.00	0.91	Other	133	394
9	FIB.adventitial	5.05	Nominal	1.00	0.63	Other	268	1,447
10	FIB.barrier_purinergic	5.04	Nominal	—	0.00	Other	1	3
11	EPI.intrahepatic_cholangiocyte_transport	4.47	Nominal	—	1.68	Other	12	42
12	MUSC.muscle_stem_cell	4.44	Nominal	—	—	Other	4	18
13	ASPC.adipose_stem_and_progenitor_cell	4.31	Nominal	—	—	Other	324	930
14	FIB.hepatic_stellate_cell	4.19	Nominal	—	0.00	Other	64	252
15	MONO.CD14	3.82	Nominal	1.60e-47	2.41	Other	2,294	4,139
16	SMC.smooth_muscle_cell	3.69	Nominal	—	—	Other	20	101
17	EPI.salivary_myoepithelial	3.67	Nominal	1.75e-05	1.41	Other	191	714
18	FIB.lung_alveolar	3.49	Nominal	—	0.00	Other	6	15
19	HEP.canalicular_transport	3.48	Nominal	0.45	1.04	Other	1,290	3,434
20	ADIPO.adipocyte	3.25	Nominal	—	—	Other	20	62
21	FIB.tracheal_subepithelial	3.01	Nominal	—	0.00	Other	0	0
22	FIB.reticular	2.86	Nonsignificant	1.00	0.48	Other	19	87
23	EPI.extrahepatic_cholangiocyte	2.71	Nonsignificant	—	1.16	Other	37	71
24	EPI.hepatic_ductular_cholangiocyte	2.28	Nonsignificant	0.90	1.14	Other	83	243
25	FIB.perivascular_interface	2.24	Nonsignificant	1.00	0.17	Other	0	0
26	EPI.salivary_serous_acinar	1.99	Nonsignificant	1.74e-04	1.22	Other	233	531
27	EPI.colonic_tuft	1.84	Nonsignificant	—	1.10	Other	7	24
28	HEP.pericentral_lipoprotein	1.66	Nonsignificant	—	0.00	Other	0	0
29	EPI.tracheal_basal	1.52	Nonsignificant	0.24	1.22	Other	398	1,120
30	EPI.skin_follicular_keratinizing	1.36	Nonsignificant	1.00	1.03	Other	30	81
31	FIB.transitioning	1.26	Nonsignificant	1.00	0.03	Other	172	497
32	GRANU.neutrophil	1.25	Nonsignificant	1.90e-03	1.66	Other	1,235	2,649
33	EPI.ileal_bile_transport	1.13	Nonsignificant	1.00	1.11	Other	61	93
34	EC.capillary	1.06	Nonsignificant	5.41e-08	1.28	Other	514	1,635
35	EPI.pancreatic_ductal_bicarbonate	1.03	Nonsignificant	1.00	1.04	Other	131	548
36	EPI.thymic_cortical	0.95	Nonsignificant	1.00	1.09	Other	442	824
37	EPI.pancreatic_ductal_perivascular	0.85	Nonsignificant	1.00	0.98	Other	4	30
38	IPSC.induced_pluripotent_stem_cell	0.81	Nonsignificant	—	—	Other	0	0
39	EPI.salivary_duct_ion_transport	0.81	Nonsignificant	1.00	0.97	Other	5	11
40	DC.mig	0.80	Nonsignificant	—	0.88	Other	89	156
41	MAC.LAM	0.79	Nonsignificant	1.90e-10	1.34	Other	914	2,064
42	EPI.pancreatic_ductal_progenitor	0.78	Nonsignificant	1.00	1.03	Other	234	873
43	EPI.renal_immature_ureteric_bud	0.67	Nonsignificant	5.78e-04	1.37	Other	217	569
44	EPI.pancreatic_acinar	0.64	Nonsignificant	0.24	1.11	Other	429	1,475
45	EPI.skin_hair_follicle_bulge	0.63	Nonsignificant	1.00	1.04	Other	51	178
46	EPI.ileal_enterocyte_absorptive	0.61	Nonsignificant	1.00	0.95	Other	118	338
47	MONO.CD16	0.56	Nonsignificant	1.00	0.15	Other	1,304	1,835
48	DC.cDC2	0.56	Nonsignificant	0.03	1.34	Other	1,189	1,793
49	EPI.tracheal_suprabasal	0.54	Nonsignificant	1.00	0.82	Other	29	56
50	FIB.skin_papillary	0.53	Nonsignificant	—	0.00	Other	0	0
51	NEU.EXC_NTNG1	0.50	Nonsignificant	—	2.11	Other	0	0
52	FIB.skin_tenogenic	0.48	Nonsignificant	—	0.00	Other	108	227
53	MAC.resident_iron	0.48	Nonsignificant	1.00	0.96	Other	16	21
54	B.age_associated	0.46	Nonsignificant	0.12	1.18	Other	207	350
55	MESO.mesothelial_cell	0.44	Nonsignificant	—	—	Other	2	18
56	EPI.skin_sebaceous_duct_luminal	0.43	Nonsignificant	1.00	0.82	Other	100	249
57	HEP.periportal_metabolic	0.43	Nonsignificant	1.00	0.06	Other	1,750	4,427
58	EPI.ileal_enterocyte_crypt	0.42	Nonsignificant	1.00	0.84	Other	67	113
59	EPI.esophageal_basal	0.40	Nonsignificant	1.00	0.79	Other	4	10
60	EPI.skin_appendage_keratinocyte	0.39	Nonsignificant	1.00	0.79	Other	87	222
61	MAC.MDM	0.39	Nonsignificant	1.00	0.96	Other	623	986
62	EC.venous	0.38	Nonsignificant	1.00	0.66	Other	516	1,387
63	EPI.bile_duct_cholangiocyte	0.37	Nonsignificant	1.00	0.84	Other	37	60
64	MAC.kupffer	0.35	Nonsignificant	7.99e-03	1.34	Other	189	530
65	EPI.ectocervical_granular	0.32	Nonsignificant	—	0.31	Other	11	23
66	SCHWN.schwann_cell	0.29	Nonsignificant	—	—	Other	7	33
67	FIB.skin_neurosecretory	0.26	Nonsignificant	—	0.00	Other	0	0
68	EPI.skin_keratinocyte_progenitor	0.25	Nonsignificant	—	0.19	Other	0	3
69	EPI.tracheal_submucosal_gland	0.24	Nonsignificant	—	0.16	Other	0	0
70	DC.cDC1	0.24	Nonsignificant	1.00	0.77	Other	55	112
71	EPI.pancreatic_islet	0.23	Nonsignificant	1.00	0.72	Other	52	132
72	EPI.renal_thick_ascending_limb	0.21	Nonsignificant	1.00	0.76	Other	453	1,153
73	EPI.skin_hair_follicle_companion	0.20	Nonsignificant	—	0.10	Other	8	12
74	PC.IgA_muocsal	0.20	Nonsignificant	2.65e-04	1.54	Other	18	31
75	EPI.renal_intercalated_cell_type_B	0.20	Nonsignificant	—	0.15	Other	6	7
76	EPI.colonic_enteroendocrine	0.18	Nonsignificant	—	0.00	Other	1	1
77	NEU.EXC_CT	0.18	Nonsignificant	0.37	1.15	Other	362	384
78	FIB.skin_sheath	0.18	Nonsignificant	1.00	0.02	Other	49	118
79	EPI.pancreatic_ductal_mucinous	0.16	Nonsignificant	1.00	0.92	Other	219	430
80	EC.arterial	0.16	Nonsignificant	1.00	0.37	Other	356	885
81	GRANU.MAST	0.14	Nonsignificant	1.00	0.00	Other	5	6
82	EPI.endocervical_secretory	0.12	Nonsignificant	—	0.00	Other	0	0
83	EPI.salivary_intercalated_defense	0.12	Nonsignificant	1.00	0.67	Other	81	161
84	ASTRO.astrocyte	0.10	Nonsignificant	—	—	Other	228	1,111
85	EPI.renal_principal_cell	0.09	Nonsignificant	1.00	0.83	Other	207	403
86	B.germinal_center	0.09	Nonsignificant	0.76	1.09	Other	233	655
87	EPI.salivary_mucous_acinar	0.09	Nonsignificant	1.00	1.01	Other	639	1,189
88	MAC.resident_cardiac	0.08	Nonsignificant	1.00	0.89	Other	485	1,074
89	EPI.cervical_suprabasal	0.08	Nonsignificant	—	0.00	Other	14	50
90	MAC.proliferating	0.07	Nonsignificant	1.00	0.72	Other	87	253
91	EPI.gastric_foveolar	0.06	Nonsignificant	—	0.00	Other	0	0
92	EPI.renal_intercalated_cell_type_A	0.05	Nonsignificant	1.00	0.57	Other	67	142
93	EPI.salivary_duct_excretory	0.05	Nonsignificant	1.00	0.52	Other	85	180
94	PC.IgG_systemic	0.04	Nonsignificant	1.00	0.36	Other	41	60
95	GRNLSA.granulosa_cell	0.04	Nonsignificant	—	—	Other	257	0
96	EPI.skin_keratinocyte_proliferating	0.04	Nonsignificant	1.00	0.66	Other	47	76
97	MAC.microglia_like	0.04	Nonsignificant	1.00	0.48	Other	124	179
98	EPI.thymic_medullary	0.03	Nonsignificant	1.00	0.53	Other	26	133
99	EC.lymphatic	0.03	Nonsignificant	1.00	0.19	Other	630	998
100	EPI.esophageal_suprabasal	0.03	Nonsignificant	1.00	0.52	Other	158	404
101	EPI.renal_distal_tubule	0.03	Nonsignificant	1.00	0.52	Other	133	361
102	EPI.skin_interfollicular_spinous	0.03	Nonsignificant	1.00	0.50	Other	260	563
103	CHOND.chondrocyte	0.03	Nonsignificant	—	—	Other	519	730
104	MG.microglia	0.03	Nonsignificant	—	—	Other	49	0
105	MAC.resident_repair	0.03	Nonsignificant	1.00	0.33	Other	796	1,426
106	NEU.EXC_IT	0.02	Nonsignificant	1.00	0.92	Other	411	192
107	T.CD4_Th2	0.02	Nonsignificant	—	1.45	Other	1	2
108	EPI.alveolar_type_1	0.02	Nonsignificant	1.00	0.38	Other	26	101
109	HPC.haematopoietic_progenitor_cell	0.02	Nonsignificant	—	—	Other	211	370
110	EC.heart_remodeling	0.02	Nonsignificant	1.00	0.08	Other	569	1,594
111	EPI.skin_keratinocyte_basal	0.02	Nonsignificant	—	0.00	Other	13	26
112	B.naive	0.01	Nonsignificant	1.00	0.94	Other	307	595
113	OLG.oligodendrocyte	0.01	Nonsignificant	—	—	Other	384	1,397
114	MEL.melanocyte	0.01	Nonsignificant	—	—	Other	79	242
115	T.CD8_transitional	0.01	Nonsignificant	0.08	1.15	Other	497	932
116	EPI.alveolar_type_2	0.01	Nonsignificant	1.00	0.28	Other	813	1,853
117	EPI.colonocyte	0.01	Nonsignificant	1.00	0.32	Other	294	815
118	PLAT.platelet	8.64e-03	Nonsignificant	—	0.00	Other	38	53
119	T.CD4_Trm	7.73e-03	Nonsignificant	0.71	1.08	Other	176	363
120	MAC.alveolar	6.98e-03	Nonsignificant	1.00	0.13	Other	1,432	3,122
121	NEU.INH_VIP	6.45e-03	Nonsignificant	1.00	0.72	Other	241	366
122	EPI.skin_sweat_duct_keratinocyte	6.23e-03	Nonsignificant	1.00	0.34	Other	146	301
123	EPI.lung_club_secretory	5.58e-03	Nonsignificant	1.00	0.37	Other	5	14
124	B.memory	5.16e-03	Nonsignificant	1.00	0.84	Other	442	882
125	T.CD8_naive	4.88e-03	Nonsignificant	0.84	1.02	Other	317	708
126	THYMO.thymocyte	4.62e-03	Nonsignificant	—	—	Other	163	495
127	ILC2.innate_lymphoid_cell_2	3.75e-03	Nonsignificant	—	—	Other	2	0
128	T.CD4_Tfh	3.70e-03	Nonsignificant	0.84	1.04	Other	47	45
129	EPI.ileal_goblet	3.60e-03	Nonsignificant	1.00	0.43	Other	181	432
130	T.CD4_transitional	3.43e-03	Nonsignificant	0.84	1.03	Other	48	110
131	T.CD4_Treg	3.11e-03	Nonsignificant	0.99	0.98	Other	244	511
132	OPC.oligodendrocyte_precursor_cell	3.02e-03	Nonsignificant	—	—	Other	413	1,269
133	SKM.type_1_slow	2.99e-03	Nonsignificant	3.88e-04	1.21	Other	923	2,478
