Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000017 · All tissues

Acute appendicitis: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Acute appendicitis

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	pericyte	10.03	Significant	1.72e-07	1.14	Specific	128	517
2	monocyte	8.80	Significant	3.30e-49	1.19	Specific	2,176	3,871
3	smooth_muscle_cell	6.70	Significant	0.12	1.08	Relevant	27	139
4	fibroblast	6.04	Significant	9.60e-10	1.10	Other	184	826
5	adipose_stem_and_progenitor_cell	5.76	Significant	4.73e-11	1.10	Other	327	954
6	muscle_stem_cell	4.97	Nominal	1.00	1.03	Other	7	27
7	adipocyte	3.10	Nominal	1.00	1.00	Other	33	111
8	dendritic_cell	1.96	Nonsignificant	1.00	0.98	Other	496	724
9	macrophage	1.51	Nonsignificant	1.00	0.92	Other	813	1,732
10	granulocyte	1.43	Nonsignificant	1.00	0.83	Other	5	6
11	platelet	0.94	Nonsignificant	—	0.43	Other	85	104
12	schwann_cell	0.91	Nonsignificant	1.00	0.94	Other	10	57
13	hepatocyte	0.88	Nonsignificant	1.00	0.93	Other	1,515	3,822
14	epithelial_cell	0.84	Nonsignificant	1.00	0.88	Other	24	47
15	thymocyte	0.46	Nonsignificant	1.00	0.85	Other	168	512
16	endothelial_cell	0.43	Nonsignificant	1.00	0.81	Other	373	974
17	plasma_cell	0.33	Nonsignificant	1.00	0.79	Other	17	24
18	B_cell	0.32	Nonsignificant	1.00	0.82	Other	356	694
19	mesothelial_cell	0.12	Nonsignificant	1.00	0.66	Other	6	36
20	innate_lymphoid_cell_2	0.08	Nonsignificant	1.00	0.70	Other	3	8
21	haematopoietic_progenitor_cell	0.04	Nonsignificant	1.00	0.66	Other	262	502
22	microglia	0.03	Nonsignificant	1.00	0.60	Other	61	129
23	induced_pluripotent_stem_cell	0.03	Nonsignificant	1.00	0.66	Other	0	0
24	granulosa_cell	0.02	Nonsignificant	1.00	0.72	Other	293	670
25	melanocyte	0.02	Nonsignificant	1.00	0.58	Other	97	309
26	T_cell	9.16e-03	Nonsignificant	1.00	0.45	Other	470	959
27	chondrocyte	6.63e-03	Nonsignificant	1.00	0.53	Other	548	1,069
28	neuron	5.82e-03	Nonsignificant	1.00	0.64	Other	330	1,328
29	astrocyte	5.12e-03	Nonsignificant	1.00	0.55	Other	256	1,203
30	cardiomyocyte	2.06e-03	Nonsignificant	1.00	0.65	Other	533	2,045
31	oligodendrocyte	1.30e-03	Nonsignificant	1.00	0.78	Other	385	1,507
32	oligodendrocyte_precursor_cell	7.64e-04	Nonsignificant	1.00	0.43	Other	461	1,454
33	skeletal_muscle_cell	6.21e-04	Nonsignificant	1.00	0.39	Other	944	2,600
34	natural_killer_cell	3.93e-04	Nonsignificant	1.00	0.46	Other	1,204	2,052

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	PERI.pericyte	10.03	Significant	—	—	—	117	0
2	MONO.CD14	9.88	Significant	1.65e-42	2.71	Specific	2,294	4,139
3	FIB.interstitial	9.32	Significant	4.16e-22	2.32	Specific	288	940
4	FIB.neurolectin_mucosa	8.14	Significant	0.13	1.54	Relevant	133	394
5	FIB.barrier_secretory	6.78	Significant	1.00	1.04	Relevant	81	228
6	SMC.smooth_muscle_cell	6.70	Significant	—	—	Relevant	20	101
7	ASPC.adipose_stem_and_progenitor_cell	5.76	Significant	—	—	Other	324	930
8	EPI.salivary_serous_acinar	5.43	Nominal	2.30e-13	1.31	Other	233	531
9	FIB.suburothelial	5.23	Nominal	1.00	0.87	Other	122	432
10	MUSC.muscle_stem_cell	4.97	Nominal	—	—	Other	4	18
11	FIB.adventitial	4.54	Nominal	1.00	0.41	Other	268	1,447
12	FIB.reticular	3.61	Nominal	1.00	0.43	Other	19	87
13	FIB.lung_alveolar	3.38	Nominal	—	0.00	Other	6	15
14	GRANU.neutrophil	3.33	Nominal	4.69e-04	1.67	Other	1,235	2,649
15	MONO.CD16	3.18	Nominal	1.00	0.11	Other	1,304	1,835
16	EPI.salivary_myoepithelial	3.11	Nominal	0.02	1.22	Other	191	714
17	ADIPO.adipocyte	3.10	Nominal	—	—	Other	20	62
18	MAC.LAM	3.10	Nominal	4.42e-08	1.35	Other	914	2,064
19	HEP.acute_phase	3.08	Nominal	4.31e-28	1.41	Other	1,441	3,641
20	FIB.tracheal_subepithelial	2.95	Nonsignificant	—	0.00	Other	0	0
21	FIB.hepatic_stellate_cell	2.85	Nonsignificant	—	0.00	Other	64	252
22	DC.mig	2.84	Nonsignificant	—	0.73	Other	89	156
23	DC.cDC1	2.78	Nonsignificant	0.23	1.32	Other	55	112
24	FIB.barrier_purinergic	2.51	Nonsignificant	—	0.00	Other	1	3
25	DC.cDC2	2.30	Nonsignificant	0.08	1.38	Other	1,189	1,793
26	EPI.intrahepatic_cholangiocyte_defense	2.22	Nonsignificant	—	1.13	Other	8	13
27	MAC.MDM	2.15	Nonsignificant	0.83	1.08	Other	623	986
28	FIB.perivascular_interface	2.04	Nonsignificant	1.00	0.18	Other	0	0
29	EPI.extrahepatic_cholangiocyte	1.97	Nonsignificant	—	0.67	Other	37	71
30	EPI.colonic_tuft	1.90	Nonsignificant	—	1.16	Other	7	24
31	MAC.resident_iron	1.73	Nonsignificant	1.00	0.96	Other	16	21
32	EPI.ileal_bile_transport	1.73	Nonsignificant	1.00	1.15	Other	61	93
33	FIB.transitioning	1.38	Nonsignificant	1.00	0.04	Other	172	497
34	HEP.pericentral_lipoprotein	1.32	Nonsignificant	—	0.80	Other	0	0
35	EPI.intrahepatic_cholangiocyte_transport	1.19	Nonsignificant	—	0.74	Other	12	42
36	EPI.skin_follicular_keratinizing	1.17	Nonsignificant	1.00	1.01	Other	30	81
37	EC.liver_sinusoidal	1.09	Nonsignificant	0.16	1.13	Other	1,083	1,925
38	EC.capillary	0.94	Nonsignificant	5.51e-25	1.45	Other	514	1,635
39	PLAT.platelet	0.94	Nonsignificant	—	0.00	Other	38	53
40	SCHWN.schwann_cell	0.91	Nonsignificant	—	—	Other	7	33
41	FIB.skin_tenogenic	0.89	Nonsignificant	—	0.00	Other	108	227
42	EPI.ectocervical_granular	0.81	Nonsignificant	—	0.66	Other	11	23
43	EPI.tracheal_basal	0.78	Nonsignificant	1.00	1.06	Other	398	1,120
44	EPI.ileal_enterocyte_absorptive	0.70	Nonsignificant	1.00	0.98	Other	118	338
45	EPI.salivary_intercalated_defense	0.68	Nonsignificant	1.00	0.87	Other	81	161
46	EPI.salivary_duct_ion_transport	0.68	Nonsignificant	1.00	0.98	Other	5	11
47	MAC.resident_repair	0.62	Nonsignificant	1.00	0.63	Other	796	1,426
48	B.age_associated	0.61	Nonsignificant	5.81e-03	1.64	Other	207	350
49	FIB.skin_papillary	0.51	Nonsignificant	—	0.00	Other	0	0
50	EPI.ileal_enterocyte_crypt	0.51	Nonsignificant	1.00	0.89	Other	67	113
51	FIB.skin_neurosecretory	0.48	Nonsignificant	—	0.00	Other	0	0
52	THYMO.thymocyte	0.46	Nonsignificant	—	—	Other	163	495
53	EPI.hepatic_ductular_cholangiocyte	0.43	Nonsignificant	1.00	0.87	Other	83	243
54	B.memory	0.42	Nonsignificant	4.78e-11	1.73	Other	442	882
55	MAC.microglia_like	0.41	Nonsignificant	1.00	0.58	Other	124	179
56	EPI.thymic_cortical	0.37	Nonsignificant	1.00	0.92	Other	442	824
57	PC.IgA_muocsal	0.36	Nonsignificant	1.49e-05	1.66	Other	18	31
58	GRANU.MAST	0.34	Nonsignificant	1.00	0.00	Other	5	6
59	EPI.renal_immature_ureteric_bud	0.34	Nonsignificant	1.00	1.02	Other	217	569
60	EC.venous	0.30	Nonsignificant	1.00	0.79	Other	516	1,387
61	EPI.ileal_goblet	0.30	Nonsignificant	1.00	0.82	Other	181	432
62	EPI.tracheal_submucosal_gland	0.30	Nonsignificant	—	0.45	Other	0	0
63	EPI.bile_duct_cholangiocyte	0.26	Nonsignificant	1.00	0.83	Other	37	60
64	EPI.esophageal_basal	0.26	Nonsignificant	1.00	0.76	Other	4	10
65	B.naive	0.24	Nonsignificant	1.00	0.47	Other	307	595
66	MAC.kupffer	0.23	Nonsignificant	1.00	0.42	Other	189	530
67	EPI.pancreatic_ductal_bicarbonate	0.22	Nonsignificant	1.00	0.75	Other	131	548
68	MAC.resident_cardiac	0.22	Nonsignificant	1.00	0.25	Other	485	1,074
69	T.CD4_Th2	0.20	Nonsignificant	—	1.53	Other	1	2
70	EPI.pancreatic_ductal_progenitor	0.20	Nonsignificant	1.00	0.77	Other	234	873
71	FIB.skin_sheath	0.20	Nonsignificant	1.00	0.03	Other	49	118
72	EPI.renal_intercalated_cell_type_B	0.19	Nonsignificant	—	0.31	Other	6	7
73	EPI.renal_proximal_tubule	0.19	Nonsignificant	1.00	0.81	Other	525	806
74	MAC.proliferating	0.17	Nonsignificant	1.00	0.39	Other	87	253
75	EPI.renal_principal_cell	0.16	Nonsignificant	1.00	0.79	Other	207	403
76	EPI.skin_hair_follicle_bulge	0.15	Nonsignificant	1.00	0.64	Other	51	178
77	EPI.colonic_enteroendocrine	0.14	Nonsignificant	—	0.17	Other	1	1
78	B.germinal_center	0.14	Nonsignificant	0.54	1.07	Other	233	655
79	EPI.skin_appendage_keratinocyte	0.12	Nonsignificant	1.00	0.65	Other	87	222
80	EPI.tracheal_suprabasal	0.12	Nonsignificant	1.00	0.78	Other	29	56
81	HEP.canalicular_transport	0.12	Nonsignificant	1.00	0.64	Other	1,290	3,434
82	MESO.mesothelial_cell	0.12	Nonsignificant	—	—	Other	2	18
83	EPI.pancreatic_acinar	0.12	Nonsignificant	1.00	0.73	Other	429	1,475
84	EPI.pancreatic_islet	0.10	Nonsignificant	1.00	0.74	Other	52	132
85	EC.arterial	0.08	Nonsignificant	1.00	0.36	Other	356	885
86	EPI.pancreatic_ductal_perivascular	0.08	Nonsignificant	1.00	0.64	Other	4	30
87	ILC2.innate_lymphoid_cell_2	0.08	Nonsignificant	—	—	Other	2	0
88	EPI.pancreatic_ductal_mucinous	0.07	Nonsignificant	1.00	0.84	Other	219	430
89	PC.IgG_systemic	0.07	Nonsignificant	1.00	0.34	Other	41	60
90	EPI.salivary_mucous_acinar	0.07	Nonsignificant	1.00	0.87	Other	639	1,189
91	HEP.periportal_metabolic	0.06	Nonsignificant	1.00	0.49	Other	1,750	4,427
92	EPI.renal_thick_ascending_limb	0.05	Nonsignificant	1.00	0.80	Other	453	1,153
93	EPI.skin_hair_follicle_companion	0.05	Nonsignificant	—	0.01	Other	8	12
94	EPI.alveolar_type_1	0.05	Nonsignificant	1.00	0.73	Other	26	101
95	EPI.cervical_suprabasal	0.04	Nonsignificant	—	0.00	Other	14	50
96	HPC.haematopoietic_progenitor_cell	0.04	Nonsignificant	—	—	Other	211	370
97	EPI.skin_keratinocyte_proliferating	0.04	Nonsignificant	1.00	0.73	Other	47	76
98	MG.microglia	0.03	Nonsignificant	—	—	Other	49	0
99	EPI.colonocyte	0.03	Nonsignificant	1.00	0.74	Other	294	815
100	T.CD8_naive	0.03	Nonsignificant	0.01	1.08	Other	317	708
101	IPSC.induced_pluripotent_stem_cell	0.03	Nonsignificant	—	—	Other	0	0
102	T.CD4_Treg	0.02	Nonsignificant	0.18	1.10	Other	244	511
103	EC.heart_remodeling	0.02	Nonsignificant	4.22e-20	1.54	Other	569	1,594
104	EPI.esophageal_suprabasal	0.02	Nonsignificant	1.00	0.48	Other	158	404
105	EPI.alveolar_type_2	0.02	Nonsignificant	1.00	0.49	Other	813	1,853
106	MAC.alveolar	0.02	Nonsignificant	1.00	0.02	Other	1,432	3,122
107	GRNLSA.granulosa_cell	0.02	Nonsignificant	—	—	Other	257	0
108	EPI.skin_interfollicular_spinous	0.02	Nonsignificant	1.00	0.48	Other	260	563
109	MEL.melanocyte	0.02	Nonsignificant	—	—	Other	79	242
110	EPI.gastric_foveolar	0.02	Nonsignificant	—	0.00	Other	0	0
111	EPI.salivary_duct_excretory	0.01	Nonsignificant	1.00	0.44	Other	85	180
112	EPI.thymic_medullary	0.01	Nonsignificant	1.00	0.51	Other	26	133
113	EPI.renal_intercalated_cell_type_A	0.01	Nonsignificant	1.00	0.48	Other	67	142
114	EPI.endocervical_secretory	0.01	Nonsignificant	—	0.00	Other	0	0
