Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000014 · All tissues

Acute alcohol intoxication: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Alcohol use disorder

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	oligodendrocyte	37.94	Significant	4.49e-27	1.16	Specific	385	1,507
2	oligodendrocyte_precursor_cell	20.18	Significant	0.04	1.11	Relevant	461	1,454
3	neuron	12.01	Significant	0.04	1.06	Relevant	330	1,328
4	melanocyte	10.97	Significant	1.00	1.03	Relevant	97	309
5	haematopoietic_progenitor_cell	10.10	Significant	1.00	1.02	Relevant	262	502
6	astrocyte	9.96	Significant	0.72	1.03	Relevant	256	1,203
7	induced_pluripotent_stem_cell	5.82	Significant	0.65	1.02	Other	0	0
8	epithelial_cell	4.94	Nominal	0.08	1.02	Other	24	47
9	dendritic_cell	3.92	Nominal	1.00	0.91	Other	496	724
10	hepatocyte	1.55	Nonsignificant	1.00	0.96	Other	1,515	3,822
11	skeletal_muscle_cell	1.24	Nonsignificant	1.00	0.88	Other	944	2,600
12	cardiomyocyte	1.01	Nonsignificant	1.00	0.93	Other	533	2,045
13	chondrocyte	0.94	Nonsignificant	1.00	0.85	Other	548	1,069
14	microglia	0.76	Nonsignificant	1.00	0.82	Other	61	129
15	schwann_cell	0.58	Nonsignificant	1.00	0.84	Other	10	57
16	granulocyte	0.52	Nonsignificant	1.00	0.87	Other	5	6
17	platelet	0.23	Nonsignificant	—	0.56	Other	85	104
18	smooth_muscle_cell	0.23	Nonsignificant	1.00	0.72	Other	27	139
19	thymocyte	0.20	Nonsignificant	1.00	0.76	Other	168	512
20	macrophage	0.16	Nonsignificant	1.00	0.74	Other	813	1,732
21	fibroblast	0.15	Nonsignificant	1.00	0.75	Other	184	826
22	innate_lymphoid_cell_2	0.12	Nonsignificant	1.00	0.81	Other	3	8
23	granulosa_cell	0.09	Nonsignificant	1.00	0.67	Other	293	670
24	endothelial_cell	0.08	Nonsignificant	1.00	0.70	Other	373	974
25	muscle_stem_cell	0.08	Nonsignificant	1.00	0.68	Other	7	27
26	monocyte	0.07	Nonsignificant	1.00	0.64	Other	2,176	3,871
27	plasma_cell	0.07	Nonsignificant	1.00	0.62	Other	17	24
28	pericyte	0.04	Nonsignificant	1.00	0.57	Other	128	517
29	B_cell	0.03	Nonsignificant	1.00	0.62	Other	356	694
30	adipose_stem_and_progenitor_cell	0.02	Nonsignificant	1.00	0.60	Other	327	954
31	T_cell	0.02	Nonsignificant	1.00	0.46	Other	470	959
32	natural_killer_cell	1.89e-03	Nonsignificant	1.00	0.48	Other	1,204	2,052
33	mesothelial_cell	6.93e-04	Nonsignificant	1.00	0.29	Other	6	36
34	adipocyte	2.61e-04	Nonsignificant	1.00	0.34	Other	33	111

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	OLG.oligodendrocyte	37.94	Significant	—	—	Specific	384	1,397
2	EPI.pancreatic_acinar	34.41	Significant	2.80e-09	1.31	Specific	429	1,475
3	EPI.intrahepatic_cholangiocyte_transport	20.66	Significant	—	1.50	Relevant	12	42
4	OPC.oligodendrocyte_precursor_cell	20.18	Significant	—	—	Relevant	413	1,269
5	DC.pDC	19.96	Significant	1.28e-08	1.39	Specific	496	1,028
6	NEU.EXC_IT	18.05	Significant	8.00e-16	2.30	—	411	192
7	EPI.bile_duct_cholangiocyte	17.76	Significant	1.00	1.26	Relevant	37	60
8	EPI.salivary_mucous_acinar	17.42	Significant	0.01	1.24	Specific	639	1,189
9	EPI.pancreatic_islet	16.53	Significant	1.00	1.17	Relevant	52	132
10	MEL.melanocyte	10.97	Significant	—	—	Relevant	79	242
11	HPC.haematopoietic_progenitor_cell	10.10	Significant	—	—	Relevant	211	370
12	ASTRO.astrocyte	9.96	Significant	—	—	Relevant	228	1,111
13	NEU.EXC_NTNG1	9.23	Significant	—	0.00	—	0	0
14	EPI.salivary_duct_excretory	8.73	Significant	1.00	1.03	Relevant	85	180
15	NEU.INH_VIP	8.33	Significant	1.00	0.56	—	241	366
16	EPI.pancreatic_ductal_bicarbonate	7.43	Significant	1.00	1.09	Relevant	131	548
17	EPI.ileal_goblet	6.70	Significant	1.00	1.06	Relevant	181	432
18	NEU.INH_LAMP5	6.16	Significant	1.00	0.38	—	263	532
19	IPSC.induced_pluripotent_stem_cell	5.82	Significant	—	—	Other	0	0
20	NEU.INH_PVALB	4.31	Nominal	1.00	0.29	Other	193	183
21	FIB.transitioning	4.21	Nominal	0.16	1.22	Other	172	497
22	EPI.pancreatic_ductal_progenitor	3.85	Nominal	1.00	1.02	Other	234	873
23	EPI.esophageal_suprabasal	3.81	Nominal	1.00	0.93	Other	158	404
24	EPI.pancreatic_ductal_perivascular	3.68	Nominal	1.00	0.97	Other	4	30
25	NEU.EXC_SYT2	3.45	Nominal	—	0.00	Other	40	77
26	EPI.endocervical_secretory	3.28	Nominal	—	0.57	Other	0	0
27	EPI.hepatic_ductular_cholangiocyte	3.15	Nominal	1.00	0.87	Other	83	243
28	EPI.colonic_enteroendocrine	2.88	Nonsignificant	—	0.58	Other	1	1
29	HEP.periportal_metabolic	2.86	Nonsignificant	8.45e-14	1.50	Other	1,750	4,427
30	EPI.intrahepatic_cholangiocyte_defense	2.83	Nonsignificant	—	0.57	Other	8	13
31	EPI.renal_proximal_tubule	2.76	Nonsignificant	1.00	0.95	Other	525	806
32	EPI.extrahepatic_cholangiocyte	2.67	Nonsignificant	—	0.51	Other	37	71
33	EPI.salivary_intercalated_defense	2.35	Nonsignificant	1.00	0.93	Other	81	161
34	EPI.cervical_suprabasal	2.30	Nonsignificant	—	0.52	Other	14	50
35	SKM.type_1_slow	2.25	Nonsignificant	9.28e-40	2.40	Other	923	2,478