134	T.CD8_Tem	2.91e-03	Nonsignificant	0.84	1.03	Other	1,083	1,857
135	NEU.INH_PVALB	2.79e-03	Nonsignificant	1.00	0.60	Other	193	183
136	T.CD8_Trm	2.50e-03	Nonsignificant	0.99	0.98	Other	211	346
137	EPI.lung_multiciliated	2.48e-03	Nonsignificant	1.00	0.18	Other	16	49
138	T.CD4_Th17	2.41e-03	Nonsignificant	0.71	1.09	Other	421	794
139	T.MAIT	2.30e-03	Nonsignificant	0.99	0.91	Other	469	855
140	NEU.EXC_SYT2	2.25e-03	Nonsignificant	—	0.00	Other	40	77
141	T.gamma_delta	2.19e-03	Nonsignificant	0.99	0.92	Other	588	1,078
142	CM.cardiomyocyte	2.02e-03	Nonsignificant	—	—	Other	524	2,032
143	T.CD4_naive	1.25e-03	Nonsignificant	0.99	0.95	Other	399	866
144	SKM.type_2_fast	1.15e-03	Nonsignificant	0.18	1.07	Other	972	2,639
145	T.CD4_Tem	1.04e-03	Nonsignificant	0.99	0.96	Other	365	697
146	T.CD4_Tcm	9.49e-04	Nonsignificant	0.84	1.00	Other	494	988
147	EPI.renal_proximal_tubule	9.14e-04	Nonsignificant	1.00	0.12	Other	525	806
148	NK.natural_killer_cell	5.35e-04	Nonsignificant	—	—	Other	1,204	2,045
149	T.CD4_cytotoxic	3.24e-04	Nonsignificant	0.99	0.78	Other	855	1,493
150	NEU.INH_LAMP5	3.04e-04	Nonsignificant	1.00	0.36	Other	263	532
151	T.CD8_Tcm	2.79e-04	Nonsignificant	0.99	0.85	Other	460	926
152	DC.pDC	1.11e-04	Nonsignificant	1.00	0.00	Other	496	1,028

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	HEP.acute_phase.complement_antiviral	19.29	Significant	7.78e-03	2.16	Specific	377	751
2	EC.liver_sinusoidal.inflammatory	17.25	Significant	—	1.21	—	223	154
3	HEP.acute_phase.inflammatory	17.11	Significant	0.17	1.58	Specific	382	649
4	HEP.acute_phase.proliferative	13.48	Significant	—	0.23	Relevant	4	6
5	HEP.acute_phase.stress_secretory	13.38	Significant	0.39	1.21	Relevant	26	3
6	HEP.acute_phase.baseline	13.05	Significant	0.39	1.19	—	946	19
7	EC.liver_sinusoidal.remodeling_lipotoxicity	12.75	Significant	—	0.60	—	90	58
8	EC.liver_sinusoidal.prostanoid	11.46	Significant	—	0.46	Relevant	11	64
9	EC.liver_sinusoidal.hypoxia_metabolic	11.10	Significant	0.19	1.48	—	183	107
10	FIB.adventitial.adhesion_lipid	9.83	Significant	3.44e-04	2.27	Specific	58	209
11	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	9.29	Significant	—	0.42	Relevant	0	0
12	FIB.barrier_purinergic.stress_GF_binding	8.91	Significant	—	0.97	Relevant	0	0
13	HEP.acute_phase.complement_metabolic	8.77	Significant	1.00	0.00	Specific	1,423	3,464
14	PERI.cardiac_skeletal	8.60	Significant	1.60e-06	2.25	—	313	630
15	FIB.adventitial.activated_remodelling	8.19	Significant	—	0.73	Relevant	141	319
16	PERI.inflammatory	8.14	Significant	0.64	1.01	—	40	77
17	FIB.interstitial.stress_secretory	8.12	Significant	0.45	1.49	—	92	56
18	FIB.interstitial.immune_interact	8.11	Significant	0.45	1.33	—	12	1
19	PERI.angiocrine	7.94	Significant	0.57	1.17	—	93	102
20	FIB.interstitial.remodeling	7.72	Significant	0.59	1.15	—	31	9
21	HEP.acute_phase.hypoxia_lipid	7.69	Significant	—	0.00	Relevant	0	0
22	FIB.barrier_secretory.homeostasis	7.66	Significant	—	0.25	Relevant	0	0
23	FIB.suburothelial.homeostasis_matrix	7.63	Significant	5.44e-03	2.33	Specific	258	921
24	EC.liver_sinusoidal.stress	7.60	Significant	—	0.00	—	413	158
25	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	7.33	Significant	—	1.15	Relevant	0	0
26	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	6.99	Significant	—	0.32	Relevant	0	0
27	FIB.interstitial.mesenchymal_APC	6.55	Significant	0.59	1.09	—	81	33
28	FIB.neurolectin_mucosa.inflammatory	6.43	Significant	0.20	1.63	Relevant	52	110
29	ASPC.mesothelial_like	6.21	Significant	0.26	1.54	Relevant	143	486
30	FIB.interstitial.mesenchymal_regulator	6.18	Significant	0.65	0.95	—	4	4
31	FIB.adventitial.mechano_chemo_sensing	6.05	Significant	0.69	1.29	Other	135	524
32	ASPC.proliferative	5.70	Significant	0.26	1.43	Other	33	85
33	FIB.reticular.ECM_builder	5.63	Significant	—	0.56	Other	0	0
34	MUSC.baseline	5.61	Significant	0.33	1.44	Other	0	0
35	MONO.CD14.remodeling	5.56	Significant	6.35e-11	1.84	Other	2,373	295
36	ASPC.remodeling	5.52	Significant	0.14	1.62	Other	106	354
37	FIB.neurolectin_mucosa.axon_responsive	5.40	Nominal	0.29	1.25	Other	10	10
38	ASPC.baseline	5.39	Nominal	2.45e-09	2.03	Other	363	170
39	ASPC.adipocyte_capillary_interface	5.36	Nominal	0.26	1.41	Other	21	54
40	ADIPO.hypoxia_remodelling	5.32	Nominal	—	0.32	Other	29	105
41	FIB.interstitial.lipid_matrix	5.28	Nominal	1.00	0.19	Other	258	191
42	FIB.barrier_secretory.remodeling	5.24	Nominal	—	0.00	Other	0	0
43	PERI.baseline	5.22	Nominal	1.00	0.25	Other	39	66
44	FIB.suburothelial.contractile_myofibroblast	5.08	Nominal	—	0.07	Other	9	0
45	SMC.metabolic	5.01	Nominal	0.01	1.84	Other	14	40
46	FIB.adventitial.complement_angiocrine	4.87	Nominal	0.99	0.93	Other	153	684
47	ASPC.inflammatory	4.83	Nominal	0.19	1.59	Other	21	61
48	FIB.adventitial.baseline	4.78	Nominal	0.99	0.92	Other	157	278
49	FIB.hepatic_stellate_cell.inflammatory	4.56	Nominal	—	1.15	Other	0	0
50	MONO.CD14.APC_like	4.53	Nominal	0.24	1.27	Other	1,686	2,493
51	MUSC.quiescent_reservoir	4.51	Nominal	0.33	1.46	Other	2	8
52	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	4.42	Nominal	—	0.00	Other	0	0
53	FIB.neurolectin_mucosa.remodeling_repair	4.32	Nominal	—	0.00	Other	4	2
54	ASPC.secretory	4.31	Nominal	1.00	0.79	Other	76	5
55	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	4.31	Nominal	—	1.13	Other	0	0
56	FIB.adventitial.mito_secretory	4.30	Nominal	0.99	0.65	Other	21	7
57	EPI.hepatic_ductular_cholangiocyte.secretory_transport	4.30	Nominal	—	0.78	Other	0	0
58	FIB.hepatic_stellate_cell.fibrogenic	4.22	Nominal	—	0.00	Other	0	0
59	FIB.adventitial.PI16_matrix	4.11	Nominal	0.99	0.38	Other	70	90
60	FIB.suburothelial.urothelial_interface	4.08	Nominal	0.95	0.17	Other	9	8
61	HEP.canalicular_transport.baseline	4.08	Nominal	0.61	1.14	Other	199	477
62	FIB.lung_alveolar.mito_secretory	4.07	Nominal	—	0.48	Other	0	0
63	MUSC.early_activation	4.05	Nominal	0.72	0.96	Other	4	32
64	EPI.salivary_myoepithelial.junctional_transport	4.01	Nominal	0.62	1.10	Other	66	121
65	HEP.canalicular_transport.pericentral_like_hypoxia	3.99	Nominal	0.52	1.19	Other	326	8
66	EPI.salivary_myoepithelial.activated	3.92	Nominal	0.62	1.07	Other	85	281
67	FIB.neurolectin_mucosa.nerve_interface	3.82	Nominal	—	0.00	Other	4	0
68	HEP.canalicular_transport.inflammatory	3.81	Nominal	4.83e-06	1.90	Other	1,335	194
69	FIB.hepatic_stellate_cell.contractile	3.80	Nominal	—	0.00	Other	0	0
70	HEP.canalicular_transport.secretory_ERAD_UPR	3.67	Nominal	0.97	0.88	Other	232	28
71	EPI.salivary_myoepithelial.baseline	3.67	Nominal	0.77	0.68	Other	42	141
72	MONO.CD14.baseline	3.61	Nominal	1.00	0.78	Other	2,268	76
73	FIB.suburothelial.inflammatory_prostanoid	3.56	Nominal	—	0.00	Other	0	0
74	IPSC.mesendo_primed	3.55	Nominal	5.87e-12	1.30	Other	0	0
75	ASPC.preadipocyte_lipid_primed	3.50	Nominal	1.00	0.52	Other	331	129
76	HEP.canalicular_transport.ductular_like_transition	3.38	Nominal	0.97	0.82	Other	400	87
77	ASPC.niche_keeping_progenitor	3.35	Nominal	1.00	0.46	Other	52	219
78	ASPC.stem_like_progenitor	3.33	Nominal	1.00	0.55	Other	300	842
79	HEP.periportal_metabolic.stress_chaperone	3.11	Nominal	—	0.51	Other	66	128
80	SMC.contractile	3.09	Nominal	0.98	0.37	Other	80	588
81	FIB.adventitial.inflammatory_activated	3.09	Nominal	0.99	0.39	Other	100	473
82	EC.liver_sinusoidal.secretory_lipoprotein	3.05	Nominal	1.00	0.00	Other	120	70
83	FIB.tracheal_subepithelial.baseline	3.01	Nominal	—	0.00	Other	0	0
84	MUSC.activated_migratory	2.98	Nonsignificant	0.95	0.18	Other	6	7
85	FIB.reticular.immune_interface	2.94	Nonsignificant	—	0.00	Other	1	6
86	ASPC.signal_integrator	2.93	Nonsignificant	—	0.00	Other	0	0
87	EPI.extrahepatic_cholangiocyte.mucin_secretory	2.82	Nonsignificant	—	0.00	Other	0	0
88	FIB.perivascular_interface.lipid_shuttle	2.75	Nonsignificant	—	0.51	Other	51	170
89	SMC.activated	2.73	Nonsignificant	0.98	0.46	Other	2	5
90	FIB.lung_alveolar.stress_interacting	2.72	Nonsignificant	—	0.00	Other	0	0
91	FIB.reticular.stress_metallothionein	2.67	Nonsignificant	—	0.22	Other	3	32
92	EPI.hepatic_ductular_cholangiocyte.ion_transport	2.66	Nonsignificant	—	0.58	Other	0	0
93	EPI.skin_hair_follicle_bulge.niche_crosstalk	2.62	Nonsignificant	—	1.32	Other	29	88
94	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	2.61	Nonsignificant	—	0.43	Other	0	0
95	EPI.extrahepatic_cholangiocyte.barrier_interface	2.60	Nonsignificant	—	0.00	Other	0	0
96	EPI.hepatic_ductular_cholangiocyte.polarity	2.55	Nonsignificant	—	0.47	Other	0	0
97	ADIPO.immature	2.53	Nonsignificant	—	0.00	Other	24	40
98	MAC.kupffer.monocyte_like	2.49	Nonsignificant	—	1.06	Other	0	0