115	T.CD4_Th17	0.01	Nonsignificant	0.18	1.11	Other	421	794
116	T.CD4_Tfh	0.01	Nonsignificant	0.94	0.98	Other	47	45
117	EPI.renal_distal_tubule	0.01	Nonsignificant	1.00	0.49	Other	133	361
118	EC.lymphatic	9.64e-03	Nonsignificant	1.00	0.20	Other	630	998
119	T.CD4_Trm	9.59e-03	Nonsignificant	0.94	0.98	Other	176	363
120	T.CD8_Tcm	9.01e-03	Nonsignificant	0.42	1.05	Other	460	926
121	T.CD8_transitional	9.00e-03	Nonsignificant	1.16e-03	1.12	Other	497	932
122	EPI.skin_keratinocyte_basal	8.79e-03	Nonsignificant	—	0.00	Other	13	26
123	NEU.EXC_IT	8.29e-03	Nonsignificant	0.12	1.12	Other	411	192
124	T.CD4_naive	7.67e-03	Nonsignificant	1.00	0.95	Other	399	866
125	T.CD4_transitional	6.96e-03	Nonsignificant	1.00	0.94	Other	48	110
126	EPI.lung_club_secretory	6.75e-03	Nonsignificant	1.00	0.45	Other	5	14
127	CHOND.chondrocyte	6.63e-03	Nonsignificant	—	—	Other	519	730
128	T.CD8_Trm	5.79e-03	Nonsignificant	1.00	0.91	Other	211	346
129	NEU.INH_VIP	5.76e-03	Nonsignificant	0.46	1.09	Other	241	366
130	ASTRO.astrocyte	5.12e-03	Nonsignificant	—	—	Other	228	1,111
131	T.gamma_delta	4.93e-03	Nonsignificant	0.88	1.00	Other	588	1,078
132	T.CD4_Tem	4.82e-03	Nonsignificant	0.42	1.04	Other	365	697
133	NEU.EXC_SYT2	3.34e-03	Nonsignificant	—	0.00	Other	40	77
134	NEU.EXC_CT	2.51e-03	Nonsignificant	0.46	1.14	Other	362	384
135	EPI.skin_keratinocyte_progenitor	2.12e-03	Nonsignificant	—	0.00	Other	0	3
136	CM.cardiomyocyte	2.06e-03	Nonsignificant	—	—	Other	524	2,032
137	T.CD8_Tem	1.96e-03	Nonsignificant	0.34	1.04	Other	1,083	1,857
138	T.CD4_Tcm	1.77e-03	Nonsignificant	1.00	0.95	Other	494	988
139	EPI.skin_sebaceous_duct_luminal	1.77e-03	Nonsignificant	1.00	0.39	Other	100	249
140	NEU.INH_PVALB	1.33e-03	Nonsignificant	0.96	0.88	Other	193	183
141	OLG.oligodendrocyte	1.30e-03	Nonsignificant	—	—	Other	384	1,397
142	T.MAIT	1.14e-03	Nonsignificant	0.53	1.03	Other	469	855
143	EPI.skin_sweat_duct_keratinocyte	8.39e-04	Nonsignificant	1.00	0.17	Other	146	301
144	SKM.type_2_fast	8.04e-04	Nonsignificant	0.05	1.11	Other	972	2,639
145	OPC.oligodendrocyte_precursor_cell	7.64e-04	Nonsignificant	—	—	Other	413	1,269
146	NK.natural_killer_cell	3.93e-04	Nonsignificant	—	—	Other	1,204	2,045
147	SKM.type_1_slow	3.74e-04	Nonsignificant	0.93	0.88	Other	923	2,478
148	NEU.INH_LAMP5	1.65e-04	Nonsignificant	0.97	0.60	Other	263	532
149	EPI.lung_multiciliated	7.62e-05	Nonsignificant	1.00	0.05	Other	16	49
150	T.CD4_cytotoxic	2.81e-05	Nonsignificant	1.00	0.66	Other	855	1,493
151	DC.pDC	2.22e-06	Nonsignificant	1.00	0.00	Other	496	1,028
152	NEU.EXC_NTNG1	1.61e-06	Nonsignificant	—	0.00	Other	0	0

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	MONO.CD14.remodeling	13.53	Significant	4.03e-13	2.10	—	2,373	295
2	MONO.CD14.APC_like	12.20	Significant	7.83e-03	1.53	Specific	1,686	2,493
3	FIB.interstitial.stress_secretory	12.15	Significant	0.17	1.76	—	92	56
4	PERI.cardiac_skeletal	11.21	Significant	2.92e-07	2.38	—	313	630
5	FIB.neurolectin_mucosa.inflammatory	10.55	Significant	0.06	1.94	Relevant	52	110
6	PERI.inflammatory	10.34	Significant	0.46	1.21	—	40	77
7	FIB.interstitial.immune_interact	10.10	Significant	0.70	1.11	—	12	1
8	PERI.angiocrine	9.88	Significant	0.55	1.08	—	93	102
9	FIB.interstitial.mesenchymal_APC	9.53	Significant	0.70	1.24	—	81	33
10	FIB.interstitial.remodeling	9.45	Significant	0.70	1.02	—	31	9
11	MONO.CD14.baseline	9.40	Significant	1.00	0.79	—	2,268	76
12	FIB.adventitial.adhesion_lipid	8.85	Significant	5.27e-06	2.42	Specific	58	209
13	FIB.neurolectin_mucosa.axon_responsive	8.65	Significant	0.36	1.17	Relevant	10	10
14	FIB.interstitial.lipid_matrix	8.48	Significant	0.99	0.44	—	258	191
15	MONO.CD14.platelet_bound	8.45	Significant	1.00	0.83	—	964	176
16	FIB.interstitial.mesenchymal_regulator	7.60	Significant	0.99	0.27	—	4	4
17	ASPC.baseline	7.58	Significant	1.09e-10	2.04	Specific	363	170
18	FIB.barrier_secretory.homeostasis	7.58	Significant	—	0.43	—	0	0
19	SMC.metabolic	7.56	Significant	0.45	1.17	—	14	40
20	FIB.suburothelial.homeostasis_matrix	7.33	Significant	0.02	2.11	Specific	258	921
21	FIB.reticular.ECM_builder	7.11	Significant	—	0.86	Relevant	0	0
22	PERI.baseline	7.09	Significant	0.98	0.43	—	39	66
23	SMC.contractile	6.97	Significant	0.22	1.47	Relevant	80	588
24	FIB.neurolectin_mucosa.remodeling_repair	6.66	Significant	—	0.00	Relevant	4	2
25	ASPC.adipocyte_capillary_interface	6.65	Significant	0.83	1.25	Relevant	21	54
26	MUSC.baseline	6.34	Significant	0.32	1.57	Relevant	0	0
27	FIB.neurolectin_mucosa.nerve_interface	6.22	Significant	—	0.00	Relevant	4	0
28	ASPC.stem_like_progenitor	6.22	Significant	0.83	1.26	Relevant	300	842
29	EPI.salivary_serous_acinar.secretory_active	5.99	Significant	2.65e-15	2.47	Other	242	69
30	ASPC.secretory	5.71	Significant	1.00	0.83	Other	76	5
31	FIB.suburothelial.contractile_myofibroblast	5.70	Significant	—	0.31	Relevant	9	0
32	ASPC.inflammatory	5.70	Significant	0.83	1.07	Other	21	61
33	FIB.barrier_secretory.remodeling	5.68	Significant	—	0.00	—	0	0
34	MONO.CD16.hepatic_mac_like	5.66	Significant	0.01	1.48	Other	803	117
35	ASPC.mesothelial_like	5.64	Significant	0.83	1.05	Other	143	486
36	MONO.CD16.inflammatory	5.50	Nominal	1.07e-04	1.63	Other	1,640	168
37	HEP.acute_phase.complement_antiviral	5.33	Nominal	3.64e-03	1.98	Other	377	751
38	DC.cDC2.monocyte_like	5.33	Nominal	1.00e-02	1.71	Other	1,285	791
39	ASPC.niche_keeping_progenitor	5.28	Nominal	1.00	0.61	Other	52	219
40	ASPC.proliferative	5.18	Nominal	0.83	1.10	Other	33	85
41	SMC.activated	5.18	Nominal	0.94	0.47	Other	2	5
42	ASPC.remodeling	5.07	Nominal	1.00	0.60	Other	106	354
43	MUSC.quiescent_reservoir	5.07	Nominal	0.32	1.45	Other	2	8
44	FIB.adventitial.activated_remodelling	4.73	Nominal	—	0.19	Other	141	319
45	FIB.adventitial.PI16_matrix	4.73	Nominal	0.52	1.31	Other	70	90
46	ASPC.signal_integrator	4.69	Nominal	—	0.00	Other	0	0
47	FIB.barrier_purinergic.stress_GF_binding	4.68	Nominal	—	0.97	Other	0	0
48	MAC.LAM.antimicrobial	4.64	Nominal	0.10	1.32	Other	389	93
49	FIB.adventitial.mechano_chemo_sensing	4.55	Nominal	0.96	0.78	Other	135	524
50	MUSC.early_activation	4.49	Nominal	0.90	0.78	Other	4	32
51	ASPC.preadipocyte_lipid_primed	4.47	Nominal	1.00	0.49	Other	331	129
52	FIB.adventitial.complement_angiocrine	4.40	Nominal	0.96	0.91	Other	153	684
53	HEP.acute_phase.inflammatory	4.40	Nominal	0.04	1.63	Other	382	649
54	GRANU.neutrophil.tissue_patrolling	4.21	Nominal	—	1.28	Other	0	0
55	FIB.suburothelial.inflammatory_prostanoid	4.13	Nominal	—	0.00	Other	0	0
56	MAC.LAM.inflammatory_APC	4.07	Nominal	5.84e-04	1.51	Other	872	165
57	FIB.adventitial.baseline	3.96	Nominal	0.96	0.86	Other	157	278
58	ADIPO.hypoxia_remodelling	3.90	Nominal	—	0.41	Other	29	105
59	FIB.lung_alveolar.mito_secretory	3.89	Nominal	—	0.48	Other	0	0
60	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	3.77	Nominal	—	0.73	Other	0	0
61	FIB.reticular.immune_interface	3.74	Nominal	—	0.00	Other	1	6
62	DC.cDC1.homeostatic_inhibitory	3.74	Nominal	—	0.69	Other	0	0
63	HEP.acute_phase.stress_secretory	3.73	Nominal	0.26	1.31	Other	26	3
64	FIB.suburothelial.urothelial_interface	3.51	Nominal	1.00	0.00	Other	9	8
65	EPI.salivary_myoepithelial.junctional_transport	3.44	Nominal	0.62	1.21	Other	66	121
66	HEP.acute_phase.proliferative	3.36	Nominal	—	0.32	Other	4	6
67	GRANU.neutrophil.primed_degranulation	3.34	Nominal	—	0.26	Other	0	0
68	EPI.salivary_myoepithelial.activated	3.29	Nominal	0.62	1.05	Other	85	281
69	FIB.hepatic_stellate_cell.inflammatory	3.28	Nominal	—	1.15	Other	0	0
70	ADIPO.immature	3.24	Nominal	—	0.03	Other	24	40
71	HEP.acute_phase.baseline	3.23	Nominal	0.26	1.19	Other	946	19
72	EPI.extrahepatic_cholangiocyte.barrier_interface	3.23	Nominal	—	0.00	Other	0	0
73	FIB.adventitial.inflammatory_activated	3.22	Nominal	0.96	0.67	Other	100	473
74	MUSC.activated_migratory	3.21	Nominal	1.00	0.00	Other	6	7
75	MONO.CD16.platelet_bound	3.14	Nominal	0.65	1.10	Other	372	508
76	EPI.salivary_myoepithelial.baseline	3.12	Nominal	0.62	0.85	Other	42	141
77	FIB.adventitial.mito_secretory	3.12	Nominal	0.96	0.28	Other	21	7
78	SCHWN.reactive_inflammatory	3.08	Nominal	—	1.27	Other	0	0
79	FIB.tracheal_subepithelial.baseline	2.95	Nonsignificant	—	0.00	Other	0	0
80	DC.cDC1.proliferative	2.92	Nonsignificant	—	0.49	Other	0	0
81	FIB.reticular.stress_metallothionein	2.91	Nonsignificant	—	0.00	Other	3	32
82	DC.mig.baseline	2.84	Nonsignificant	—	0.00	Other	1	0
83	ASPC.activated	2.81	Nonsignificant	1.00	0.07	Other	164	162
84	ADIPO.thermogenic	2.79	Nonsignificant	—	0.14	Other	0	0
85	FIB.reticular.stromal_niche	2.79	Nonsignificant	0.91	0.43	Other	0	0
86	FIB.hepatic_stellate_cell.contractile	2.77	Nonsignificant	—	0.32	Other	0	0
87	DC.cDC2.migratory	2.73	Nonsignificant	0.47	1.32	Other	185	39
88	DC.cDC1.activated	2.72	Nonsignificant	—	0.00	Other	0	0
89	DC.cDC1.cross_presenting	2.70	Nonsignificant	—	0.00	Other	0	0
90	EPI.ectocervical_granular.immune_interact	2.70	Nonsignificant	—	1.15	Other	0	0
91	FIB.lung_alveolar.stress_interacting	2.69	Nonsignificant	—	0.00	Other	0	0
92	MAC.MDM.inflammatory_phagocytic	2.67	Nonsignificant	0.60	1.29	Other	199	52
93	FIB.hepatic_stellate_cell.fibrogenic	2.64	Nonsignificant	—	0.00	Other	0	0
94	GRANU.neutrophil.antiviral_endotoxin	2.61	Nonsignificant	—	0.00	Other	0	0
95	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	2.46	Nonsignificant	—	1.15	Other	0	0
96	MAC.resident_iron.heme_catabolism	2.45	Nonsignificant	0.36	1.24	Other	30	51
97	PLAT.megakaryocytic	2.44	Nonsignificant	—	0.97	Other	0	0
98	FIB.perivascular_interface.lipid_shuttle	2.38	Nonsignificant	—	0.51	Other	51	170
99	MONO.CD16.baseline	2.28	Nonsignificant	1.00	0.82	Other	50	1
100	EC.liver_sinusoidal.inflammatory	2.25	Nonsignificant	—	1.16	Other	223	154
101	MONO.CD14.inflammatory	2.24	Nonsignificant	1.00	0.24	Other	92	134
102	MAC.resident_iron.APC_iron_sensing	2.23	Nonsignificant	0.36	1.31	Other	211	114
103	EPI.colonic_tuft.homeostatic	2.23	Nonsignificant	—	0.73	Other	0	0
104	FIB.perivascular_interface.vascular_BM_remodelling	2.15	Nonsignificant	—	0.30	Other	0	0
105	EC.capillary.angiogenic_tip	2.05	Nonsignificant	7.90e-04	1.92	Other	186	218
106	MAC.MDM.complement_resolving	2.04	Nonsignificant	0.75	0.82	Other	440	860