36	HEP.acute_phase	1.85	Nonsignificant	0.11	1.10	Other	1,441	3,641
37	EC.lymphatic	1.52	Nonsignificant	5.25e-07	1.26	Other	630	998
38	EPI.salivary_duct_ion_transport	1.26	Nonsignificant	1.00	0.86	Other	5	11
39	EPI.salivary_serous_acinar	1.04	Nonsignificant	1.00	0.72	Other	233	531
40	CM.cardiomyocyte	1.01	Nonsignificant	—	—	Other	524	2,032
41	CHOND.chondrocyte	0.94	Nonsignificant	—	—	Other	519	730
42	NEU.EXC_CT	0.88	Nonsignificant	1.00	0.00	Other	362	384
43	EPI.renal_thick_ascending_limb	0.84	Nonsignificant	1.00	0.65	Other	453	1,153
44	GRANU.MAST	0.83	Nonsignificant	4.69e-04	1.76	Other	5	6
45	DC.cDC1	0.82	Nonsignificant	1.00	0.63	Other	55	112
46	MAC.microglia_like	0.81	Nonsignificant	0.24	1.22	Other	124	179
47	MG.microglia	0.76	Nonsignificant	—	—	Other	49	0
48	EPI.colonic_tuft	0.75	Nonsignificant	—	0.11	Other	7	24
49	DC.cDC2	0.74	Nonsignificant	1.00	0.20	Other	1,189	1,793
50	T.CD4_Th2	0.68	Nonsignificant	—	2.06	Other	1	2
51	FIB.reticular	0.62	Nonsignificant	0.61	1.10	Other	19	87
52	EPI.lung_club_secretory	0.60	Nonsignificant	1.00	0.78	Other	5	14
53	SCHWN.schwann_cell	0.58	Nonsignificant	—	—	Other	7	33
54	SKM.type_2_fast	0.50	Nonsignificant	1.00	0.21	Other	972	2,639
55	EPI.gastric_foveolar	0.46	Nonsignificant	—	0.00	Other	0	0
56	EPI.esophageal_basal	0.45	Nonsignificant	1.00	0.66	Other	4	10
57	FIB.neurolectin_mucosa	0.39	Nonsignificant	0.61	1.08	Other	133	394
58	EPI.renal_principal_cell	0.39	Nonsignificant	1.00	0.54	Other	207	403
59	EPI.ileal_bile_transport	0.39	Nonsignificant	1.00	0.65	Other	61	93
60	MAC.resident_cardiac	0.37	Nonsignificant	4.08e-05	1.27	Other	485	1,074
61	EPI.alveolar_type_2	0.36	Nonsignificant	1.00	0.45	Other	813	1,853
62	MAC.MDM	0.36	Nonsignificant	0.05	1.16	Other	623	986
63	EPI.ileal_enterocyte_crypt	0.32	Nonsignificant	1.00	0.46	Other	67	113
64	EPI.ectocervical_granular	0.32	Nonsignificant	—	0.00	Other	11	23
65	EPI.tracheal_suprabasal	0.27	Nonsignificant	1.00	0.51	Other	29	56
66	FIB.tracheal_subepithelial	0.23	Nonsignificant	—	1.27	Other	0	0
67	PLAT.platelet	0.23	Nonsignificant	—	0.00	Other	38	53
68	SMC.smooth_muscle_cell	0.23	Nonsignificant	—	—	Other	20	101
69	EPI.tracheal_submucosal_gland	0.21	Nonsignificant	—	0.00	Other	0	0
70	FIB.suburothelial	0.20	Nonsignificant	0.70	1.03	Other	122	432
71	THYMO.thymocyte	0.20	Nonsignificant	—	—	Other	163	495
72	PC.IgG_systemic	0.18	Nonsignificant	0.02	1.32	Other	41	60
73	T.CD4_transitional	0.17	Nonsignificant	0.13	1.15	Other	48	110
74	B.age_associated	0.16	Nonsignificant	0.46	1.13	Other	207	350
75	FIB.skin_tenogenic	0.14	Nonsignificant	—	0.97	Other	108	227
76	FIB.perivascular_interface	0.14	Nonsignificant	0.83	0.98	Other	0	0
77	FIB.lung_alveolar	0.14	Nonsignificant	—	0.95	Other	6	15
78	EPI.lung_multiciliated	0.13	Nonsignificant	1.00	0.53	Other	16	49
79	B.germinal_center	0.13	Nonsignificant	0.47	1.13	Other	233	655
80	MAC.resident_iron	0.12	Nonsignificant	1.00	0.83	Other	16	21
81	EPI.skin_interfollicular_spinous	0.12	Nonsignificant	1.00	0.40	Other	260	563
82	FIB.barrier_secretory	0.12	Nonsignificant	0.56	1.22	Other	81	228
83	ILC2.innate_lymphoid_cell_2	0.12	Nonsignificant	—	—	Other	2	0
84	EPI.thymic_medullary	0.12	Nonsignificant	1.00	0.37	Other	26	133
85	EPI.ileal_enterocyte_absorptive	0.11	Nonsignificant	1.00	0.39	Other	118	338
86	FIB.skin_sheath	0.11	Nonsignificant	0.83	0.96	Other	49	118
87	MAC.resident_repair	0.10	Nonsignificant	1.00	0.94	Other	796	1,426
88	EPI.thymic_cortical	0.10	Nonsignificant	1.00	0.42	Other	442	824
89	GRNLSA.granulosa_cell	0.09	Nonsignificant	—	—	Other	257	0
90	FIB.skin_papillary	0.09	Nonsignificant	—	0.78	Other	0	0
91	T.gamma_delta	0.08	Nonsignificant	4.18e-04	1.21	Other	588	1,078
92	FIB.barrier_purinergic	0.08	Nonsignificant	—	0.77	Other	1	3
93	MONO.CD14	0.08	Nonsignificant	1.91e-21	1.36	Other	2,294	4,139
94	MUSC.muscle_stem_cell	0.08	Nonsignificant	—	—	Other	4	18
95	FIB.skin_neurosecretory	0.08	Nonsignificant	—	0.75	Other	0	0
96	HEP.pericentral_lipoprotein	0.07	Nonsignificant	—	0.00	Other	0	0
97	FIB.hepatic_stellate_cell	0.07	Nonsignificant	—	0.72	Other	64	252
98	EPI.colonocyte	0.07	Nonsignificant	1.00	0.42	Other	294	815
99	EC.liver_sinusoidal	0.06	Nonsignificant	1.00	0.98	Other	1,083	1,925
100	MAC.kupffer	0.06	Nonsignificant	1.00	0.78	Other	189	530
101	EPI.pancreatic_ductal_mucinous	0.06	Nonsignificant	1.00	0.37	Other	219	430
102	EPI.renal_distal_tubule	0.06	Nonsignificant	1.00	0.48	Other	133	361
103	EPI.skin_sweat_duct_keratinocyte	0.06	Nonsignificant	1.00	0.80	Other	146	301
104	PC.IgA_muocsal	0.05	Nonsignificant	1.00	0.36	Other	18	31
105	EPI.tracheal_basal	0.04	Nonsignificant	1.00	0.32	Other	398	1,120
106	PERI.pericyte	0.04	Nonsignificant	—	—	Other	117	0
107	T.CD4_Tem	0.04	Nonsignificant	0.82	1.04	Other	365	697
108	T.CD8_Trm	0.04	Nonsignificant	0.65	1.06	Other	211	346
