Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000015 · All tissues

Acute alcohol intoxication, ICD10: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Alcohol use disorder

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	cardiomyocyte	14.39	Significant	3.32e-29	1.27	Specific	533	2,045
2	dendritic_cell	9.35	Significant	0.02	1.13	Other	496	724
3	oligodendrocyte	8.65	Significant	3.80e-22	1.23	Specific	385	1,507
4	haematopoietic_progenitor_cell	7.81	Significant	0.47	1.12	Relevant	262	502
5	melanocyte	7.18	Significant	0.25	1.15	Relevant	97	309
6	epithelial_cell	4.66	Nominal	1.43e-09	1.10	Other	24	47
7	oligodendrocyte_precursor_cell	4.65	Nominal	0.04	1.17	Other	461	1,454
8	neuron	2.17	Nonsignificant	1.00	1.00	Other	330	1,328
9	hepatocyte	1.61	Nonsignificant	1.00	0.99	Other	1,515	3,822
10	astrocyte	1.50	Nonsignificant	0.90	1.04	Other	256	1,203
11	innate_lymphoid_cell_2	1.04	Nonsignificant	1.00	0.85	Other	3	8
12	induced_pluripotent_stem_cell	0.96	Nonsignificant	1.00	0.99	Other	0	0
13	B_cell	0.87	Nonsignificant	1.00	0.81	Other	356	694
14	chondrocyte	0.71	Nonsignificant	1.00	0.80	Other	548	1,069
15	schwann_cell	0.53	Nonsignificant	1.00	0.73	Other	10	57
16	smooth_muscle_cell	0.51	Nonsignificant	1.00	0.70	Other	27	139
17	T_cell	0.36	Nonsignificant	1.00	0.71	Other	470	959
18	fibroblast	0.32	Nonsignificant	0.66	1.03	Other	184	826
19	granulocyte	0.31	Nonsignificant	1.00	0.86	Other	5	6
20	pericyte	0.27	Nonsignificant	1.00	0.60	Other	128	517
21	skeletal_muscle_cell	0.25	Nonsignificant	1.00	0.80	Other	944	2,600
22	macrophage	0.24	Nonsignificant	1.00	0.62	Other	813	1,732
23	endothelial_cell	0.20	Nonsignificant	1.00	0.57	Other	373	974
24	plasma_cell	0.15	Nonsignificant	1.00	0.53	Other	17	24
25	monocyte	0.11	Nonsignificant	1.00	0.51	Other	2,176	3,871
26	natural_killer_cell	0.10	Nonsignificant	1.00	0.87	Other	1,204	2,052
27	platelet	0.07	Nonsignificant	—	0.00	Other	85	104
28	thymocyte	0.04	Nonsignificant	1.00	0.45	Other	168	512
29	muscle_stem_cell	0.04	Nonsignificant	1.00	0.46	Other	7	27
30	granulosa_cell	0.02	Nonsignificant	1.00	0.44	Other	293	670
31	adipose_stem_and_progenitor_cell	0.01	Nonsignificant	1.00	0.37	Other	327	954
32	mesothelial_cell	6.83e-03	Nonsignificant	1.00	0.40	Other	6	36
33	microglia	2.56e-03	Nonsignificant	1.00	0.34	Other	61	129
34	adipocyte	3.59e-05	Nonsignificant	1.00	0.22	Other	33	111

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.salivary_mucous_acinar	61.70	Significant	6.47e-20	1.48	Specific	639	1,189
2	DC.pDC	49.10	Significant	3.01e-11	1.36	Specific	496	1,028
3	EPI.ileal_goblet	25.09	Significant	0.01	1.39	Specific	181	432
4	CM.cardiomyocyte	14.39	Significant	—	—	Specific	524	2,032
5	FIB.transitioning	11.64	Significant	0.06	1.17	Relevant	172	497
6	EPI.bile_duct_cholangiocyte	11.52	Significant	0.76	1.34	Relevant	37	60
7	OLG.oligodendrocyte	8.65	Significant	—	—	Specific	384	1,397
8	HPC.haematopoietic_progenitor_cell	7.81	Significant	—	—	Relevant	211	370
9	EPI.pancreatic_acinar	7.53	Significant	0.76	1.11	Relevant	429	1,475
10	EPI.pancreatic_islet	7.19	Significant	1.00	1.24	Other	52	132
11	MEL.melanocyte	7.18	Significant	—	—	Relevant	79	242
12	EPI.salivary_duct_ion_transport	6.84	Significant	1.00	1.24	Relevant	5	11
13	EPI.pancreatic_ductal_progenitor	6.63	Significant	0.76	1.22	Relevant	234	873
14	EPI.salivary_duct_excretory	5.82	Significant	1.00	1.07	Relevant	85	180
15	EPI.esophageal_suprabasal	5.52	Significant	1.00	1.09	Other	158	404
16	EPI.endocervical_secretory	4.74	Nominal	—	0.47	Other	0	0
17	OPC.oligodendrocyte_precursor_cell	4.65	Nominal	—	—	Other	413	1,269
18	EPI.ileal_enterocyte_crypt	4.13	Nominal	1.00	0.99	Other	67	113
19	EPI.renal_proximal_tubule	3.92	Nominal	1.00	1.07	Other	525	806
20	NEU.EXC_IT	3.66	Nominal	5.33e-15	1.88	Other	411	192
21	HEP.periportal_metabolic	3.44	Nominal	6.42e-41	1.76	Other	1,750	4,427
22	EPI.alveolar_type_2	3.36	Nominal	1.00	0.92	Other	813	1,853
23	EPI.ileal_bile_transport	3.35	Nominal	1.00	1.08	Other	61	93
24	EPI.colonic_enteroendocrine	3.33	Nominal	—	0.56	Other	1	1
25	EPI.pancreatic_ductal_perivascular	2.94	Nonsignificant	1.00	0.85	Other	4	30
26	EPI.salivary_intercalated_defense	2.61	Nonsignificant	1.00	0.92	Other	81	161
27	EPI.intrahepatic_cholangiocyte_transport	2.58	Nonsignificant	—	0.53	Other	12	42
28	EC.lymphatic	2.15	Nonsignificant	1.15e-13	1.51	Other	630	998
29	EPI.lung_club_secretory	2.11	Nonsignificant	1.00	1.08	Other	5	14
30	DC.cDC1	1.69	Nonsignificant	1.00	0.71	Other	55	112
31	EPI.ileal_enterocyte_absorptive	1.62	Nonsignificant	1.00	0.77	Other	118	338
32	ASTRO.astrocyte	1.50	Nonsignificant	—	—	Other	228	1,111
33	EPI.pancreatic_ductal_bicarbonate	1.49	Nonsignificant	1.00	0.64	Other	131	548
34	T.CD4_Th2	1.47	Nonsignificant	—	1.40	Other	1	2
35	EPI.colonic_tuft	1.46	Nonsignificant	—	0.25	Other	7	24
36	DC.cDC2	1.43	Nonsignificant	1.00	0.09	Other	1,189	1,793
37	FIB.reticular	1.41	Nonsignificant	0.94	1.04	Other	19	87
38	MAC.microglia_like	1.35	Nonsignificant	0.18	1.32	Other	124	179
39	EPI.intrahepatic_cholangiocyte_defense	1.17	Nonsignificant	—	0.06	Other	8	13
40	EPI.extrahepatic_cholangiocyte	1.15	Nonsignificant	—	0.04	Other	37	71
41	T.CD4_Th17	1.14	Nonsignificant	1.57e-03	1.38	Other	421	794
42	HEP.acute_phase	1.13	Nonsignificant	1.00	0.84	Other	1,441	3,641
43	B.naive	1.12	Nonsignificant	2.23e-15	1.83	Other	307	595
44	EPI.colonocyte	1.08	Nonsignificant	1.00	0.52	Other	294	815
45	EPI.salivary_serous_acinar	1.08	Nonsignificant	1.00	0.56	Other	233	531
46	ILC2.innate_lymphoid_cell_2	1.04	Nonsignificant	—	—	Other	2	0
47	EPI.thymic_cortical	1.00	Nonsignificant	1.00	0.74	Other	442	824
48	NEU.INH_VIP	1.00	Nonsignificant	1.00	0.55	Other	241	366
49	IPSC.induced_pluripotent_stem_cell	0.96	Nonsignificant	—	—	Other	0	0
50	NEU.INH_LAMP5	0.95	Nonsignificant	1.00	0.43	Other	263	532
51	EPI.gastric_foveolar	0.94	Nonsignificant	—	0.06	Other	0	0
52	T.CD8_naive	0.87	Nonsignificant	3.43e-14	1.39	Other	317	708
53	EPI.cervical_suprabasal	0.79	Nonsignificant	—	0.00	Other	14	50
54	CHOND.chondrocyte	0.71	Nonsignificant	—	—	Other	519	730
55	NEU.EXC_SYT2	0.70	Nonsignificant	—	0.00	Other	40	77
56	EPI.skin_interfollicular_spinous	0.70	Nonsignificant	1.00	0.52	Other	260	563
57	EPI.esophageal_basal	0.68	Nonsignificant	1.00	0.47	Other	4	10
58	EPI.renal_thick_ascending_limb	0.66	Nonsignificant	1.00	0.40	Other	453	1,153
59	FIB.neurolectin_mucosa	0.63	Nonsignificant	0.94	1.06	Other	133	394
60	B.memory	0.61	Nonsignificant	1.00	0.27	Other	442	882
61	T.CD4_naive	0.59	Nonsignificant	1.98e-12	1.25	Other	399	866
62	EPI.ectocervical_granular	0.59	Nonsignificant	—	0.00	Other	11	23
63	SKM.type_1_slow	0.58	Nonsignificant	3.01e-19	1.57	Other	923	2,478
64	SCHWN.schwann_cell	0.53	Nonsignificant	—	—	Other	7	33
65	MAC.resident_repair	0.52	Nonsignificant	6.40e-06	1.33	Other	796	1,426
66	SMC.smooth_muscle_cell	0.51	Nonsignificant	—	—	Other	20	101
67	GRANU.MAST	0.49	Nonsignificant	9.43e-04	1.83	Other	5	6
68	PC.IgG_systemic	0.42	Nonsignificant	0.05	1.29	Other	41	60
69	T.CD4_Tcm	0.42	Nonsignificant	1.00	0.96	Other	494	988
70	DC.mig	0.39	Nonsignificant	—	0.00	Other	89	156
71	NEU.EXC_NTNG1	0.38	Nonsignificant	—	0.00	Other	0	0
72	MAC.resident_iron	0.36	Nonsignificant	1.00	0.96	Other	16	21
73	T.CD4_transitional	0.36	Nonsignificant	1.00	0.86	Other	48	110
74	T.CD4_Tfh	0.35	Nonsignificant	1.00	0.85	Other	47	45
75	EPI.tracheal_submucosal_gland	0.33	Nonsignificant	—	0.00	Other	0	0
76	MAC.MDM	0.32	Nonsignificant	0.90	1.05	Other	623	986
77	EPI.alveolar_type_1	0.30	Nonsignificant	1.00	0.42	Other	26	101
78	PERI.pericyte	0.27	Nonsignificant	—	—	Other	117	0
79	FIB.lung_alveolar	0.27	Nonsignificant	—	1.37	Other	6	15
80	EPI.thymic_medullary	0.22	Nonsignificant	1.00	0.35	Other	26	133
81	FIB.barrier_secretory	0.21	Nonsignificant	0.94	1.19	Other	81	228
82	EPI.renal_principal_cell	0.21	Nonsignificant	1.00	0.35	Other	207	403
83	MAC.LAM	0.21	Nonsignificant	1.00	0.90	Other	914	2,064
84	B.germinal_center	0.19	Nonsignificant	1.00	0.09	Other	233	655
85	EC.arterial	0.19	Nonsignificant	0.04	1.16	Other	356	885
86	T.CD4_Treg	0.19	Nonsignificant	1.00	0.73	Other	244	511
87	T.CD8_Trm	0.18	Nonsignificant	1.00	0.78	Other	211	346
88	EC.capillary	0.16	Nonsignificant	0.94	1.01	Other	514	1,635
89	EPI.skin_keratinocyte_proliferating	0.14	Nonsignificant	1.00	0.36	Other	47	76