107	FIB.transitioning.matrix_stress	2.02	Nonsignificant	—	0.55	Other	47	138
108	MAC.LAM.lipid_opsonization	1.96	Nonsignificant	1.00	0.73	Other	45	14
109	MAC.MDM.APC_dendritic	1.88	Nonsignificant	0.75	0.90	Other	48	15
110	DC.cDC2.tolerogenic_regulatory	1.80	Nonsignificant	0.98	0.77	Other	44	4
111	DC.cDC2.antiviral	1.80	Nonsignificant	0.98	0.63	Other	100	37
112	EC.liver_sinusoidal.prostanoid	1.79	Nonsignificant	—	1.20	Other	11	64
113	EPI.ileal_bile_transport.absorptive_xenobiotic	1.75	Nonsignificant	0.59	0.91	Other	11	12
114	EPI.ileal_bile_transport.detox_transcytosis	1.66	Nonsignificant	—	0.25	Other	0	1
115	DC.cDC1.baseline	1.64	Nonsignificant	—	0.00	Other	0	0
116	MAC.MDM.LAM_like	1.63	Nonsignificant	0.75	0.92	Other	12	14
117	EPI.colonic_tuft.activated	1.58	Nonsignificant	—	0.00	Other	0	0
118	MONO.CD14.repair_M2_like	1.53	Nonsignificant	1.00	0.02	Other	550	1,495
119	FIB.transitioning.motility_remodelling	1.53	Nonsignificant	—	0.00	Other	0	0
120	HEP.acute_phase.complement_metabolic	1.49	Nonsignificant	1.00	0.03	Other	1,423	3,464
121	ADIPO.inflammatory	1.49	Nonsignificant	—	0.00	Other	0	0
122	EPI.salivary_myoepithelial.contractile_repair	1.45	Nonsignificant	—	0.00	Other	3	9
123	HEP.pericentral_lipoprotein.UPR_redox	1.41	Nonsignificant	—	0.67	Other	0	0
124	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	1.39	Nonsignificant	—	0.32	Other	0	0
125	DC.cDC2.adhesion_signaling	1.38	Nonsignificant	0.98	0.38	Other	35	9
126	EC.liver_sinusoidal.remodeling_lipotoxicity	1.37	Nonsignificant	—	0.75	Other	90	58
127	FIB.perivascular_interface.vasomotor_tone	1.36	Nonsignificant	—	0.00	Other	0	0
128	MAC.resident_repair.lipid_phagocytic	1.34	Nonsignificant	0.46	1.41	Other	228	604
129	EPI.ectocervical_granular.inflammatory	1.32	Nonsignificant	—	0.32	Other	0	0
130	MAC.kupffer.monocyte_like	1.24	Nonsignificant	—	1.65	Other	0	0
131	HEP.pericentral_lipoprotein.ApoB_coagulation	1.24	Nonsignificant	—	0.00	Other	0	0
132	DC.cDC2.lipid_metabolic	1.19	Nonsignificant	—	0.00	Other	0	0
133	EC.capillary.migratory	1.19	Nonsignificant	0.88	1.10	Other	181	509
134	SCHWN.translation_boost	1.18	Nonsignificant	—	0.67	Other	8	1
135	EPI.skin_follicular_keratinizing.upper_infundibulum	1.18	Nonsignificant	—	0.07	Other	8	2
136	EPI.skin_follicular_keratinizing.transit_amplifying	1.17	Nonsignificant	—	0.00	Other	21	49
137	EPI.skin_follicular_keratinizing.root_infundibulum	1.13	Nonsignificant	—	0.00	Other	0	0
138	FIB.transitioning.secretory_procollagen	1.11	Nonsignificant	—	0.00	Other	0	0
139	EPI.ileal_enterocyte_crypt.villus_transition	1.09	Nonsignificant	—	1.47	Other	7	10
140	EC.capillary.postcap_venule	1.05	Nonsignificant	0.42	1.28	Other	355	261
141	DC.cDC2.pro_inflammatory	1.04	Nonsignificant	0.98	0.29	Other	3	5
142	EC.capillary.stress	1.02	Nonsignificant	1.00	0.92	Other	44	36
143	EPI.renal_immature_ureteric_bud.defense_secretory	1.01	Nonsignificant	0.39	1.19	Other	45	76
144	EC.liver_sinusoidal.hypoxia_metabolic	1.01	Nonsignificant	0.63	1.18	Other	183	107
145	EC.venous.quiescent_homeostatic	1.00	Nonsignificant	3.27e-03	1.53	Other	456	360
146	MAC.resident_iron.heme_recycling	0.99	Nonsignificant	—	0.00	Other	30	37
147	MAC.resident_iron.stress_tolerogenic	0.93	Nonsignificant	—	0.00	Other	0	0
148	MONO.CD16.patrolling	0.92	Nonsignificant	1.00	0.00	Other	797	216
149	FIB.skin_tenogenic.baseline	0.89	Nonsignificant	—	0.00	Other	0	2
150	EC.capillary.baseline	0.89	Nonsignificant	1.00	0.87	Other	246	560
151	EC.capillary.activated	0.88	Nonsignificant	1.00	0.72	Other	2	5
152	EPI.hepatic_ductular_cholangiocyte.secretory_transport	0.88	Nonsignificant	—	0.73	Other	0	0
153	HEP.acute_phase.hypoxia_lipid	0.88	Nonsignificant	—	0.00	Other	0	0
154	THYMO.SP_CD4_naive	0.87	Nonsignificant	0.10	1.43	Other	65	75
155	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.86	Nonsignificant	0.22	1.37	Other	11	22
156	EC.venous.remodeling_stalk	0.86	Nonsignificant	0.13	1.38	Other	559	566
157	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.85	Nonsignificant	—	0.00	Other	0	0
158	FIB.transitioning.ISG_primed_interface	0.84	Nonsignificant	—	0.00	Other	17	80
159	MAC.LAM.perivascular_angiocrine	0.82	Nonsignificant	—	0.00	Other	53	138
160	THYMO.CD8aa_IELp	0.82	Nonsignificant	—	0.83	Other	1	7
161	MONO.CD14.cord_tolerance	0.81	Nonsignificant	1.00	0.03	Other	864	753
162	EPI.extrahepatic_cholangiocyte.mucin_secretory	0.80	Nonsignificant	—	0.00	Other	0	0
163	EPI.tracheal_basal.homeostatic_progenitor	0.79	Nonsignificant	0.67	0.76	Other	285	74
164	THYMO.DP_early	0.78	Nonsignificant	4.80e-06	1.77	Other	326	313
165	EPI.salivary_intercalated_defense.basal_EMT	0.78	Nonsignificant	—	0.41	Other	0	0
166	EPI.tracheal_basal.activated_stress	0.77	Nonsignificant	0.67	0.97	Other	32	0
167	FIB.barrier_purinergic.lipid_secretory	0.76	Nonsignificant	—	0.00	Other	0	0
168	EPI.ileal_enterocyte_absorptive.villus_tip	0.76	Nonsignificant	0.19	1.63	Other	4	3
169	EC.capillary.angiocrine	0.76	Nonsignificant	1.00	0.63	Other	250	630
170	B.memory.pDC_imprint	0.74	Nonsignificant	0.04	1.58	Other	157	103
171	B.age_associated.activated	0.71	Nonsignificant	—	0.42	Other	18	22
172	HEP.periportal_metabolic.stress_chaperone	0.69	Nonsignificant	—	1.10	Other	66	128
173	EPI.salivary_duct_ion_transport.baseline	0.68	Nonsignificant	—	—	Other	0	0
174	MAC.microglia_like.inflammatory_chemokine	0.68	Nonsignificant	—	0.61	Other	20	32
175	EC.capillary.inflammatory	0.65	Nonsignificant	1.00	0.47	Other	27	51
176	EPI.ileal_goblet.immature	0.65	Nonsignificant	—	1.59	Other	0	0
177	MAC.resident_repair.antigen_presenting	0.64	Nonsignificant	0.81	0.91	Other	244	113
178	EPI.ileal_enterocyte_absorptive.brush_border	0.63	Nonsignificant	0.88	0.49	Other	580	1,717
179	DC.cDC2.proliferative	0.63	Nonsignificant	—	0.00	Other	39	71
180	EPI.ileal_enterocyte_crypt.bile_transport	0.61	Nonsignificant	0.52	1.28	Other	2	0
181	MAC.resident_repair.chemokine_angiocrine	0.60	Nonsignificant	0.81	0.91	Other	87	138
182	B.germinal_center.DZ_M_phase	0.59	Nonsignificant	—	1.47	Other	0	0
183	EPI.hepatic_ductular_cholangiocyte.polarity	0.58	Nonsignificant	—	0.78	Other	0	0
184	EPI.hepatic_ductular_cholangiocyte.stress	0.57	Nonsignificant	—	1.01	Other	0	0
185	B.age_associated.migratory	0.56	Nonsignificant	0.82	0.61	Other	2	2
186	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.56	Nonsignificant	—	1.32	Other	29	88
187	EPI.pancreatic_acinar.quiet_dedifferentiation	0.55	Nonsignificant	0.52	1.14	Other	142	171
188	MAC.LAM.lipid_phagocytosis	0.54	Nonsignificant	1.00	0.18	Other	369	328
189	EPI.ileal_enterocyte_crypt.baseline	0.54	Nonsignificant	0.55	1.09	Other	11	6
190	B.age_associated.naive_transitional	0.52	Nonsignificant	—	0.00	Other	0	0
191	FIB.skin_papillary.baseline	0.51	Nonsignificant	—	0.00	Other	0	0
192	MAC.resident_repair.stress_iron	0.49	Nonsignificant	0.81	1.13	Other	48	97
193	MAC.resident_repair.ECM_stromal_crosstalk	0.48	Nonsignificant	0.88	0.73	Other	95	158
194	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.48	Nonsignificant	—	0.43	Other	0	0
195	B.memory.baseline	0.48	Nonsignificant	3.73e-03	1.53	Other	472	99
196	EPI.salivary_intercalated_defense.inflammatory	0.48	Nonsignificant	0.48	1.03	Other	152	360
197	FIB.skin_neurosecretory.baseline	0.48	Nonsignificant	—	0.00	Other	0	0
198	EPI.tracheal_submucosal_gland.ductal_luminal	0.47	Nonsignificant	—	0.73	Other	0	0
199	EPI.hepatic_ductular_cholangiocyte.ion_transport	0.47	Nonsignificant	—	0.58	Other	0	0
200	EC.liver_sinusoidal.stress	0.46	Nonsignificant	—	0.00	Other	413	158
201	T.CD4_Th2.tissue_adapted	0.46	Nonsignificant	—	0.97	Other	0	0
202	EPI.renal_principal_cell.inflammatory	0.46	Nonsignificant	0.75	1.31	Other	74	157
203	EPI.bile_duct_cholangiocyte.secretory_mucin	0.45	Nonsignificant	—	0.76	Other	7	12
204	EC.venous.adipose_lipid	0.45	Nonsignificant	0.46	1.18	Other	254	476
205	EC.liver_sinusoidal.secretory_lipoprotein	0.43	Nonsignificant	0.99	0.10	Other	120	70
206	EPI.colonocyte.distal_absorptive	0.43	Nonsignificant	—	1.87	Other	0	0
207	EPI.ectocervical_granular.secretory_apocrine	0.43	Nonsignificant	—	0.00	Other	0	0
208	GRANU.MAST.activated_repair	0.41	Nonsignificant	—	0.71	Other	0	1
209	MAC.LAM.anti_inflammatory	0.41	Nonsignificant	1.00	0.10	Other	86	132
210	PC.IgA_muocsal.migratory	0.40	Nonsignificant	0.68	1.08	Other	4	1
211	EPI.renal_principal_cell.canonical_vasopressin	0.40	Nonsignificant	0.80	1.23	Other	2	0
212	EPI.ileal_enterocyte_crypt.proliferative_S	0.40	Nonsignificant	0.75	0.78	Other	4	2
213	EC.arterial.angiogenic_tip	0.40	Nonsignificant	—	1.26	Other	30	37
214	EC.heart_remodeling.capillary_metabolic	0.39	Nonsignificant	0.24	1.41	Other	54	414
215	EPI.thymic_cortical.baseline	0.39	Nonsignificant	0.43	1.07	Other	185	386
216	HEP.periportal_metabolic.apolipoprotein_secretory	0.39	Nonsignificant	0.52	1.17	Other	43	110
217	EPI.thymic_cortical.Notch_interface	0.39	Nonsignificant	—	0.11	Other	82	137
218	PC.IgA_muocsal.baseline	0.38	Nonsignificant	0.73	0.94	Other	3	5
219	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	0.38	Nonsignificant	—	1.44	Other	0	0
220	EPI.colonic_enteroendocrine.progenitor	0.38	Nonsignificant	—	0.97	Other	0	0
221	THYMO.SP_CD8_naive	0.38	Nonsignificant	1.00	0.89	Other	297	177
222	B.naive.receptor_recycle	0.35	Nonsignificant	0.34	1.33	Other	51	0
223	B.naive.baseline	0.35	Nonsignificant	0.40	1.31	Other	10	13
224	THYMO.SP_CD8_naive_stress	0.34	Nonsignificant	1.00	0.54	Other	1	1
225	B.memory.migratory	0.33	Nonsignificant	1.00	0.65	Other	123	208
226	EPI.thymic_cortical.secretory_remodeling	0.33	Nonsignificant	—	0.00	Other	4	1
227	MESO.secretory_structural	0.33	Nonsignificant	—	0.86	Other	0	0
228	MAC.resident_cardiac.antigen_presenting	0.33	Nonsignificant	0.45	1.47	Other	52	27
229	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.32	Nonsignificant	—	0.00	Other	0	0
230	PC.IgA_muocsal.activated	0.32	Nonsignificant	0.73	0.92	Other	17	8
231	EPI.alveolar_type_1.activated	0.32	Nonsignificant	—	1.64	Other	0	0
232	EPI.pancreatic_ductal_bicarbonate.baseline	0.32	Nonsignificant	0.45	1.15	Other	11	42
233	MAC.resident_iron.redox_metabolic	0.32	Nonsignificant	1.00	0.00	Other	4	4
234	EPI.esophageal_basal.activated_progenitor	0.32	Nonsignificant	0.04	1.93	Other	1	0