109	B.naive	0.04	Nonsignificant	0.47	1.01	Other	307	595
110	EC.arterial	0.04	Nonsignificant	1.00	0.97	Other	356	885
111	T.CD4_Th17	0.03	Nonsignificant	0.81	1.08	Other	421	794
112	EPI.renal_immature_ureteric_bud	0.03	Nonsignificant	1.00	0.26	Other	217	569
113	T.CD4_Tfh	0.03	Nonsignificant	0.82	1.01	Other	47	45
114	EPI.renal_intercalated_cell_type_A	0.02	Nonsignificant	1.00	0.26	Other	67	142
115	DC.mig	0.02	Nonsignificant	—	0.00	Other	89	156
116	ASPC.adipose_stem_and_progenitor_cell	0.02	Nonsignificant	—	—	Other	324	930
117	FIB.interstitial	0.02	Nonsignificant	1.00	0.71	Other	288	940
118	EC.venous	0.02	Nonsignificant	1.00	0.81	Other	516	1,387
119	T.CD8_transitional	0.02	Nonsignificant	0.43	1.06	Other	497	932
120	T.CD4_Trm	0.02	Nonsignificant	0.82	1.00	Other	176	363
121	T.CD4_Treg	0.02	Nonsignificant	0.82	1.01	Other	244	511
122	FIB.adventitial	0.02	Nonsignificant	1.00	0.62	Other	268	1,447
123	B.memory	0.02	Nonsignificant	1.00	0.88	Other	442	882
124	T.CD8_naive	0.02	Nonsignificant	1.00	0.89	Other	317	708
125	HEP.canalicular_transport	0.02	Nonsignificant	1.00	0.00	Other	1,290	3,434
126	EC.heart_remodeling	0.01	Nonsignificant	0.11	1.11	Other	569	1,594
127	EPI.skin_hair_follicle_companion	0.01	Nonsignificant	—	0.00	Other	8	12
128	MAC.LAM	0.01	Nonsignificant	1.00	0.66	Other	914	2,064
129	T.CD4_naive	9.80e-03	Nonsignificant	1.00	0.84	Other	399	866
130	EPI.skin_hair_follicle_bulge	8.72e-03	Nonsignificant	1.00	0.28	Other	51	178
131	EC.capillary	6.75e-03	Nonsignificant	1.00	0.54	Other	514	1,635
132	MAC.proliferating	5.49e-03	Nonsignificant	1.00	0.82	Other	87	253
133	T.CD4_Tcm	5.25e-03	Nonsignificant	1.00	0.84	Other	494	988
134	MONO.CD16	5.14e-03	Nonsignificant	1.00	0.64	Other	1,304	1,835
135	EPI.renal_intercalated_cell_type_B	4.63e-03	Nonsignificant	—	0.00	Other	6	7
136	T.MAIT	3.03e-03	Nonsignificant	1.00	0.74	Other	469	855
137	EPI.skin_appendage_keratinocyte	2.47e-03	Nonsignificant	1.00	0.20	Other	87	222
138	EPI.skin_keratinocyte_progenitor	2.00e-03	Nonsignificant	—	0.00	Other	0	3
139	NK.natural_killer_cell	1.89e-03	Nonsignificant	—	—	Other	1,204	2,045
140	EPI.skin_keratinocyte_proliferating	1.77e-03	Nonsignificant	1.00	0.19	Other	47	76
141	T.CD4_cytotoxic	1.39e-03	Nonsignificant	0.82	0.99	Other	855	1,493
142	EPI.alveolar_type_1	1.28e-03	Nonsignificant	1.00	0.12	Other	26	101
143	T.CD8_Tcm	1.06e-03	Nonsignificant	1.00	0.57	Other	460	926
144	GRANU.neutrophil	1.00e-03	Nonsignificant	1.00	0.00	Other	1,235	2,649
145	MESO.mesothelial_cell	6.93e-04	Nonsignificant	—	—	Other	2	18
146	T.CD8_Tem	6.91e-04	Nonsignificant	0.82	1.00	Other	1,083	1,857
147	EPI.salivary_myoepithelial	4.50e-04	Nonsignificant	1.00	0.08	Other	191	714
148	ADIPO.adipocyte	2.61e-04	Nonsignificant	—	—	Other	20	62
149	EPI.skin_sebaceous_duct_luminal	2.06e-04	Nonsignificant	1.00	0.07	Other	100	249
150	EPI.skin_follicular_keratinizing	1.91e-04	Nonsignificant	1.00	0.07	Other	30	81
151	EPI.skin_keratinocyte_basal	1.51e-04	Nonsignificant	—	0.00	Other	13	26
152	MAC.alveolar	8.91e-06	Nonsignificant	1.00	0.36	Other	1,432	3,122

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.pancreatic_acinar.quiet_dedifferentiation	75.12	Significant	1.97e-04	1.95	—	142	171
2	OLG.regulatory_activated	54.01	Significant	3.43e-05	2.40	Specific	196	614
3	OLG.regulatory	49.40	Significant	4.57e-14	2.78	—	353	73
4	EPI.pancreatic_acinar.baseline	46.35	Significant	1.55e-03	1.72	—	274	163
5	OLG.vesicle_trafficking	38.83	Significant	0.88	0.98	—	124	10
6	OLG.stress	37.08	Significant	0.88	1.04	—	232	8
7	OLG.myelinating_mature	33.85	Significant	1.00	0.77	—	363	94
8	OLG.myelinating_stress	33.46	Significant	1.00	0.42	—	232	62
9	EPI.pancreatic_acinar.inflammatory_regenerative	32.64	Significant	0.67	1.12	Relevant	25	113
10	EPI.pancreatic_islet.beta	29.56	Significant	0.05	1.50	—	42	57
11	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	27.24	Significant	—	1.15	—	0	0
12	EPI.pancreatic_acinar.stress	25.22	Significant	1.00	0.70	—	28	28
13	NEU.EXC_IT.structural	24.92	Significant	6.71e-05	2.53	—	171	41
14	DC.pDC.immature_metabolic	24.72	Significant	0.27	1.40	Relevant	78	124
15	OPC.homeostatic	24.14	Significant	6.33e-05	2.82	—	394	160
16	DC.pDC.baseline	23.90	Significant	0.69	1.03	Relevant	88	123
17	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	23.75	Significant	—	0.00	—	0	0
18	NEU.EXC_IT.adhesion	21.61	Significant	0.19	1.58	—	252	108
19	EPI.bile_duct_cholangiocyte.inflammatory_APC	20.42	Significant	—	0.76	—	2	0
20	ASTRO.synaptic_interaction	20.09	Significant	3.47e-03	1.66	Specific	76	334
21	NEU.EXC_IT.guidance	18.87	Significant	0.76	1.12	—	274	63
22	HPC.MEP	18.60	Significant	7.77e-03	1.89	Specific	599	1,195
23	IPSC.mesenchymal_primed	18.13	Significant	9.19e-12	1.39	Relevant	0	0
24	OPC.proliferative_immune_interact	17.96	Significant	0.97	0.66	Relevant	180	373