99	ADIPO.thermogenic	2.39	Nonsignificant	—	0.14	Other	0	0
100	EPI.colonic_tuft.homeostatic	2.37	Nonsignificant	—	0.73	Other	0	0
101	HEP.canalicular_transport.injury_stress	2.35	Nonsignificant	1.00	0.45	Other	289	24
102	MONO.CD14.platelet_bound	2.28	Nonsignificant	1.00	0.43	Other	964	176
103	FIB.perivascular_interface.vascular_BM_remodelling	2.24	Nonsignificant	—	0.00	Other	0	0
104	ASPC.activated	2.23	Nonsignificant	1.00	0.10	Other	164	162
105	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	2.21	Nonsignificant	0.70	1.11	Other	40	191
106	EPI.salivary_serous_acinar.secretory_active	2.16	Nonsignificant	7.61e-04	2.00	Other	242	69
107	FIB.reticular.stromal_niche	2.08	Nonsignificant	0.95	0.25	Other	0	0
108	FIB.barrier_purinergic.lipid_secretory	1.95	Nonsignificant	—	0.00	Other	0	0
109	FIB.transitioning.matrix_stress	1.92	Nonsignificant	—	0.57	Other	47	138
110	DC.cDC2.lipid_metabolic	1.83	Nonsignificant	—	1.06	Other	0	0
111	EPI.pancreatic_acinar.quiet_dedifferentiation	1.76	Nonsignificant	0.37	1.15	Other	142	171
112	HEP.pericentral_lipoprotein.UPR_redox	1.76	Nonsignificant	—	0.67	Other	0	0
113	EPI.salivary_myoepithelial.contractile_repair	1.73	Nonsignificant	—	0.00	Other	3	9
114	EPI.renal_immature_ureteric_bud.defense_secretory	1.72	Nonsignificant	0.55	1.22	Other	45	76
115	GRANU.neutrophil.tissue_patrolling	1.64	Nonsignificant	—	1.28	Other	0	0
116	MONO.CD16.hepatic_mac_like	1.63	Nonsignificant	0.18	1.14	Other	803	117
117	EPI.tracheal_basal.homeostatic_progenitor	1.59	Nonsignificant	0.14	1.85	Other	285	74
118	EPI.skin_follicular_keratinizing.transit_amplifying	1.56	Nonsignificant	—	0.38	Other	21	49
119	HEP.pericentral_lipoprotein.ApoB_coagulation	1.56	Nonsignificant	—	0.00	Other	0	0
120	EC.capillary.migratory	1.45	Nonsignificant	0.45	1.31	Other	181	509
121	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	1.43	Nonsignificant	—	0.00	Other	5	3
122	FIB.perivascular_interface.vasomotor_tone	1.42	Nonsignificant	—	0.00	Other	0	0
123	EPI.tracheal_basal.activated_stress	1.42	Nonsignificant	0.58	0.83	Other	32	0
124	HEP.periportal_metabolic.apolipoprotein_secretory	1.39	Nonsignificant	0.78	1.17	Other	43	110
125	ADIPO.inflammatory	1.34	Nonsignificant	—	0.00	Other	0	0
126	EC.capillary.postcap_venule	1.34	Nonsignificant	0.34	1.40	Other	355	261
127	MAC.LAM.antimicrobial	1.33	Nonsignificant	0.04	1.46	Other	389	93
128	EPI.skin_follicular_keratinizing.upper_infundibulum	1.33	Nonsignificant	—	0.00	Other	8	2
129	EPI.colonic_tuft.activated	1.33	Nonsignificant	—	0.00	Other	0	0
130	FIB.transitioning.motility_remodelling	1.24	Nonsignificant	—	0.00	Other	0	0
131	IPSC.mesodermal_primed	1.21	Nonsignificant	1.00	0.91	Other	0	0
132	DC.cDC2.monocyte_like	1.21	Nonsignificant	0.01	1.62	Other	1,285	791
133	GRANU.neutrophil.primed_degranulation	1.20	Nonsignificant	—	0.26	Other	0	0
134	EPI.ileal_bile_transport.absorptive_xenobiotic	1.17	Nonsignificant	0.28	1.44	Other	11	12
135	EPI.pancreatic_ductal_bicarbonate.baseline	1.17	Nonsignificant	0.70	1.26	Other	11	42
136	EPI.skin_follicular_keratinizing.root_infundibulum	1.11	Nonsignificant	—	0.00	Other	0	0
137	EC.capillary.baseline	1.09	Nonsignificant	0.96	1.00	Other	246	560
138	EPI.thymic_cortical.baseline	1.07	Nonsignificant	0.07	1.82	Other	185	386
139	FIB.transitioning.secretory_procollagen	1.07	Nonsignificant	—	0.00	Other	0	0
140	HEP.canalicular_transport.sterol_lipid_biosynthesis	1.05	Nonsignificant	—	0.00	Other	10	20
141	EPI.thymic_cortical.Notch_interface	1.04	Nonsignificant	—	0.00	Other	82	137
142	EPI.hepatic_ductular_cholangiocyte.stress	1.04	Nonsignificant	—	0.00	Other	0	0
143	EC.capillary.angiocrine	1.03	Nonsignificant	0.96	0.96	Other	250	630
144	MONO.CD16.inflammatory	1.03	Nonsignificant	0.06	1.16	Other	1,640	168
145	EPI.ileal_bile_transport.detox_transcytosis	1.02	Nonsignificant	—	0.00	Other	0	1
146	EC.capillary.stress	1.00	Nonsignificant	0.96	0.83	Other	44	36
147	EPI.pancreatic_ductal_bicarbonate.stress	0.99	Nonsignificant	—	0.16	Other	12	33
148	GRANU.neutrophil.antiviral_endotoxin	0.99	Nonsignificant	—	0.00	Other	0	0
149	IPSC.axial_identity_primed	0.96	Nonsignificant	1.00	1.00	Other	0	0
150	EPI.pancreatic_acinar.baseline	0.96	Nonsignificant	0.44	1.07	Other	274	163
151	HEP.periportal_metabolic.urea_onecarbon_secretory	0.95	Nonsignificant	0.02	1.22	Other	1,332	3,053
152	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.95	Nonsignificant	—	1.29	Other	39	82
153	EPI.ileal_enterocyte_crypt.villus_transition	0.95	Nonsignificant	—	1.50	Other	7	10
154	EPI.pancreatic_ductal_perivascular.baseline	0.94	Nonsignificant	0.53	1.05	Other	1	5
155	MAC.LAM.inflammatory_APC	0.92	Nonsignificant	4.14e-03	1.52	Other	872	165
156	EPI.skin_sebaceous_duct_luminal.immune_interface	0.86	Nonsignificant	—	1.24	Other	0	0
157	EC.capillary.inflammatory	0.85	Nonsignificant	0.96	0.88	Other	27	51
158	EPI.pancreatic_ductal_bicarbonate.activated	0.84	Nonsignificant	0.70	0.93	Other	10	7
159	EPI.pancreatic_ductal_progenitor.baseline	0.84	Nonsignificant	4.13e-03	2.33	Other	179	702
160	EC.capillary.angiogenic_tip	0.84	Nonsignificant	0.96	0.72	Other	186	218
161	EC.venous.adipose_lipid	0.84	Nonsignificant	0.06	1.41	Other	254	476
162	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	0.84	Nonsignificant	—	1.44	Other	0	0
163	SCHWN.reactive_inflammatory	0.83	Nonsignificant	—	1.44	Other	0	0
164	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	0.82	Nonsignificant	—	0.00	Other	0	0
165	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	0.82	Nonsignificant	0.88	0.66	Other	219	533
166	MESO.activated_stress	0.81	Nonsignificant	—	0.69	Other	0	0
167	EPI.salivary_duct_ion_transport.baseline	0.81	Nonsignificant	—	—	Other	0	0
168	DC.mig.baseline	0.80	Nonsignificant	—	0.00	Other	1	0
169	EC.venous.remodeling_stalk	0.80	Nonsignificant	7.01e-03	1.62	Other	559	566
170	EPI.tracheal_suprabasal.transitional_wound	0.79	Nonsignificant	—	0.17	Other	16	1
171	IPSC.stromal_primed	0.79	Nonsignificant	1.00	0.97	Other	0	0
172	EPI.ectocervical_granular.immune_interact	0.78	Nonsignificant	—	1.15	Other	0	0
173	MAC.resident_iron.heme_catabolism	0.78	Nonsignificant	0.25	1.26	Other	30	51
174	FIB.transitioning.ISG_primed_interface	0.77	Nonsignificant	—	0.00	Other	17	80
175	EPI.pancreatic_ductal_progenitor.ciliated_transport	0.74	Nonsignificant	—	0.00	Other	105	368
176	NEU.EXC_NTNG1.synaptic	0.73	Nonsignificant	—	0.67	Other	0	0
177	MESO.secretory_structural	0.73	Nonsignificant	—	0.28	Other	0	0
178	EPI.ectocervical_granular.inflammatory	0.73	Nonsignificant	—	0.32	Other	0	0
179	EPI.pancreatic_acinar.stress	0.72	Nonsignificant	1.00	0.87	Other	28	28
180	EPI.pancreatic_ductal_perivascular.protective_antioxidant	0.71	Nonsignificant	—	0.00	Other	11	69
181	EPI.pancreatic_acinar.inflammatory_regenerative	0.69	Nonsignificant	0.23	1.29	Other	25	113
182	B.age_associated.activated	0.68	Nonsignificant	—	0.66	Other	18	22
183	HEP.periportal_metabolic.stress_checkpoint	0.68	Nonsignificant	0.83	1.05	Other	234	786
184	EPI.pancreatic_islet.delta	0.66	Nonsignificant	—	1.04	Other	0	0
185	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.66	Nonsignificant	—	0.00	Other	0	0
186	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.66	Nonsignificant	—	0.00	Other	6	9
187	EPI.thymic_cortical.secretory_remodeling	0.65	Nonsignificant	—	0.00	Other	4	1
188	EC.venous.quiescent_homeostatic	0.64	Nonsignificant	0.06	1.36	Other	456	360
189	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.64	Nonsignificant	0.70	0.95	Other	14	32
190	EPI.ileal_enterocyte_absorptive.villus_tip	0.62	Nonsignificant	0.59	0.87	Other	4	3
191	EPI.ileal_enterocyte_absorptive.brush_border	0.60	Nonsignificant	0.51	1.27	Other	580	1,717
192	EC.capillary.activated	0.57	Nonsignificant	0.98	0.29	Other	2	5
193	MAC.resident_iron.APC_iron_sensing	0.57	Nonsignificant	0.25	1.27	Other	211	114
194	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	0.56	Nonsignificant	0.07	1.75	Other	2	9
195	EPI.pancreatic_ductal_progenitor.ADM_like	0.56	Nonsignificant	—	0.00	Other	0	0
196	DC.cDC2.migratory	0.55	Nonsignificant	0.98	1.06	Other	185	39
197	MESO.antiviral	0.55	Nonsignificant	—	0.20	Other	3	8
198	FIB.skin_papillary.baseline	0.53	Nonsignificant	—	0.00	Other	0	0
199	MAC.LAM.lipid_opsonization	0.52	Nonsignificant	1.00	0.63	Other	45	14
200	NEU.EXC_CT.Ca2_sensor	0.52	Nonsignificant	—	1.59	Other	0	0
201	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	0.52	Nonsignificant	—	0.00	Other	0	0