235	MAC.microglia_like.phagocytic_redox	0.31	Nonsignificant	—	0.00	Other	0	0
236	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	0.30	Nonsignificant	—	1.04	Other	39	82
237	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	0.30	Nonsignificant	—	1.40	Other	0	0
238	GRANU.MAST.resting_granule	0.29	Nonsignificant	—	0.00	Other	0	0
239	EPI.pancreatic_ductal_bicarbonate.stress	0.29	Nonsignificant	—	0.44	Other	12	33
240	B.naive.purinergic	0.29	Nonsignificant	8.20e-03	1.50	Other	384	820
241	B.naive.remodeling	0.29	Nonsignificant	1.00	1.02	Other	135	230
242	EPI.ileal_goblet.baseline	0.28	Nonsignificant	0.52	1.36	Other	16	2
243	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	0.28	Nonsignificant	0.45	1.28	Other	40	191
244	PC.IgA_muocsal.plasmablast	0.28	Nonsignificant	0.68	1.09	Other	5	4
245	EPI.pancreatic_acinar.inflammatory_regenerative	0.27	Nonsignificant	0.96	1.08	Other	25	113
246	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.26	Nonsignificant	—	0.00	Other	5	3
247	THYMO.SP_CD8_transitional	0.26	Nonsignificant	1.00	0.50	Other	32	75
248	GRANU.MAST.activated_acute	0.25	Nonsignificant	—	0.00	Other	0	0
249	B.memory.preactivated	0.25	Nonsignificant	1.00	0.81	Other	173	174
250	B.naive.antigen_presenting_ready	0.24	Nonsignificant	1.00	0.86	Other	48	73
251	FIB.skin_sheath.neuro_vascular_interface	0.24	Nonsignificant	—	0.59	Other	0	0
252	B.memory.activated	0.24	Nonsignificant	1.00	0.22	Other	105	29
253	EPI.ileal_goblet.inflammatory_mucin	0.24	Nonsignificant	0.96	0.07	Other	6	9
254	EPI.pancreatic_islet.delta	0.24	Nonsignificant	—	1.04	Other	0	0
255	B.naive.metabolic	0.24	Nonsignificant	1.00	0.89	Other	50	79
256	EC.venous.activated	0.23	Nonsignificant	0.99	0.95	Other	247	752
257	EPI.renal_thick_ascending_limb.barrier_repair	0.23	Nonsignificant	0.73	1.19	Other	141	284
258	EPI.ileal_goblet.stress_metallothionein	0.23	Nonsignificant	—	0.00	Other	4	11
259	HEP.canalicular_transport.inflammatory	0.23	Nonsignificant	5.04e-04	1.34	Other	1,335	194
260	B.naive.proteostasis	0.22	Nonsignificant	1.00	0.79	Other	49	69
261	MAC.proliferating.stress	0.22	Nonsignificant	—	0.35	Other	87	136
262	FIB.skin_sheath.ECM_immune	0.21	Nonsignificant	—	0.44	Other	0	0
263	EPI.pancreatic_ductal_bicarbonate.activated	0.21	Nonsignificant	0.73	0.97	Other	10	7
264	EPI.pancreatic_ductal_progenitor.baseline	0.21	Nonsignificant	0.31	1.21	Other	179	702
265	MAC.resident_cardiac.phagocytic_homeostasis	0.21	Nonsignificant	0.90	0.73	Other	564	1,221
266	EPI.tracheal_suprabasal.transitional_wound	0.20	Nonsignificant	—	0.43	Other	16	1
267	EPI.colonocyte.ionocyte_BEST4	0.20	Nonsignificant	0.67	1.47	Other	103	188
268	EPI.renal_proximal_tubule.detox_antioxidant	0.19	Nonsignificant	0.62	1.24	Other	394	77
269	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	0.19	Nonsignificant	—	0.00	Other	0	0
270	EPI.renal_intercalated_cell_type_B.baseline	0.19	Nonsignificant	—	0.00	Other	3	1
271	EPI.renal_proximal_tubule.onecarbon_peroxisome	0.18	Nonsignificant	0.77	0.62	Other	58	89
272	MESO.antiviral	0.18	Nonsignificant	—	0.34	Other	3	8
273	HEP.periportal_metabolic.stress_checkpoint	0.18	Nonsignificant	0.30	1.14	Other	234	786
274	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	0.18	Nonsignificant	—	0.00	Other	6	9
275	EC.venous.baseline	0.18	Nonsignificant	1.00	0.47	Other	346	807
276	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	0.18	Nonsignificant	0.78	0.86	Other	219	533
277	EPI.ileal_enterocyte_crypt.secretory_precursor	0.17	Nonsignificant	—	0.00	Other	0	0
278	ILC2.activated	0.17	Nonsignificant	—	0.35	Other	0	0
279	EPI.pancreatic_ductal_progenitor.ADM_like	0.17	Nonsignificant	—	0.00	Other	0	0
280	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.17	Nonsignificant	—	0.00	Other	19	54
281	MAC.kupffer.fibrogenic	0.17	Nonsignificant	—	0.36	Other	0	0
282	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	0.16	Nonsignificant	0.44	1.24	Other	33	34
283	T.CD4_Treg.tissue_effector	0.16	Nonsignificant	0.34	1.12	Other	16	13
284	EPI.pancreatic_islet.beta	0.16	Nonsignificant	0.24	1.14	Other	42	57
285	FIB.skin_sheath.stress_chaperone	0.15	Nonsignificant	—	0.00	Other	0	0
286	THYMO.DP_early_stress	0.15	Nonsignificant	—	0.00	Other	0	0
287	MAC.proliferating.DNA_replication	0.15	Nonsignificant	0.73	0.76	Other	3	6
288	HPC.GMP_granulocytic	0.14	Nonsignificant	—	0.00	Other	3	3
289	GRNLSA.stress_metabolic	0.14	Nonsignificant	—	0.94	Other	1	2
290	B.germinal_center.DZ_S_phase	0.14	Nonsignificant	—	0.58	Other	0	0
291	MAC.kupffer.stress	0.14	Nonsignificant	0.43	1.08	Other	9	3
292	PC.IgG_systemic.secretory	0.13	Nonsignificant	0.11	1.28	Other	0	0
293	B.naive.restrained	0.13	Nonsignificant	1.00	0.26	Other	183	353
294	T.CD4_naive.gut_prone	0.13	Nonsignificant	0.99	1.23	Other	35	70
295	EPI.skin_keratinocyte_proliferating.anchor_remodel	0.12	Nonsignificant	—	1.13	Other	0	0
296	HPC.CLP_B_primed	0.12	Nonsignificant	—	1.12	Other	0	0
297	HEP.canalicular_transport.secretory_ERAD_UPR	0.12	Nonsignificant	1.00	0.98	Other	232	28
298	EPI.pancreatic_ductal_progenitor.ciliated_transport	0.12	Nonsignificant	—	0.00	Other	105	368
299	B.naive.activated	0.12	Nonsignificant	1.00	0.44	Other	77	127
300	EPI.tracheal_submucosal_gland.acinar_serous	0.12	Nonsignificant	—	0.00	Other	0	0
301	MAC.resident_cardiac.inflammatory_reparative	0.12	Nonsignificant	0.90	0.70	Other	31	96
302	EC.arterial.homeostatic	0.11	Nonsignificant	0.88	1.18	Other	24	3
303	EPI.renal_immature_ureteric_bud.osmoprotective	0.11	Nonsignificant	0.96	0.74	Other	126	44
304	MEL.neurotrophic_migratory	0.11	Nonsignificant	—	1.66	Other	0	0
305	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.10	Nonsignificant	0.46	1.15	Other	14	32
306	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.10	Nonsignificant	—	0.00	Other	0	0
307	EC.arterial.inflammatory	0.10	Nonsignificant	0.88	1.08	Other	63	50
308	MESO.baseline	0.10	Nonsignificant	0.67	0.95	Other	0	6
309	IPSC.mesendo_primed	0.10	Nonsignificant	5.37e-07	1.23	Other	0	0
310	HEP.canalicular_transport.pericentral_like_hypoxia	0.09	Nonsignificant	1.00	0.78	Other	326	8
311	EPI.bile_duct_cholangiocyte.inflammatory_APC	0.09	Nonsignificant	—	0.00	Other	2	0
312	EPI.pancreatic_ductal_perivascular.baseline	0.09	Nonsignificant	0.40	1.11	Other	1	5
313	EC.arterial.elastic	0.08	Nonsignificant	0.88	1.11	Other	22	45
314	EPI.esophageal_basal.junctional_barrier	0.08	Nonsignificant	—	0.00	Other	0	0
315	EPI.cervical_suprabasal.inflammatory_repair	0.08	Nonsignificant	—	0.42	Other	0	0
316	EPI.pancreatic_acinar.stress	0.08	Nonsignificant	1.00	0.94	Other	28	28
317	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.08	Nonsignificant	—	0.97	Other	0	0
318	HEP.periportal_metabolic.urea_onecarbon_secretory	0.08	Nonsignificant	0.30	1.09	Other	1,332	3,053
319	T.CD8_Tcm.NK_like	0.08	Nonsignificant	0.17	1.19	Other	334	581
320	EPI.skin_interfollicular_spinous.transition_basal	0.07	Nonsignificant	2.23e-05	1.48	Other	100	127
321	HEP.canalicular_transport.baseline	0.07	Nonsignificant	1.00	0.89	Other	199	477
322	EC.arterial.arteriole_gas_exchange	0.07	Nonsignificant	0.88	0.93	Other	238	131
323	HPC.GMP_inflammatory	0.07	Nonsignificant	0.77	1.12	Other	20	10
324	EPI.pancreatic_ductal_perivascular.protective_antioxidant	0.07	Nonsignificant	—	0.00	Other	11	69
325	EPI.salivary_mucous_acinar.baseline	0.07	Nonsignificant	—	—	Other	394	683
326	PLAT.adhesion	0.07	Nonsignificant	—	0.00	Other	0	0
327	MG.expanding	0.06	Nonsignificant	0.76	1.18	Other	2	1
328	EC.arterial.arteriole_interface	0.06	Nonsignificant	0.88	0.92	Other	31	12
329	CM.contractile_oxphos	0.06	Nonsignificant	0.38	1.13	Other	6	19
330	EPI.esophageal_suprabasal.basal_transitional	0.06	Nonsignificant	1.57e-03	1.62	Other	44	67
331	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.06	Nonsignificant	—	0.00	Other	0	0
332	EPI.skin_appendage_keratinocyte.transit_amplifying	0.06	Nonsignificant	—	0.00	Other	109	358
333	EPI.pancreatic_acinar.baseline	0.06	Nonsignificant	1.00	0.91	Other	274	163
334	MAC.kupffer.tolerogenic	0.05	Nonsignificant	—	0.00	Other	45	49
335	GRNLSA.EMT_insulin_signaling	0.05	Nonsignificant	0.64	1.24	Other	47	84
336	PC.IgG_systemic.interacting	0.05	Nonsignificant	0.67	0.92	Other	0	0
337	ILC2.migratory	0.05	Nonsignificant	—	0.44	Other	0	0
338	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.05	Nonsignificant	—	0.07	Other	10	20
339	MAC.alveolar.inflammatory	0.05	Nonsignificant	0.02	1.35	Other	208	312
340	EPI.skin_hair_follicle_bulge.anagen_growth	0.05	Nonsignificant	—	0.09	Other	0	0
341	EPI.renal_distal_tubule.ion_transport	0.04	Nonsignificant	—	1.02	Other	0	0
342	EPI.renal_principal_cell.activated_acute	0.04	Nonsignificant	0.95	0.79	Other	29	59
343	EC.venous.cardiac_structural	0.04	Nonsignificant	1.00	0.22	Other	102	229
344	IPSC.neuroendocrine_primed	0.04	Nonsignificant	—	0.86	Other	0	0
345	EC.arterial.ion_pump	0.04	Nonsignificant	0.88	0.99	Other	3	2
346	EC.arterial.mito_contact	0.04	Nonsignificant	0.88	0.77	Other	14	5
347	NEU.EXC_IT.structural	0.04	Nonsignificant	0.55	1.21	Other	171	41
348	T.CD8_naive.splicing_enriched	0.04	Nonsignificant	0.63	1.08	Other	120	16
349	T.CD8_naive.lipid_synthesis	0.04	Nonsignificant	0.22	1.47	Other	6	4
350	MAC.kupffer.inflammatory	0.04	Nonsignificant	—	0.00	Other	7	4
351	EC.arterial.metabolic	0.04	Nonsignificant	0.88	0.81	Other	195	159
352	T.CD8_naive.effector_transition	0.04	Nonsignificant	0.55	1.16	Other	35	62
353	EPI.endocervical_secretory.squamous_barrier	0.04	Nonsignificant	—	0.67	Other	0	0
354	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	0.04	Nonsignificant	1.00	0.12	Other	7	16
355	MEL.dedifferentiated_migratory	0.04	Nonsignificant	—	1.00	Other	0	0
356	MAC.microglia_like.patrolling_adhesive	0.04	Nonsignificant	—	0.00	Other	0	0
357	T.CD4_Th17.migratory	0.03	Nonsignificant	0.23	1.13	Other	13	23
358	ASTRO.A2_reactive	0.03	Nonsignificant	0.37	1.22	Other	10	37
359	MG.phagocytic_APC	0.03	Nonsignificant	0.76	0.93	Other	25	8
360	EPI.skin_hair_follicle_bulge.quiescent	0.03	Nonsignificant	1.00	0.00	Other	56	69
361	T.CD8_naive.vesicle_secretory	0.03	Nonsignificant	0.91	0.94	Other	42	0
362	T.CD4_Th2.precursor	0.03	Nonsignificant	—	0.00	Other	0	0