25	OPC.premyelinating	17.57	Significant	0.97	0.26	—	185	12
26	EPI.salivary_mucous_acinar.baseline	17.42	Significant	—	—	Relevant	394	683
27	IPSC.neural_primed	16.52	Significant	5.06e-03	1.24	Relevant	0	0
28	MEL.mature_oxidative_traffic	16.49	Significant	8.49e-03	1.83	—	247	285
29	EPI.pancreatic_acinar.metabolic_onecarbon	15.51	Significant	1.00	0.20	—	287	328
30	NEU.EXC_IT.transitional	15.13	Significant	0.99	0.50	—	237	142
31	EPI.bile_duct_cholangiocyte.secretory_mucin	14.95	Significant	—	0.00	Relevant	7	12
32	EPI.pancreatic_islet.delta	14.85	Significant	—	0.13	Relevant	0	0
33	IPSC.midbrain_primed	14.47	Significant	0.65	1.09	Relevant	0	0
34	ASTRO.hypoxia_angiogenic	14.35	Significant	0.75	1.19	Relevant	5	18
35	NEU.EXC_NTNG1.nuclear_reg	13.97	Significant	—	0.67	—	0	0
36	EPI.pancreatic_acinar.adhesion_remodeling	13.79	Significant	1.00	0.22	Relevant	210	784
37	NEU.INH_VIP.nuclear_reg	13.62	Significant	—	1.16	—	20	4
38	ASTRO.stress_mito	13.51	Significant	1.00	0.94	—	47	110
39	ASTRO.homeostatic	12.64	Significant	0.42	1.25	—	200	431
40	NEU.EXC_IT.callosal	12.59	Significant	0.99	0.18	—	286	119
41	NEU.EXC_IT.neuromodulated	12.40	Significant	0.99	0.21	—	176	116
42	HPC.MPP_activated	11.88	Significant	—	0.56	—	0	0
43	OLG.reactive_repair	11.55	Significant	1.00	0.02	—	385	385
44	EPI.salivary_duct_excretory.stress	11.09	Significant	0.50	1.33	Relevant	33	68
45	ASTRO.immature_lipid	11.02	Significant	0.75	1.10	Relevant	23	113
46	NEU.INH_VIP.canonical_disinhibitory	10.74	Significant	0.10	1.53	—	59	38
47	HPC.MPP_IEG	10.48	Significant	0.95	0.90	—	45	46
48	DC.pDC.poised_migratory	10.25	Significant	0.96	0.47	Relevant	54	95
49	MEL.stress_glucocorticoid	10.13	Significant	0.96	0.69	Relevant	11	34
50	NEU.INH_VIP.regulatory_remodeling	9.87	Significant	—	0.27	—	6	1
51	EPI.pancreatic_ductal_bicarbonate.activated	9.65	Significant	0.29	1.48	—	10	7
52	MEL.dedifferentiated_migratory	9.63	Significant	—	0.00	—	0	0
53	NEU.INH_LAMP5.exc_inh_balance	9.32	Significant	—	0.94	—	46	2
54	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	9.14	Significant	—	0.00	—	0	0
55	IPSC.stress	9.13	Significant	0.65	1.08	Other	0	0
56	ASTRO.A2_reactive	9.07	Significant	1.00	0.76	Relevant	10	37
57	NEU.INH_VIP.opioid	8.96	Significant	—	0.21	—	50	9
58	IPSC.endoderm_primed	8.32	Significant	1.00	0.86	Relevant	0	0
59	EPI.pancreatic_ductal_bicarbonate.baseline	8.14	Significant	0.29	1.50	Relevant	11	42
60	MEL.secretory_quiescent	8.05	Significant	0.96	0.44	—	19	13
61	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	7.99	Significant	—	0.28	Relevant	0	0
62	NEU.INH_VIP.excitatory_coupled	7.89	Significant	—	0.00	—	13	0
63	EPI.ileal_goblet.baseline	7.84	Significant	0.13	1.76	—	16	2
64	EPI.salivary_duct_excretory.baseline	7.67	Significant	0.90	0.43	Relevant	23	57
65	IPSC.neuroendocrine_primed	7.65	Significant	—	0.59	Relevant	0	0
66	NEU.INH_VIP.serotonergic	7.48	Significant	—	0.00	—	9	2
67	EPI.pancreatic_ductal_bicarbonate.inflammatory	7.40	Significant	0.68	1.07	Relevant	14	32
68	EPI.ileal_goblet.stress_metallothionein	7.37	Significant	—	0.03	Relevant	4	11
69	NEU.INH_VIP.cannabinoid	7.16	Significant	—	0.00	—	0	0
70	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	7.01	Significant	0.77	0.70	Relevant	40	191
71	HPC.LMPP	6.97	Significant	0.95	0.45	—	65	31
72	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	6.81	Significant	0.68	0.93	Relevant	219	533
73	NEU.INH_PVALB.chandelier	6.53	Significant	9.43e-04	2.33	—	19	16
74	HPC.GMP_granulocytic	6.48	Significant	—	0.00	Other	3	3
75	HPC.GMP_inflammatory	6.31	Significant	0.95	0.51	—	20	10
76	EPI.ileal_goblet.inflammatory_mucin	6.08	Significant	0.93	0.28	Relevant	6	9
77	ASTRO.neuromodulatory	5.91	Significant	1.00	0.65	Other	34	172
78	FIB.transitioning.ISG_primed_interface	5.74	Significant	—	0.74	Relevant	17	80
79	NEU.INH_VIP.matrix	5.54	Significant	—	0.00	—	24	77
80	HEP.periportal_metabolic.inflammatory_activated	5.44	Nominal	3.25e-06	2.15	Other	712	1,610
81	EPI.hepatic_ductular_cholangiocyte.secretory_transport	5.37	Nominal	—	1.44	Other	0	0
82	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	5.07	Nominal	—	0.00	Other	49	237
83	EPI.salivary_serous_acinar.seromucous_like	4.96	Nominal	—	2.08	Other	0	0
84	EPI.hepatic_ductular_cholangiocyte.polarity	4.93	Nominal	—	0.70	Other	0	0
85	NEU.EXC_SYT2.synaptic	4.89	Nominal	—	0.48	Other	0	0
86	IPSC.stromal_primed	4.80	Nominal	1.00	0.87	Other	0	0
87	FIB.transitioning.matrix_stress	4.63	Nominal	—	0.18	Other	47	138
88	NEU.INH_LAMP5.glial_interface	4.58	Nominal	—	6.94e-17	Other	0	0
89	EPI.esophageal_suprabasal.differentiating_keratin	4.41	Nominal	0.01	2.12	Other	131	61
90	EPI.esophageal_suprabasal.proliferative_G2M	4.37	Nominal	—	0.23	Other	0	0
91	EPI.salivary_intercalated_defense.inflammatory	4.33	Nominal	0.08	1.41	Other	152	360