202	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	0.51	Nonsignificant	0.21	1.39	Other	33	34
203	MAC.LAM.perivascular_angiocrine	0.51	Nonsignificant	—	0.00	Other	53	138
204	EPI.ileal_enterocyte_crypt.bile_transport	0.50	Nonsignificant	0.32	1.35	Other	2	0
205	EPI.colonic_enteroendocrine.progenitor	0.50	Nonsignificant	—	0.97	Other	0	0
206	MONO.CD14.inflammatory	0.49	Nonsignificant	1.00	0.71	Other	92	134
207	DC.cDC2.tolerogenic_regulatory	0.49	Nonsignificant	0.98	0.99	Other	44	4
208	FIB.skin_tenogenic.baseline	0.48	Nonsignificant	—	0.00	Other	0	2
209	EPI.esophageal_basal.activated_progenitor	0.48	Nonsignificant	0.04	1.91	Other	1	0
210	MAC.MDM.inflammatory_phagocytic	0.47	Nonsignificant	0.38	1.27	Other	199	52
211	EPI.ileal_enterocyte_crypt.baseline	0.47	Nonsignificant	0.77	0.92	Other	11	6
212	EC.arterial.angiogenic_tip	0.47	Nonsignificant	—	1.25	Other	30	37
213	DC.cDC2.antiviral	0.46	Nonsignificant	0.98	0.83	Other	100	37
214	EPI.salivary_intercalated_defense.basal_EMT	0.44	Nonsignificant	—	1.49	Other	0	0
215	EPI.salivary_serous_acinar.quiescent	0.44	Nonsignificant	1.00	0.05	Other	178	493
216	EPI.renal_principal_cell.inflammatory	0.43	Nonsignificant	0.78	1.43	Other	74	157
217	EPI.bile_duct_cholangiocyte.secretory_mucin	0.42	Nonsignificant	—	0.46	Other	7	12
218	EPI.renal_thick_ascending_limb.barrier_repair	0.42	Nonsignificant	0.10	1.25	Other	141	284
219	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	0.40	Nonsignificant	—	0.18	Other	0	0
220	MAC.MDM.APC_dendritic	0.40	Nonsignificant	0.42	1.13	Other	48	15
221	MAC.MDM.LAM_like	0.39	Nonsignificant	0.42	1.14	Other	12	14
222	DC.cDC1.proliferative	0.39	Nonsignificant	—	0.89	Other	0	0
223	EPI.renal_thick_ascending_limb.canonical_salt_transporter	0.39	Nonsignificant	0.03	1.28	Other	322	317
224	MAC.resident_iron.stress_tolerogenic	0.37	Nonsignificant	—	0.18	Other	0	0
225	SCHWN.translation_boost	0.36	Nonsignificant	—	0.56	Other	8	1
226	B.age_associated.migratory	0.36	Nonsignificant	0.81	0.66	Other	2	2
227	EPI.endocervical_secretory.squamous_barrier	0.36	Nonsignificant	—	0.67	Other	0	0
228	GRNLSA.stress_metabolic	0.35	Nonsignificant	—	1.22	Other	1	2
229	DC.cDC1.baseline	0.35	Nonsignificant	—	0.49	Other	0	0
230	MAC.LAM.lipid_phagocytosis	0.35	Nonsignificant	1.00	0.39	Other	369	328
231	EPI.ileal_enterocyte_crypt.proliferative_S	0.33	Nonsignificant	0.77	0.78	Other	4	2
232	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.33	Nonsignificant	—	0.00	Other	2	0
233	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.33	Nonsignificant	—	0.97	Other	0	0
234	MONO.CD16.platelet_bound	0.32	Nonsignificant	1.00	0.88	Other	372	508
235	MONO.CD14.repair_M2_like	0.32	Nonsignificant	1.00	0.02	Other	550	1,495
236	EPI.pancreatic_islet.beta	0.31	Nonsignificant	0.23	1.22	Other	42	57
237	B.age_associated.naive_transitional	0.31	Nonsignificant	—	0.00	Other	0	0
238	EPI.skin_keratinocyte_progenitor.activated_stress	0.31	Nonsignificant	—	0.38	Other	0	0
239	EPI.renal_immature_ureteric_bud.osmoprotective	0.31	Nonsignificant	0.91	0.80	Other	126	44
240	NEU.EXC_NTNG1.nuclear_reg	0.30	Nonsignificant	—	0.00	Other	0	0
241	EPI.tracheal_submucosal_gland.ductal_luminal	0.30	Nonsignificant	—	0.00	Other	0	0
242	MAC.MDM.complement_resolving	0.30	Nonsignificant	0.97	0.61	Other	440	860
243	EC.venous.baseline	0.30	Nonsignificant	0.98	0.74	Other	346	807
244	EPI.ectocervical_granular.secretory_apocrine	0.30	Nonsignificant	—	0.00	Other	0	0
245	MESO.baseline	0.30	Nonsignificant	0.88	0.58	Other	0	6
246	DC.cDC2.adhesion_signaling	0.29	Nonsignificant	0.98	0.45	Other	35	9
247	B.germinal_center.DZ_M_phase	0.29	Nonsignificant	—	1.47	Other	0	0
248	DC.cDC1.cross_presenting	0.29	Nonsignificant	—	0.52	Other	0	0
249	EC.venous.activated	0.27	Nonsignificant	0.56	1.06	Other	247	752
250	ASTRO.neuromodulatory	0.27	Nonsignificant	0.34	1.29	Other	34	172
251	FIB.skin_neurosecretory.baseline	0.26	Nonsignificant	—	0.00	Other	0	0
252	EC.arterial.inflammatory	0.24	Nonsignificant	0.46	1.33	Other	63	50
253	DC.cDC1.activated	0.24	Nonsignificant	—	0.00	Other	0	0
254	DC.cDC2.pro_inflammatory	0.24	Nonsignificant	0.98	0.57	Other	3	5
255	EPI.skin_sebaceous_duct_luminal.detox_repair	0.24	Nonsignificant	1.00	0.00	Other	137	94
256	PC.IgA_muocsal.baseline	0.23	Nonsignificant	0.90	0.97	Other	3	5
257	NEU.EXC_CT.Ca2_signaling	0.22	Nonsignificant	—	0.66	Other	68	17
258	MONO.CD14.cord_tolerance	0.22	Nonsignificant	1.00	0.04	Other	864	753
259	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.21	Nonsignificant	—	0.00	Other	0	0
260	PC.IgA_muocsal.migratory	0.21	Nonsignificant	0.41	1.19	Other	4	1
261	FIB.skin_sheath.ECM_immune	0.21	Nonsignificant	—	0.80	Other	0	0
262	FIB.skin_sheath.neuro_vascular_interface	0.21	Nonsignificant	—	0.23	Other	0	0
263	EC.arterial.homeostatic	0.20	Nonsignificant	0.78	1.16	Other	24	3
264	EPI.tracheal_suprabasal.secretory_immune	0.20	Nonsignificant	—	0.00	Other	0	0
265	EC.arterial.arteriole_gas_exchange	0.20	Nonsignificant	0.80	1.02	Other	238	131
266	MAC.resident_repair.lipid_phagocytic	0.20	Nonsignificant	0.10	1.51	Other	228	604
267	EPI.renal_intercalated_cell_type_B.baseline	0.20	Nonsignificant	—	0.00	Other	3	1
268	EC.arterial.ion_pump	0.19	Nonsignificant	0.80	1.12	Other	3	2
269	HEP.periportal_metabolic.acute_phase_barrier	0.19	Nonsignificant	1.00	0.90	Other	533	138
270	EPI.tracheal_submucosal_gland.acinar_serous	0.19	Nonsignificant	—	0.00	Other	0	0
271	MAC.LAM.anti_inflammatory	0.18	Nonsignificant	1.00	0.18	Other	86	132
272	MAC.resident_iron.heme_recycling	0.18	Nonsignificant	—	0.00	Other	30	37
273	PC.IgA_muocsal.activated	0.18	Nonsignificant	0.90	0.87	Other	17	8
274	ASTRO.stress_acute	0.17	Nonsignificant	0.34	1.22	Other	60	56
275	MONO.CD16.baseline	0.17	Nonsignificant	1.00	0.70	Other	50	1
276	EC.venous.cardiac_structural	0.17	Nonsignificant	0.97	0.74	Other	102	229
277	NEU.EXC_CT.remodeling	0.17	Nonsignificant	—	0.21	Other	23	1
278	GRANU.MAST.activated_repair	0.16	Nonsignificant	—	0.57	Other	0	1
279	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.16	Nonsignificant	0.99	0.13	Other	7	16
280	IPSC.endoderm_primed	0.15	Nonsignificant	1.00	0.97	Other	0	0
281	GRNLSA.EMT_insulin_signaling	0.15	Nonsignificant	0.70	1.31	Other	47	84
282	EPI.esophageal_basal.junctional_barrier	0.15	Nonsignificant	—	0.00	Other	0	0
283	ASTRO.A2_reactive	0.15	Nonsignificant	0.86	1.06	Other	10	37
284	EPI.renal_thick_ascending_limb.cation_flux	0.15	Nonsignificant	0.91	0.99	Other	57	95
285	EPI.cervical_suprabasal.inflammatory_repair	0.15	Nonsignificant	—	0.42	Other	0	0
286	EC.heart_remodeling.capillary_metabolic	0.15	Nonsignificant	0.17	1.49	Other	54	414
287	GRANU.MAST.resting_granule	0.14	Nonsignificant	—	0.09	Other	0	0
288	EPI.salivary_intercalated_defense.inflammatory	0.13	Nonsignificant	0.75	1.09	Other	152	360
289	EC.arterial.arteriole_interface	0.13	Nonsignificant	0.80	0.90	Other	31	12
290	EPI.skin_interfollicular_spinous.transition_basal	0.13	Nonsignificant	1.07e-04	1.50	Other	100	127
291	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.12	Nonsignificant	—	0.00	Other	19	54
292	EPI.alveolar_type_1.activated	0.12	Nonsignificant	—	1.64	Other	0	0
293	B.germinal_center.DZ_S_phase	0.12	Nonsignificant	—	0.58	Other	0	0
294	EC.arterial.mito_contact	0.11	Nonsignificant	0.80	0.94	Other	14	5
295	EPI.skin_appendage_keratinocyte.transit_amplifying	0.11	Nonsignificant	—	0.00	Other	109	358
296	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.11	Nonsignificant	—	1.13	Other	0	0
297	HPC.GMP_granulocytic	0.11	Nonsignificant	—	0.14	Other	3	3
298	FIB.skin_sheath.stress_chaperone	0.11	Nonsignificant	—	0.00	Other	0	0
299	ASTRO.synaptic_interaction	0.11	Nonsignificant	0.86	1.08	Other	76	334
300	MESO.activated_migratory	0.10	Nonsignificant	—	0.00	Other	0	0
301	MAC.resident_cardiac.phagocytic_homeostasis	0.10	Nonsignificant	0.58	1.05	Other	564	1,221
302	MAC.resident_iron.redox_metabolic	0.10	Nonsignificant	0.98	0.37	Other	4	4
303	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	0.09	Nonsignificant	—	0.00	Other	0	0
304	EPI.skin_hair_follicle_bulge.anagen_growth	0.09	Nonsignificant	—	0.00	Other	0	0
305	PC.IgA_muocsal.plasmablast	0.09	Nonsignificant	0.90	0.69	Other	5	4
306	EPI.skin_hair_follicle_bulge.quiescent	0.09	Nonsignificant	1.00	0.00	Other	56	69
307	PC.IgG_systemic.secretory	0.09	Nonsignificant	0.16	1.29	Other	0	0
308	EPI.salivary_mucous_acinar.baseline	0.09	Nonsignificant	—	—	Other	394	683
309	ASTRO.hypoxia_angiogenic	0.08	Nonsignificant	0.86	1.04	Other	5	18
310	MAC.proliferating.DNA_replication	0.08	Nonsignificant	0.31	1.09	Other	3	6