363	IPSC.stromal_primed	0.03	Nonsignificant	1.00	0.98	Other	0	0
364	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.03	Nonsignificant	—	0.00	Other	0	0
365	PC.IgG_systemic.metabolic	0.03	Nonsignificant	0.10	1.37	Other	46	63
366	EPI.salivary_serous_acinar.quiescent	0.03	Nonsignificant	1.00	0.05	Other	178	493
367	HEP.canalicular_transport.injury_stress	0.03	Nonsignificant	1.00	0.78	Other	289	24
368	T.CD8_naive.baseline	0.03	Nonsignificant	0.97	0.91	Other	142	2
369	EPI.thymic_medullary.proliferative_APC	0.03	Nonsignificant	—	1.09	Other	0	0
370	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	0.03	Nonsignificant	0.91	0.70	Other	449	1,034
371	T.CD8_transitional.APC_like	0.03	Nonsignificant	0.05	1.08	Other	205	62
372	NEU.INH_VIP.serotonergic	0.03	Nonsignificant	—	0.61	Other	9	2
373	T.CD8_naive.nfkb_related	0.03	Nonsignificant	0.54	1.25	Other	1	0
374	T.CD4_Trm.central_like	0.03	Nonsignificant	1.96e-03	1.28	Other	38	31
375	IPSC.axial_identity_primed	0.03	Nonsignificant	1.00	0.99	Other	0	0
376	EPI.alveolar_type_2.stress_response	0.03	Nonsignificant	0.31	1.14	Other	675	1,562
377	T.CD8_naive.cytokine_dampened	0.02	Nonsignificant	0.91	0.99	Other	71	4
378	CHOND.angiogenic	0.02	Nonsignificant	—	1.46	Other	0	0
379	IPSC.canonical_pluripotent	0.02	Nonsignificant	1.00	0.92	Other	0	0
380	GRNLSA.chemokine_mechanosensory	0.02	Nonsignificant	0.75	1.15	Other	1	0
381	EPI.alveolar_type_2.baseline_surfactant	0.02	Nonsignificant	0.32	1.11	Other	64	9
382	MG.baseline	0.02	Nonsignificant	0.76	0.88	Other	16	5
383	T.CD4_Trm.activated	0.02	Nonsignificant	0.72	1.16	Other	32	26
384	EPI.renal_thick_ascending_limb.remodeling	0.02	Nonsignificant	0.74	1.06	Other	152	92
385	EPI.renal_principal_cell.intercalated_like	0.02	Nonsignificant	0.81	1.02	Other	63	66
386	B.germinal_center.LZ_selection	0.02	Nonsignificant	—	0.00	Other	0	0
387	EPI.lung_club_secretory.ciliogenesis_primed	0.02	Nonsignificant	—	1.47	Other	0	0
388	NEU.INH_VIP.enkephalinergic	0.02	Nonsignificant	—	1.42	Other	0	0
389	HEP.canalicular_transport.ductular_like_transition	0.02	Nonsignificant	1.00	0.24	Other	400	87
390	T.CD4_Tfh.effector_migratory	0.02	Nonsignificant	0.60	1.10	Other	122	57
391	T.CD4_naive.proteostasis	0.02	Nonsignificant	0.99	1.09	Other	14	9
392	EC.heart_remodeling.activated_acute	0.02	Nonsignificant	0.24	1.39	Other	102	186
393	HPC.MEP	0.02	Nonsignificant	0.77	1.08	Other	599	1,195
394	EPI.colonic_enteroendocrine.Lcell_peptide	0.02	Nonsignificant	—	0.00	Other	0	0
395	EPI.skin_keratinocyte_basal.basement_anchoring	0.02	Nonsignificant	—	0.97	Other	0	0
396	MESO.activated_migratory	0.02	Nonsignificant	—	0.00	Other	0	0
397	EPI.salivary_duct_excretory.baseline	0.02	Nonsignificant	0.59	1.17	Other	23	57
398	EPI.tracheal_suprabasal.secretory_immune	0.02	Nonsignificant	—	0.00	Other	0	0
399	T.CD4_transitional.primed_helper_effector	0.02	Nonsignificant	0.42	1.13	Other	19	43
400	PC.IgG_systemic.stress	0.02	Nonsignificant	—	0.00	Other	1	5
401	SCHWN.axon_contact_cardiac	0.02	Nonsignificant	1.00	0.00	Other	18	63
402	EPI.gastric_foveolar.baseline	0.02	Nonsignificant	—	0.00	Other	0	0
403	EPI.renal_thick_ascending_limb.cation_flux	0.02	Nonsignificant	0.73	1.15	Other	57	95
404	NEU.EXC_CT.Ca2_sensor	0.02	Nonsignificant	—	1.32	Other	0	0
405	EC.lymphatic.valve	0.02	Nonsignificant	—	0.87	Other	0	0
406	EPI.renal_intercalated_cell_type_A.acid_secretion	0.02	Nonsignificant	0.14	1.36	Other	12	6
407	EPI.esophageal_suprabasal.differentiating_keratin	0.01	Nonsignificant	0.82	0.79	Other	131	61
408	T.CD4_Tem.inflammatory	0.01	Nonsignificant	0.48	1.11	Other	28	6
409	THYMO.proliferative_G2M	0.01	Nonsignificant	—	0.00	Other	164	413
410	ILC2.quiescent	0.01	Nonsignificant	—	0.00	Other	0	0
411	T.gamma_delta.early_effector	0.01	Nonsignificant	0.63	1.04	Other	89	0
412	EPI.thymic_medullary.canonical_alarmin	0.01	Nonsignificant	0.37	1.30	Other	8	17
413	EC.lymphatic.tip_migratory	0.01	Nonsignificant	0.76	1.20	Other	23	37
414	EC.lymphatic.scavenger	0.01	Nonsignificant	0.76	1.07	Other	203	257
415	T.CD4_Tfh.canonical_GC_helper	0.01	Nonsignificant	0.60	1.10	Other	1	2
416	NEU.INH_VIP.LAMP5_hybrid	0.01	Nonsignificant	—	0.95	Other	1	9
417	EPI.thymic_medullary.stress_APC	0.01	Nonsignificant	0.79	0.68	Other	2	4
418	HEP.periportal_metabolic.acute_phase_barrier	0.01	Nonsignificant	1.00	0.80	Other	533	138
419	T.CD4_naive.homeostatic	0.01	Nonsignificant	0.99	1.06	Other	215	108
420	T.CD8_naive.innate_like	0.01	Nonsignificant	0.97	0.54	Other	10	1
421	EPI.thymic_medullary.hormone_xeno_barrier	0.01	Nonsignificant	—	0.02	Other	0	8
422	ASTRO.neuromodulatory	0.01	Nonsignificant	0.57	1.13	Other	34	172
423	THYMO.proliferative_S	0.01	Nonsignificant	1.00	0.22	Other	163	418
424	IPSC.endoderm_primed	0.01	Nonsignificant	1.00	0.87	Other	0	0
425	MESO.activated_stress	0.01	Nonsignificant	—	0.00	Other	0	0
426	MAC.alveolar.lipid_autophagy	0.01	Nonsignificant	—	0.00	Other	35	44
427	EPI.renal_distal_tubule.stress	0.01	Nonsignificant	—	0.86	Other	0	0
428	T.CD8_Trm.inflammatory	0.01	Nonsignificant	0.47	1.12	Other	124	176
429	HPC.LMPP	0.01	Nonsignificant	0.91	0.77	Other	65	31
430	EC.heart_remodeling.translation_boost	0.01	Nonsignificant	—	1.66	Other	0	0
431	MAC.alveolar.capillary_interacting	0.01	Nonsignificant	0.80	1.10	Other	113	181
432	EPI.esophageal_suprabasal.proliferative_exit	9.79e-03	Nonsignificant	—	0.13	Other	0	0
433	EPI.skin_interfollicular_spinous.stress_oxidative	9.63e-03	Nonsignificant	—	0.00	Other	0	0
434	T.CD4_Tfh.suppression_exhaustion	9.51e-03	Nonsignificant	0.90	0.89	Other	0	2
435	EPI.skin_hair_follicle_companion.activated_migratory	9.46e-03	Nonsignificant	—	0.00	Other	0	0
436	MEL.secretory_quiescent	9.36e-03	Nonsignificant	1.00	0.59	Other	19	13
437	T.CD4_naive.proteostasis_mitoprot	9.23e-03	Nonsignificant	0.99	0.99	Other	15	37
438	EPI.alveolar_type_2.injury_primed	9.19e-03	Nonsignificant	0.32	1.09	Other	434	245
439	T.CD4_transitional.APC_interacting	9.01e-03	Nonsignificant	0.19	1.27	Other	10	14
440	CHOND.pro_inflammatory	8.91e-03	Nonsignificant	0.51	1.11	Other	181	351
441	EPI.salivary_duct_excretory.stress	8.73e-03	Nonsignificant	0.84	0.69	Other	33	68
442	T.CD4_Tcm.migratory_cilium	8.66e-03	Nonsignificant	0.62	1.10	Other	5	10
443	IPSC.stress	8.61e-03	Nonsignificant	5.11e-03	1.28	Other	0	0
444	CHOND.activated_fibro_like	8.57e-03	Nonsignificant	0.49	1.16	Other	531	188
445	T.CD4_Trm.metal_stress	8.26e-03	Nonsignificant	0.72	1.10	Other	34	58
446	GRNLSA.proliferative_migratory	8.02e-03	Nonsignificant	0.75	1.05	Other	248	292
447	MAC.alveolar.stress_metabolic	7.15e-03	Nonsignificant	0.84	0.69	Other	116	148
448	OLG.stress	7.12e-03	Nonsignificant	0.36	1.15	Other	232	8
449	ASTRO.hypoxia_angiogenic	7.12e-03	Nonsignificant	0.91	1.12	Other	5	18
450	EC.lymphatic.activated	7.01e-03	Nonsignificant	0.88	0.91	Other	47	73
451	MEL.stress_glucocorticoid	6.95e-03	Nonsignificant	1.00	0.41	Other	11	34
452	T.CD4_naive.mature	6.89e-03	Nonsignificant	0.99	0.98	Other	211	100
453	T.CD8_transitional.effector_primed	6.88e-03	Nonsignificant	0.10	1.07	Other	435	151
454	T.CD4_Trm.baseline	6.87e-03	Nonsignificant	0.72	1.00	Other	31	21
455	EPI.renal_intercalated_cell_type_A.PC_transitional	6.75e-03	Nonsignificant	—	0.00	Other	203	407
456	EPI.renal_principal_cell.injury_repair	6.56e-03	Nonsignificant	0.99	0.26	Other	26	9
457	T.CD4_Trm.stress_adaptive	6.41e-03	Nonsignificant	0.72	0.99	Other	8	22
458	T.CD8_Trm.muscosal_Tc17	6.31e-03	Nonsignificant	0.47	1.21	Other	19	38
459	EPI.alveolar_type_1.baseline	6.19e-03	Nonsignificant	1.00	0.00	Other	8	0
460	T.CD4_Tcm.DC_interact	6.16e-03	Nonsignificant	0.36	1.10	Other	72	32
461	T.CD8_Tem.signaling_turnover	5.92e-03	Nonsignificant	0.65	1.07	Other	425	683
462	T.CD4_Th17.baseline	5.90e-03	Nonsignificant	0.73	0.96	Other	51	5
463	EPI.skin_sebaceous_duct_luminal.immune_interface	5.83e-03	Nonsignificant	—	1.24	Other	0	0
464	T.CD4_naive.resist_bystander	5.83e-03	Nonsignificant	0.99	1.01	Other	40	25
465	CHOND.remodeling	5.76e-03	Nonsignificant	—	0.58	Other	5	0
466	EPI.skin_interfollicular_spinous.upper_lipid	5.66e-03	Nonsignificant	—	0.59	Other	6	6
467	T.CD4_naive.survival_neddylation	5.66e-03	Nonsignificant	0.99	1.01	Other	26	38
468	HEP.periportal_metabolic.inflammatory_activated	5.65e-03	Nonsignificant	1.00	0.62	Other	712	1,610
469	NEU.EXC_SYT2.synaptic	5.43e-03	Nonsignificant	—	0.48	Other	0	0
470	T.CD8_transitional.stress	5.26e-03	Nonsignificant	—	1.53	Other	24	34
471	HPC.MPP_activated	5.23e-03	Nonsignificant	—	0.00	Other	0	0
472	EPI.renal_thick_ascending_limb.canonical_salt_transporter	5.22e-03	Nonsignificant	0.75	0.88	Other	322	317
473	ASTRO.stress_mito	5.19e-03	Nonsignificant	0.57	1.15	Other	47	110
474	T.CD4_transitional.primed_cytotoxic	5.12e-03	Nonsignificant	0.60	1.07	Other	28	30
475	NEU.INH_VIP.nuclear_reg	5.06e-03	Nonsignificant	—	0.76	Other	20	4
476	MEL.mature_oxidative_traffic	4.95e-03	Nonsignificant	1.00	0.10	Other	247	285
477	EC.lymphatic.baseline	4.95e-03	Nonsignificant	0.98	0.57	Other	38	72
478	EPI.ectocervical_granular.proliferative_basal	4.91e-03	Nonsignificant	—	0.00	Other	0	0
479	T.CD4_naive.neddylation_mitoprot	4.61e-03	Nonsignificant	0.99	0.97	Other	93	56
480	T.CD8_Trm.cytotoxic	4.61e-03	Nonsignificant	0.73	1.02	Other	165	85
481	B.germinal_center.LZ_memory_precursor	4.58e-03	Nonsignificant	—	0.00	Other	0	0
482	T.CD4_Treg.central_naive_like	4.50e-03	Nonsignificant	0.34	1.08	Other	333	45
483	MAC.alveolar.biosynthetic_sterol_heme	4.44e-03	Nonsignificant	0.80	1.02	Other	347	40
484	T.CD4_naive.survival	4.40e-03	Nonsignificant	0.99	1.00	Other	12	17
485	T.CD8_naive.mito_proteostasis	4.37e-03	Nonsignificant	0.97	0.76	Other	428	100
486	T.CD4_Tcm.imprinted_splicing	4.33e-03	Nonsignificant	0.64	1.09	Other	6	17
487	EPI.lung_club_secretory.inflammatory	4.32e-03	Nonsignificant	—	0.00	Other	0	0
488	T.CD4_Tcm.stress	4.28e-03	Nonsignificant	0.62	1.16	Other	5	11
489	T.MAIT.early_activation	4.12e-03	Nonsignificant	5.19e-03	1.20	Other	57	4
490	EPI.lung_club_secretory.ciliogenesis_axoneme	4.09e-03	Nonsignificant	—	0.00	Other	0	0
491	T.CD4_transitional.tissue_enagement	4.04e-03	Nonsignificant	0.70	0.94	Other	5	11