90	FIB.tracheal_subepithelial	0.13	Nonsignificant	—	1.16	Other	0	0
91	MONO.CD14	0.13	Nonsignificant	3.47e-04	1.16	Other	2,294	4,139
92	T.CD4_Trm	0.12	Nonsignificant	1.00	0.63	Other	176	363
93	HEP.canalicular_transport	0.12	Nonsignificant	1.00	0.12	Other	1,290	3,434
94	PC.IgA_muocsal	0.11	Nonsignificant	1.00	0.51	Other	18	31
95	NK.natural_killer_cell	0.10	Nonsignificant	—	—	Other	1,204	2,045
96	NEU.INH_PVALB	0.09	Nonsignificant	1.00	0.23	Other	193	183
97	T.CD4_Tem	0.09	Nonsignificant	1.00	0.61	Other	365	697
98	EPI.hepatic_ductular_cholangiocyte	0.09	Nonsignificant	1.00	0.29	Other	83	243
99	EPI.renal_intercalated_cell_type_A	0.08	Nonsignificant	1.00	0.31	Other	67	142
100	EPI.skin_keratinocyte_basal	0.08	Nonsignificant	—	0.00	Other	13	26
101	EC.venous	0.07	Nonsignificant	1.00	0.60	Other	516	1,387
102	T.CD8_Tcm	0.07	Nonsignificant	1.00	0.63	Other	460	926
103	PLAT.platelet	0.07	Nonsignificant	—	0.00	Other	38	53
104	EPI.renal_immature_ureteric_bud	0.07	Nonsignificant	1.00	0.26	Other	217	569
105	EPI.lung_multiciliated	0.06	Nonsignificant	1.00	0.27	Other	16	49
106	MONO.CD16	0.05	Nonsignificant	1.00	0.87	Other	1,304	1,835
107	EPI.renal_distal_tubule	0.05	Nonsignificant	1.00	0.34	Other	133	361
108	EPI.tracheal_suprabasal	0.05	Nonsignificant	1.00	0.35	Other	29	56
109	T.CD8_transitional	0.05	Nonsignificant	1.00	0.57	Other	497	932
110	FIB.perivascular_interface	0.04	Nonsignificant	1.00	0.97	Other	0	0
111	HEP.pericentral_lipoprotein	0.04	Nonsignificant	—	0.00	Other	0	0
112	EPI.renal_intercalated_cell_type_B	0.04	Nonsignificant	—	0.00	Other	6	7
113	MAC.resident_cardiac	0.04	Nonsignificant	1.00	0.48	Other	485	1,074
114	EC.liver_sinusoidal	0.04	Nonsignificant	1.00	0.71	Other	1,083	1,925
115	THYMO.thymocyte	0.04	Nonsignificant	—	—	Other	163	495
116	MUSC.muscle_stem_cell	0.04	Nonsignificant	—	—	Other	4	18
117	EC.heart_remodeling	0.03	Nonsignificant	1.00	0.77	Other	569	1,594
118	FIB.barrier_purinergic	0.03	Nonsignificant	—	0.92	Other	1	3
119	FIB.skin_neurosecretory	0.03	Nonsignificant	—	0.92	Other	0	0
120	FIB.interstitial	0.03	Nonsignificant	1.00	0.85	Other	288	940
121	GRNLSA.granulosa_cell	0.02	Nonsignificant	—	—	Other	257	0
122	EPI.skin_follicular_keratinizing	0.01	Nonsignificant	1.00	0.25	Other	30	81
123	MAC.proliferating	0.01	Nonsignificant	1.00	0.41	Other	87	253
124	T.gamma_delta	0.01	Nonsignificant	1.00	0.74	Other	588	1,078
125	B.age_associated	0.01	Nonsignificant	1.00	0.00	Other	207	350
126	ASPC.adipose_stem_and_progenitor_cell	0.01	Nonsignificant	—	—	Other	324	930
127	FIB.hepatic_stellate_cell	0.01	Nonsignificant	—	0.77	Other	64	252
128	T.MAIT	7.22e-03	Nonsignificant	1.00	0.47	Other	469	855
129	MESO.mesothelial_cell	6.83e-03	Nonsignificant	—	—	Other	2	18
130	FIB.skin_tenogenic	4.27e-03	Nonsignificant	—	0.53	Other	108	227
131	MAC.kupffer	2.69e-03	Nonsignificant	1.00	0.27	Other	189	530
132	MG.microglia	2.56e-03	Nonsignificant	—	—	Other	49	0
133	FIB.adventitial	2.37e-03	Nonsignificant	1.00	0.60	Other	268	1,447
134	FIB.skin_sheath	2.03e-03	Nonsignificant	1.00	0.84	Other	49	118
135	EPI.skin_sweat_duct_keratinocyte	1.81e-03	Nonsignificant	1.00	0.31	Other	146	301
136	FIB.suburothelial	1.69e-03	Nonsignificant	1.00	0.70	Other	122	432
137	T.CD8_Tem	1.57e-03	Nonsignificant	1.00	0.42	Other	1,083	1,857
138	EPI.skin_keratinocyte_progenitor	5.80e-04	Nonsignificant	—	0.00	Other	0	3
139	NEU.EXC_CT	5.73e-04	Nonsignificant	1.00	0.07	Other	362	384
140	EPI.salivary_myoepithelial	3.58e-04	Nonsignificant	1.00	0.10	Other	191	714
141	EPI.skin_hair_follicle_bulge	2.16e-04	Nonsignificant	1.00	0.14	Other	51	178
142	T.CD4_cytotoxic	1.18e-04	Nonsignificant	1.00	0.33	Other	855	1,493
143	EPI.skin_appendage_keratinocyte	9.96e-05	Nonsignificant	1.00	0.13	Other	87	222
144	GRANU.neutrophil	6.52e-05	Nonsignificant	1.00	0.00	Other	1,235	2,649
145	FIB.skin_papillary	5.77e-05	Nonsignificant	—	0.05	Other	0	0
146	EPI.tracheal_basal	5.69e-05	Nonsignificant	1.00	0.08	Other	398	1,120
147	EPI.pancreatic_ductal_mucinous	4.93e-05	Nonsignificant	1.00	0.05	Other	219	430
148	EPI.skin_hair_follicle_companion	3.91e-05	Nonsignificant	—	0.00	Other	8	12
149	ADIPO.adipocyte	3.59e-05	Nonsignificant	—	—	Other	20	62
150	SKM.type_2_fast	3.43e-05	Nonsignificant	1.00	0.00	Other	972	2,639
151	EPI.skin_sebaceous_duct_luminal	2.44e-05	Nonsignificant	1.00	0.05	Other	100	249
152	MAC.alveolar	3.17e-06	Nonsignificant	1.00	0.06	Other	1,432	3,122

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.salivary_mucous_acinar.baseline	61.70	Significant	—	—	Specific	394	683
2	DC.pDC.baseline	57.90	Significant	0.76	0.99	Relevant	88	123
3	DC.pDC.immature_metabolic	57.00	Significant	0.76	1.23	Relevant	78	124
4	DC.pDC.poised_migratory	30.47	Significant	0.98	0.31	Relevant	54	95
5	EPI.ileal_goblet.baseline	27.90	Significant	0.25	1.61	—	16	2
6	EPI.ileal_goblet.stress_metallothionein	26.40	Significant	—	0.00	Relevant	4	11
7	EPI.ileal_goblet.inflammatory_mucin	24.09	Significant	0.92	0.26	Relevant	6	9
8	EPI.pancreatic_acinar.quiet_dedifferentiation	20.10	Significant	6.53e-04	1.71	—	142	171
9	HPC.MEP	17.76	Significant	8.07e-03	1.68	Specific	599	1,195
10	CM.mito_proteostasis	16.63	Significant	0.32	1.34	—	329	29
11	CM.anti_inflammatory	16.55	Significant	0.32	1.30	Specific	424	1,503
12	CM.oxidative_phospho	16.14	Significant	0.47	1.20	Relevant	266	792
13	CM.sarcomere_actin_interface	15.89	Significant	0.32	1.36	—	450	78
14	CM.translation_boost_RPL	15.18	Significant	0.55	1.13	—	129	1
15	FIB.transitioning.ISG_primed_interface	14.88	Significant	—	0.72	Relevant	17	80
16	CM.mechano_activated	14.82	Significant	0.32	1.46	—	205	134
17	EPI.ileal_goblet.immature	14.55	Significant	—	0.00	Relevant	0	0
18	CM.translation_boost_RPS	14.51	Significant	0.90	0.79	—	69	16
19	CM.osmoprotection	14.05	Significant	0.67	1.01	Relevant	34	57
20	EPI.pancreatic_islet.beta	14.05	Significant	0.07	1.37	Relevant	42	57
21	FIB.transitioning.matrix_stress	13.18	Significant	—	0.10	Relevant	47	138
22	CM.baseline	13.09	Significant	1.00	0.41	—	393	0
23	EPI.bile_duct_cholangiocyte.inflammatory_APC	12.65	Significant	—	0.22	—	2	0
24	OLG.regulatory_activated	12.55	Significant	2.16e-03	1.93	Specific	196	614
25	EPI.salivary_serous_acinar.seromucous_like	11.47	Significant	—	2.40	Relevant	0	0
26	EPI.esophageal_suprabasal.proliferative_G2M	10.66	Significant	—	2.10	Relevant	0	0
27	EPI.ileal_enterocyte_crypt.secretory_precursor	10.58	Significant	—	1.90	Relevant	0	0
28	OLG.regulatory	10.58	Significant	4.94e-04	1.78	—	353	73
29	EPI.bile_duct_cholangiocyte.secretory_mucin	10.32	Significant	—	0.00	Relevant	7	12
30	EPI.pancreatic_acinar.baseline	9.82	Significant	0.05	1.39	—	274	163
31	FIB.transitioning.secretory_procollagen	9.16	Significant	—	0.00	Relevant	0	0
32	OLG.vesicle_trafficking	8.81	Significant	0.76	1.11	—	124	10
33	HPC.MPP_activated	8.77	Significant	—	0.38	—	0	0
34	OLG.myelinating_mature	8.56	Significant	1.00	0.94	—	363	94
35	MEL.mature_oxidative_traffic	8.48	Significant	0.28	1.54	—	247	285
36	OLG.myelinating_stress	8.43	Significant	1.00	0.58	—	232	62
37	OLG.stress	7.82	Significant	1.00	0.83	—	232	8
38	MEL.secretory_quiescent	7.23	Significant	0.71	0.97	—	19	13
39	NEU.EXC_IT.structural	7.17	Significant	1.16e-08	2.36	Specific	171	41
40	MEL.stress_glucocorticoid	7.16	Significant	0.71	0.76	Relevant	11	34
41	EPI.pancreatic_acinar.inflammatory_regenerative	6.99	Significant	0.06	1.47	Other	25	113
42	EPI.pancreatic_ductal_progenitor.baseline	6.98	Significant	0.07	1.85	Relevant	179	702
43	EPI.salivary_duct_ion_transport.baseline	6.84	Significant	—	—	—	0	0
44	EPI.endocervical_secretory.secretory_translocon	6.81	Significant	—	0.67	Relevant	0	0
45	EPI.colonocyte.goblet_interface	6.51	Significant	—	1.82	Other	11	21
46	EPI.salivary_duct_excretory.stress	6.46	Significant	0.58	1.05	Relevant	33	68
47	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	6.35	Significant	—	0.97	Relevant	0	0
48	EPI.pancreatic_ductal_progenitor.ciliated_transport	6.30	Significant	—	0.00	Relevant	105	368
49	EPI.alveolar_type_2.injury_primed	6.25	Significant	4.27e-15	2.68	Specific	434	245
50	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	6.14	Significant	—	0.00	—	0	0
51	FIB.transitioning.motility_remodelling	6.09	Significant	—	0.00	Other	0	0
52	HPC.GMP_inflammatory	5.85	Significant	0.97	0.73	Other	20	10