92	EPI.pancreatic_ductal_perivascular.protective_antioxidant	4.33	Nominal	—	0.64	Other	11	69
93	EPI.pancreatic_ductal_bicarbonate.stress	4.28	Nominal	—	0.00	Other	12	33
94	EPI.hepatic_ductular_cholangiocyte.ion_transport	4.28	Nominal	—	0.58	Other	0	0
95	EPI.endocervical_secretory.secretory_translocon	4.25	Nominal	—	0.67	Other	0	0
96	NEU.INH_PVALB.nuclear_reg	4.25	Nominal	0.67	0.82	Other	25	12
97	NEU.INH_LAMP5.rosehip	4.13	Nominal	—	0.00	Other	0	0
98	EPI.pancreatic_ductal_progenitor.baseline	3.99	Nominal	0.07	1.83	Other	179	702
99	NEU.INH_PVALB.metabotropic	3.98	Nominal	—	0.00	Other	0	0
100	EPI.salivary_intercalated_defense.basal_EMT	3.86	Nominal	—	0.54	Other	0	0
101	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	3.85	Nominal	—	0.73	Other	0	0
102	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	3.82	Nominal	—	0.00	Other	0	0
103	NEU.EXC_NTNG1.synaptic	3.80	Nominal	—	0.00	Other	0	0
104	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	3.77	Nominal	—	0.97	Other	0	0
105	EPI.pancreatic_ductal_progenitor.ciliated_transport	3.76	Nominal	—	0.04	Other	105	368
106	NEU.INH_PVALB.serotonergic	3.70	Nominal	—	0.00	Other	0	0
107	HEP.periportal_metabolic.stress_chaperone	3.54	Nominal	—	0.29	Other	66	128
108	EPI.salivary_serous_acinar.quiescent	3.43	Nominal	9.79e-07	2.10	Other	178	493
109	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	3.38	Nominal	—	0.08	Other	5	3
110	EPI.pancreatic_ductal_perivascular.baseline	3.26	Nominal	0.92	0.01	Other	1	5
111	HEP.acute_phase.proliferative	3.17	Nominal	—	1.28	Other	4	6
112	NEU.INH_LAMP5.projecting	3.11	Nominal	—	0.00	Other	0	0
113	HEP.acute_phase.complement_antiviral	3.02	Nominal	0.04	1.76	Other	377	751
114	EPI.renal_proximal_tubule.detox_antioxidant	3.02	Nominal	0.02	2.38	Other	394	77
115	EPI.cervical_suprabasal.inflammatory_repair	2.93	Nonsignificant	—	0.73	Other	0	0
116	MEL.neurotrophic_migratory	2.93	Nonsignificant	—	0.00	Other	0	0
117	EPI.extrahepatic_cholangiocyte.mucin_secretory	2.92	Nonsignificant	—	0.42	Other	0	0
118	IPSC.canonical_pluripotent	2.87	Nonsignificant	1.00	0.85	Other	0	0
119	EPI.pancreatic_ductal_progenitor.ADM_like	2.82	Nonsignificant	—	0.00	Other	0	0
120	FIB.transitioning.secretory_procollagen	2.81	Nonsignificant	—	0.00	Other	0	0
121	NEU.INH_VIP.develop_niche	2.80	Nonsignificant	—	0.00	Other	0	0
122	EPI.esophageal_suprabasal.proliferative_S	2.78	Nonsignificant	—	0.00	Other	26	41
123	EPI.ileal_goblet.immature	2.78	Nonsignificant	—	0.00	Other	0	0
124	HEP.periportal_metabolic.canonical_urea_cycle	2.75	Nonsignificant	0.95	0.91	Other	1,464	269
125	HEP.periportal_metabolic.xenobiotic_detox	2.73	Nonsignificant	0.95	0.89	Other	1,440	139
126	HEP.periportal_metabolic.urea_onecarbon_secretory	2.68	Nonsignificant	0.95	1.06	Other	1,332	3,053
127	SKM.type_1_slow.contractile	2.58	Nonsignificant	1.37e-03	2.41	Other	596	8
128	EC.lymphatic.activated	2.56	Nonsignificant	0.62	1.06	Other	47	73
129	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	2.56	Nonsignificant	—	0.00	Other	0	0
130	EPI.colonic_enteroendocrine.progenitor	2.55	Nonsignificant	—	0.00	Other	0	0
131	NEU.INH_PVALB.fastspike	2.53	Nonsignificant	—	0.00	Other	24	22
132	NEU.INH_VIP.LAMP5_hybrid	2.53	Nonsignificant	—	0.00	Other	1	9
133	HEP.periportal_metabolic.acute_phase_barrier	2.50	Nonsignificant	0.95	1.05	Other	533	138
134	IPSC.mesodermal_primed	2.49	Nonsignificant	1.00	0.72	Other	0	0
135	NEU.INH_PVALB.neuromodulatory	2.42	Nonsignificant	—	0.00	Other	0	0
136	EPI.renal_proximal_tubule.onecarbon_peroxisome	2.41	Nonsignificant	0.76	0.59	Other	58	89
137	EPI.extrahepatic_cholangiocyte.barrier_interface	2.40	Nonsignificant	—	0.00	Other	0	0
138	EPI.esophageal_suprabasal.proliferative_exit	2.38	Nonsignificant	—	0.00	Other	0	0
139	FIB.transitioning.motility_remodelling	2.34	Nonsignificant	—	0.00	Other	0	0
140	EC.lymphatic.tip_migratory	2.33	Nonsignificant	0.17	1.28	Other	23	37
141	SKM.type_1_slow.glycolytic	2.29	Nonsignificant	0.60	1.11	Other	362	647
142	EPI.colonic_enteroendocrine.Lcell_peptide	2.29	Nonsignificant	—	0.00	Other	0	0
143	CM.inflammatory	2.25	Nonsignificant	—	2.21	Other	0	0
144	EPI.hepatic_ductular_cholangiocyte.stress	2.19	Nonsignificant	—	0.00	Other	0	0
145	EPI.esophageal_suprabasal.basal_transitional	2.09	Nonsignificant	1.00	0.00	Other	44	67
146	ASTRO.stress_acute	2.01	Nonsignificant	1.00	0.16	Other	60	56
147	HPC.CLP_B_primed	2.01	Nonsignificant	—	0.00	Other	0	0
148	HEP.acute_phase.complement_metabolic	1.92	Nonsignificant	0.88	1.09	Other	1,423	3,464
149	CHOND.activated_fibro_like	1.91	Nonsignificant	3.06e-04	1.40	Other	531	188
150	NEU.INH_VIP.enkephalinergic	1.89	Nonsignificant	—	0.00	Other	0	0
151	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	1.83	Nonsignificant	—	0.00	Other	0	0