492	T.CD4_Trm.helper_like	4.02e-03	Nonsignificant	0.72	0.96	Other	84	147
493	T.CD8_Trm.homeostatic	4.00e-03	Nonsignificant	0.83	0.96	Other	42	5
494	T.CD4_transitional.baseline	3.98e-03	Nonsignificant	0.70	0.95	Other	59	97
495	EPI.lung_club_secretory.canonical_surfactant	3.73e-03	Nonsignificant	—	0.00	Other	74	104
496	NEU.INH_PVALB.nuclear_reg	3.65e-03	Nonsignificant	0.17	1.48	Other	25	12
497	T.CD8_Tem.baseline	3.52e-03	Nonsignificant	0.65	1.02	Other	458	356
498	NEU.INH_VIP.regulatory_remodeling	3.50e-03	Nonsignificant	—	0.12	Other	6	1
499	T.CD8_Tcm.effector_bias	3.42e-03	Nonsignificant	1.00	0.95	Other	199	329
500	T.CD4_naive.neddylation	3.30e-03	Nonsignificant	0.99	0.95	Other	104	222
501	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	3.30e-03	Nonsignificant	0.70	1.22	Other	2	9
502	EPI.colonocyte.proximal_transport	3.28e-03	Nonsignificant	0.97	0.79	Other	24	12
503	EPI.skin_interfollicular_spinous.baseline	3.23e-03	Nonsignificant	0.99	0.74	Other	35	3
504	EPI.colonocyte.secretory_boost	3.17e-03	Nonsignificant	0.97	0.77	Other	98	91
505	T.CD4_naive.survival_mitoprot	3.14e-03	Nonsignificant	0.99	1.06	Other	13	7
506	T.CD4_Treg.APC_interactive	3.02e-03	Nonsignificant	0.96	0.84	Other	118	28
507	EPI.colonocyte.junction_remodeling	2.87e-03	Nonsignificant	0.97	0.55	Other	218	305
508	EPI.skin_keratinocyte_progenitor.activated_stress	2.77e-03	Nonsignificant	—	0.38	Other	0	0
509	T.CD4_naive.mature_mitoprot	2.70e-03	Nonsignificant	0.99	0.88	Other	212	476
510	B.germinal_center.LZ_survival	2.67e-03	Nonsignificant	—	0.00	Other	0	0
511	ASTRO.stress_acute	2.62e-03	Nonsignificant	0.91	1.02	Other	60	56
512	EPI.colonocyte.crypt_progenitor	2.56e-03	Nonsignificant	0.97	0.53	Other	115	265
513	THYMO.DN_preTCR	2.55e-03	Nonsignificant	1.00	0.16	Other	41	71
514	T.CD8_Tem.early_helper_like	2.55e-03	Nonsignificant	0.29	1.07	Other	445	755
515	T.CD4_Tfh.precursor_migratory	2.53e-03	Nonsignificant	0.90	0.81	Other	72	27
516	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	2.46e-03	Nonsignificant	—	0.43	Other	0	0
517	ASTRO.A1_reactive	2.40e-03	Nonsignificant	0.99	0.90	Other	433	394
518	CHOND.articular_collagen	2.37e-03	Nonsignificant	1.00	0.47	Other	551	266
519	EPI.pancreatic_islet.alpha	2.34e-03	Nonsignificant	—	0.00	Other	152	330
520	T.MAIT.migratory	2.34e-03	Nonsignificant	0.76	1.16	Other	10	1
521	T.CD8_Tcm.baseline	2.31e-03	Nonsignificant	1.00	0.92	Other	90	89
522	NK.cytokine_lung_immediate_early	2.30e-03	Nonsignificant	0.28	1.11	Other	424	274
523	T.CD4_Tem.long_term_memory	2.28e-03	Nonsignificant	0.48	1.10	Other	314	587
524	T.CD4_Trm.cytotoxic_effector	2.04e-03	Nonsignificant	0.88	0.85	Other	118	77
525	EPI.skin_interfollicular_spinous.stress_UPR	1.97e-03	Nonsignificant	—	0.00	Other	0	0
526	NEU.EXC_IT.neuromodulated	1.85e-03	Nonsignificant	0.55	1.18	Other	176	116
527	EPI.skin_interfollicular_spinous.early_differentiation	1.83e-03	Nonsignificant	0.99	0.21	Other	89	19
528	EPI.skin_sweat_duct_keratinocyte.signal_gate	1.76e-03	Nonsignificant	—	1.13	Other	43	26
529	HPC.MPP_IEG	1.75e-03	Nonsignificant	0.91	0.67	Other	45	46
530	T.CD4_Tcm.effector_like	1.75e-03	Nonsignificant	0.64	1.05	Other	293	533
531	NEU.EXC_CT.remodeling	1.72e-03	Nonsignificant	—	0.51	Other	23	1
532	EPI.skin_keratinocyte_proliferating.early_spinous_transition	1.72e-03	Nonsignificant	—	0.00	Other	135	290
533	NK.immature_bridge	1.70e-03	Nonsignificant	0.75	1.03	Other	117	122
534	NEU.INH_VIP.matrix	1.58e-03	Nonsignificant	—	0.10	Other	24	77
535	IPSC.mesodermal_primed	1.51e-03	Nonsignificant	1.00	0.80	Other	0	0
536	T.CD8_Trm.dendritic_recruiter	1.48e-03	Nonsignificant	0.94	0.69	Other	47	85
537	MAC.kupffer.metabolic	1.45e-03	Nonsignificant	—	0.00	Other	25	36
538	EPI.esophageal_suprabasal.proliferative_S	1.43e-03	Nonsignificant	—	0.00	Other	26	41
539	T.CD4_Th17.cytotoxic	1.41e-03	Nonsignificant	0.73	0.98	Other	332	123
540	NK.adaptive_axis_baseline	1.40e-03	Nonsignificant	0.11	1.07	Other	1,008	153
541	EPI.renal_thick_ascending_limb.salt_sensing	1.33e-03	Nonsignificant	0.75	0.94	Other	73	103
542	IPSC.neural_primed	1.32e-03	Nonsignificant	1.00	0.73	Other	0	0
543	NEU.INH_VIP.excitatory_coupled	1.32e-03	Nonsignificant	—	0.01	Other	13	0
544	GRNLSA.lipid_hypoxia	1.29e-03	Nonsignificant	0.75	1.02	Other	28	0
545	OPC.proliferative_immune_interact	1.28e-03	Nonsignificant	0.53	1.14	Other	180	373
546	NEU.INH_VIP.develop_niche	1.27e-03	Nonsignificant	—	0.12	Other	0	0
547	SKM.type_1_slow.glycolytic	1.25e-03	Nonsignificant	0.03	1.38	Other	362	647
548	MAC.alveolar.scavenging_endocytic	1.13e-03	Nonsignificant	—	0.00	Other	140	283
549	T.CD4_Tcm.crosstalk_myeloid	1.11e-03	Nonsignificant	0.64	1.09	Other	5	4
550	EPI.skin_sweat_duct_keratinocyte.proliferative_S	1.08e-03	Nonsignificant	—	0.00	Other	0	0
551	EPI.cervical_suprabasal.secretory_vesicle	1.00e-03	Nonsignificant	—	0.00	Other	0	0
552	NK.adaptive_classII_inhibitory	9.17e-04	Nonsignificant	0.35	1.06	Other	880	154
553	CM.baseline	8.97e-04	Nonsignificant	1.00	0.97	Other	393	0
554	T.gamma_delta.cytotoxic_effector	8.77e-04	Nonsignificant	0.83	0.94	Other	349	109
555	EPI.renal_distal_tubule.ciliated_remodelling	8.75e-04	Nonsignificant	—	0.13	Other	0	0
556	SKM.type_2_fast.oxidative_IIa	8.58e-04	Nonsignificant	0.08	1.12	Other	946	56
557	HEP.periportal_metabolic.xenobiotic_detox	8.52e-04	Nonsignificant	1.00	0.43	Other	1,440	139
558	EPI.skin_keratinocyte_basal.spinous_transition	8.52e-04	Nonsignificant	—	0.00	Other	0	0
559	EPI.pancreatic_acinar.metabolic_onecarbon	8.41e-04	Nonsignificant	1.00	0.60	Other	287	328
560	ASTRO.synaptic_interaction	8.41e-04	Nonsignificant	0.99	0.82	Other	76	334
561	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	8.09e-04	Nonsignificant	—	0.28	Other	0	0
562	NK.cytokine_tissue_resident	8.00e-04	Nonsignificant	0.75	1.09	Other	74	82
563	EPI.endocervical_secretory.secretory_translocon	7.99e-04	Nonsignificant	—	0.00	Other	0	0
564	HEP.periportal_metabolic.canonical_urea_cycle	7.94e-04	Nonsignificant	1.00	0.32	Other	1,464	269
565	NEU.INH_PVALB.neuromodulatory	7.66e-04	Nonsignificant	—	0.41	Other	0	0
566	EC.heart_remodeling.perivascular	7.58e-04	Nonsignificant	0.99	1.03	Other	124	408
567	OPC.premyelinating	7.41e-04	Nonsignificant	0.53	1.13	Other	185	12
568	T.CD4_Tem.transitional_CM	7.31e-04	Nonsignificant	0.82	0.98	Other	31	20
569	SKM.type_2_fast.glycolytic_IIx_IIb	7.13e-04	Nonsignificant	0.10	1.09	Other	565	1,482
570	EPI.skin_sweat_duct_keratinocyte.barrier	7.06e-04	Nonsignificant	—	0.09	Other	0	0
571	EPI.skin_keratinocyte_basal.transit_amplifying	6.84e-04	Nonsignificant	—	0.00	Other	0	0
572	EPI.skin_interfollicular_spinous.proliferative	6.72e-04	Nonsignificant	—	0.00	Other	0	0
573	NEU.INH_PVALB.fastspike	6.69e-04	Nonsignificant	—	0.17	Other	24	22
574	T.CD4_naive.purinergic	6.64e-04	Nonsignificant	0.99	0.73	Other	49	1
575	ASTRO.homeostatic	6.38e-04	Nonsignificant	0.99	0.76	Other	200	431
576	T.CD4_Tcm.regulatory_poised	6.21e-04	Nonsignificant	0.64	1.09	Other	2	3
577	IPSC.mesenchymal_primed	6.00e-04	Nonsignificant	1.00	0.75	Other	0	0
578	T.CD4_Tcm.Tfh_like	5.85e-04	Nonsignificant	0.64	1.03	Other	102	214
579	NK.cytokine_repair_primed	5.77e-04	Nonsignificant	0.30	1.10	Other	266	11
580	T.CD8_Tem.TEMRA	5.43e-04	Nonsignificant	0.88	0.97	Other	920	1,088
581	T.CD4_Tcm.Th2_like	5.42e-04	Nonsignificant	0.62	1.14	Other	23	55
582	NEU.EXC_IT.adhesion	5.39e-04	Nonsignificant	0.75	1.01	Other	252	108
583	CM.inflammatory	5.35e-04	Nonsignificant	—	1.48	Other	0	0
584	T.CD4_Tcm.APC_mimicry	5.21e-04	Nonsignificant	0.62	1.11	Other	54	43
585	GRNLSA.cholesterol_mevalonate	5.10e-04	Nonsignificant	0.75	0.84	Other	9	4
586	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	5.07e-04	Nonsignificant	—	0.00	Other	0	0
587	EPI.colonocyte.goblet_interface	4.99e-04	Nonsignificant	—	0.00	Other	11	21
588	T.gamma_delta.central_memory	4.90e-04	Nonsignificant	0.63	1.02	Other	460	919
589	NEU.INH_PVALB.chandelier	4.81e-04	Nonsignificant	0.75	0.67	Other	19	16
590	EPI.lung_multiciliated.mature_motile_cilia	4.73e-04	Nonsignificant	—	1.53	Other	0	0
591	EPI.skin_interfollicular_spinous.inflammatory	4.68e-04	Nonsignificant	—	0.00	Other	0	0
592	OLG.myelinating_mature	4.63e-04	Nonsignificant	0.64	1.08	Other	363	94
593	NK.adaptive_immature_precursor	4.48e-04	Nonsignificant	0.99	1.00	Other	358	111
594	T.CD4_Tem.cytotoxic_effector	4.44e-04	Nonsignificant	0.82	0.90	Other	225	398
595	OPC.homeostatic	4.35e-04	Nonsignificant	0.72	0.88	Other	394	160
596	IPSC.proliferative	4.31e-04	Nonsignificant	1.00	0.60	Other	0	0
597	T.CD4_naive.Treg_like	4.12e-04	Nonsignificant	0.99	0.68	Other	121	72
598	EC.heart_remodeling.remodeling_secretory	3.95e-04	Nonsignificant	0.99	0.93	Other	605	1,341
599	T.CD8_Tem.stress_adapted	3.90e-04	Nonsignificant	0.88	0.96	Other	607	520
600	NEU.INH_VIP.opioid	3.81e-04	Nonsignificant	—	0.00	Other	50	9
601	T.CD8_transitional.Trm_primed	3.68e-04	Nonsignificant	0.90	0.98	Other	108	15
602	EPI.esophageal_suprabasal.proliferative_G2M	3.33e-04	Nonsignificant	—	0.00	Other	0	0
603	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	3.05e-04	Nonsignificant	—	0.00	Other	0	0
604	CM.sarcomere_actin_interface	3.00e-04	Nonsignificant	1.00	0.97	Other	450	78
605	T.CD8_transitional.early	2.93e-04	Nonsignificant	0.96	0.89	Other	327	55
606	NEU.EXC_IT.transitional	2.80e-04	Nonsignificant	0.66	1.10	Other	237	142
607	NEU.INH_VIP.cannabinoid	2.79e-04	Nonsignificant	—	0.00	Other	0	0
608	GRNLSA.secretory_remodeling	2.31e-04	Nonsignificant	0.75	0.86	Other	90	25
609	NEU.INH_LAMP5.rosehip	2.26e-04	Nonsignificant	—	0.00	Other	0	0
610	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	1.95e-04	Nonsignificant	—	0.00	Other	0	0
611	T.CD4_Tcm.tissue_homing	1.93e-04	Nonsignificant	0.93	0.96	Other	78	46
612	NEU.INH_LAMP5.exc_inh_balance	1.74e-04	Nonsignificant	—	0.13	Other	46	2
613	NEU.INH_LAMP5.projecting	1.72e-04	Nonsignificant	—	0.27	Other	0	0
614	NEU.INH_PVALB.metabotropic	1.68e-04	Nonsignificant	—	0.00	Other	0	0
615	SKM.type_1_slow.oxidative	1.66e-04	Nonsignificant	1.00	0.81	Other	802	251
616	T.CD4_Tcm.baseline	1.51e-04	Nonsignificant	0.93	0.94	Other	61	31
617	NEU.EXC_CT.projector	1.46e-04	Nonsignificant	0.66	0.92	Other	87	26