53	EPI.esophageal_suprabasal.proliferative_S	5.83	Significant	—	0.21	Relevant	26	41
54	EPI.pancreatic_acinar.stress	5.81	Significant	0.84	0.98	Other	28	28
55	MEL.dedifferentiated_migratory	5.81	Significant	—	0.00	Other	0	0
56	HPC.GMP_granulocytic	5.58	Significant	—	0.00	Other	3	3
57	EPI.salivary_duct_excretory.baseline	5.54	Significant	0.58	0.87	Other	23	57
58	EPI.esophageal_suprabasal.proliferative_exit	5.46	Nominal	—	0.04	Relevant	0	0
59	EPI.esophageal_suprabasal.differentiating_keratin	5.42	Nominal	0.69	0.76	Other	131	61
60	OPC.homeostatic	5.36	Nominal	8.94e-03	2.28	Other	394	160
61	EPI.pancreatic_ductal_progenitor.ADM_like	4.79	Nominal	—	0.00	Other	0	0
62	EPI.ileal_enterocyte_crypt.baseline	4.76	Nominal	0.23	1.54	Other	11	6
63	EPI.salivary_intercalated_defense.inflammatory	4.61	Nominal	1.75e-03	1.71	Other	152	360
64	EPI.pancreatic_ductal_perivascular.protective_antioxidant	4.56	Nominal	—	0.94	Other	11	69
65	HEP.periportal_metabolic.canonical_urea_cycle	4.54	Nominal	9.34e-03	1.72	Other	1,464	269
66	OPC.premyelinating	4.39	Nominal	0.88	0.89	Other	185	12
67	EPI.renal_proximal_tubule.detox_antioxidant	4.30	Nominal	8.11e-03	2.47	Other	394	77
68	HEP.periportal_metabolic.xenobiotic_detox	4.18	Nominal	0.64	1.21	Other	1,440	139
69	EPI.esophageal_suprabasal.basal_transitional	4.15	Nominal	0.69	0.77	Other	44	67
70	EPI.ileal_enterocyte_crypt.proliferative_G2M	4.10	Nominal	—	0.04	Other	19	54
71	OPC.proliferative_immune_interact	3.98	Nominal	0.98	0.11	Other	180	373
72	HEP.periportal_metabolic.urea_onecarbon_secretory	3.96	Nominal	0.68	1.12	Other	1,332	3,053
73	EPI.lung_club_secretory.canonical_surfactant	3.92	Nominal	—	0.75	Other	74	104
74	HPC.MPP_IEG	3.86	Nominal	0.97	0.67	Other	45	46
75	CM.inflammatory	3.80	Nominal	—	0.00	Other	0	0
76	HEP.periportal_metabolic.inflammatory_activated	3.78	Nominal	1.00	0.86	Other	712	1,610
77	HEP.periportal_metabolic.stress_chaperone	3.75	Nominal	—	0.26	Other	66	128
78	HPC.LMPP	3.75	Nominal	0.97	0.43	Other	65	31
79	EC.lymphatic.activated	3.70	Nominal	0.28	1.23	Other	47	73
80	NEU.EXC_IT.guidance	3.58	Nominal	1.00	0.81	Other	274	63
81	IPSC.neural_primed	3.56	Nominal	0.16	1.12	Other	0	0
82	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	3.48	Nominal	—	1.15	Other	0	0
83	EPI.renal_proximal_tubule.onecarbon_peroxisome	3.40	Nominal	0.72	0.62	Other	58	89
84	EPI.ileal_bile_transport.absorptive_xenobiotic	3.40	Nominal	0.50	0.92	Other	11	12
85	EPI.ileal_bile_transport.detox_transcytosis	3.22	Nominal	—	0.00	Other	0	1
86	EPI.ileal_enterocyte_crypt.proliferative_S	3.15	Nominal	0.97	0.29	Other	4	2
87	FIB.reticular.stress_metallothionein	3.11	Nominal	—	0.12	Other	3	32
88	EPI.salivary_intercalated_defense.basal_EMT	3.11	Nominal	—	0.29	Other	0	0
89	IPSC.midbrain_primed	3.07	Nominal	1.00	1.04	Other	0	0
90	EPI.ileal_enterocyte_crypt.villus_transition	3.04	Nominal	—	0.00	Other	7	10
91	ASTRO.synaptic_interaction	3.04	Nominal	0.20	1.31	Other	76	334
92	EPI.lung_club_secretory.ciliogenesis_primed	2.97	Nonsignificant	—	0.37	Other	0	0
93	IPSC.mesenchymal_primed	2.94	Nonsignificant	5.21e-05	1.20	Other	0	0
94	NEU.EXC_IT.callosal	2.92	Nonsignificant	1.00	0.94	Other	286	119
95	EPI.pancreatic_islet.delta	2.88	Nonsignificant	—	0.13	Other	0	0
96	FIB.reticular.immune_interface	2.88	Nonsignificant	—	0.73	Other	1	6
97	NEU.EXC_IT.adhesion	2.87	Nonsignificant	1.00	0.62	Other	252	108
98	T.CD4_Th17.migratory	2.85	Nonsignificant	0.32	1.28	Other	13	23
99	EC.lymphatic.tip_migratory	2.84	Nonsignificant	0.65	1.02	Other	23	37
100	EPI.ileal_enterocyte_crypt.bile_transport	2.81	Nonsignificant	0.97	0.28	Other	2	0
101	EPI.colonic_enteroendocrine.Lcell_peptide	2.80	Nonsignificant	—	0.00	Other	0	0
102	T.CD4_Th2.tissue_adapted	2.79	Nonsignificant	—	0.97	Other	0	0
103	IPSC.neuroendocrine_primed	2.56	Nonsignificant	—	1.03	Other	0	0
104	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	2.49	Nonsignificant	—	0.00	Other	0	0
105	DC.cDC1.homeostatic_inhibitory	2.46	Nonsignificant	—	1.21	Other	0	0
106	ASTRO.homeostatic	2.46	Nonsignificant	0.27	1.24	Other	200	431
107	EPI.pancreatic_acinar.metabolic_onecarbon	2.46	Nonsignificant	1.00	0.38	Other	287	328
108	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	2.31	Nonsignificant	0.45	1.32	Other	40	191
109	NEU.EXC_IT.neuromodulated	2.29	Nonsignificant	1.00	0.42	Other	176	116
110	EC.lymphatic.baseline	2.29	Nonsignificant	0.65	0.98	Other	38	72
111	IPSC.stress	2.26	Nonsignificant	1.00	0.93	Other	0	0
112	HEP.acute_phase.complement_antiviral	2.25	Nonsignificant	2.95e-03	1.80	Other	377	751
113	MEL.neurotrophic_migratory	2.22	Nonsignificant	—	0.00	Other	0	0
114	ASTRO.stress_mito	2.19	Nonsignificant	1.00	0.85	Other	47	110
115	EPI.alveolar_type_2.baseline_surfactant	2.09	Nonsignificant	1.00	0.52	Other	64	9
116	EPI.colonocyte.secretory_boost	2.09	Nonsignificant	0.04	1.83	Other	98	91
117	MAC.microglia_like.inflammatory_chemokine	2.06	Nonsignificant	—	0.32	Other	20	32
118	IPSC.endoderm_primed	2.05	Nonsignificant	1.00	0.95	Other	0	0
119	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	2.01	Nonsignificant	—	0.00	Other	0	0
120	EPI.pancreatic_ductal_perivascular.baseline	1.91	Nonsignificant	1.00	0.00	Other	1	5
121	EPI.colonic_tuft.homeostatic	1.91	Nonsignificant	—	0.73	Other	0	0
122	EPI.ileal_enterocyte_absorptive.villus_tip	1.90	Nonsignificant	1.20e-03	2.38	Other	4	3
123	HEP.acute_phase.proliferative	1.90	Nonsignificant	—	0.98	Other	4	6
124	DC.cDC2.migratory	1.88	Nonsignificant	0.44	1.19	Other	185	39
125	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	1.86	Nonsignificant	0.59	0.99	Other	219	533
126	DC.cDC2.adhesion_signaling	1.84	Nonsignificant	0.50	1.10	Other	35	9
127	DC.cDC2.monocyte_like	1.83	Nonsignificant	0.44	1.19	Other	1,285	791
128	EPI.pancreatic_ductal_bicarbonate.baseline	1.81	Nonsignificant	0.43	1.38	Other	11	42
129	EPI.alveolar_type_2.stress_response	1.79	Nonsignificant	1.00	0.00	Other	675	1,562
130	DC.cDC2.antiviral	1.74	Nonsignificant	0.50	1.08	Other	100	37
131	EPI.pancreatic_acinar.adhesion_remodeling	1.71	Nonsignificant	1.00	0.15	Other	210	784
132	ASTRO.hypoxia_angiogenic	1.71	Nonsignificant	1.00	0.98	Other	5	18
133	DC.cDC1.activated	1.67	Nonsignificant	—	0.17	Other	0	0
134	NEU.INH_VIP.nuclear_reg	1.60	Nonsignificant	—	1.09	Other	20	4
135	B.naive.restrained	1.59	Nonsignificant	1.21e-04	1.82	Other	183	353
136	NEU.INH_LAMP5.exc_inh_balance	1.56	Nonsignificant	—	0.94	Other	46	2
137	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	1.56	Nonsignificant	—	0.42	Other	0	0
138	NEU.EXC_IT.transitional	1.55	Nonsignificant	1.00	0.03	Other	237	142
139	B.memory.preactivated	1.54	Nonsignificant	1.50e-04	1.85	Other	173	174
140	EPI.esophageal_basal.junctional_barrier	1.50	Nonsignificant	—	1.21	Other	0	0
141	DC.cDC1.cross_presenting	1.48	Nonsignificant	—	0.00	Other	0	0
142	ASTRO.immature_lipid	1.46	Nonsignificant	1.00	0.91	Other	23	113
143	HEP.periportal_metabolic.acute_phase_barrier	1.45	Nonsignificant	1.00	0.20	Other	533	138
144	CM.contractile_oxphos	1.44	Nonsignificant	1.00	0.00	Other	6	19
145	DC.cDC1.baseline	1.43	Nonsignificant	—	0.00	Other	0	0
146	EPI.pancreatic_ductal_bicarbonate.activated	1.42	Nonsignificant	0.59	0.93	Other	10	7
147	CHOND.activated_fibro_like	1.39	Nonsignificant	1.11e-05	1.54	Other	531	188
148	HEP.acute_phase.complement_metabolic	1.39	Nonsignificant	0.16	1.33	Other	1,423	3,464
149	EPI.cervical_suprabasal.inflammatory_repair	1.37	Nonsignificant	—	0.73	Other	0	0
150	ILC2.activated	1.36	Nonsignificant	—	0.35	Other	0	0
151	NEU.INH_VIP.canonical_disinhibitory	1.36	Nonsignificant	0.15	1.42	Other	59	38
152	EPI.ileal_enterocyte_absorptive.brush_border	1.35	Nonsignificant	0.98	0.23	Other	580	1,717
153	NK.immature_bridge	1.35	Nonsignificant	0.72	1.05	Other	117	122
154	MAC.microglia_like.phagocytic_redox	1.33	Nonsignificant	—	0.00	Other	0	0
155	EPI.renal_thick_ascending_limb.canonical_salt_transporter	1.33	Nonsignificant	8.70e-03	1.40	Other	322	317
156	HEP.periportal_metabolic.apolipoprotein_secretory	1.33	Nonsignificant	1.00	0.24	Other	43	110
157	ILC2.quiescent	1.32	Nonsignificant	—	0.44	Other	0	0
158	ASTRO.A2_reactive	1.32	Nonsignificant	1.00	0.70	Other	10	37
159	EPI.extrahepatic_cholangiocyte.mucin_secretory	1.30	Nonsignificant	—	0.00	Other	0	0