311	EPI.renal_principal_cell.canonical_vasopressin	0.08	Nonsignificant	0.83	1.16	Other	2	0
312	GRANU.MAST.activated_acute	0.07	Nonsignificant	—	0.00	Other	0	0
313	MAC.kupffer.stress	0.07	Nonsignificant	0.31	1.18	Other	9	3
314	NEU.EXC_IT.structural	0.07	Nonsignificant	0.68	1.11	Other	171	41
315	EPI.thymic_medullary.proliferative_APC	0.07	Nonsignificant	—	1.26	Other	0	0
316	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.07	Nonsignificant	0.91	0.68	Other	11	22
317	EC.arterial.metabolic	0.07	Nonsignificant	1.00	0.45	Other	195	159
318	EC.lymphatic.tip_migratory	0.07	Nonsignificant	0.30	1.41	Other	23	37
319	EC.arterial.elastic	0.07	Nonsignificant	0.80	0.95	Other	22	45
320	EPI.salivary_duct_excretory.baseline	0.07	Nonsignificant	0.13	1.35	Other	23	57
321	EPI.renal_intercalated_cell_type_A.PC_transitional	0.07	Nonsignificant	—	0.25	Other	203	407
322	MEL.neurotrophic_migratory	0.07	Nonsignificant	—	1.80	Other	0	0
323	MAC.microglia_like.inflammatory_chemokine	0.07	Nonsignificant	—	0.34	Other	20	32
324	EPI.esophageal_suprabasal.basal_transitional	0.07	Nonsignificant	8.40e-03	1.72	Other	44	67
325	SCHWN.axon_contact_cardiac	0.06	Nonsignificant	1.00	0.00	Other	18	63
326	ASTRO.immature_lipid	0.06	Nonsignificant	1.00	0.72	Other	23	113
327	NEU.EXC_CT.projector	0.06	Nonsignificant	1.00	0.00	Other	87	26
328	EC.heart_remodeling.translation_boost	0.06	Nonsignificant	—	1.66	Other	0	0
329	EPI.gastric_foveolar.baseline	0.06	Nonsignificant	—	0.00	Other	0	0
330	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	0.06	Nonsignificant	0.90	0.72	Other	449	1,034
331	HEP.periportal_metabolic.inflammatory_activated	0.06	Nonsignificant	1.00	0.50	Other	712	1,610
332	MG.expanding	0.06	Nonsignificant	0.82	1.23	Other	2	1
333	IPSC.proliferative	0.06	Nonsignificant	1.00	0.78	Other	0	0
334	EC.heart_remodeling.activated_acute	0.05	Nonsignificant	0.33	1.39	Other	102	186
335	ASTRO.A1_reactive	0.05	Nonsignificant	1.00	0.64	Other	433	394
336	EPI.renal_distal_tubule.ion_transport	0.05	Nonsignificant	—	0.53	Other	0	0
337	MAC.proliferating.stress	0.05	Nonsignificant	—	0.00	Other	87	136
338	EPI.renal_intercalated_cell_type_A.acid_secretion	0.05	Nonsignificant	0.84	0.69	Other	12	6
339	B.naive.restrained	0.05	Nonsignificant	0.01	1.16	Other	183	353
340	EPI.ileal_enterocyte_crypt.secretory_precursor	0.05	Nonsignificant	—	0.00	Other	0	0
341	CM.contractile_oxphos	0.05	Nonsignificant	0.96	1.12	Other	6	19
342	MAC.kupffer.tolerogenic	0.04	Nonsignificant	—	0.12	Other	45	49
343	EPI.renal_distal_tubule.stress	0.04	Nonsignificant	—	0.58	Other	0	0
344	EPI.skin_hair_follicle_companion.activated_migratory	0.04	Nonsignificant	—	0.00	Other	0	0
345	CHOND.remodeling	0.04	Nonsignificant	—	0.80	Other	5	0
346	B.germinal_center.LZ_selection	0.04	Nonsignificant	—	0.00	Other	0	0
347	EPI.colonocyte.distal_absorptive	0.04	Nonsignificant	—	1.48	Other	0	0
348	MAC.kupffer.inflammatory	0.04	Nonsignificant	—	0.00	Other	7	4
349	EPI.skin_keratinocyte_basal.basement_anchoring	0.04	Nonsignificant	—	0.97	Other	0	0
350	T.CD4_Th2.tissue_adapted	0.04	Nonsignificant	—	0.97	Other	0	0
351	EPI.colonic_enteroendocrine.Lcell_peptide	0.04	Nonsignificant	—	0.00	Other	0	0
352	B.memory.preactivated	0.04	Nonsignificant	0.44	1.11	Other	173	174
353	EC.lymphatic.scavenger	0.04	Nonsignificant	0.57	1.04	Other	203	257
354	EPI.ectocervical_granular.proliferative_basal	0.04	Nonsignificant	—	0.00	Other	0	0
355	MAC.kupffer.fibrogenic	0.04	Nonsignificant	—	0.30	Other	0	0
356	EC.lymphatic.valve	0.04	Nonsignificant	—	0.42	Other	0	0
357	EPI.thymic_medullary.hormone_xeno_barrier	0.04	Nonsignificant	—	0.21	Other	0	8
358	MAC.resident_cardiac.antigen_presenting	0.03	Nonsignificant	0.58	1.14	Other	52	27
359	EPI.skin_keratinocyte_proliferating.detox_repair	0.03	Nonsignificant	—	0.00	Other	0	0
360	EPI.thymic_medullary.stress_APC	0.03	Nonsignificant	0.77	0.66	Other	2	4
361	EPI.pancreatic_islet.alpha	0.03	Nonsignificant	—	0.00	Other	152	330
362	EPI.renal_distal_tubule.repair	0.03	Nonsignificant	—	0.20	Other	34	102
363	OLG.regulatory	0.03	Nonsignificant	1.60e-03	1.15	Other	353	73
364	EPI.renal_principal_cell.intercalated_like	0.03	Nonsignificant	0.96	0.83	Other	63	66
365	MG.phagocytic_APC	0.03	Nonsignificant	0.82	1.03	Other	25	8
366	T.CD8_transitional.APC_like	0.03	Nonsignificant	0.67	1.11	Other	205	62
367	PC.IgG_systemic.metabolic	0.03	Nonsignificant	0.16	1.24	Other	46	63
368	CHOND.activated_fibro_like	0.03	Nonsignificant	0.53	1.07	Other	531	188
369	EPI.ileal_goblet.immature	0.03	Nonsignificant	—	1.44	Other	0	0
370	NEU.EXC_IT.neuromodulated	0.03	Nonsignificant	0.68	1.07	Other	176	116
371	EPI.esophageal_suprabasal.differentiating_keratin	0.03	Nonsignificant	0.27	1.18	Other	131	61
372	HPC.GMP_inflammatory	0.03	Nonsignificant	0.74	1.16	Other	20	10
373	THYMO.SP_CD8_transitional	0.03	Nonsignificant	0.16	1.31	Other	32	75
374	NEU.EXC_IT.transitional	0.03	Nonsignificant	0.58	1.20	Other	237	142
375	ASTRO.stress_mito	0.03	Nonsignificant	1.00	0.57	Other	47	110
376	CHOND.articular_collagen	0.03	Nonsignificant	0.53	1.00	Other	551	266
377	MEL.dedifferentiated_migratory	0.02	Nonsignificant	—	1.01	Other	0	0
378	EPI.thymic_medullary.canonical_alarmin	0.02	Nonsignificant	0.77	0.85	Other	8	17
379	PC.IgG_systemic.interacting	0.02	Nonsignificant	0.84	0.75	Other	0	0
380	OLG.regulatory_activated	0.02	Nonsignificant	1.00	0.99	Other	196	614
381	GRNLSA.chemokine_mechanosensory	0.02	Nonsignificant	0.70	1.19	Other	1	0
382	EPI.renal_thick_ascending_limb.remodeling	0.02	Nonsignificant	1.00	0.44	Other	152	92
383	NEU.INH_VIP.nuclear_reg	0.02	Nonsignificant	—	1.09	Other	20	4
384	OLG.stress	0.02	Nonsignificant	0.25	1.08	Other	232	8
385	HPC.CLP_B_primed	0.02	Nonsignificant	—	0.81	Other	0	0
386	CHOND.pro_inflammatory	0.02	Nonsignificant	0.53	1.01	Other	181	351
387	THYMO.DN_preTCR	0.02	Nonsignificant	0.16	1.21	Other	41	71
388	HEP.periportal_metabolic.canonical_urea_cycle	0.02	Nonsignificant	1.00	0.29	Other	1,464	269
389	MAC.resident_repair.antigen_presenting	0.02	Nonsignificant	0.99	1.05	Other	244	113
390	MAC.resident_cardiac.inflammatory_reparative	0.02	Nonsignificant	0.58	1.03	Other	31	96
391	EC.heart_remodeling.angiocrine	0.02	Nonsignificant	0.87	1.06	Other	182	525
392	EPI.skin_sweat_duct_keratinocyte.signal_gate	0.02	Nonsignificant	—	1.24	Other	43	26
393	EPI.alveolar_type_2.stress_response	0.02	Nonsignificant	0.38	1.23	Other	675	1,562
394	EPI.renal_thick_ascending_limb.salt_sensing	0.02	Nonsignificant	1.00	0.71	Other	73	103
395	CHOND.angiogenic	0.02	Nonsignificant	—	0.39	Other	0	0
396	B.germinal_center.LZ_memory_precursor	0.02	Nonsignificant	—	0.00	Other	0	0
397	EPI.esophageal_suprabasal.proliferative_exit	0.02	Nonsignificant	—	0.00	Other	0	0
398	IPSC.mesenchymal_primed	0.02	Nonsignificant	1.00	0.76	Other	0	0
399	NEU.INH_VIP.serotonergic	0.02	Nonsignificant	—	0.52	Other	9	2
400	MG.baseline	0.02	Nonsignificant	0.88	0.79	Other	16	5
401	EPI.lung_club_secretory.ciliogenesis_axoneme	0.02	Nonsignificant	—	0.34	Other	0	0
402	NEU.EXC_IT.adhesion	0.02	Nonsignificant	1.00	0.92	Other	252	108
403	GRNLSA.proliferative_migratory	0.02	Nonsignificant	0.70	1.19	Other	248	292
404	T.CD4_Treg.tissue_effector	0.02	Nonsignificant	0.14	1.34	Other	16	13
405	IPSC.stress	0.02	Nonsignificant	1.00	0.71	Other	0	0
406	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	0.02	Nonsignificant	—	0.00	Other	49	237
407	MAC.microglia_like.phagocytic_redox	0.02	Nonsignificant	—	0.00	Other	0	0
408	T.CD4_Trm.central_like	0.02	Nonsignificant	0.04	1.22	Other	38	31
409	EC.lymphatic.activated	0.01	Nonsignificant	0.57	1.02	Other	47	73
410	HEP.periportal_metabolic.xenobiotic_detox	0.01	Nonsignificant	1.00	0.18	Other	1,440	139
411	MAC.resident_repair.chemokine_angiocrine	0.01	Nonsignificant	0.99	0.74	Other	87	138
412	EC.lymphatic.baseline	0.01	Nonsignificant	0.99	0.48	Other	38	72
413	IPSC.neuroendocrine_primed	0.01	Nonsignificant	—	0.20	Other	0	0
414	PLAT.adhesion	0.01	Nonsignificant	—	0.48	Other	0	0
415	B.naive.antigen_presenting_ready	0.01	Nonsignificant	0.99	1.04	Other	48	73
416	EPI.colonocyte.proximal_transport	0.01	Nonsignificant	0.89	1.00	Other	24	12
417	NEU.INH_VIP.LAMP5_hybrid	0.01	Nonsignificant	—	1.00	Other	1	9
418	EPI.colonocyte.crypt_progenitor	0.01	Nonsignificant	0.30	1.26	Other	115	265
419	EPI.salivary_duct_excretory.stress	0.01	Nonsignificant	0.93	0.48	Other	33	68
420	T.CD4_Tfh.canonical_GC_helper	0.01	Nonsignificant	0.43	1.22	Other	1	2
421	T.CD4_Trm.stress_adaptive	0.01	Nonsignificant	0.71	1.10	Other	8	22