152	SKM.type_1_slow.oxidative	1.79	Nonsignificant	1.00	0.09	Other	802	251
153	NEU.EXC_CT.projector	1.73	Nonsignificant	0.02	1.44	Other	87	26
154	EPI.cervical_suprabasal.secretory_vesicle	1.68	Nonsignificant	—	0.00	Other	0	0
155	HEP.acute_phase.baseline	1.66	Nonsignificant	0.99	0.66	Other	946	19
156	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	1.66	Nonsignificant	—	0.00	Other	0	0
157	HEP.periportal_metabolic.apolipoprotein_secretory	1.61	Nonsignificant	1.00	0.39	Other	43	110
158	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	1.61	Nonsignificant	—	0.00	Other	6	9
159	T.CD4_Th2.tissue_adapted	1.58	Nonsignificant	—	0.97	Other	0	0
160	HEP.acute_phase.inflammatory	1.44	Nonsignificant	0.99	0.58	Other	382	649
161	EPI.renal_thick_ascending_limb.canonical_salt_transporter	1.41	Nonsignificant	6.67e-03	1.53	Other	322	317
162	EC.lymphatic.baseline	1.40	Nonsignificant	0.83	0.95	Other	38	72
163	CM.mechano_activated	1.36	Nonsignificant	0.02	2.18	Other	205	134
164	CHOND.remodeling	1.35	Nonsignificant	—	0.51	Other	5	0
165	EPI.endocervical_secretory.squamous_barrier	1.32	Nonsignificant	—	0.00	Other	0	0
166	EPI.pancreatic_islet.alpha	1.31	Nonsignificant	—	0.00	Other	152	330
167	ASTRO.A1_reactive	1.30	Nonsignificant	1.00	0.01	Other	433	394
168	EPI.salivary_duct_ion_transport.baseline	1.26	Nonsignificant	—	—	Other	0	0
169	DC.cDC1.homeostatic_inhibitory	1.25	Nonsignificant	—	1.21	Other	0	0
170	FIB.reticular.immune_interface	1.18	Nonsignificant	—	0.00	Other	1	6
171	NEU.EXC_SYT2.nuclear_reg	1.15	Nonsignificant	—	0.00	Other	0	0
172	MAC.microglia_like.inflammatory_chemokine	1.14	Nonsignificant	—	0.00	Other	20	32
173	EPI.lung_club_secretory.ciliogenesis_primed	1.10	Nonsignificant	—	0.79	Other	0	0
174	DC.cDC2.tolerogenic_regulatory	1.09	Nonsignificant	0.44	1.33	Other	44	4
175	CM.anti_inflammatory	1.08	Nonsignificant	0.52	1.22	Other	424	1,503
176	CM.sarcomere_actin_interface	1.06	Nonsignificant	0.15	1.58	Other	450	78
177	CM.oxidative_phospho	1.06	Nonsignificant	0.52	1.19	Other	266	792
178	DC.cDC2.migratory	1.06	Nonsignificant	0.44	1.26	Other	185	39
179	CM.translation_boost_RPL	1.03	Nonsignificant	0.52	1.29	Other	129	1
180	GRANU.MAST.activated_repair	1.02	Nonsignificant	—	0.64	Other	0	1
181	CM.mito_proteostasis	1.02	Nonsignificant	0.84	0.99	Other	329	29
182	EPI.lung_club_secretory.canonical_surfactant	1.02	Nonsignificant	—	0.61	Other	74	104
183	EPI.colonic_tuft.homeostatic	0.97	Nonsignificant	—	0.42	Other	0	0
184	IPSC.axial_identity_primed	0.97	Nonsignificant	1.00	0.46	Other	0	0
185	EPI.renal_thick_ascending_limb.remodeling	0.97	Nonsignificant	1.00	0.95	Other	152	92
186	CM.baseline	0.95	Nonsignificant	0.98	0.52	Other	393	0
187	CM.translation_boost_RPS	0.92	Nonsignificant	0.98	0.49	Other	69	16
188	MG.expanding	0.91	Nonsignificant	0.53	1.14	Other	2	1
189	CM.osmoprotection	0.90	Nonsignificant	0.98	0.69	Other	34	57
190	DC.cDC2.adhesion_signaling	0.90	Nonsignificant	0.99	0.83	Other	35	9
191	EPI.alveolar_type_2.injury_primed	0.87	Nonsignificant	1.06e-09	1.77	Other	434	245
192	EPI.lung_multiciliated.mature_motile_cilia	0.86	Nonsignificant	—	1.53	Other	0	0
193	HEP.periportal_metabolic.stress_checkpoint	0.85	Nonsignificant	1.00	1.33e-03	Other	234	786
194	FIB.reticular.stress_metallothionein	0.85	Nonsignificant	—	0.22	Other	3	32
195	MAC.MDM.APC_dendritic	0.84	Nonsignificant	0.08	1.32	Other	48	15
196	T.CD4_transitional.tissue_enagement	0.83	Nonsignificant	0.44	1.33	Other	5	11
197	IPSC.mesendo_primed	0.82	Nonsignificant	1.00	0.48	Other	0	0
198	EPI.ileal_enterocyte_crypt.secretory_precursor	0.80	Nonsignificant	—	1.13	Other	0	0
199	EPI.renal_thick_ascending_limb.barrier_repair	0.80	Nonsignificant	1.00	0.93	Other	141	284
200	MG.phagocytic_APC	0.78	Nonsignificant	0.53	1.13	Other	25	8
201	SCHWN.axon_contact_cardiac	0.76	Nonsignificant	0.04	1.83	Other	18	63
202	EPI.salivary_serous_acinar.secretory_active	0.76	Nonsignificant	1.00	0.00	Other	242	69
203	EPI.renal_principal_cell.injury_repair	0.75	Nonsignificant	0.14	1.54	Other	26	9
204	HEP.acute_phase.stress_secretory	0.74	Nonsignificant	0.99	0.23	Other	26	3
205	DC.cDC1.baseline	0.73	Nonsignificant	—	0.00	Other	0	0
206	DC.cDC1.cross_presenting	0.72	Nonsignificant	—	0.00	Other	0	0
207	MG.baseline	0.70	Nonsignificant	0.61	0.92	Other	16	5
208	DC.cDC1.proliferative	0.69	Nonsignificant	—	0.00	Other	0	0
209	DC.cDC1.activated	0.68	Nonsignificant	—	0.00	Other	0	0
210	EPI.esophageal_basal.junctional_barrier	0.67	Nonsignificant	—	1.01	Other	0	0
211	EPI.ectocervical_granular.proliferative_basal	0.63	Nonsignificant	—	1.15	Other	0	0
212	GRANU.MAST.resting_granule	0.63	Nonsignificant	—	0.00	Other	0	0
213	GRANU.MAST.activated_acute	0.63	Nonsignificant	—	0.00	Other	0	0
214	DC.cDC2.antiviral	0.62	Nonsignificant	0.99	0.71	Other	100	37
215	THYMO.SP_CD8_transitional	0.59	Nonsignificant	1.62e-03	2.02	Other	32	75