160	EPI.ectocervical_granular.proliferative_basal	1.26	Nonsignificant	—	1.15	Other	0	0
161	DC.cDC1.proliferative	1.21	Nonsignificant	—	0.00	Other	0	0
162	HPC.CLP_B_primed	1.21	Nonsignificant	—	0.00	Other	0	0
163	NEU.INH_VIP.cannabinoid	1.19	Nonsignificant	—	0.50	Other	0	0
164	B.naive.antigen_presenting_ready	1.18	Nonsignificant	0.95	1.05	Other	48	73
165	NEU.EXC_SYT2.synaptic	1.14	Nonsignificant	—	0.48	Other	0	0
166	T.CD8_naive.cytokine_dampened	1.13	Nonsignificant	0.34	1.33	Other	71	4
167	OLG.reactive_repair	1.13	Nonsignificant	1.00	0.00	Other	385	385
168	EPI.salivary_serous_acinar.quiescent	1.12	Nonsignificant	0.23	1.56	Other	178	493
169	IPSC.mesodermal_primed	1.11	Nonsignificant	1.00	0.88	Other	0	0
170	HEP.acute_phase.inflammatory	1.09	Nonsignificant	0.67	1.07	Other	382	649
171	NEU.INH_VIP.serotonergic	1.09	Nonsignificant	—	0.41	Other	9	2
172	B.naive.activated	1.09	Nonsignificant	0.95	0.93	Other	77	127
173	EPI.thymic_cortical.baseline	1.06	Nonsignificant	0.23	1.44	Other	185	386
174	B.naive.remodeling	1.06	Nonsignificant	0.95	0.88	Other	135	230
175	B.naive.purinergic	1.06	Nonsignificant	0.95	0.81	Other	384	820
176	NEU.INH_VIP.regulatory_remodeling	1.04	Nonsignificant	—	0.00	Other	6	1
177	DC.cDC2.tolerogenic_regulatory	1.02	Nonsignificant	1.00	0.67	Other	44	4
178	EPI.renal_thick_ascending_limb.remodeling	1.02	Nonsignificant	0.40	1.17	Other	152	92
179	T.CD8_naive.splicing_enriched	1.01	Nonsignificant	0.34	1.31	Other	120	16
180	EPI.colonocyte.ionocyte_BEST4	1.01	Nonsignificant	1.00	1.01	Other	103	188
181	EPI.colonic_tuft.activated	1.01	Nonsignificant	—	0.00	Other	0	0
182	EPI.extrahepatic_cholangiocyte.barrier_interface	1.00	Nonsignificant	—	0.00	Other	0	0
183	MAC.resident_iron.stress_tolerogenic	0.99	Nonsignificant	—	1.13	Other	0	0
184	EPI.skin_interfollicular_spinous.stress_oxidative	0.98	Nonsignificant	—	0.68	Other	0	0
185	EPI.thymic_cortical.Notch_interface	0.97	Nonsignificant	—	0.00	Other	82	137
186	B.naive.proteostasis	0.94	Nonsignificant	0.95	0.87	Other	49	69
187	EPI.gastric_foveolar.baseline	0.94	Nonsignificant	—	0.00	Other	0	0
188	NEU.INH_VIP.excitatory_coupled	0.94	Nonsignificant	—	0.08	Other	13	0
189	CHOND.angiogenic	0.93	Nonsignificant	—	0.57	Other	0	0
190	EPI.skin_interfollicular_spinous.early_differentiation	0.93	Nonsignificant	0.36	1.22	Other	89	19
191	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	0.93	Nonsignificant	—	0.00	Other	49	237
192	T.CD8_naive.nfkb_related	0.92	Nonsignificant	0.72	1.07	Other	1	0
193	EPI.colonocyte.distal_absorptive	0.91	Nonsignificant	—	0.65	Other	0	0
194	T.CD8_naive.baseline	0.91	Nonsignificant	0.39	1.22	Other	142	2
195	EPI.thymic_cortical.secretory_remodeling	0.90	Nonsignificant	—	0.27	Other	4	1
196	T.CD4_naive.neddylation_mitoprot	0.89	Nonsignificant	0.58	1.41	Other	93	56
197	EPI.skin_interfollicular_spinous.baseline	0.89	Nonsignificant	0.36	1.34	Other	35	3
198	EPI.salivary_serous_acinar.secretory_active	0.87	Nonsignificant	0.99	0.41	Other	242	69
199	FIB.neurolectin_mucosa.inflammatory	0.86	Nonsignificant	0.21	1.30	Other	52	110
200	SMC.metabolic	0.85	Nonsignificant	7.94e-03	1.64	Other	14	40
201	B.naive.metabolic	0.85	Nonsignificant	0.95	0.57	Other	50	79
202	PC.IgG_systemic.metabolic	0.85	Nonsignificant	0.09	1.38	Other	46	63
203	B.naive.baseline	0.84	Nonsignificant	0.95	0.79	Other	10	13
204	FIB.neurolectin_mucosa.axon_responsive	0.84	Nonsignificant	0.17	1.56	Other	10	10
205	NEU.INH_VIP.opioid	0.83	Nonsignificant	—	0.00	Other	50	9
206	B.naive.receptor_recycle	0.81	Nonsignificant	0.95	0.66	Other	51	0
207	B.memory.activated	0.81	Nonsignificant	0.06	1.45	Other	105	29
208	T.CD8_naive.innate_like	0.80	Nonsignificant	0.86	0.93	Other	10	1
209	ASTRO.neuromodulatory	0.80	Nonsignificant	1.00	0.77	Other	34	172
210	EPI.colonic_enteroendocrine.progenitor	0.80	Nonsignificant	—	0.00	Other	0	0
211	T.CD4_Th17.baseline	0.78	Nonsignificant	0.72	0.87	Other	51	5
212	T.CD8_naive.lipid_synthesis	0.76	Nonsignificant	1.00	0.57	Other	6	4
213	CHOND.remodeling	0.76	Nonsignificant	—	0.29	Other	5	0
214	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.74	Nonsignificant	—	0.00	Other	0	0
215	T.CD8_naive.vesicle_secretory	0.73	Nonsignificant	0.92	0.84	Other	42	0
216	EPI.colonocyte.proximal_transport	0.72	Nonsignificant	1.00	0.79	Other	24	12
217	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.71	Nonsignificant	1.00	0.00	Other	11	22
218	NEU.EXC_NTNG1.nuclear_reg	0.70	Nonsignificant	—	0.67	Other	0	0
219	T.CD4_naive.survival_mitoprot	0.70	Nonsignificant	0.72	1.09	Other	13	7
220	T.CD4_naive.homeostatic	0.70	Nonsignificant	0.68	1.13	Other	215	108
221	T.CD4_Tcm.baseline	0.68	Nonsignificant	0.32	1.45	Other	61	31
222	T.CD8_Trm.dendritic_recruiter	0.68	Nonsignificant	0.26	1.18	Other	47	85
223	T.CD4_naive.mature_mitoprot	0.68	Nonsignificant	0.68	1.16	Other	212	476
224	SKM.type_1_slow.contractile	0.68	Nonsignificant	0.07	1.68	Other	596	8
225	EPI.skin_interfollicular_spinous.stress_UPR	0.67	Nonsignificant	—	0.00	Other	0	0
226	HEP.acute_phase.baseline	0.66	Nonsignificant	1.00	0.19	Other	946	19
227	SKM.type_1_slow.oxidative	0.66	Nonsignificant	0.28	1.29	Other	802	251
228	MAC.resident_repair.ECM_stromal_crosstalk	0.65	Nonsignificant	0.76	1.13	Other	95	158
229	EPI.colonocyte.junction_remodeling	0.65	Nonsignificant	1.00	0.50	Other	218	305
230	T.CD4_naive.Treg_like	0.64	Nonsignificant	0.68	1.21	Other	121	72
231	T.CD4_naive.mature	0.63	Nonsignificant	0.68	1.18	Other	211	100
232	NEU.INH_LAMP5.glial_interface	0.63	Nonsignificant	—	0.00	Other	0	0
233	T.CD4_naive.survival	0.62	Nonsignificant	0.77	1.03	Other	12	17
234	T.CD4_transitional.tissue_enagement	0.62	Nonsignificant	0.05	1.71	Other	5	11
235	NEU.INH_LAMP5.rosehip	0.62	Nonsignificant	—	0.00	Other	0	0
236	T.CD4_Tcm.regulatory_poised	0.61	Nonsignificant	0.32	1.50	Other	2	3
237	EPI.skin_interfollicular_spinous.proliferative	0.61	Nonsignificant	—	0.00	Other	0	0
238	T.CD4_Th2.precursor	0.60	Nonsignificant	—	0.00	Other	0	0
239	HEP.periportal_metabolic.stress_checkpoint	0.58	Nonsignificant	1.00	5.33e-03	Other	234	786
240	T.CD4_Trm.activated	0.57	Nonsignificant	0.26	1.25	Other	32	26
241	PC.IgG_systemic.interacting	0.57	Nonsignificant	0.15	1.33	Other	0	0
242	GRANU.MAST.activated_acute	0.56	Nonsignificant	—	0.19	Other	0	0
243	EPI.colonocyte.crypt_progenitor	0.56	Nonsignificant	1.00	0.08	Other	115	265
244	T.CD4_Tfh.effector_migratory	0.56	Nonsignificant	0.16	1.52	Other	122	57
245	SCHWN.translation_boost	0.55	Nonsignificant	—	0.20	Other	8	1
246	EPI.endocervical_secretory.squamous_barrier	0.55	Nonsignificant	—	0.00	Other	0	0
247	PERI.inflammatory	0.55	Nonsignificant	0.22	1.43	Other	40	77
248	MAC.resident_repair.chemokine_angiocrine	0.54	Nonsignificant	0.76	1.03	Other	87	138
249	SCHWN.axon_contact_cardiac	0.52	Nonsignificant	0.82	0.61	Other	18	63
250	B.memory.baseline	0.51	Nonsignificant	1.00	0.80	Other	472	99
251	SCHWN.reactive_inflammatory	0.51	Nonsignificant	—	0.00	Other	0	0
252	T.CD4_Treg.Tr1_like	0.50	Nonsignificant	—	0.83	Other	8	8
253	GRANU.MAST.activated_repair	0.50	Nonsignificant	—	0.30	Other	0	1
254	DC.cDC2.proliferative	0.49	Nonsignificant	—	0.00	Other	39	71
255	NEU.INH_VIP.develop_niche	0.49	Nonsignificant	—	0.00	Other	0	0
256	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.48	Nonsignificant	0.59	0.94	Other	14	32
257	T.CD4_transitional.primed_helper_effector	0.48	Nonsignificant	0.37	1.32	Other	19	43
258	NEU.INH_VIP.LAMP5_hybrid	0.47	Nonsignificant	—	0.00	Other	1	9
259	T.CD4_Tcm.Tfh_like	0.47	Nonsignificant	0.90	1.06	Other	102	214
260	T.CD4_Tcm.Th2_like	0.47	Nonsignificant	0.90	1.20	Other	23	55
261	T.CD4_Tcm.retro_ZNF117	0.46	Nonsignificant	0.90	0.94	Other	5	9
262	T.CD4_Tcm.APC_mimicry	0.46	Nonsignificant	0.90	1.08	Other	54	43
263	MAC.resident_repair.antigen_presenting	0.46	Nonsignificant	0.76	0.94	Other	244	113
264	T.CD4_Tcm.stress	0.45	Nonsignificant	0.90	0.98	Other	5	11
265	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.45	Nonsignificant	—	1.04	Other	10	20
266	EPI.skin_interfollicular_spinous.upper_lipid	0.45	Nonsignificant	—	0.00	Other	6	6
267	MONO.CD14.APC_like	0.44	Nonsignificant	1.74e-03	1.26	Other	1,686	2,493
268	B.memory.pDC_imprint	0.44	Nonsignificant	1.00	0.65	Other	157	103
269	T.CD4_Tcm.imprinted_splicing	0.44	Nonsignificant	0.90	1.08	Other	6	17