422	T.CD4_Th2.precursor	0.01	Nonsignificant	—	0.00	Other	0	0
423	T.CD8_transitional.effector_primed	0.01	Nonsignificant	0.67	1.07	Other	435	151
424	EPI.pancreatic_acinar.metabolic_onecarbon	0.01	Nonsignificant	1.00	0.34	Other	287	328
425	EPI.renal_principal_cell.injury_repair	0.01	Nonsignificant	0.96	0.41	Other	26	9
426	MAC.alveolar.stress_metabolic	0.01	Nonsignificant	0.23	1.53	Other	116	148
427	DC.cDC2.proliferative	0.01	Nonsignificant	—	0.00	Other	39	71
428	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.01	Nonsignificant	—	0.00	Other	0	0
429	B.germinal_center.LZ_survival	1.00e-02	Nonsignificant	—	0.00	Other	0	0
430	MAC.alveolar.lipid_autophagy	9.78e-03	Nonsignificant	—	0.82	Other	35	44
431	T.CD4_transitional.APC_interacting	9.68e-03	Nonsignificant	0.63	1.18	Other	10	14
432	EPI.skin_sweat_duct_keratinocyte.proliferative_S	9.65e-03	Nonsignificant	—	0.23	Other	0	0
433	B.naive.baseline	9.58e-03	Nonsignificant	0.99	0.92	Other	10	13
434	NEU.INH_VIP.enkephalinergic	9.37e-03	Nonsignificant	—	0.83	Other	0	0
435	T.CD8_naive.nfkb_related	9.03e-03	Nonsignificant	0.69	1.28	Other	1	0
436	MAC.microglia_like.patrolling_adhesive	9.01e-03	Nonsignificant	—	0.00	Other	0	0
437	EPI.cervical_suprabasal.secretory_vesicle	9.00e-03	Nonsignificant	—	0.00	Other	0	0
438	ASTRO.homeostatic	8.91e-03	Nonsignificant	1.00	0.20	Other	200	431
439	SKM.type_1_slow.glycolytic	8.82e-03	Nonsignificant	0.01	1.46	Other	362	647
440	T.CD4_Trm.activated	8.78e-03	Nonsignificant	0.75	1.07	Other	32	26
441	T.CD8_Tem.baseline	8.52e-03	Nonsignificant	0.19	1.10	Other	458	356
442	EPI.renal_principal_cell.activated_acute	8.47e-03	Nonsignificant	0.96	0.39	Other	29	59
443	EPI.lung_multiciliated.mature_motile_cilia	8.37e-03	Nonsignificant	—	1.53	Other	0	0
444	T.CD4_transitional.tissue_enagement	8.25e-03	Nonsignificant	0.63	1.08	Other	5	11
445	MAC.resident_repair.ECM_stromal_crosstalk	8.18e-03	Nonsignificant	0.99	0.58	Other	95	158
446	MAC.alveolar.inflammatory	8.18e-03	Nonsignificant	0.45	1.14	Other	208	312
447	MEL.mature_oxidative_traffic	7.97e-03	Nonsignificant	0.98	0.66	Other	247	285
448	T.CD4_Trm.helper_like	7.95e-03	Nonsignificant	0.75	0.96	Other	84	147
449	T.CD4_Tcm.stress	7.86e-03	Nonsignificant	0.42	1.17	Other	5	11
450	HPC.MEP	7.68e-03	Nonsignificant	0.99	0.87	Other	599	1,195
451	MONO.CD16.patrolling	7.53e-03	Nonsignificant	1.00	0.00	Other	797	216
452	EC.heart_remodeling.remodeling_secretory	7.41e-03	Nonsignificant	1.00	0.68	Other	605	1,341
453	EPI.skin_interfollicular_spinous.stress_oxidative	7.18e-03	Nonsignificant	—	0.00	Other	0	0
454	EPI.colonocyte.secretory_boost	7.10e-03	Nonsignificant	0.91	0.66	Other	98	91
455	T.CD8_Trm.muscosal_Tc17	6.76e-03	Nonsignificant	0.22	1.21	Other	19	38
456	T.CD8_naive.splicing_enriched	6.53e-03	Nonsignificant	0.69	1.03	Other	120	16
457	OPC.homeostatic	6.34e-03	Nonsignificant	0.12	1.38	Other	394	160
458	T.CD8_naive.baseline	6.33e-03	Nonsignificant	0.69	1.07	Other	142	2
459	EPI.alveolar_type_2.baseline_surfactant	6.28e-03	Nonsignificant	0.91	0.91	Other	64	9
460	HPC.MPP_IEG	6.14e-03	Nonsignificant	0.99	1.01	Other	45	46
461	EPI.colonocyte.ionocyte_BEST4	6.14e-03	Nonsignificant	0.30	1.36	Other	103	188
462	ILC2.activated	6.10e-03	Nonsignificant	—	0.00	Other	0	0
463	T.CD4_Trm.baseline	6.09e-03	Nonsignificant	0.75	0.98	Other	31	21
464	EPI.skin_interfollicular_spinous.baseline	5.95e-03	Nonsignificant	0.96	0.43	Other	35	3
465	B.naive.metabolic	5.93e-03	Nonsignificant	0.99	0.93	Other	50	79
466	EPI.lung_club_secretory.inflammatory	5.88e-03	Nonsignificant	—	0.79	Other	0	0
467	MEL.stress_glucocorticoid	5.86e-03	Nonsignificant	0.98	0.54	Other	11	34
468	B.memory.activated	5.81e-03	Nonsignificant	1.00	0.98	Other	105	29
469	MEL.secretory_quiescent	5.73e-03	Nonsignificant	0.98	0.30	Other	19	13
470	DC.cDC1.homeostatic_inhibitory	5.55e-03	Nonsignificant	—	0.00	Other	0	0
471	MAC.alveolar.biosynthetic_sterol_heme	5.18e-03	Nonsignificant	0.45	1.17	Other	347	40
472	T.gamma_delta.early_effector	5.18e-03	Nonsignificant	0.16	1.24	Other	89	0
473	NEU.EXC_IT.guidance	5.18e-03	Nonsignificant	1.00	0.74	Other	274	63
474	NEU.INH_VIP.matrix	5.09e-03	Nonsignificant	—	0.57	Other	24	77
475	NEU.INH_PVALB.nuclear_reg	5.00e-03	Nonsignificant	0.19	1.41	Other	25	12
476	EPI.colonocyte.junction_remodeling	4.97e-03	Nonsignificant	0.91	0.65	Other	218	305
477	EPI.alveolar_type_1.baseline	4.81e-03	Nonsignificant	1.00	0.00	Other	8	0
478	T.MAIT.migratory	4.74e-03	Nonsignificant	0.40	1.35	Other	10	1
479	T.CD8_Trm.dendritic_recruiter	4.70e-03	Nonsignificant	0.70	1.13	Other	47	85
480	THYMO.DP_early	4.32e-03	Nonsignificant	0.16	1.10	Other	326	313
481	EPI.skin_interfollicular_spinous.inflammatory	4.16e-03	Nonsignificant	—	0.00	Other	0	0
482	ILC2.migratory	4.11e-03	Nonsignificant	—	0.23	Other	0	0
483	B.naive.proteostasis	4.11e-03	Nonsignificant	0.99	0.84	Other	49	69
484	T.CD4_Trm.metal_stress	4.07e-03	Nonsignificant	0.51	1.20	Other	34	58
485	T.MAIT.early_activation	4.01e-03	Nonsignificant	0.18	1.45	Other	57	4
486	EC.heart_remodeling.perivascular	4.01e-03	Nonsignificant	0.97	0.91	Other	124	408
487	T.CD8_naive.effector_transition	3.95e-03	Nonsignificant	0.69	1.02	Other	35	62
488	NK.cytokine_lung_immediate_early	3.94e-03	Nonsignificant	0.69	1.24	Other	424	274
489	MAC.resident_repair.stress_iron	3.77e-03	Nonsignificant	0.99	0.66	Other	48	97
490	T.CD4_Th17.cytotoxic	3.68e-03	Nonsignificant	0.61	1.04	Other	332	123
491	EPI.skin_interfollicular_spinous.early_differentiation	3.68e-03	Nonsignificant	0.96	0.30	Other	89	19
492	NEU.EXC_SYT2.synaptic	3.65e-03	Nonsignificant	—	0.48	Other	0	0
493	THYMO.SP_CD8_naive_stress	3.63e-03	Nonsignificant	1.00	0.96	Other	1	1
494	T.CD8_Trm.inflammatory	3.62e-03	Nonsignificant	0.83	1.02	Other	124	176
495	T.CD8_naive.lipid_synthesis	3.58e-03	Nonsignificant	0.69	1.05	Other	6	4
496	MAC.alveolar.capillary_interacting	3.48e-03	Nonsignificant	0.80	0.65	Other	113	181
497	EPI.alveolar_type_2.injury_primed	3.42e-03	Nonsignificant	0.91	0.70	Other	434	245
498	EPI.lung_club_secretory.ciliogenesis_primed	3.38e-03	Nonsignificant	—	0.37	Other	0	0
499	EPI.skin_interfollicular_spinous.upper_lipid	3.35e-03	Nonsignificant	—	0.00	Other	6	6
500	EPI.skin_interfollicular_spinous.proliferative	3.21e-03	Nonsignificant	—	0.00	Other	0	0
501	EPI.pancreatic_acinar.adhesion_remodeling	3.16e-03	Nonsignificant	1.00	0.30	Other	210	784
502	NEU.INH_PVALB.fastspike	3.12e-03	Nonsignificant	—	0.00	Other	24	22
503	B.naive.purinergic	3.05e-03	Nonsignificant	0.99	0.84	Other	384	820
504	EPI.esophageal_suprabasal.proliferative_S	2.82e-03	Nonsignificant	—	0.00	Other	26	41
505	T.CD8_naive.cytokine_dampened	2.82e-03	Nonsignificant	0.94	0.83	Other	71	4
506	T.CD4_Tcm.migratory_cilium	2.80e-03	Nonsignificant	0.42	1.14	Other	5	10
507	T.CD4_Trm.cytotoxic_effector	2.77e-03	Nonsignificant	0.86	0.88	Other	118	77
508	EPI.skin_interfollicular_spinous.stress_UPR	2.71e-03	Nonsignificant	—	0.00	Other	0	0
509	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	2.68e-03	Nonsignificant	—	0.21	Other	0	0
510	T.CD4_transitional.baseline	2.65e-03	Nonsignificant	0.63	1.02	Other	59	97
511	GRNLSA.cholesterol_mevalonate	2.61e-03	Nonsignificant	0.70	1.08	Other	9	4
512	T.CD4_Tem.long_term_memory	2.57e-03	Nonsignificant	0.79	1.11	Other	314	587
513	T.CD4_Tfh.effector_migratory	2.56e-03	Nonsignificant	0.96	0.91	Other	122	57
514	T.CD8_naive.mito_proteostasis	2.51e-03	Nonsignificant	0.69	1.04	Other	428	100
515	EPI.renal_distal_tubule.ciliated_remodelling	2.47e-03	Nonsignificant	—	0.00	Other	0	0
516	IPSC.canonical_pluripotent	2.44e-03	Nonsignificant	1.00	0.73	Other	0	0
517	T.CD8_naive.vesicle_secretory	2.42e-03	Nonsignificant	0.83	0.92	Other	42	0
518	B.naive.activated	2.41e-03	Nonsignificant	0.99	0.80	Other	77	127
519	NEU.INH_PVALB.chandelier	2.35e-03	Nonsignificant	0.32	1.17	Other	19	16
520	MAC.kupffer.metabolic	2.33e-03	Nonsignificant	—	0.00	Other	25	36
521	T.CD8_Tem.TEMRA	2.29e-03	Nonsignificant	0.92	1.03	Other	920	1,088
522	EC.heart_remodeling.remodeling_stalk	2.22e-03	Nonsignificant	1.00	0.43	Other	33	111
523	EPI.skin_keratinocyte_basal.transit_amplifying	2.21e-03	Nonsignificant	—	0.00	Other	0	0
524	T.CD4_naive.mature	2.20e-03	Nonsignificant	0.69	1.06	Other	211	100
525	NK.immature_bridge	2.13e-03	Nonsignificant	0.69	1.11	Other	117	122
526	T.CD4_naive.homeostatic	2.10e-03	Nonsignificant	0.73	1.06	Other	215	108
527	T.CD8_Tem.signaling_turnover	2.08e-03	Nonsignificant	0.92	1.08	Other	425	683
528	T.CD4_Tcm.imprinted_splicing	2.07e-03	Nonsignificant	0.42	1.13	Other	6	17