618	T.MAIT.MAPK_brake	1.38e-04	Nonsignificant	0.97	0.96	Other	44	66
619	EPI.skin_sweat_duct_keratinocyte.repair	1.33e-04	Nonsignificant	—	0.00	Other	0	0
620	T.CD4_Tcm.secretory	1.29e-04	Nonsignificant	0.80	1.03	Other	20	11
621	NK.adaptive_HLAE_tuned	1.24e-04	Nonsignificant	0.35	1.04	Other	1,124	189
622	NEU.INH_VIP.canonical_disinhibitory	1.17e-04	Nonsignificant	1.00	0.09	Other	59	38
623	IPSC.midbrain_primed	1.15e-04	Nonsignificant	1.00	0.55	Other	0	0
624	ASTRO.immature_lipid	1.14e-04	Nonsignificant	0.99	0.51	Other	23	113
625	T.CD4_Tcm.synapse_dynamics	9.88e-05	Nonsignificant	0.93	0.96	Other	15	10
626	T.CD4_cytotoxic.NK_adapted	9.46e-05	Nonsignificant	0.05	1.18	Other	82	33
627	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	9.00e-05	Nonsignificant	—	0.00	Other	0	0
628	EPI.renal_distal_tubule.repair	8.58e-05	Nonsignificant	—	0.00	Other	34	102
629	CM.osmoprotection	8.55e-05	Nonsignificant	1.00	1.01	Other	34	57
630	SKM.type_1_slow.contractile	8.41e-05	Nonsignificant	1.00	0.37	Other	596	8
631	EC.heart_remodeling.remodeling_stalk	8.11e-05	Nonsignificant	0.99	0.71	Other	33	111
632	NEU.INH_LAMP5.glial_interface	7.81e-05	Nonsignificant	—	0.00	Other	0	0
633	CM.mito_proteostasis	7.43e-05	Nonsignificant	1.00	1.01	Other	329	29
634	T.CD8_Tem.motility_primed	7.15e-05	Nonsignificant	0.85	1.02	Other	269	4
635	EC.heart_remodeling.angiocrine	7.01e-05	Nonsignificant	0.99	0.56	Other	182	525
636	T.CD4_naive.activated_stress	7.01e-05	Nonsignificant	0.99	0.50	Other	339	429
637	EPI.skin_sebaceous_duct_luminal.detox_repair	6.98e-05	Nonsignificant	1.00	9.54e-03	Other	137	94
638	NEU.INH_PVALB.serotonergic	6.82e-05	Nonsignificant	—	0.00	Other	0	0
639	NEU.EXC_IT.guidance	6.63e-05	Nonsignificant	1.00	0.64	Other	274	63
640	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	6.12e-05	Nonsignificant	—	0.00	Other	0	0
641	NK.cytokine_biosynthetic_primed	6.08e-05	Nonsignificant	0.78	1.03	Other	360	21
642	CM.mechano_activated	6.03e-05	Nonsignificant	1.00	0.95	Other	205	134
643	EPI.pancreatic_acinar.adhesion_remodeling	5.93e-05	Nonsignificant	1.00	0.47	Other	210	784
644	OLG.regulatory_activated	5.06e-05	Nonsignificant	0.64	1.18	Other	196	614
645	T.CD4_Treg.Tr1_like	4.52e-05	Nonsignificant	—	0.00	Other	8	8
646	CM.oxidative_phospho	4.14e-05	Nonsignificant	1.00	0.99	Other	266	792
647	T.MAIT.quiescent	3.63e-05	Nonsignificant	0.97	0.83	Other	100	5
648	EPI.lung_multiciliated.baseline	3.54e-05	Nonsignificant	—	0.30	Other	0	7
649	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	3.38e-05	Nonsignificant	—	0.00	Other	49	237
650	T.CD8_Tcm.helper_like	3.03e-05	Nonsignificant	1.00	0.63	Other	81	159
651	EPI.salivary_serous_acinar.seromucous_like	2.89e-05	Nonsignificant	—	0.00	Other	0	0
652	NEU.EXC_CT.Ca2_signaling	2.50e-05	Nonsignificant	—	0.03	Other	68	17
653	GRNLSA.angiocrine_mechanosensory	2.36e-05	Nonsignificant	—	0.00	Other	0	0
654	T.MAIT.cytotoxic	1.71e-05	Nonsignificant	0.97	0.79	Other	52	15
655	NEU.EXC_IT.callosal	1.63e-05	Nonsignificant	1.00	0.52	Other	286	119
656	T.CD4_cytotoxic.terminal_effector	1.63e-05	Nonsignificant	0.84	0.99	Other	286	21
657	T.CD4_cytotoxic.baseline	1.63e-05	Nonsignificant	0.47	1.21	Other	0	0
658	T.MAIT.stress	1.62e-05	Nonsignificant	—	0.00	Other	0	0
659	GRNLSA.p53_damage	1.51e-05	Nonsignificant	—	0.00	Other	13	10
660	NK.cytokine_axis_baseline	1.47e-05	Nonsignificant	0.99	0.94	Other	1,172	116
661	T.CD4_Tcm.RNA_control	1.29e-05	Nonsignificant	0.98	0.76	Other	96	4
662	EPI.lung_multiciliated.stress	1.20e-05	Nonsignificant	—	0.00	Other	67	165
663	OLG.regulatory	9.60e-06	Nonsignificant	0.79	0.94	Other	353	73
664	EPI.skin_keratinocyte_proliferating.detox_repair	9.50e-06	Nonsignificant	—	0.00	Other	0	0
665	T.MAIT.vesicle	9.01e-06	Nonsignificant	0.97	0.57	Other	37	65
666	OLG.myelinating_stress	8.19e-06	Nonsignificant	0.64	1.06	Other	232	62
667	NK.adaptive_terminal_cytotoxic	8.12e-06	Nonsignificant	0.99	0.94	Other	485	802
668	T.CD8_Tcm.gut_homing	7.15e-06	Nonsignificant	1.00	0.45	Other	380	112
669	T.CD4_cytotoxic.precursor	6.52e-06	Nonsignificant	0.47	1.14	Other	156	67
670	OLG.reactive_repair	5.46e-06	Nonsignificant	0.79	0.95	Other	385	385
671	DC.pDC.poised_migratory	3.95e-06	Nonsignificant	0.28	1.28	Other	54	95
672	T.CD4_Tcm.retro_ZNF117	3.88e-06	Nonsignificant	0.98	0.63	Other	5	9
673	CM.translation_boost_RPL	2.44e-06	Nonsignificant	1.00	0.87	Other	129	1
674	NK.cytokine_vascular_patrolling	2.20e-06	Nonsignificant	0.99	0.89	Other	863	94
675	DC.pDC.baseline	2.04e-06	Nonsignificant	0.28	1.24	Other	88	123
676	NEU.EXC_NTNG1.synaptic	2.01e-06	Nonsignificant	—	0.67	Other	0	0
677	CM.translation_boost_RPS	1.65e-06	Nonsignificant	1.00	0.88	Other	69	16
678	NK.cytokine_quiescent	1.48e-06	Nonsignificant	0.99	0.91	Other	623	1,062
679	NK.adaptive_adipose_stress	1.41e-06	Nonsignificant	0.99	0.82	Other	374	39
680	NEU.EXC_NTNG1.nuclear_reg	1.27e-06	Nonsignificant	—	0.00	Other	0	0
681	DC.pDC.immature_metabolic	8.52e-07	Nonsignificant	0.85	0.70	Other	78	124
682	NK.cytokine_tissue_activation	7.41e-07	Nonsignificant	0.99	0.84	Other	267	450
683	OLG.vesicle_trafficking	4.55e-07	Nonsignificant	1.00	0.48	Other	124	10
684	T.CD4_cytotoxic.activated	2.86e-07	Nonsignificant	0.94	0.74	Other	3	1
685	NK.adaptive_biosynthetic_primed	1.90e-07	Nonsignificant	0.99	0.76	Other	244	405
686	CM.anti_inflammatory	7.31e-08	Nonsignificant	1.00	0.65	Other	424	1,503
687	EPI.renal_distal_tubule.immune_modulatory	4.08e-08	Nonsignificant	—	0.00	Other	0	0
688	NEU.EXC_SYT2.nuclear_reg	6.83e-10	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

116 unique genes. Showing 1–116. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
LTBR	01-High	0.72	10.25	G1	C1	—	monocyte (Tier: specific) MONO.CD14.APC_like (Tier: specific)	9 cells — complete matches	21	43
HLX-AS1	01-High	0.71	12.96	G1	C1	—	—	29 cells — complete matches	72	241
HLX	01-High	0.71	11.57	G1	C1	—	—	36 cells — complete matches	73	243
ENPEP	01-High	0.67	16.28	G1	C1	—	pericyte (Tier: specific) smooth_muscle_cell (Tier: relevant) FIB.barrier_secretory (Tier: relevant) SMC.smooth_muscle_cell (Tier: relevant) FIB.neurolectin_mucosa.axon_responsive (Tier: relevant)	41 cells — complete matches	9	32
ENSG00000256433	01-High	0.63	13.43	G1	C1	—	—	—	14	28
ENSG00000305986	01-High	0.60	17.25	G1	C1	—	—	—	43	107
SCNN1A	01-High	0.56	11.18	G1	C1	EPI.renal_principal_cell (L1S), EPI.hepatic_ductular_cholangiocyte.ion_transport (L2)	—	33 cells — complete matches	15	33
ENSG00000296435	01-High	0.54	9.99	G1	C1	—	—	—	38	96
CRISPLD2	01-High	0.54	3.33	G1	C1	FIB.barrier_secretory.homeostasis (L2), SMC.activated (L2)	monocyte (Tier: specific) pericyte (Tier: specific) FIB.interstitial (Tier: specific) MONO.CD14 (Tier: specific) FIB.adventitial.adhesion_lipid (Tier: specific) FIB.suburothelial.homeostasis_matrix (Tier: specific) smooth_muscle_cell (Tier: relevant) FIB.neurolectin_mucosa (Tier: relevant) SMC.smooth_muscle_cell (Tier: relevant) FIB.neurolectin_mucosa.inflammatory (Tier: relevant) FIB.neurolectin_mucosa.nerve_interface (Tier: relevant) FIB.suburothelial.contractile_myofibroblast (Tier: relevant) SMC.contractile (Tier: relevant)	78 cells — complete matches	18	52
LINC02817	01-High	0.54	12.83	G1	C1	—	—	—	26	87
TNFRSF1A	01-High	0.53	11.08	G1	C1	EPI.ileal_enterocyte_absorptive.brush_border (L2)	—	17 cells — complete matches	22	43
ENSG00000294570	01-High	0.53	11.77	G1	C1	—	—	—	11	63
PLEKHG6	01-High	0.51	9.39	G1	C1	—	—	38 cells — complete matches	13	33
ENSG00000296502	01-High	0.51	8.21	G1	C1	—	—	—	45	107
ENSG00000286231	01-High	0.50	8.44	G1	C1	—	—	—	45	124
MTARC1	01-High	0.50	7.80	G1	C1	—	—	—	56	174
CD27	01-High	0.49	6.27	G1	C1	B.memory (L1S), B.memory.baseline (L2), NK.adaptive_immature_precursor (L2), T.CD4_cytotoxic.precursor (L2), T.CD4_transitional.primed_helper_effector (L2), T.CD8_Tem.early_helper_like (L2), T.CD8_transitional.APC_like (L2), T.gamma_delta.central_memory (L2), THYMO.CD8aa_IELp (L2), THYMO.SP_CD4_naive (L2)	—	124 cells — complete matches	20	36
CD27-AS1	01-High	0.47	5.90	G1	C1	—	—	—	12	30
HLA-DRA	01-High	0.47	4.03	G1	C1	B_cell (L1), dendritic_cell (L1), DC.mig (L1S), EC.capillary.postcap_venule (L2), EPI.renal_distal_tubule.stress (L2), EPI.skin_sebaceous_duct_luminal.immune_interface (L2), FIB.interstitial.mesenchymal_APC (L2), MAC.resident_repair.antigen_presenting (L2), MONO.CD14.APC_like (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_transitional.APC_like (L2)	monocyte (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD14.APC_like (Tier: specific) FIB.neurolectin_mucosa (Tier: relevant) FIB.neurolectin_mucosa.inflammatory (Tier: relevant) FIB.neurolectin_mucosa.nerve_interface (Tier: relevant) FIB.neurolectin_mucosa.remodeling_repair (Tier: relevant)	194 cells — complete matches	693	1,237
ENSG00000299769	01-High	0.46	5.32	G1	C1	—	—	—	333	727
TAPBPL	01-High	0.46	5.09	G1	C1	—	—	EPI.cervical_suprabasal.secretory_vesicle (L2)	17	36
C1orf115	01-High	0.45	5.18	G1	C1	—	—	33 cells — complete matches	42	112
ENSG00000286974	01-High	0.45	4.03	G1	C1	—	—	—	95	225
VAMP1	01-High	0.44	3.30	G1	C1	—	—	27 cells — complete matches	12	49
ENSG00000276232	01-High	0.44	3.16	G1	C1	—	—	—	8	24
SCARNA10	01-High	0.44	3.16	G1	C1	—	—	—	8	24
ENSG00000299747	01-High	0.38	3.08	G1	C1	—	—	—	346	745
MICA-AS1	02-Medium	0.54	9.58	G1	C2	—	—	—	210	470
OSR1	02-Medium	0.54	23.21	G2	C2	ASPC.niche_keeping_progenitor (L2)	pericyte (Tier: specific) FIB.interstitial (Tier: specific) ASPC.baseline (Tier: specific) FIB.suburothelial.homeostasis_matrix (Tier: specific) smooth_muscle_cell (Tier: relevant) FIB.barrier_secretory (Tier: relevant) FIB.neurolectin_mucosa (Tier: relevant) SMC.smooth_muscle_cell (Tier: relevant) FIB.neurolectin_mucosa.axon_responsive (Tier: relevant) FIB.neurolectin_mucosa.inflammatory (Tier: relevant) FIB.neurolectin_mucosa.nerve_interface (Tier: relevant) FIB.neurolectin_mucosa.remodeling_repair (Tier: relevant) FIB.reticular.ECM_builder (Tier: relevant) SMC.contractile (Tier: relevant)	58 cells — complete matches	1	5
ENSG00000288587	02-Medium	0.53	9.38	G1	C2	—	—	—	257	555
MICA	02-Medium	0.53	9.00	G1	C2	—	—	7 cells — complete matches	277	593