270	T.CD8_naive.effector_transition	0.44	Nonsignificant	1.00	0.17	Other	35	62
271	T.CD4_naive.neddylation	0.44	Nonsignificant	1.00	0.53	Other	104	222
272	GRANU.MAST.resting_granule	0.43	Nonsignificant	—	0.00	Other	0	0
273	FIB.neurolectin_mucosa.nerve_interface	0.42	Nonsignificant	—	0.00	Other	4	0
274	MAC.MDM.complement_resolving	0.42	Nonsignificant	0.40	1.15	Other	440	860
275	MAC.MDM.APC_dendritic	0.42	Nonsignificant	0.38	1.23	Other	48	15
276	T.CD4_Tcm.secretory	0.42	Nonsignificant	0.92	0.81	Other	20	11
277	EPI.hepatic_ductular_cholangiocyte.ion_transport	0.42	Nonsignificant	—	1.32	Other	0	0
278	T.CD4_Tcm.RNA_control	0.42	Nonsignificant	0.92	0.84	Other	96	4
279	T.CD8_naive.mito_proteostasis	0.41	Nonsignificant	0.72	1.08	Other	428	100
280	EPI.esophageal_basal.activated_progenitor	0.40	Nonsignificant	1.00	0.00	Other	1	0
281	IPSC.canonical_pluripotent	0.39	Nonsignificant	1.00	0.88	Other	0	0
282	NEU.INH_VIP.matrix	0.39	Nonsignificant	—	0.00	Other	24	77
283	EPI.tracheal_submucosal_gland.ductal_luminal	0.39	Nonsignificant	—	0.73	Other	0	0
284	DC.mig.baseline	0.39	Nonsignificant	—	0.00	Other	1	0
285	T.CD4_Tcm.synapse_dynamics	0.39	Nonsignificant	0.90	1.00	Other	15	10
286	MAC.resident_iron.APC_iron_sensing	0.38	Nonsignificant	0.48	1.25	Other	211	114
287	MAC.resident_repair.stress_iron	0.38	Nonsignificant	0.76	0.81	Other	48	97
288	ILC2.migratory	0.38	Nonsignificant	—	0.00	Other	0	0
289	T.CD4_Tcm.tissue_homing	0.38	Nonsignificant	0.92	0.82	Other	78	46
290	T.CD4_Tcm.migratory_cilium	0.38	Nonsignificant	0.90	1.26	Other	5	10
291	EC.arterial.metabolic	0.37	Nonsignificant	0.37	1.16	Other	195	159
292	T.CD4_Tcm.DC_interact	0.37	Nonsignificant	0.92	0.77	Other	72	32
293	HEP.acute_phase.stress_secretory	0.37	Nonsignificant	1.00	0.15	Other	26	3
294	T.CD4_naive.purinergic	0.36	Nonsignificant	1.00	0.37	Other	49	1
295	MONO.CD14.inflammatory	0.36	Nonsignificant	0.45	1.20	Other	92	134
296	T.CD4_naive.resist_bystander	0.36	Nonsignificant	1.00	0.38	Other	40	25
297	EPI.renal_principal_cell.injury_repair	0.36	Nonsignificant	0.23	1.37	Other	26	9
298	PERI.baseline	0.36	Nonsignificant	0.29	1.33	Other	39	66
299	FIB.barrier_secretory.homeostasis	0.36	Nonsignificant	—	0.00	Other	0	0
300	FIB.reticular.stromal_niche	0.35	Nonsignificant	0.91	0.52	Other	0	0
301	T.CD4_Tcm.crosstalk_myeloid	0.35	Nonsignificant	0.92	0.66	Other	5	4
302	T.CD8_Trm.inflammatory	0.35	Nonsignificant	0.19	1.18	Other	124	176
303	DC.cDC2.pro_inflammatory	0.35	Nonsignificant	1.00	0.42	Other	3	5
304	EPI.skin_interfollicular_spinous.transition_basal	0.35	Nonsignificant	0.99	0.26	Other	100	127
305	MAC.resident_iron.redox_metabolic	0.35	Nonsignificant	0.92	0.95	Other	4	4
306	EPI.alveolar_type_1.baseline	0.34	Nonsignificant	0.11	1.64	Other	8	0
307	NEU.INH_LAMP5.projecting	0.34	Nonsignificant	—	0.00	Other	0	0
308	T.CD4_transitional.baseline	0.34	Nonsignificant	0.99	0.68	Other	59	97
309	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.34	Nonsignificant	—	0.00	Other	0	0
310	MAC.resident_repair.lipid_phagocytic	0.33	Nonsignificant	0.76	0.81	Other	228	604
311	T.CD4_naive.survival_neddylation	0.33	Nonsignificant	1.00	0.23	Other	26	38
312	SMC.contractile	0.33	Nonsignificant	0.96	0.78	Other	80	588
313	EPI.lung_multiciliated.mature_motile_cilia	0.33	Nonsignificant	—	1.53	Other	0	0
314	NEU.INH_VIP.enkephalinergic	0.32	Nonsignificant	—	0.00	Other	0	0
315	FIB.neurolectin_mucosa.remodeling_repair	0.32	Nonsignificant	—	0.00	Other	4	2
316	FIB.lung_alveolar.mito_secretory	0.31	Nonsignificant	—	0.48	Other	0	0
317	NK.cytokine_tissue_resident	0.31	Nonsignificant	1.00	1.08	Other	74	82
318	T.CD4_transitional.APC_interacting	0.31	Nonsignificant	0.99	0.56	Other	10	14
319	T.CD4_Tfh.suppression_exhaustion	0.30	Nonsignificant	0.88	0.88	Other	0	2
320	NEU.INH_PVALB.chandelier	0.30	Nonsignificant	0.08	1.32	Other	19	16
321	EPI.thymic_medullary.canonical_alarmin	0.29	Nonsignificant	0.26	1.42	Other	8	17
322	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.29	Nonsignificant	—	1.05	Other	0	0
323	T.CD4_naive.gut_prone	0.29	Nonsignificant	0.68	1.20	Other	35	70
324	SMC.activated	0.29	Nonsignificant	0.96	0.51	Other	2	5
325	DC.cDC2.lipid_metabolic	0.29	Nonsignificant	—	0.00	Other	0	0
326	SKM.type_1_slow.glycolytic	0.29	Nonsignificant	1.00	0.00	Other	362	647
327	T.CD4_Tfh.precursor_migratory	0.29	Nonsignificant	0.55	1.18	Other	72	27
328	MAC.LAM.inflammatory_APC	0.28	Nonsignificant	0.05	1.29	Other	872	165
329	EPI.renal_principal_cell.intercalated_like	0.28	Nonsignificant	0.23	1.42	Other	63	66
330	B.memory.migratory	0.28	Nonsignificant	1.00	0.15	Other	123	208
331	EPI.skin_keratinocyte_proliferating.early_spinous_transition	0.28	Nonsignificant	—	0.87	Other	135	290
332	MAC.LAM.lipid_opsonization	0.28	Nonsignificant	0.44	1.21	Other	45	14
333	FIB.reticular.ECM_builder	0.27	Nonsignificant	—	0.00	Other	0	0
334	EPI.tracheal_submucosal_gland.acinar_serous	0.27	Nonsignificant	—	0.00	Other	0	0
335	EPI.pancreatic_ductal_bicarbonate.stress	0.27	Nonsignificant	—	0.00	Other	12	33
336	EC.arterial.inflammatory	0.24	Nonsignificant	0.69	1.05	Other	63	50
337	B.germinal_center.DZ_S_phase	0.24	Nonsignificant	—	0.34	Other	0	0
338	B.germinal_center.LZ_selection	0.24	Nonsignificant	—	0.58	Other	0	0
339	EPI.thymic_medullary.proliferative_APC	0.24	Nonsignificant	—	0.15	Other	0	0
340	EC.arterial.elastic	0.24	Nonsignificant	0.69	1.10	Other	22	45
341	EC.capillary.angiocrine	0.24	Nonsignificant	0.12	1.38	Other	250	630
342	T.CD4_Th17.cytotoxic	0.23	Nonsignificant	0.04	1.51	Other	332	123
343	EPI.renal_principal_cell.canonical_vasopressin	0.23	Nonsignificant	0.77	1.03	Other	2	0
344	EC.lymphatic.valve	0.23	Nonsignificant	—	0.04	Other	0	0
345	MAC.MDM.LAM_like	0.23	Nonsignificant	0.84	0.93	Other	12	14
346	HEP.canalicular_transport.inflammatory	0.22	Nonsignificant	0.02	1.11	Other	1,335	194
347	B.germinal_center.LZ_memory_precursor	0.22	Nonsignificant	—	0.00	Other	0	0
348	MAC.resident_iron.heme_recycling	0.22	Nonsignificant	—	0.00	Other	30	37
349	EPI.cervical_suprabasal.secretory_vesicle	0.22	Nonsignificant	—	0.00	Other	0	0
350	T.CD4_Trm.metal_stress	0.21	Nonsignificant	0.03	1.43	Other	34	58
351	FIB.lung_alveolar.stress_interacting	0.21	Nonsignificant	—	0.00	Other	0	0
352	CHOND.articular_collagen	0.20	Nonsignificant	1.00	0.63	Other	551	266
353	T.CD8_Tcm.helper_like	0.20	Nonsignificant	4.56e-03	1.31	Other	81	159
354	EPI.skin_keratinocyte_basal.spinous_transition	0.20	Nonsignificant	—	0.97	Other	0	0
355	MONO.CD14.remodeling	0.19	Nonsignificant	0.33	1.07	Other	2,373	295
356	MONO.CD14.platelet_bound	0.19	Nonsignificant	0.65	1.04	Other	964	176
357	EC.arterial.homeostatic	0.19	Nonsignificant	0.69	1.02	Other	24	3
358	T.CD4_Tfh.canonical_GC_helper	0.19	Nonsignificant	0.97	0.43	Other	1	2
359	T.CD4_Treg.APC_interactive	0.19	Nonsignificant	0.05	1.43	Other	118	28
360	T.CD4_transitional.primed_cytotoxic	0.19	Nonsignificant	0.99	0.30	Other	28	30
361	B.germinal_center.LZ_survival	0.19	Nonsignificant	—	0.00	Other	0	0
362	EC.arterial.mito_contact	0.18	Nonsignificant	0.82	0.95	Other	14	5
363	EPI.thymic_medullary.stress_APC	0.18	Nonsignificant	0.60	0.90	Other	2	4
364	PC.IgA_muocsal.plasmablast	0.18	Nonsignificant	0.31	1.27	Other	5	4
365	MAC.MDM.inflammatory_phagocytic	0.17	Nonsignificant	0.98	0.64	Other	199	52
366	EC.capillary.activated	0.17	Nonsignificant	0.59	1.30	Other	2	5
367	MAC.LAM.antimicrobial	0.17	Nonsignificant	1.00	0.89	Other	389	93
368	EPI.renal_distal_tubule.repair	0.17	Nonsignificant	—	0.77	Other	34	102
369	EC.capillary.inflammatory	0.17	Nonsignificant	0.97	0.97	Other	27	51
370	EPI.lung_club_secretory.inflammatory	0.16	Nonsignificant	—	0.00	Other	0	0
371	EPI.renal_thick_ascending_limb.barrier_repair	0.16	Nonsignificant	1.00	0.58	Other	141	284
372	EC.capillary.baseline	0.16	Nonsignificant	0.97	0.85	Other	246	560
373	T.CD4_naive.proteostasis_mitoprot	0.16	Nonsignificant	1.00	0.06	Other	15	37
374	MAC.microglia_like.patrolling_adhesive	0.16	Nonsignificant	—	0.00	Other	0	0
375	EPI.renal_immature_ureteric_bud.defense_secretory	0.16	Nonsignificant	0.49	1.13	Other	45	76
376	EPI.hepatic_ductular_cholangiocyte.stress	0.15	Nonsignificant	—	1.01	Other	0	0
377	T.CD4_Treg.central_naive_like	0.15	Nonsignificant	0.99	0.76	Other	333	45
378	EC.capillary.angiogenic_tip	0.15	Nonsignificant	0.97	0.96	Other	186	218