216	DC.cDC2.monocyte_like	0.58	Nonsignificant	0.99	0.63	Other	1,285	791
217	SKM.type_2_fast.oxidative_IIa	0.57	Nonsignificant	7.35e-05	2.39	Other	946	56
218	MAC.microglia_like.phagocytic_redox	0.57	Nonsignificant	—	0.00	Other	0	0
219	EPI.colonocyte.distal_absorptive	0.54	Nonsignificant	—	1.95	Other	0	0
220	EPI.tracheal_suprabasal.secretory_immune	0.53	Nonsignificant	—	0.90	Other	0	0
221	EPI.colonic_tuft.activated	0.53	Nonsignificant	—	0.00	Other	0	0
222	CM.contractile_oxphos	0.52	Nonsignificant	0.98	0.37	Other	6	19
223	FIB.neurolectin_mucosa.axon_responsive	0.51	Nonsignificant	0.38	1.37	Other	10	10
224	THYMO.SP_CD4_naive	0.47	Nonsignificant	3.40e-04	2.03	Other	65	75
225	GRNLSA.EMT_insulin_signaling	0.46	Nonsignificant	0.70	1.23	Other	47	84
226	EPI.gastric_foveolar.baseline	0.46	Nonsignificant	—	0.00	Other	0	0
227	EPI.skin_sweat_duct_keratinocyte.barrier	0.45	Nonsignificant	—	1.52	Other	0	0
228	MAC.microglia_like.patrolling_adhesive	0.44	Nonsignificant	—	0.17	Other	0	0
229	EPI.ileal_enterocyte_crypt.baseline	0.44	Nonsignificant	0.64	1.21	Other	11	6
230	FIB.neurolectin_mucosa.nerve_interface	0.43	Nonsignificant	—	0.00	Other	4	0
231	EPI.ileal_bile_transport.detox_transcytosis	0.42	Nonsignificant	—	0.46	Other	0	1
232	MAC.resident_cardiac.phagocytic_homeostasis	0.42	Nonsignificant	0.04	1.73	Other	564	1,221
233	EPI.renal_principal_cell.canonical_vasopressin	0.41	Nonsignificant	0.90	0.81	Other	2	0
234	SCHWN.reactive_inflammatory	0.41	Nonsignificant	—	0.00	Other	0	0
235	FIB.neurolectin_mucosa.inflammatory	0.41	Nonsignificant	0.71	0.79	Other	52	110
236	MAC.MDM.inflammatory_phagocytic	0.39	Nonsignificant	0.84	1.03	Other	199	52
237	FIB.reticular.ECM_builder	0.39	Nonsignificant	—	0.37	Other	0	0
238	EPI.ileal_bile_transport.absorptive_xenobiotic	0.38	Nonsignificant	0.85	0.46	Other	11	12
239	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.38	Nonsignificant	1.00	0.10	Other	11	22
240	EPI.esophageal_basal.activated_progenitor	0.38	Nonsignificant	1.00	0.00	Other	1	0
241	SKM.type_2_fast.glycolytic_IIx_IIb	0.37	Nonsignificant	1.00	0.00	Other	565	1,482
242	IPSC.proliferative	0.36	Nonsignificant	1.00	0.32	Other	0	0
243	EPI.renal_principal_cell.activated_acute	0.36	Nonsignificant	0.90	0.87	Other	29	59
244	MONO.CD14.inflammatory	0.35	Nonsignificant	0.08	1.38	Other	92	134
245	PC.IgG_systemic.metabolic	0.33	Nonsignificant	0.40	1.26	Other	46	63
246	SCHWN.translation_boost	0.33	Nonsignificant	—	0.00	Other	8	1
247	FIB.reticular.stromal_niche	0.33	Nonsignificant	0.90	0.44	Other	0	0
248	NEU.EXC_CT.Ca2_sensor	0.33	Nonsignificant	—	0.41	Other	0	0
249	MAC.resident_cardiac.antigen_presenting	0.31	Nonsignificant	0.89	0.57	Other	52	27
250	SMC.contractile	0.31	Nonsignificant	0.18	1.30	Other	80	588
251	EPI.skin_interfollicular_spinous.upper_lipid	0.30	Nonsignificant	—	1.29	Other	6	6
252	THYMO.DP_early_stress	0.30	Nonsignificant	—	1.01	Other	0	0
253	EPI.renal_thick_ascending_limb.cation_flux	0.29	Nonsignificant	1.00	0.37	Other	57	95
254	MAC.resident_iron.stress_tolerogenic	0.29	Nonsignificant	—	0.99	Other	0	0
255	EPI.renal_thick_ascending_limb.salt_sensing	0.28	Nonsignificant	1.00	0.76	Other	73	103
256	SMC.metabolic	0.27	Nonsignificant	0.37	1.13	Other	14	40
257	DC.cDC2.proliferative	0.27	Nonsignificant	—	0.00	Other	39	71
258	FIB.suburothelial.inflammatory_prostanoid	0.27	Nonsignificant	—	1.16	Other	0	0
259	PLAT.adhesion	0.27	Nonsignificant	—	0.48	Other	0	0
260	EPI.renal_principal_cell.intercalated_like	0.26	Nonsignificant	0.90	0.81	Other	63	66
261	CHOND.articular_collagen	0.26	Nonsignificant	1.00	0.58	Other	551	266
262	EPI.ileal_enterocyte_crypt.bile_transport	0.26	Nonsignificant	0.93	0.75	Other	2	0
263	FIB.suburothelial.contractile_myofibroblast	0.24	Nonsignificant	—	0.37	Other	9	0
264	FIB.suburothelial.homeostasis_matrix	0.24	Nonsignificant	0.32	1.48	Other	258	921
265	EPI.tracheal_submucosal_gland.ductal_luminal	0.24	Nonsignificant	—	0.42	Other	0	0
266	FIB.tracheal_subepithelial.baseline	0.23	Nonsignificant	—	0.00	Other	0	0
267	ASPC.proliferative	0.23	Nonsignificant	0.24	1.33	Other	33	85
268	B.age_associated.activated	0.22	Nonsignificant	—	0.53	Other	18	22
269	FIB.neurolectin_mucosa.remodeling_repair	0.22	Nonsignificant	—	0.00	Other	4	2
270	B.germinal_center.LZ_memory_precursor	0.22	Nonsignificant	—	0.79	Other	0	0
271	EPI.ileal_enterocyte_crypt.villus_transition	0.21	Nonsignificant	—	0.11	Other	7	10
272	FIB.barrier_secretory.homeostasis	0.21	Nonsignificant	—	0.25	Other	0	0
273	EPI.ileal_enterocyte_absorptive.villus_tip	0.21	Nonsignificant	2.99e-05	1.68	Other	4	3
274	EPI.renal_distal_tubule.repair	0.21	Nonsignificant	—	1.12	Other	34	102
275	PC.IgG_systemic.stress	0.20	Nonsignificant	—	0.43	Other	1	5
276	T.CD8_Trm.dendritic_recruiter	0.20	Nonsignificant	0.42	1.20	Other	47	85