529	T.CD4_Th17.baseline	2.06e-03	Nonsignificant	0.87	0.92	Other	51	5
530	B.naive.receptor_recycle	2.05e-03	Nonsignificant	0.99	0.83	Other	51	0
531	MAC.alveolar.scavenging_endocytic	2.04e-03	Nonsignificant	—	0.00	Other	140	283
532	EPI.skin_keratinocyte_basal.spinous_transition	2.00e-03	Nonsignificant	—	0.00	Other	0	0
533	EPI.lung_multiciliated.baseline	1.98e-03	Nonsignificant	—	0.05	Other	0	7
534	NK.cytokine_tissue_resident	1.89e-03	Nonsignificant	0.69	1.18	Other	74	82
535	CM.baseline	1.88e-03	Nonsignificant	1.00	0.98	Other	393	0
536	T.CD4_transitional.primed_helper_effector	1.87e-03	Nonsignificant	0.63	1.02	Other	19	43
537	T.CD4_Tcm.Th2_like	1.85e-03	Nonsignificant	0.42	1.17	Other	23	55
538	T.CD4_Tfh.suppression_exhaustion	1.84e-03	Nonsignificant	0.96	0.98	Other	0	2
539	T.CD4_Th17.migratory	1.81e-03	Nonsignificant	0.61	1.05	Other	13	23
540	T.MAIT.quiescent	1.75e-03	Nonsignificant	0.94	0.96	Other	100	5
541	SKM.type_2_fast.oxidative_IIa	1.71e-03	Nonsignificant	9.00e-03	1.11	Other	946	56
542	PC.IgG_systemic.stress	1.67e-03	Nonsignificant	—	0.00	Other	1	5
543	T.CD4_Treg.APC_interactive	1.63e-03	Nonsignificant	0.86	0.90	Other	118	28
544	B.memory.baseline	1.57e-03	Nonsignificant	1.00	0.82	Other	472	99
545	T.MAIT.MAPK_brake	1.55e-03	Nonsignificant	0.94	0.91	Other	44	66
546	SKM.type_1_slow.oxidative	1.52e-03	Nonsignificant	1.00	0.67	Other	802	251
547	T.CD4_Tcm.Tfh_like	1.52e-03	Nonsignificant	0.37	1.12	Other	102	214
548	EPI.lung_multiciliated.stress	1.46e-03	Nonsignificant	—	0.00	Other	67	165
549	NEU.INH_PVALB.neuromodulatory	1.41e-03	Nonsignificant	—	0.00	Other	0	0
550	T.CD8_transitional.early	1.39e-03	Nonsignificant	0.76	0.92	Other	327	55
551	EPI.renal_proximal_tubule.onecarbon_peroxisome	1.34e-03	Nonsignificant	2.67e-03	1.94	Other	58	89
552	T.CD8_naive.innate_like	1.34e-03	Nonsignificant	0.94	0.60	Other	10	1
553	ILC2.quiescent	1.33e-03	Nonsignificant	—	0.00	Other	0	0
554	OPC.proliferative_immune_interact	1.32e-03	Nonsignificant	0.93	0.88	Other	180	373
555	T.gamma_delta.cytotoxic_effector	1.31e-03	Nonsignificant	0.80	1.00	Other	349	109
556	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	1.28e-03	Nonsignificant	—	0.37	Other	0	0
557	CM.inflammatory	1.25e-03	Nonsignificant	—	1.40	Other	0	0
558	T.CD4_transitional.primed_cytotoxic	1.19e-03	Nonsignificant	0.65	0.94	Other	28	30
559	B.naive.remodeling	1.16e-03	Nonsignificant	0.99	0.70	Other	135	230
560	SKM.type_1_slow.contractile	1.14e-03	Nonsignificant	1.00	0.41	Other	596	8
561	T.CD4_naive.neddylation	1.14e-03	Nonsignificant	0.99	1.01	Other	104	222
562	THYMO.SP_CD4_naive	1.06e-03	Nonsignificant	1.00	0.93	Other	65	75
563	T.CD8_Tcm.effector_bias	1.05e-03	Nonsignificant	0.59	1.16	Other	199	329
564	T.CD8_Trm.homeostatic	1.00e-03	Nonsignificant	0.91	0.85	Other	42	5
565	T.MAIT.vesicle	9.93e-04	Nonsignificant	0.95	0.70	Other	37	65
566	EPI.endocervical_secretory.secretory_translocon	9.57e-04	Nonsignificant	—	0.00	Other	0	0
567	NEU.INH_VIP.regulatory_remodeling	9.47e-04	Nonsignificant	—	0.00	Other	6	1
568	T.CD4_Tcm.DC_interact	9.34e-04	Nonsignificant	0.37	1.13	Other	72	32
569	T.CD8_Trm.cytotoxic	9.04e-04	Nonsignificant	0.84	0.97	Other	165	85
570	EPI.esophageal_suprabasal.proliferative_G2M	8.99e-04	Nonsignificant	—	0.00	Other	0	0
571	T.CD4_naive.resist_bystander	8.99e-04	Nonsignificant	0.99	1.06	Other	40	25
572	OLG.reactive_repair	8.82e-04	Nonsignificant	1.00	0.76	Other	385	385
573	EPI.skin_keratinocyte_proliferating.early_spinous_transition	8.65e-04	Nonsignificant	—	0.00	Other	135	290
574	EPI.ileal_goblet.inflammatory_mucin	8.34e-04	Nonsignificant	0.95	0.80	Other	6	9
575	NEU.INH_PVALB.metabotropic	8.19e-04	Nonsignificant	—	0.00	Other	0	0
576	NEU.INH_VIP.develop_niche	8.09e-04	Nonsignificant	—	0.00	Other	0	0
577	EPI.colonocyte.goblet_interface	7.90e-04	Nonsignificant	—	0.00	Other	11	21
578	T.CD4_naive.gut_prone	7.87e-04	Nonsignificant	0.99	1.07	Other	35	70
579	T.CD4_Tem.inflammatory	7.82e-04	Nonsignificant	0.79	0.98	Other	28	6
580	OLG.vesicle_trafficking	7.81e-04	Nonsignificant	1.00	0.78	Other	124	10
581	OLG.myelinating_mature	7.71e-04	Nonsignificant	1.00	0.84	Other	363	94
582	THYMO.proliferative_S	7.47e-04	Nonsignificant	1.00	0.75	Other	163	418
583	OPC.premyelinating	7.27e-04	Nonsignificant	0.99	0.25	Other	185	12
584	T.CD4_naive.mature_mitoprot	7.21e-04	Nonsignificant	0.99	0.94	Other	212	476
585	T.CD4_naive.neddylation_mitoprot	7.06e-04	Nonsignificant	0.99	1.01	Other	93	56
586	THYMO.SP_CD8_naive	6.99e-04	Nonsignificant	1.00	0.61	Other	297	177
587	NEU.INH_VIP.excitatory_coupled	6.99e-04	Nonsignificant	—	0.00	Other	13	0
588	T.CD8_transitional.Trm_primed	6.92e-04	Nonsignificant	0.76	0.91	Other	108	15
589	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	6.85e-04	Nonsignificant	—	0.00	Other	0	0
590	T.CD4_naive.survival	6.61e-04	Nonsignificant	0.99	1.05	Other	12	17
591	T.CD8_Tem.stress_adapted	6.32e-04	Nonsignificant	0.96	0.89	Other	607	520
592	NK.cytokine_biosynthetic_primed	6.22e-04	Nonsignificant	0.69	1.12	Other	360	21
593	EPI.renal_proximal_tubule.detox_antioxidant	6.02e-04	Nonsignificant	0.97	0.27	Other	394	77
594	NEU.INH_LAMP5.exc_inh_balance	5.92e-04	Nonsignificant	—	0.58	Other	46	2
595	NK.adaptive_classII_inhibitory	5.86e-04	Nonsignificant	0.69	1.10	Other	880	154
596	T.CD4_Tfh.precursor_migratory	5.50e-04	Nonsignificant	0.97	0.69	Other	72	27
597	EPI.ileal_goblet.stress_metallothionein	5.45e-04	Nonsignificant	—	0.00	Other	4	11
598	NK.adaptive_terminal_cytotoxic	5.27e-04	Nonsignificant	0.94	1.00	Other	485	802
599	NK.adaptive_axis_baseline	5.25e-04	Nonsignificant	0.99	0.98	Other	1,008	153
600	T.MAIT.cytotoxic	5.07e-04	Nonsignificant	0.95	0.52	Other	52	15
601	T.CD8_Tcm.NK_like	4.99e-04	Nonsignificant	0.59	1.23	Other	334	581
602	T.CD4_cytotoxic.terminal_effector	4.93e-04	Nonsignificant	0.72	0.99	Other	286	21
603	EPI.skin_sweat_duct_keratinocyte.repair	4.87e-04	Nonsignificant	—	0.00	Other	0	0
604	NEU.INH_VIP.opioid	4.83e-04	Nonsignificant	—	0.00	Other	50	9
605	T.CD4_Tem.transitional_CM	4.73e-04	Nonsignificant	0.79	1.01	Other	31	20
606	CM.sarcomere_actin_interface	4.39e-04	Nonsignificant	1.00	1.00	Other	450	78
607	T.CD4_naive.survival_mitoprot	4.38e-04	Nonsignificant	0.99	1.00	Other	13	7
608	T.CD4_naive.survival_neddylation	4.25e-04	Nonsignificant	0.99	0.94	Other	26	38
609	HPC.LMPP	4.05e-04	Nonsignificant	0.99	0.53	Other	65	31
610	T.CD4_cytotoxic.baseline	3.73e-04	Nonsignificant	0.59	1.17	Other	0	0
611	EPI.ileal_goblet.baseline	3.69e-04	Nonsignificant	0.95	0.21	Other	16	2
612	THYMO.CD8aa_IELp	3.59e-04	Nonsignificant	—	0.00	Other	1	7
613	NK.adaptive_immature_precursor	3.56e-04	Nonsignificant	0.69	1.11	Other	358	111
614	EPI.skin_sweat_duct_keratinocyte.barrier	3.52e-04	Nonsignificant	—	0.00	Other	0	0
615	GRNLSA.secretory_remodeling	3.52e-04	Nonsignificant	0.90	0.61	Other	90	25
616	THYMO.DP_early_stress	3.49e-04	Nonsignificant	—	0.15	Other	0	0
617	GRNLSA.lipid_hypoxia	3.48e-04	Nonsignificant	0.90	0.64	Other	28	0
618	NK.cytokine_axis_baseline	3.38e-04	Nonsignificant	1.00	0.94	Other	1,172	116
619	T.CD4_Tcm.effector_like	3.34e-04	Nonsignificant	0.79	0.99	Other	293	533
620	T.CD4_Treg.central_naive_like	3.26e-04	Nonsignificant	0.86	0.80	Other	333	45
621	T.CD4_naive.Treg_like	3.20e-04	Nonsignificant	0.99	0.97	Other	121	72
622	B.memory.migratory	3.06e-04	Nonsignificant	1.00	0.75	Other	123	208
623	NK.cytokine_repair_primed	2.91e-04	Nonsignificant	0.86	1.09	Other	266	11
624	GRNLSA.angiocrine_mechanosensory	2.91e-04	Nonsignificant	—	0.00	Other	0	0
625	CM.mito_proteostasis	2.78e-04	Nonsignificant	1.00	1.03	Other	329	29
626	NK.cytokine_quiescent	2.78e-04	Nonsignificant	0.94	1.01	Other	623	1,062
627	T.CD4_cytotoxic.activated	2.74e-04	Nonsignificant	0.59	1.11	Other	3	1
628	T.CD4_Tcm.synapse_dynamics	2.72e-04	Nonsignificant	0.79	1.06	Other	15	10
629	T.CD4_Treg.Tr1_like	2.61e-04	Nonsignificant	—	0.00	Other	8	8
630	T.CD4_Tcm.tissue_homing	2.52e-04	Nonsignificant	0.79	0.95	Other	78	46
631	EPI.salivary_serous_acinar.seromucous_like	2.45e-04	Nonsignificant	—	0.00	Other	0	0
632	T.CD8_Tem.early_helper_like	2.30e-04	Nonsignificant	0.96	0.82	Other	445	755
633	T.gamma_delta.central_memory	2.09e-04	Nonsignificant	0.99	0.47	Other	460	919
634	SKM.type_2_fast.glycolytic_IIx_IIb	1.94e-04	Nonsignificant	0.84	0.91	Other	565	1,482
635	T.CD4_Tcm.crosstalk_myeloid	1.84e-04	Nonsignificant	0.79	0.97	Other	5	4
636	T.CD4_Tcm.regulatory_poised	1.83e-04	Nonsignificant	0.79	1.01	Other	2	3
637	T.CD4_cytotoxic.NK_adapted	1.83e-04	Nonsignificant	0.59	1.21	Other	82	33