379	PC.IgG_systemic.stress	0.15	Nonsignificant	—	0.00	Other	1	5
380	T.CD4_Tem.inflammatory	0.15	Nonsignificant	0.43	1.12	Other	28	6
381	PERI.cardiac_skeletal	0.15	Nonsignificant	1.00	0.27	Other	313	630
382	EC.capillary.migratory	0.14	Nonsignificant	0.97	0.79	Other	181	509
383	THYMO.DN_preTCR	0.14	Nonsignificant	0.19	1.38	Other	41	71
384	T.CD4_Trm.helper_like	0.14	Nonsignificant	0.79	0.99	Other	84	147
385	IPSC.stromal_primed	0.14	Nonsignificant	1.00	0.80	Other	0	0
386	EPI.thymic_medullary.hormone_xeno_barrier	0.13	Nonsignificant	—	0.00	Other	0	8
387	EPI.renal_thick_ascending_limb.cation_flux	0.13	Nonsignificant	1.00	0.42	Other	57	95
388	PC.IgA_muocsal.baseline	0.13	Nonsignificant	0.64	1.06	Other	3	5
389	PERI.angiocrine	0.13	Nonsignificant	1.00	0.58	Other	93	102
390	FIB.tracheal_subepithelial.baseline	0.13	Nonsignificant	—	0.00	Other	0	0
391	MONO.CD16.platelet_bound	0.13	Nonsignificant	0.31	1.16	Other	372	508
392	T.CD4_Tcm.effector_like	0.13	Nonsignificant	1.00	0.03	Other	293	533
393	MONO.CD16.hepatic_mac_like	0.13	Nonsignificant	0.31	1.09	Other	803	117
394	NK.cytokine_tissue_activation	0.13	Nonsignificant	1.00	1.03	Other	267	450
395	EC.capillary.postcap_venule	0.12	Nonsignificant	0.97	0.79	Other	355	261
396	HEP.canalicular_transport.injury_stress	0.12	Nonsignificant	0.99	1.01	Other	289	24
397	EC.lymphatic.scavenger	0.12	Nonsignificant	1.00	0.53	Other	203	257
398	T.CD4_Trm.baseline	0.12	Nonsignificant	0.79	0.99	Other	31	21
399	PC.IgA_muocsal.migratory	0.11	Nonsignificant	0.74	0.98	Other	4	1
400	MAC.resident_iron.heme_catabolism	0.11	Nonsignificant	0.97	0.34	Other	30	51
401	EC.arterial.arteriole_interface	0.11	Nonsignificant	0.95	0.90	Other	31	12
402	PLAT.adhesion	0.11	Nonsignificant	—	0.48	Other	0	0
403	EPI.renal_principal_cell.activated_acute	0.10	Nonsignificant	0.98	0.55	Other	29	59
404	EPI.renal_intercalated_cell_type_A.PC_transitional	0.10	Nonsignificant	—	0.00	Other	203	407
405	T.CD4_Trm.stress_adaptive	0.10	Nonsignificant	0.26	1.20	Other	8	22
406	EPI.renal_thick_ascending_limb.salt_sensing	0.10	Nonsignificant	1.00	0.32	Other	73	103
407	EPI.skin_keratinocyte_basal.transit_amplifying	0.10	Nonsignificant	—	0.00	Other	0	0
408	T.CD8_Trm.homeostatic	0.10	Nonsignificant	1.00	0.76	Other	42	5
409	T.CD4_naive.proteostasis	0.10	Nonsignificant	1.00	0.03	Other	14	9
410	EPI.tracheal_suprabasal.secretory_immune	0.10	Nonsignificant	—	0.90	Other	0	0
411	EC.liver_sinusoidal.remodeling_lipotoxicity	0.10	Nonsignificant	—	0.84	Other	90	58
412	EC.capillary.stress	0.10	Nonsignificant	0.97	0.63	Other	44	36
413	EC.arterial.ion_pump	0.09	Nonsignificant	0.69	1.06	Other	3	2
414	EC.arterial.angiogenic_tip	0.09	Nonsignificant	—	0.00	Other	30	37
415	T.CD4_Tem.transitional_CM	0.09	Nonsignificant	0.79	0.96	Other	31	20
416	MONO.CD14.repair_M2_like	0.09	Nonsignificant	1.00	0.89	Other	550	1,495
417	EC.arterial.arteriole_gas_exchange	0.09	Nonsignificant	0.99	0.80	Other	238	131
418	EC.venous.baseline	0.09	Nonsignificant	0.13	1.16	Other	346	807
419	T.CD8_transitional.Trm_primed	0.09	Nonsignificant	0.48	1.04	Other	108	15
420	FIB.perivascular_interface.vasomotor_tone	0.09	Nonsignificant	—	1.21	Other	0	0
421	MAC.LAM.anti_inflammatory	0.09	Nonsignificant	1.00	0.50	Other	86	132
422	EC.venous.remodeling_stalk	0.08	Nonsignificant	0.77	1.01	Other	559	566
423	T.CD4_Treg.tissue_effector	0.08	Nonsignificant	0.99	0.40	Other	16	13
424	MONO.CD16.inflammatory	0.08	Nonsignificant	0.27	1.10	Other	1,640	168
425	NEU.INH_PVALB.metabotropic	0.08	Nonsignificant	—	0.36	Other	0	0
426	EC.heart_remodeling.angiocrine	0.08	Nonsignificant	0.15	1.18	Other	182	525
427	T.CD8_transitional.effector_primed	0.08	Nonsignificant	0.48	1.04	Other	435	151
428	PC.IgA_muocsal.activated	0.08	Nonsignificant	0.96	0.79	Other	17	8
429	EPI.renal_intercalated_cell_type_A.acid_secretion	0.08	Nonsignificant	0.20	1.25	Other	12	6
430	CHOND.pro_inflammatory	0.07	Nonsignificant	1.00	0.34	Other	181	351
431	ASTRO.stress_acute	0.07	Nonsignificant	1.00	0.27	Other	60	56
432	FIB.interstitial.immune_interact	0.07	Nonsignificant	0.70	1.05	Other	12	1
433	THYMO.SP_CD8_transitional	0.07	Nonsignificant	0.62	1.16	Other	32	75
434	MONO.CD14.baseline	0.07	Nonsignificant	1.00	0.64	Other	2,268	76
435	T.CD8_Trm.muscosal_Tc17	0.07	Nonsignificant	1.00	0.72	Other	19	38
436	PC.IgG_systemic.secretory	0.07	Nonsignificant	1.00	0.09	Other	0	0
437	T.CD4_Trm.central_like	0.07	Nonsignificant	0.98	0.83	Other	38	31
438	GRNLSA.EMT_insulin_signaling	0.07	Nonsignificant	0.87	1.20	Other	47	84
439	T.CD4_Tem.long_term_memory	0.06	Nonsignificant	0.93	0.82	Other	314	587
440	T.CD8_transitional.APC_like	0.06	Nonsignificant	0.48	1.02	Other	205	62
441	EC.liver_sinusoidal.inflammatory	0.06	Nonsignificant	—	0.55	Other	223	154
442	MUSC.baseline	0.06	Nonsignificant	0.40	1.18	Other	0	0
443	ASPC.proliferative	0.06	Nonsignificant	0.43	1.28	Other	33	85
444	FIB.interstitial.mesenchymal_regulator	0.06	Nonsignificant	0.71	1.05	Other	4	4
445	EC.venous.quiescent_homeostatic	0.06	Nonsignificant	0.90	0.90	Other	456	360
446	HEP.canalicular_transport.pericentral_like_hypoxia	0.06	Nonsignificant	0.99	0.91	Other	326	8
447	THYMO.SP_CD8_naive_stress	0.06	Nonsignificant	0.83	1.00	Other	1	1
448	ASPC.inflammatory	0.06	Nonsignificant	0.55	1.15	Other	21	61
449	EC.liver_sinusoidal.hypoxia_metabolic	0.05	Nonsignificant	0.55	1.10	Other	183	107
450	EC.venous.adipose_lipid	0.05	Nonsignificant	0.20	1.19	Other	254	476
451	HEP.pericentral_lipoprotein.ApoB_coagulation	0.05	Nonsignificant	—	0.67	Other	0	0
452	MAC.resident_cardiac.phagocytic_homeostasis	0.05	Nonsignificant	0.01	1.49	Other	564	1,221
453	GRNLSA.chemokine_mechanosensory	0.05	Nonsignificant	0.87	1.08	Other	1	0
454	THYMO.SP_CD8_naive	0.05	Nonsignificant	0.30	1.17	Other	297	177
455	EC.liver_sinusoidal.prostanoid	0.05	Nonsignificant	—	0.41	Other	11	64
456	NK.cytokine_lung_immediate_early	0.05	Nonsignificant	1.00	1.00	Other	424	274
457	EPI.renal_principal_cell.inflammatory	0.05	Nonsignificant	0.98	0.40	Other	74	157
458	GRNLSA.cholesterol_mevalonate	0.04	Nonsignificant	0.87	1.12	Other	9	4
459	FIB.barrier_purinergic.lipid_secretory	0.04	Nonsignificant	—	0.48	Other	0	0
460	T.CD4_Trm.cytotoxic_effector	0.04	Nonsignificant	0.98	0.74	Other	118	77
461	EPI.renal_intercalated_cell_type_B.baseline	0.04	Nonsignificant	—	0.00	Other	3	1
462	EC.venous.cardiac_structural	0.04	Nonsignificant	0.13	1.34	Other	102	229
463	T.CD4_Tem.cytotoxic_effector	0.04	Nonsignificant	0.43	1.11	Other	225	398
464	EPI.skin_interfollicular_spinous.inflammatory	0.04	Nonsignificant	—	0.00	Other	0	0
465	GRNLSA.stress_metabolic	0.04	Nonsignificant	—	0.28	Other	1	2
466	ASPC.adipocyte_capillary_interface	0.04	Nonsignificant	0.55	1.15	Other	21	54
467	FIB.interstitial.stress_secretory	0.04	Nonsignificant	0.46	1.19	Other	92	56
468	HEP.pericentral_lipoprotein.UPR_redox	0.04	Nonsignificant	—	0.00	Other	0	0
469	T.CD8_Tcm.baseline	0.03	Nonsignificant	1.00	0.88	Other	90	89
470	EPI.renal_immature_ureteric_bud.osmoprotective	0.03	Nonsignificant	0.99	0.53	Other	126	44
471	THYMO.CD8aa_IELp	0.03	Nonsignificant	—	0.09	Other	1	7
472	MUSC.quiescent_reservoir	0.03	Nonsignificant	0.40	1.16	Other	2	8
473	FIB.perivascular_interface.vascular_BM_remodelling	0.03	Nonsignificant	—	0.00	Other	0	0
474	NEU.INH_PVALB.nuclear_reg	0.03	Nonsignificant	0.81	0.80	Other	25	12
475	T.MAIT.migratory	0.03	Nonsignificant	0.40	1.11	Other	10	1
476	MUSC.activated_migratory	0.03	Nonsignificant	0.40	1.37	Other	6	7
477	FIB.perivascular_interface.lipid_shuttle	0.03	Nonsignificant	—	0.00	Other	51	170
478	IPSC.proliferative	0.03	Nonsignificant	1.00	0.69	Other	0	0
479	EPI.lung_multiciliated.stress	0.03	Nonsignificant	—	0.08	Other	67	165
480	MESO.activated_stress	0.03	Nonsignificant	—	2.22e-16	Other	0	0
481	THYMO.DP_early_stress	0.03	Nonsignificant	—	0.17	Other	0	0
482	T.gamma_delta.cytotoxic_effector	0.03	Nonsignificant	0.04	1.08	Other	349	109
483	FIB.skin_neurosecretory.baseline	0.03	Nonsignificant	—	0.00	Other	0	0
484	EPI.skin_follicular_keratinizing.root_infundibulum	0.02	Nonsignificant	—	1.34	Other	0	0
485	MAC.resident_cardiac.inflammatory_reparative	0.02	Nonsignificant	0.81	0.70	Other	31	96
486	EPI.hepatic_ductular_cholangiocyte.secretory_transport	0.02	Nonsignificant	—	0.17	Other	0	0
487	B.age_associated.migratory	0.02	Nonsignificant	0.34	1.18	Other	2	2