AIF1	02-Medium	0.52	7.54	G1	C2	IPSC.mesodermal_primed (L2), T.CD4_Tcm.stress (L2)	monocyte (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD14.APC_like (Tier: specific)	118 cells — complete matches	433	801
HCP5	02-Medium	0.51	12.12	G1	C2	—	—	—	510	867
CFB	02-Medium	0.50	1.88	G1	C2	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement (L2), MAC.LAM.lipid_opsonization (L2), MAC.alveolar.scavenging_endocytic (L2), MAC.resident_repair.ECM_stromal_crosstalk (L2)	FIB.barrier_secretory (Tier: relevant) FIB.neurolectin_mucosa.nerve_interface (Tier: relevant)	94 cells — complete matches	508	1,239
HLA-DQB2	02-Medium	0.50	7.22	G1	C2	—	—	60 cells — complete matches	205	497
MICB	02-Medium	0.49	9.26	G1	C2	—	—	43 cells — complete matches	294	633
ENSG00000233902	02-Medium	0.48	9.91	G1	C2	—	—	—	150	247
HSPA1B	02-Medium	0.48	6.79	G1	C2	ASTRO.stress_acute (L2), B.memory.activated (L2), B.naive.activated (L2), DC.cDC2.tolerogenic_regulatory (L2), EC.capillary.inflammatory (L2), EC.liver_sinusoidal.stress (L2), EPI.alveolar_type_2.stress_response (L2), EPI.colonocyte.crypt_progenitor (L2), EPI.pancreatic_acinar.stress (L2), EPI.pancreatic_ductal_bicarbonate.stress (L2), EPI.renal_distal_tubule.stress (L2), EPI.renal_principal_cell.activated_acute (L2), EPI.skin_interfollicular_spinous.stress_UPR (L2), EPI.tracheal_basal.activated_stress (L2), FIB.skin_sheath.stress_chaperone (L2), GRNLSA.EMT_insulin_signaling (L2), HEP.canalicular_transport.inflammatory (L2), ILC2.activated (L2), MAC.kupffer.stress (L2), MONO.CD14.cord_tolerance (L2), OLG.stress (L2), PC.IgA_muocsal.plasmablast (L2), SMC.activated (L2), T.CD8_Trm.inflammatory (L2), T.CD8_transitional.stress (L2), T.MAIT.stress (L2), THYMO.DP_early_stress (L2), THYMO.SP_CD8_naive_stress (L2)	FIB.neurolectin_mucosa.inflammatory (Tier: relevant) FIB.neurolectin_mucosa.nerve_interface (Tier: relevant) MUSC.baseline (Tier: relevant)	88 cells — complete matches	60	376
CLIC1	02-Medium	0.48	8.01	G1	C2	PC.IgG_systemic.secretory (L2)	—	10 cells — complete matches	159	256
CSNK2B	02-Medium	0.48	8.02	G1	C2	—	—	—	54	128
ENSG00000263020	02-Medium	0.48	7.94	G1	C2	—	—	—	54	128
HLA-B	02-Medium	0.47	8.15	G1	C2	EC.heart_remodeling.remodeling_stalk (L2), EPI.hepatic_ductular_cholangiocyte.barrier_chemokine (L2), EPI.intrahepatic_cholangiocyte_defense.secretory_barrier (L2), EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo (L2), EPI.pancreatic_ductal_perivascular.protective_antioxidant (L2), FIB.skin_sheath.ECM_immune (L2), OPC.proliferative_immune_interact (L2), SMC.metabolic (L2)	FIB.neurolectin_mucosa.nerve_interface (Tier: relevant) FIB.reticular.ECM_builder (Tier: relevant)	130 cells — complete matches	493	836
MIR6891	02-Medium	0.47	8.03	G1	C2	—	—	—	474	812
GPANK1	02-Medium	0.47	7.47	G1	C2	—	—	6 cells — complete matches	27	43
ENSG00000298426	02-Medium	0.46	6.13	G1	C2	—	—	—	317	607
NKX2-3	02-Medium	0.46	9.43	G1	C2	—	—	29 cells — complete matches	0	0
FBN2	02-Medium	0.46	6.81	G1	C2	NEU.INH_PVALB.metabotropic (L2)	MONO.CD14.APC_like (Tier: specific)	29 cells — complete matches	9	19
ENSG00000301948	02-Medium	0.45	7.96	G1	C2	—	—	—	217	398
HLA-DPA3	02-Medium	0.45	7.72	G1	C2	—	—	—	217	398
APOM	02-Medium	0.45	8.63	G1	C2	EPI.ileal_bile_transport.absorptive_xenobiotic (L2)	—	13 cells — complete matches	14	16
SNHG32	02-Medium	0.45	7.85	G2	C1	—	—	—	38	69
BAG6	02-Medium	0.45	8.58	G1	C2	—	—	MONO.CD16.inflammatory (L2)	73	116
SNORD52	02-Medium	0.44	7.15	G2	C1	—	—	—	32	55
RXRB	02-Medium	0.44	6.52	G1	C2	—	—	8 cells — complete matches	11	29
MSH5	02-Medium	0.44	9.11	G1	C2	—	—	13 cells — complete matches	7	14
HSD17B8	02-Medium	0.44	5.42	G1	C2	—	—	6 cells — complete matches	3	8
SAPCD1-AS1	02-Medium	0.43	7.64	G1	C2	—	—	MAC.LAM.perivascular_angiocrine (L2)	27	56
LINC01475	02-Medium	0.43	10.02	G1	C2	—	FIB.adventitial.adhesion_lipid (Tier: specific)	27 cells — complete matches	0	0
TNXB	02-Medium	0.43	4.58	G2	C1	GRANU.neutrophil.antiviral_endotoxin (L2)	FIB.interstitial (Tier: specific) FIB.barrier_secretory (Tier: relevant) ASPC.stem_like_progenitor (Tier: relevant)	27 cells — complete matches	153	526
HLA-DQB1	02-Medium	0.43	3.95	G1	C2	MONO.CD14.APC_like (L2), PC.IgG_systemic.stress (L2), T.CD4_Tcm.APC_mimicry (L2), T.CD4_Treg.APC_interactive (L2), T.CD4_transitional.APC_interacting (L2), T.CD8_transitional.APC_like (L2)	MONO.CD14 (Tier: specific) MONO.CD14.APC_like (Tier: specific)	133 cells — complete matches	703	1,314
MSH5-SAPCD1	02-Medium	0.42	7.40	G1	C2	—	—	15 cells — complete matches	7	13
COL11A2	02-Medium	0.42	7.87	G2	C2	—	—	17 cells — complete matches	205	381
SLC27A6	02-Medium	0.42	2.74	G1	C2	—	MUSC.baseline (Tier: relevant)	42 cells — complete matches	8	16
ENSG00000303029	02-Medium	0.42	3.58	G1	C2	—	—	—	234	380
RNF5	02-Medium	0.42	6.31	G2	C2	—	—	SKM.type_1_slow (L1S), EPI.salivary_serous_acinar.secretory_active (L2), SKM.type_1_slow.oxidative (L2)	128	173
SLC44A4	02-Medium	0.41	5.81	G1	C2	EPI.hepatic_ductular_cholangiocyte.ion_transport (L2), EPI.intrahepatic_cholangiocyte_transport.mucin_secretory (L2), EPI.pancreatic_ductal_bicarbonate.barrier_mucin (L2)	—	46 cells — complete matches	23	31
ENSG00000310104	02-Medium	0.41	5.65	G1	C2	—	—	—	9	30
GPR35	02-Medium	0.41	3.03	G1	C2	—	monocyte (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD14.APC_like (Tier: specific)	78 cells — complete matches	14	36
PANCR	02-Medium	0.40	12.62	G2	C2	—	FIB.adventitial.adhesion_lipid (Tier: specific)	6 cells — complete matches	0	0
PITX2	02-Medium	0.40	10.65	G2	C2	—	FIB.suburothelial.homeostasis_matrix (Tier: specific) FIB.suburothelial.contractile_myofibroblast (Tier: relevant) MUSC.baseline (Tier: relevant)	31 cells — complete matches	0	0
SNORD48	02-Medium	0.40	8.24	G2	C2	—	—	—	1	6
ENSG00000294466	02-Medium	0.40	4.50	G1	C2	—	—	—	58	138
HLA-DQA2	02-Medium	0.39	8.94	G2	C2	T.CD4_Trm.metal_stress (L2), T.CD4_transitional.APC_interacting (L2)	MONO.CD14.APC_like (Tier: specific)	127 cells — complete matches	173	495
TSBP1-AS1	02-Medium	0.39	5.84	G2	C2	—	—	—	106	195
C6orf47	02-Medium	0.39	8.34	G2	C2	—	—	11 cells — complete matches	86	156
NFKBIL1	02-Medium	0.39	4.82	G2	C2	—	—	4 cells — complete matches	101	243
PRRC2A	02-Medium	0.38	7.13	G1	C2	—	—	—	110	204
MIR6832	02-Medium	0.38	7.09	G1	C2	—	—	—	99	170
MICB-DT	02-Medium	0.38	8.16	G2	C2	—	—	—	131	286
ENSG00000301753	02-Medium	0.38	6.00	G2	C2	—	—	—	8	24
ENSG00000301898	02-Medium	0.38	7.09	G2	C2	—	—	—	0	0
MPIG6B	02-Medium	0.38	7.24	G2	C2	MONO.CD14.platelet_bound (L2), MONO.CD16.platelet_bound (L2)	FIB.reticular.ECM_builder (Tier: relevant)	27 cells — complete matches	1	15
ATP6V1G2	02-Medium	0.37	5.13	G2	C2	—	MONO.CD14.APC_like (Tier: specific)	12 cells — complete matches	73	194
ATP6V1G2-DDX39B	02-Medium	0.37	5.06	G2	C2	—	MONO.CD14.APC_like (Tier: specific)	11 cells — complete matches	69	185
LINC01376	02-Medium	0.37	20.15	G2	C2	—	—	10 cells — complete matches	12	20
SALL4	02-Medium	0.37	5.75	G1	C2	—	—	9 cells — complete matches	3	5
AGPAT1	02-Medium	0.37	6.37	G2	C2	—	—	6 cells — complete matches	27	58
AQP12B	02-Medium	0.36	4.62	G1	C2	EPI.pancreatic_acinar.baseline (L2), EPI.pancreatic_acinar.metabolic_onecarbon (L2)	—	9 cells — complete matches	10	24
ENSG00000297040	02-Medium	0.36	9.90	G2	C2	—	—	—	180	389
MCCD1	02-Medium	0.36	4.22	G2	C2	—	—	—	35	113
LY6G5B	02-Medium	0.36	8.14	G2	C2	—	—	26 cells — complete matches	11	17
ENSG00000219159	02-Medium	0.36	4.12	G1	C2	—	—	—	10	23
CAPN10	02-Medium	0.35	2.94	G1	C2	—	—	17 cells — complete matches	11	32
NEU1	02-Medium	0.34	6.06	G2	C2	—	—	7 cells — complete matches	26	37
DDX39B	02-Medium	0.33	5.16	G2	C2	—	—	—	112	383
SNORD84	02-Medium	0.32	5.40	G2	C2	—	—	—	59	180
TNF	02-Medium	0.32	3.30	G2	C2	B.naive.activated (L2), EC.capillary.inflammatory (L2), EPI.ectocervical_granular.inflammatory (L2), EPI.renal_principal_cell.inflammatory (L2), ILC2.activated (L2), MAC.alveolar.inflammatory (L2), MAC.microglia_like.inflammatory_chemokine (L2), T.CD4_Trm.activated (L2), T.CD4_cytotoxic.NK_adapted (L2), T.CD8_Trm.inflammatory (L2)	MONO.CD14.APC_like (Tier: specific)	111 cells — complete matches	75	194
DDX39B-AS1	02-Medium	0.32	4.77	G2	C2	—	—	12 cells — complete matches	56	182
ENSG00000299760	02-Medium	0.32	4.77	G2	C2	—	—	—	56	182
ATF6B	02-Medium	0.31	4.34	G2	C2	—	—	B.age_associated.naive_transitional (L2), EC.lymphatic.valve (L2)	71	164
ENSG00000291111	02-Medium	0.31	6.57	G2	C2	—	—	—	212	386
EHMT2-AS1	02-Medium	0.31	4.35	G2	C2	—	—	16 cells — complete matches	4	5
LTA	02-Medium	0.31	3.30	G1	C2	—	—	105 cells — complete matches	226	418
HLA-DPB2	02-Medium	0.30	6.11	G2	C2	—	—	—	211	384
TIFA	02-Medium	0.30	4.00	G1	C2	—	—	21 cells — complete matches	2	3
ENSG00000289406	02-Medium	0.30	3.55	G1	C2	—	—	—	201	390
ENSG00000284829	02-Medium	0.30	4.57	G2	C2	—	—	—	41	114
FKBPL	02-Medium	0.30	4.37	G2	C2	—	FIB.barrier_secretory (Tier: relevant)	19 cells — complete matches	46	125
ALPK1	02-Medium	0.30	5.67	G1	C2	—	—	16 cells — complete matches	1	1
DLEU1	02-Medium	0.30	9.68	G2	C2	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier (L2)	—	25 cells — complete matches	7	6
LST1	02-Medium	0.30	5.17	G1	C2	granulocyte (L1), macrophage (L1), monocyte (L1), MAC.MDM (L1S), MONO.CD16 (L1S), ILC2.activated (L2), MAC.MDM.inflammatory_phagocytic (L2), MONO.CD14.baseline (L2)	monocyte (Tier: specific) MONO.CD14 (Tier: specific) MONO.CD14.APC_like (Tier: specific)	106 cells — complete matches	183	440
LTB	02-Medium	0.29	3.81	G1	C2	T.CD4_Tcm (L1S), T.CD4_Tem (L1S), T.CD4_transitional (L1S), T.CD8_Tcm (L1S), T.CD8_transitional (L1S), B.germinal_center.LZ_survival (L2), DC.mig.baseline (L2), HPC.CLP_B_primed (L2), ILC2.activated (L2), T.CD4_Trm.helper_like (L2), T.CD4_cytotoxic.precursor (L2), T.CD8_naive.baseline (L2), T.gamma_delta.central_memory (L2), THYMO.SP_CD8_naive (L2)	MONO.CD14.APC_like (Tier: specific)	165 cells — complete matches	127	281
RAB3GAP2	02-Medium	0.29	5.15	G2	C2	—	—	15 cells — complete matches	9	15
ENSG00000229836	02-Medium	0.26	1.10	G2	C2	—	—	—	5	4
AP1AR	02-Medium	0.24	2.84	G1	C2	—	—	13 cells — complete matches	2	2
AP1AR-DT	02-Medium	0.23	2.47	G1	C2	—	—	—	2	2

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.