638	DC.pDC.poised_migratory	1.82e-04	Nonsignificant	0.56	1.29	Other	54	95
639	T.CD4_Tem.cytotoxic_effector	1.60e-04	Nonsignificant	0.87	0.86	Other	225	398
640	EPI.lung_club_secretory.canonical_surfactant	1.55e-04	Nonsignificant	—	0.00	Other	74	104
641	T.CD4_Tcm.RNA_control	1.48e-04	Nonsignificant	0.79	0.95	Other	96	4
642	GRNLSA.p53_damage	1.46e-04	Nonsignificant	—	0.00	Other	13	10
643	T.CD8_Tem.motility_primed	1.46e-04	Nonsignificant	0.96	0.74	Other	269	4
644	NK.adaptive_HLAE_tuned	1.43e-04	Nonsignificant	0.91	1.02	Other	1,124	189
645	CM.mechano_activated	1.38e-04	Nonsignificant	1.00	0.92	Other	205	134
646	NEU.INH_VIP.canonical_disinhibitory	1.33e-04	Nonsignificant	1.00	0.22	Other	59	38
647	NEU.INH_LAMP5.rosehip	1.32e-04	Nonsignificant	—	0.00	Other	0	0
648	NEU.INH_LAMP5.glial_interface	1.29e-04	Nonsignificant	—	0.00	Other	0	0
649	EPI.renal_distal_tubule.immune_modulatory	1.24e-04	Nonsignificant	—	0.00	Other	0	0
650	IPSC.neural_primed	1.19e-04	Nonsignificant	1.00	0.56	Other	0	0
651	CM.oxidative_phospho	1.19e-04	Nonsignificant	1.00	1.00	Other	266	792
652	T.CD8_transitional.stress	1.16e-04	Nonsignificant	—	0.15	Other	24	34
653	T.CD4_naive.proteostasis	1.11e-04	Nonsignificant	0.99	0.81	Other	14	9
654	NEU.EXC_IT.callosal	1.05e-04	Nonsignificant	1.00	0.34	Other	286	119
655	NEU.INH_PVALB.serotonergic	9.62e-05	Nonsignificant	—	0.00	Other	0	0
656	DC.pDC.baseline	9.30e-05	Nonsignificant	0.94	0.90	Other	88	123
657	T.CD4_Tcm.baseline	9.16e-05	Nonsignificant	0.79	0.96	Other	61	31
658	NK.cytokine_tissue_activation	8.57e-05	Nonsignificant	1.00	0.77	Other	267	450
659	B.memory.pDC_imprint	8.46e-05	Nonsignificant	1.00	0.78	Other	157	103
660	CM.osmoprotection	8.27e-05	Nonsignificant	1.00	0.96	Other	34	57
661	T.CD4_Tcm.secretory	7.27e-05	Nonsignificant	0.79	0.99	Other	20	11
662	DC.pDC.immature_metabolic	6.58e-05	Nonsignificant	0.94	0.49	Other	78	124
663	NK.adaptive_biosynthetic_primed	6.07e-05	Nonsignificant	1.00	0.72	Other	244	405
664	NK.cytokine_vascular_patrolling	5.84e-05	Nonsignificant	1.00	0.71	Other	863	94
665	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	5.84e-05	Nonsignificant	—	0.00	Other	0	0
666	T.CD4_Tcm.retro_ZNF117	5.49e-05	Nonsignificant	0.79	0.93	Other	5	9
667	NK.adaptive_adipose_stress	5.46e-05	Nonsignificant	1.00	0.66	Other	374	39
668	T.CD4_naive.purinergic	5.02e-05	Nonsignificant	0.99	0.74	Other	49	1
669	T.MAIT.stress	4.85e-05	Nonsignificant	—	0.00	Other	0	0
670	CM.translation_boost_RPL	4.81e-05	Nonsignificant	1.00	0.88	Other	129	1
671	NEU.INH_VIP.cannabinoid	4.60e-05	Nonsignificant	—	0.00	Other	0	0
672	OLG.myelinating_stress	4.52e-05	Nonsignificant	1.00	0.46	Other	232	62
673	T.CD4_naive.proteostasis_mitoprot	4.23e-05	Nonsignificant	0.99	0.59	Other	15	37
674	NEU.INH_LAMP5.projecting	4.08e-05	Nonsignificant	—	0.00	Other	0	0
675	T.CD4_cytotoxic.precursor	3.58e-05	Nonsignificant	0.76	0.84	Other	156	67
676	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	3.03e-05	Nonsignificant	—	0.00	Other	0	0
677	T.CD8_Tcm.baseline	2.54e-05	Nonsignificant	0.99	0.87	Other	90	89
678	T.CD4_naive.activated_stress	2.51e-05	Nonsignificant	0.99	0.64	Other	339	429
679	T.CD4_Tcm.APC_mimicry	2.29e-05	Nonsignificant	0.92	0.77	Other	54	43
680	T.CD8_Tcm.helper_like	1.47e-05	Nonsignificant	0.99	0.61	Other	81	159
681	IPSC.midbrain_primed	1.19e-05	Nonsignificant	1.00	0.52	Other	0	0
682	PLAT.megakaryocytic	1.02e-05	Nonsignificant	—	0.00	Other	0	0
683	CM.translation_boost_RPS	9.28e-06	Nonsignificant	1.00	0.84	Other	69	16
684	T.CD8_Tcm.gut_homing	7.24e-06	Nonsignificant	0.99	0.62	Other	380	112
685	CM.anti_inflammatory	3.04e-06	Nonsignificant	1.00	0.76	Other	424	1,503
686	THYMO.proliferative_G2M	1.14e-06	Nonsignificant	—	0.00	Other	164	413
687	HPC.MPP_activated	1.81e-08	Nonsignificant	—	0.00	Other	0	0
688	NEU.EXC_SYT2.nuclear_reg	1.41e-10	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

40 unique genes. Showing 1–40. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
HLX-AS1	01-High	0.80	18.76	G1	C1	—	FIB.adventitial.activated_remodelling (Tier: relevant)	29 cells — complete matches	72	241
LTBR	01-High	0.76	10.15	G1	C1	—	—	9 cells — complete matches	21	43
HLX	01-High	0.73	12.21	G1	C1	—	FIB.adventitial.activated_remodelling (Tier: relevant) FIB.barrier_purinergic.stress_GF_binding (Tier: relevant)	36 cells — complete matches	73	243
ENSG00000256433	01-High	0.64	9.75	G1	C1	—	—	—	14	28
CRISPLD2	01-High	0.59	2.53	G1	C1	FIB.barrier_secretory.homeostasis (L2), SMC.activated (L2)	pericyte (Tier: specific) FIB.interstitial (Tier: specific) FIB.adventitial.adhesion_lipid (Tier: specific) FIB.suburothelial.homeostasis_matrix (Tier: specific) FIB.adventitial.activated_remodelling (Tier: relevant) FIB.barrier_purinergic.stress_GF_binding (Tier: relevant) FIB.neurolectin_mucosa.inflammatory (Tier: relevant)	78 cells — complete matches	18	52
SCNN1A	01-High	0.58	8.75	G1	C1	EPI.renal_principal_cell (L1S), EPI.hepatic_ductular_cholangiocyte.ion_transport (L2)	EPI.intrahepatic_cholangiocyte_defense.raft_maturation (Tier: relevant)	33 cells — complete matches	15	33
ENSG00000305986	01-High	0.57	10.87	G1	C1	—	—	—	43	107
ENSG00000294548	01-High	0.57	12.67	G1	C1	—	—	—	35	77
LINC02817	01-High	0.56	12.78	G1	C1	—	—	—	26	87
MTARC1	01-High	0.54	9.96	G1	C1	—	—	—	56	174
ENSG00000294570	01-High	0.52	8.86	G1	C1	—	—	—	11	63
ENSG00000286231	01-High	0.52	8.22	G1	C1	—	—	—	45	124
TNFRSF1A	01-High	0.52	5.78	G1	C1	EPI.ileal_enterocyte_absorptive.brush_border (L2)	—	17 cells — complete matches	22	43
ENSG00000296502	01-High	0.51	7.56	G1	C1	—	—	—	45	107
PLEKHG6	01-High	0.51	5.14	G1	C1	—	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling (Tier: relevant) EPI.intrahepatic_cholangiocyte_transport.mucin_secretory (Tier: relevant)	38 cells — complete matches	13	33
CD27	01-High	0.49	3.99	G1	C1	B.memory (L1S), B.memory.baseline (L2), NK.adaptive_immature_precursor (L2), T.CD4_cytotoxic.precursor (L2), T.CD4_transitional.primed_helper_effector (L2), T.CD8_Tem.early_helper_like (L2), T.CD8_transitional.APC_like (L2), T.gamma_delta.central_memory (L2), THYMO.CD8aa_IELp (L2), THYMO.SP_CD4_naive (L2)	—	124 cells — complete matches	20	36
CD27-AS1	01-High	0.48	3.58	G1	C1	—	—	—	12	30
VAMP1-AS1	01-High	0.47	3.38	G1	C1	—	—	—	10	24
TAPBPL	01-High	0.47	3.10	G1	C1	—	—	EPI.cervical_suprabasal.secretory_vesicle (L2)	17	36
C1orf115	01-High	0.46	4.71	G1	C1	—	—	33 cells — complete matches	42	112
VAMP1	01-High	0.46	2.14	G1	C1	—	—	27 cells — complete matches	12	49
ENSG00000276232	01-High	0.45	2.05	G1	C1	—	—	—	8	24
SCARNA10	01-High	0.45	2.05	G1	C1	—	—	—	8	24
ENSG00000305396	01-High	0.44	0.70	G1	C1	—	—	—	14	32
NKX2-3	02-Medium	0.47	7.55	G1	C2	—	—	29 cells — complete matches	0	0
PITX2	02-Medium	0.43	10.72	G2	C2	—	FIB.suburothelial.homeostasis_matrix (Tier: specific) FIB.barrier_purinergic.stress_GF_binding (Tier: relevant)	31 cells — complete matches	0	0
PANCR	02-Medium	0.42	12.16	G2	C2	—	FIB.adventitial.adhesion_lipid (Tier: specific)	6 cells — complete matches	0	0
LINC01475	02-Medium	0.41	7.84	G2	C2	—	FIB.adventitial.adhesion_lipid (Tier: specific)	27 cells — complete matches	0	0
COL25A1	02-Medium	0.41	5.17	G2	C2	—	pericyte (Tier: specific) FIB.adventitial.adhesion_lipid (Tier: specific)	32 cells — complete matches	0	0
SALL4	02-Medium	0.39	5.02	G1	C2	—	—	9 cells — complete matches	3	5
ENSG00000307264	02-Medium	0.38	9.30	G2	C2	—	—	—	0	0
HLA-DQB1	02-Medium	0.38	3.12	G1	C2	MONO.CD14.APC_like (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_transitional.APC_like (L2)	—	133 cells — complete matches	703	1,314
HCP5	02-Medium	0.37	10.05	G2	C2	—	—	—	510	867
LINC01376	02-Medium	0.36	14.07	G2	C2	—	—	10 cells — complete matches	12	20
ENSG00000288692	02-Medium	0.34	7.32	G2	C2	—	—	—	0	0
OSR1	02-Medium	0.34	18.73	G2	C2	ASPC.niche_keeping_progenitor (L2)	pericyte (Tier: specific) FIB.interstitial (Tier: specific) FIB.suburothelial.homeostasis_matrix (Tier: specific) FIB.barrier_secretory.homeostasis (Tier: relevant) FIB.neurolectin_mucosa.inflammatory (Tier: relevant)	58 cells — complete matches	1	5
MICB	02-Medium	0.27	8.20	G2	C2	—	—	43 cells — complete matches	294	633
MICB-DT	02-Medium	0.25	7.36	G2	C2	—	—	—	131	286
LINC01082	02-Medium	0.20	6.70	G2	C2	FIB.interstitial.mesenchymal_regulator (L2)	pericyte (Tier: specific) FIB.interstitial (Tier: specific) FIB.suburothelial.homeostasis_matrix (Tier: specific)	28 cells — complete matches	20	49
ENSG00000268505	02-Medium	0.18	6.96	G2	C2	—	—	—	16	44

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.