488	EPI.ectocervical_granular.inflammatory	0.02	Nonsignificant	—	0.32	Other	0	0
489	MAC.LAM.lipid_phagocytosis	0.02	Nonsignificant	1.00	0.11	Other	369	328
490	EPI.hepatic_ductular_cholangiocyte.polarity	0.02	Nonsignificant	—	0.10	Other	0	0
491	T.CD8_Trm.cytotoxic	0.02	Nonsignificant	1.00	0.38	Other	165	85
492	ASPC.preadipocyte_lipid_primed	0.02	Nonsignificant	0.55	1.04	Other	331	129
493	T.CD4_naive.activated_stress	0.02	Nonsignificant	1.00	0.00	Other	339	429
494	ASTRO.A1_reactive	0.02	Nonsignificant	1.00	0.11	Other	433	394
495	HEP.canalicular_transport.secretory_ERAD_UPR	0.02	Nonsignificant	0.99	0.84	Other	232	28
496	THYMO.proliferative_S	0.02	Nonsignificant	1.00	0.77	Other	163	418
497	MONO.CD16.baseline	0.02	Nonsignificant	1.00	0.84	Other	50	1
498	MAC.resident_cardiac.antigen_presenting	0.02	Nonsignificant	0.81	0.98	Other	52	27
499	EPI.tracheal_suprabasal.transitional_wound	0.02	Nonsignificant	—	0.00	Other	16	1
500	FIB.hepatic_stellate_cell.fibrogenic	0.02	Nonsignificant	—	0.73	Other	0	0
501	FIB.interstitial.remodeling	0.02	Nonsignificant	0.96	0.98	Other	31	9
502	EPI.alveolar_type_1.activated	0.02	Nonsignificant	—	0.00	Other	0	0
503	EPI.renal_distal_tubule.ion_transport	0.02	Nonsignificant	—	0.40	Other	0	0
504	MAC.proliferating.stress	0.02	Nonsignificant	—	0.00	Other	87	136
505	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.02	Nonsignificant	—	0.00	Other	5	3
506	EPI.skin_follicular_keratinizing.upper_infundibulum	0.02	Nonsignificant	—	0.26	Other	8	2
507	EPI.lung_multiciliated.baseline	0.02	Nonsignificant	—	0.00	Other	0	7
508	IPSC.axial_identity_primed	0.02	Nonsignificant	1.00	0.72	Other	0	0
509	THYMO.SP_CD4_naive	0.02	Nonsignificant	0.88	0.93	Other	65	75
510	EPI.skin_sweat_duct_keratinocyte.barrier	0.01	Nonsignificant	—	1.24	Other	0	0
511	FIB.barrier_secretory.remodeling	0.01	Nonsignificant	—	0.00	Other	0	0
512	MUSC.early_activation	0.01	Nonsignificant	0.95	0.39	Other	4	32
513	T.gamma_delta.early_effector	0.01	Nonsignificant	0.92	0.99	Other	89	0
514	EPI.lung_club_secretory.ciliogenesis_axoneme	0.01	Nonsignificant	—	0.00	Other	0	0
515	FIB.adventitial.inflammatory_activated	0.01	Nonsignificant	0.39	1.09	Other	100	473
516	MAC.proliferating.DNA_replication	0.01	Nonsignificant	0.52	0.96	Other	3	6
517	T.CD8_Tem.signaling_turnover	0.01	Nonsignificant	0.16	1.08	Other	425	683
518	T.CD8_Tcm.gut_homing	0.01	Nonsignificant	1.00	0.68	Other	380	112
519	NEU.EXC_SYT2.nuclear_reg	0.01	Nonsignificant	—	0.00	Other	0	0
520	ASPC.stem_like_progenitor	9.21e-03	Nonsignificant	0.38	1.17	Other	300	842
521	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	8.86e-03	Nonsignificant	—	0.00	Other	6	9
522	EPI.skin_keratinocyte_proliferating.anchor_remodel	8.45e-03	Nonsignificant	—	0.00	Other	0	0
523	FIB.hepatic_stellate_cell.contractile	7.91e-03	Nonsignificant	—	0.00	Other	0	0
524	B.germinal_center.DZ_M_phase	7.82e-03	Nonsignificant	—	0.00	Other	0	0
525	ASPC.activated	7.66e-03	Nonsignificant	0.99	0.91	Other	164	162
526	EC.heart_remodeling.capillary_metabolic	7.51e-03	Nonsignificant	1.00	0.98	Other	54	414
527	GRNLSA.secretory_remodeling	7.46e-03	Nonsignificant	0.98	0.79	Other	90	25
528	MAC.kupffer.fibrogenic	7.16e-03	Nonsignificant	—	1.06	Other	0	0
529	MESO.activated_migratory	7.14e-03	Nonsignificant	—	0.23	Other	0	0
530	MESO.antiviral	7.13e-03	Nonsignificant	—	0.00	Other	3	8
531	MG.expanding	7.08e-03	Nonsignificant	0.10	1.32	Other	2	1
532	IPSC.mesendo_primed	6.93e-03	Nonsignificant	1.00	0.73	Other	0	0
533	ASPC.baseline	6.63e-03	Nonsignificant	0.99	1.00	Other	363	170
534	EPI.renal_distal_tubule.stress	6.53e-03	Nonsignificant	—	0.00	Other	0	0
535	THYMO.proliferative_G2M	6.10e-03	Nonsignificant	—	0.00	Other	164	413
536	MONO.CD16.patrolling	6.07e-03	Nonsignificant	1.00	0.73	Other	797	216
537	T.CD8_transitional.stress	5.93e-03	Nonsignificant	—	0.28	Other	24	34
538	MAC.LAM.perivascular_angiocrine	5.86e-03	Nonsignificant	—	0.00	Other	53	138
539	EPI.skin_follicular_keratinizing.transit_amplifying	5.75e-03	Nonsignificant	—	0.00	Other	21	49
540	EC.heart_remodeling.remodeling_secretory	5.69e-03	Nonsignificant	1.00	0.91	Other	605	1,341
541	MAC.kupffer.inflammatory	5.45e-03	Nonsignificant	—	0.40	Other	7	4
542	FIB.barrier_purinergic.stress_GF_binding	5.38e-03	Nonsignificant	—	0.00	Other	0	0
543	ASPC.remodeling	5.38e-03	Nonsignificant	0.99	0.97	Other	106	354
544	T.MAIT.MAPK_brake	5.37e-03	Nonsignificant	0.40	1.08	Other	44	66
545	B.age_associated.naive_transitional	5.36e-03	Nonsignificant	—	0.00	Other	0	0
546	ASPC.secretory	5.33e-03	Nonsignificant	0.99	0.89	Other	76	5
547	T.MAIT.early_activation	5.27e-03	Nonsignificant	0.40	1.08	Other	57	4
548	EC.venous.activated	5.27e-03	Nonsignificant	1.00	0.29	Other	247	752
549	THYMO.DP_early	5.24e-03	Nonsignificant	1.00	0.11	Other	326	313
550	EPI.ectocervical_granular.secretory_apocrine	5.07e-03	Nonsignificant	—	0.00	Other	0	0
551	EPI.pancreatic_islet.alpha	4.83e-03	Nonsignificant	—	0.00	Other	152	330
552	FIB.hepatic_stellate_cell.inflammatory	4.79e-03	Nonsignificant	—	0.00	Other	0	0
553	T.CD8_transitional.early	4.73e-03	Nonsignificant	1.00	0.75	Other	327	55
554	HEP.canalicular_transport.baseline	4.47e-03	Nonsignificant	0.99	0.89	Other	199	477
555	FIB.skin_tenogenic.baseline	4.27e-03	Nonsignificant	—	0.00	Other	0	2
556	HEP.canalicular_transport.ductular_like_transition	4.23e-03	Nonsignificant	0.99	0.90	Other	400	87
557	FIB.suburothelial.urothelial_interface	3.92e-03	Nonsignificant	0.09	1.44	Other	9	8
558	GRNLSA.lipid_hypoxia	3.32e-03	Nonsignificant	0.98	0.68	Other	28	0
559	T.MAIT.cytotoxic	3.31e-03	Nonsignificant	0.40	1.11	Other	52	15
560	FIB.skin_sheath.stress_chaperone	3.28e-03	Nonsignificant	—	0.35	Other	0	0
561	ASPC.signal_integrator	2.85e-03	Nonsignificant	—	0.59	Other	0	0
562	MAC.kupffer.monocyte_like	2.81e-03	Nonsignificant	—	0.21	Other	0	0
563	NEU.EXC_NTNG1.synaptic	2.62e-03	Nonsignificant	—	0.00	Other	0	0
564	FIB.adventitial.adhesion_lipid	2.55e-03	Nonsignificant	1.00	1.03	Other	58	209
565	MAC.kupffer.tolerogenic	2.48e-03	Nonsignificant	—	0.43	Other	45	49
566	NK.cytokine_axis_baseline	2.37e-03	Nonsignificant	1.00	0.90	Other	1,172	116
567	FIB.skin_sheath.ECM_immune	2.20e-03	Nonsignificant	—	0.00	Other	0	0
568	GRNLSA.proliferative_migratory	2.12e-03	Nonsignificant	0.98	0.47	Other	248	292
569	NEU.INH_PVALB.fastspike	2.07e-03	Nonsignificant	—	0.00	Other	24	22
570	MG.phagocytic_APC	1.99e-03	Nonsignificant	0.84	0.89	Other	25	8
571	T.CD8_Tem.baseline	1.89e-03	Nonsignificant	0.77	1.02	Other	458	356
572	T.gamma_delta.central_memory	1.82e-03	Nonsignificant	0.92	0.92	Other	460	919
573	NK.adaptive_axis_baseline	1.78e-03	Nonsignificant	1.00	0.95	Other	1,008	153
574	NEU.INH_PVALB.serotonergic	1.77e-03	Nonsignificant	—	0.00	Other	0	0
575	EPI.ectocervical_granular.immune_interact	1.76e-03	Nonsignificant	—	0.00	Other	0	0
576	MESO.secretory_structural	1.53e-03	Nonsignificant	—	0.20	Other	0	0
577	FIB.interstitial.mesenchymal_APC	1.49e-03	Nonsignificant	1.00	0.82	Other	81	33
578	MG.baseline	1.48e-03	Nonsignificant	0.84	0.85	Other	16	5
579	ASPC.niche_keeping_progenitor	1.46e-03	Nonsignificant	0.99	0.72	Other	52	219
580	EC.liver_sinusoidal.stress	1.37e-03	Nonsignificant	—	0.00	Other	413	158
581	T.MAIT.quiescent	1.32e-03	Nonsignificant	0.96	0.87	Other	100	5
582	NEU.EXC_CT.projector	1.30e-03	Nonsignificant	0.08	1.21	Other	87	26
583	B.age_associated.activated	1.18e-03	Nonsignificant	—	0.00	Other	18	22
584	EPI.salivary_myoepithelial.contractile_repair	1.15e-03	Nonsignificant	—	1.01	Other	3	9
585	EC.heart_remodeling.translation_boost	9.97e-04	Nonsignificant	—	0.22	Other	0	0
586	EC.heart_remodeling.activated_acute	8.44e-04	Nonsignificant	1.00	0.74	Other	102	186
587	EPI.renal_distal_tubule.ciliated_remodelling	7.96e-04	Nonsignificant	—	0.00	Other	0	0
588	EPI.skin_keratinocyte_progenitor.activated_stress	7.95e-04	Nonsignificant	—	0.38	Other	0	0
589	FIB.suburothelial.inflammatory_prostanoid	6.96e-04	Nonsignificant	—	0.00	Other	0	0
590	T.CD4_cytotoxic.precursor	6.74e-04	Nonsignificant	0.66	1.16	Other	156	67
591	GRNLSA.p53_damage	6.60e-04	Nonsignificant	—	0.00	Other	13	10
592	T.CD8_Tcm.effector_bias	6.21e-04	Nonsignificant	1.00	0.31	Other	199	329
593	NK.cytokine_vascular_patrolling	5.83e-04	Nonsignificant	1.00	0.88	Other	863	94
594	FIB.skin_sheath.neuro_vascular_interface	5.41e-04	Nonsignificant	—	6.94e-17	Other	0	0
595	FIB.suburothelial.contractile_myofibroblast	5.35e-04	Nonsignificant	—	0.00	Other	9	0
596	T.CD8_Tem.early_helper_like	5.32e-04	Nonsignificant	0.95	1.02	Other	445	755
597	EPI.skin_hair_follicle_bulge.anagen_growth	5.28e-04	Nonsignificant	—	0.92	Other	0	0
598	MESO.baseline	5.22e-04	Nonsignificant	0.86	0.71	Other	0	6
599	NK.cytokine_biosynthetic_primed	5.16e-04	Nonsignificant	1.00	0.92	Other	360	21
600	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	4.96e-04	Nonsignificant	—	0.97	Other	39	82
601	EPI.salivary_myoepithelial.baseline	4.72e-04	Nonsignificant	0.97	1.03	Other	42	141
602	HEP.acute_phase.hypoxia_lipid	4.68e-04	Nonsignificant	—	0.00	Other	0	0
603	EC.liver_sinusoidal.secretory_lipoprotein	4.61e-04	Nonsignificant	1.00	0.00	Other	120	70
604	T.MAIT.stress	4.49e-04	Nonsignificant	—	0.39	Other	0	0
605	NK.cytokine_quiescent	4.42e-04	Nonsignificant	1.00	0.92	Other	623	1,062
606	EPI.skin_keratinocyte_basal.basement_anchoring	4.21e-04	Nonsignificant	—	0.00	Other	0	0
607	MAC.kupffer.stress	3.00e-04	Nonsignificant	0.95	0.67	Other	9	3
608	EPI.salivary_myoepithelial.junctional_transport	2.74e-04	Nonsignificant	0.97	0.89	Other	66	121
609	T.MAIT.vesicle	2.58e-04	Nonsignificant	0.96	0.60	Other	37	65
610	EPI.skin_hair_follicle_bulge.niche_crosstalk	2.14e-04	Nonsignificant	—	0.00	Other	29	88
611	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	1.97e-04	Nonsignificant	—	1.44	Other	0	0
612	GRNLSA.angiocrine_mechanosensory	1.92e-04	Nonsignificant	—	0.00	Other	0	0
613	NK.cytokine_repair_primed	1.82e-04	Nonsignificant	1.00	0.93	Other	266	11
614	EPI.skin_hair_follicle_bulge.quiescent	1.73e-04	Nonsignificant	0.77	0.84	Other	56	69
615	NK.adaptive_classII_inhibitory	1.73e-04	Nonsignificant	1.00	0.88	Other	880	154
616	FIB.interstitial.lipid_matrix	1.49e-04	Nonsignificant	1.00	0.47	Other	258	191
617	EC.heart_remodeling.remodeling_stalk	1.38e-04	Nonsignificant	1.00	0.50	Other	33	111
618	FIB.suburothelial.homeostasis_matrix	1.37e-04	Nonsignificant	1.00	0.00	Other	258	921
619	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	1.26e-04	Nonsignificant	0.93	1.15	Other	7	16
620	T.CD8_Tem.TEMRA	1.13e-04	Nonsignificant	0.96	0.98	Other	920	1,088
621	EPI.salivary_myoepithelial.activated	1.04e-04	Nonsignificant	0.97	0.62	Other	85	281
622	FIB.adventitial.PI16_matrix	9.88e-05	Nonsignificant	1.00	0.85	Other	70	90
623	GRANU.neutrophil.antiviral_endotoxin	9.23e-05	Nonsignificant	—	0.00	Other	0	0
624	GRANU.neutrophil.primed_degranulation	9.16e-05	Nonsignificant	—	0.64	Other	0	0
625	ADIPO.thermogenic	9.01e-05	Nonsignificant	—	1.09	Other	0	0
626	EPI.tracheal_basal.activated_stress	8.78e-05	Nonsignificant	0.33	1.27	Other	32	0
627	FIB.adventitial.baseline	8.41e-05	Nonsignificant	1.00	0.85	Other	157	278
628	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	8.28e-05	Nonsignificant	—	0.97	Other	0	0
629	T.CD4_cytotoxic.NK_adapted	6.20e-05	Nonsignificant	0.85	1.01	Other	82	33
630	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	6.03e-05	Nonsignificant	—	0.00	Other	0	0
631	FIB.skin_papillary.baseline	5.77e-05	Nonsignificant	—	0.00	Other	0	0
632	T.CD4_cytotoxic.baseline	5.50e-05	Nonsignificant	0.85	1.09	Other	0	0
633	SKM.type_2_fast.oxidative_IIa	5.46e-05	Nonsignificant	0.08	1.02	Other	946	56
634	NK.adaptive_immature_precursor	5.40e-05	Nonsignificant	1.00	0.89	Other	358	111
635	FIB.adventitial.mechano_chemo_sensing	4.78e-05	Nonsignificant	1.00	0.77	Other	135	524
636	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	4.25e-05	Nonsignificant	—	0.00	Other	0	0
637	EPI.skin_sebaceous_duct_luminal.detox_repair	4.23e-05	Nonsignificant	0.29	1.30	Other	137	94
638	EC.heart_remodeling.perivascular	4.16e-05	Nonsignificant	1.00	0.48	Other	124	408
639	NK.adaptive_HLAE_tuned	3.75e-05	Nonsignificant	1.00	0.82	Other	1,124	189
640	EPI.tracheal_basal.homeostatic_progenitor	3.63e-05	Nonsignificant	0.91	0.57	Other	285	74
641	ADIPO.hypoxia_remodelling	3.48e-05	Nonsignificant	—	0.00	Other	29	105
642	T.CD4_cytotoxic.terminal_effector	3.44e-05	Nonsignificant	0.85	0.93	Other	286	21
643	ASPC.mesothelial_like	2.65e-05	Nonsignificant	0.99	0.53	Other	143	486
644	PLAT.megakaryocytic	2.55e-05	Nonsignificant	—	0.00	Other	0	0
645	ADIPO.inflammatory	2.41e-05	Nonsignificant	—	0.28	Other	0	0
646	NEU.EXC_CT.remodeling	2.26e-05	Nonsignificant	—	0.00	Other	23	1
647	EPI.skin_hair_follicle_companion.activated_migratory	2.18e-05	Nonsignificant	—	0.00	Other	0	0
648	FIB.adventitial.activated_remodelling	2.09e-05	Nonsignificant	—	0.22	Other	141	319
649	MAC.alveolar.capillary_interacting	2.02e-05	Nonsignificant	0.22	1.26	Other	113	181
650	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	1.94e-05	Nonsignificant	0.78	0.71	Other	449	1,034
651	T.CD8_Tem.stress_adapted	1.75e-05	Nonsignificant	0.96	0.94	Other	607	520
652	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	1.71e-05	Nonsignificant	0.53	1.02	Other	2	9
653	NK.adaptive_biosynthetic_primed	1.56e-05	Nonsignificant	1.00	0.84	Other	244	405
654	T.CD8_Tcm.NK_like	1.28e-05	Nonsignificant	1.00	0.07	Other	334	581
655	FIB.adventitial.complement_angiocrine	1.11e-05	Nonsignificant	1.00	0.65	Other	153	684
656	NK.adaptive_adipose_stress	9.51e-06	Nonsignificant	1.00	0.71	Other	374	39
657	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	8.83e-06	Nonsignificant	—	0.00	Other	0	0
658	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	7.10e-06	Nonsignificant	—	0.00	Other	0	0
659	EPI.skin_hair_follicle_companion.gap_junction_contractile	5.89e-06	Nonsignificant	—	0.00	Other	0	0
660	EPI.renal_distal_tubule.immune_modulatory	5.88e-06	Nonsignificant	—	0.00	Other	0	0
661	MAC.kupffer.metabolic	4.51e-06	Nonsignificant	—	0.00	Other	25	36
662	NEU.INH_PVALB.neuromodulatory	4.17e-06	Nonsignificant	—	0.00	Other	0	0
663	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	3.41e-06	Nonsignificant	0.93	0.63	Other	33	34
664	EPI.skin_appendage_keratinocyte.transit_amplifying	3.07e-06	Nonsignificant	—	0.00	Other	109	358
665	NEU.EXC_CT.Ca2_signaling	3.04e-06	Nonsignificant	—	0.00	Other	68	17
666	NK.adaptive_terminal_cytotoxic	1.33e-06	Nonsignificant	1.00	0.57	Other	485	802
667	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	1.32e-06	Nonsignificant	—	0.00	Other	0	0
668	T.CD4_cytotoxic.activated	9.77e-07	Nonsignificant	0.85	0.87	Other	3	1
669	MAC.alveolar.stress_metabolic	9.61e-07	Nonsignificant	0.54	1.13	Other	116	148
670	ADIPO.immature	8.94e-07	Nonsignificant	—	0.00	Other	24	40
671	MONO.CD14.cord_tolerance	8.82e-07	Nonsignificant	1.00	0.05	Other	864	753
672	FIB.adventitial.mito_secretory	8.53e-07	Nonsignificant	1.00	0.49	Other	21	7
673	MAC.alveolar.inflammatory	7.36e-07	Nonsignificant	0.59	1.05	Other	208	312
674	T.CD8_Tem.motility_primed	4.99e-07	Nonsignificant	0.96	0.80	Other	269	4
675	EPI.skin_sebaceous_duct_luminal.immune_interface	3.32e-07	Nonsignificant	—	0.00	Other	0	0
676	GRANU.neutrophil.tissue_patrolling	2.82e-07	Nonsignificant	—	0.00	Other	0	0
677	EPI.skin_sweat_duct_keratinocyte.repair	1.39e-07	Nonsignificant	—	0.85	Other	0	0
678	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	1.25e-07	Nonsignificant	—	0.92	Other	0	0
679	MAC.alveolar.biosynthetic_sterol_heme	6.39e-08	Nonsignificant	0.90	0.78	Other	347	40
680	MAC.alveolar.lipid_autophagy	3.76e-08	Nonsignificant	—	0.00	Other	35	44
681	EPI.skin_sweat_duct_keratinocyte.signal_gate	2.75e-08	Nonsignificant	—	0.00	Other	43	26
682	SKM.type_2_fast.glycolytic_IIx_IIb	4.86e-09	Nonsignificant	0.77	0.97	Other	565	1,482
683	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	2.16e-09	Nonsignificant	—	0.00	Other	0	0
684	MAC.alveolar.scavenging_endocytic	1.56e-09	Nonsignificant	—	0.00	Other	140	283
685	NEU.EXC_CT.Ca2_sensor	1.03e-10	Nonsignificant	—	0.00	Other	0	0
686	EPI.skin_keratinocyte_proliferating.detox_repair	3.91e-12	Nonsignificant	—	0.00	Other	0	0
687	EPI.skin_sweat_duct_keratinocyte.proliferative_S	2.22e-12	Nonsignificant	—	0.00	Other	0	0
688	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	1.12e-15	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

0 unique genes. Showing 0–0. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Browsers	Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.