277	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.20	Nonsignificant	—	0.00	Other	19	54
278	EPI.skin_interfollicular_spinous.stress_UPR	0.19	Nonsignificant	—	0.79	Other	0	0
279	FIB.perivascular_interface.vasomotor_tone	0.19	Nonsignificant	—	0.69	Other	0	0
280	THYMO.DP_early	0.19	Nonsignificant	0.77	1.11	Other	326	313
281	B.germinal_center.LZ_selection	0.19	Nonsignificant	—	0.73	Other	0	0
282	T.CD4_transitional.APC_interacting	0.19	Nonsignificant	0.66	1.22	Other	10	14
283	DC.cDC2.pro_inflammatory	0.19	Nonsignificant	0.99	0.40	Other	3	5
284	THYMO.proliferative_G2M	0.18	Nonsignificant	—	0.00	Other	164	413
285	EPI.tracheal_submucosal_gland.acinar_serous	0.18	Nonsignificant	—	0.00	Other	0	0
286	NEU.EXC_CT.remodeling	0.18	Nonsignificant	—	0.00	Other	23	1
287	PLAT.megakaryocytic	0.17	Nonsignificant	—	0.00	Other	0	0
288	MAC.resident_iron.APC_iron_sensing	0.17	Nonsignificant	0.99	1.00	Other	211	114
289	THYMO.DN_preTCR	0.17	Nonsignificant	0.88	1.01	Other	41	71
290	ILC2.quiescent	0.17	Nonsignificant	—	0.44	Other	0	0
291	FIB.skin_sheath.neuro_vascular_interface	0.17	Nonsignificant	—	1.03	Other	0	0
292	NEU.EXC_CT.Ca2_signaling	0.17	Nonsignificant	—	0.00	Other	68	17
293	EPI.thymic_medullary.proliferative_APC	0.17	Nonsignificant	—	0.56	Other	0	0
294	EPI.ileal_enterocyte_crypt.proliferative_S	0.17	Nonsignificant	0.93	0.53	Other	4	2
295	THYMO.SP_CD8_naive	0.17	Nonsignificant	0.99	0.76	Other	297	177
296	B.germinal_center.LZ_survival	0.16	Nonsignificant	—	0.37	Other	0	0
297	MAC.resident_cardiac.inflammatory_reparative	0.16	Nonsignificant	0.89	0.80	Other	31	96
298	EPI.colonocyte.secretory_boost	0.16	Nonsignificant	0.94	1.04	Other	98	91
299	EPI.thymic_medullary.canonical_alarmin	0.16	Nonsignificant	0.14	1.51	Other	8	17
300	FIB.lung_alveolar.mito_secretory	0.16	Nonsignificant	—	0.48	Other	0	0
301	EPI.skin_interfollicular_spinous.baseline	0.16	Nonsignificant	0.71	1.12	Other	35	3
302	MAC.kupffer.fibrogenic	0.16	Nonsignificant	—	0.66	Other	0	0
303	GRNLSA.lipid_hypoxia	0.16	Nonsignificant	0.70	1.13	Other	28	0
304	PC.IgG_systemic.interacting	0.15	Nonsignificant	0.73	1.05	Other	0	0
305	EC.liver_sinusoidal.inflammatory	0.15	Nonsignificant	—	0.71	Other	223	154
306	MAC.kupffer.monocyte_like	0.15	Nonsignificant	—	1.13	Other	0	0
307	B.age_associated.migratory	0.15	Nonsignificant	0.41	1.12	Other	2	2
308	EPI.skin_interfollicular_spinous.early_differentiation	0.15	Nonsignificant	0.71	1.01	Other	89	19
309	T.CD4_naive.activated_stress	0.14	Nonsignificant	0.24	1.47	Other	339	429
310	MAC.resident_repair.ECM_stromal_crosstalk	0.14	Nonsignificant	0.76	1.20	Other	95	158
311	EPI.renal_principal_cell.inflammatory	0.14	Nonsignificant	0.96	0.42	Other	74	157
312	FIB.skin_tenogenic.baseline	0.14	Nonsignificant	—	0.00	Other	0	2
313	T.gamma_delta.cytotoxic_effector	0.14	Nonsignificant	0.43	1.06	Other	349	109
314	EPI.colonocyte.goblet_interface	0.14	Nonsignificant	—	0.88	Other	11	21
315	CHOND.angiogenic	0.14	Nonsignificant	—	0.00	Other	0	0
316	B.naive.restrained	0.13	Nonsignificant	6.24e-04	1.22	Other	183	353
317	EPI.thymic_cortical.secretory_remodeling	0.13	Nonsignificant	—	0.11	Other	4	1
318	FIB.suburothelial.urothelial_interface	0.13	Nonsignificant	1.00	0.00	Other	9	8
319	T.CD4_Tem.inflammatory	0.13	Nonsignificant	0.52	1.18	Other	28	6
320	EC.liver_sinusoidal.remodeling_lipotoxicity	0.13	Nonsignificant	—	0.96	Other	90	58
321	T.CD4_transitional.baseline	0.13	Nonsignificant	0.86	1.01	Other	59	97
322	FIB.perivascular_interface.lipid_shuttle	0.13	Nonsignificant	—	0.00	Other	51	170
323	MUSC.baseline	0.12	Nonsignificant	0.28	1.59	Other	0	0
324	FIB.barrier_purinergic.lipid_secretory	0.12	Nonsignificant	—	0.48	Other	0	0
325	EPI.alveolar_type_2.baseline_surfactant	0.12	Nonsignificant	1.00	0.48	Other	64	9
326	EPI.colonocyte.ionocyte_BEST4	0.11	Nonsignificant	0.94	1.07	Other	103	188
327	FIB.perivascular_interface.vascular_BM_remodelling	0.11	Nonsignificant	—	0.00	Other	0	0
328	T.gamma_delta.early_effector	0.11	Nonsignificant	0.79	1.02	Other	89	0
329	EPI.colonocyte.proximal_transport	0.11	Nonsignificant	0.94	1.01	Other	24	12
330	MAC.resident_repair.chemokine_angiocrine	0.10	Nonsignificant	0.86	0.91	Other	87	138
331	EPI.alveolar_type_2.stress_response	0.10	Nonsignificant	1.00	0.11	Other	675	1,562
332	ILC2.migratory	0.10	Nonsignificant	—	0.35	Other	0	0
333	MAC.resident_iron.heme_recycling	0.10	Nonsignificant	—	0.66	Other	30	37
334	FIB.lung_alveolar.stress_interacting	0.10	Nonsignificant	—	0.00	Other	0	0
335	MAC.resident_repair.antigen_presenting	0.10	Nonsignificant	0.76	1.14	Other	244	113
336	MONO.CD14.baseline	0.10	Nonsignificant	3.19e-06	1.19	Other	2,268	76
337	THYMO.SP_CD8_naive_stress	0.10	Nonsignificant	0.99	0.24	Other	1	1
338	B.memory.preactivated	0.10	Nonsignificant	0.26	1.13	Other	173	174
339	PERI.baseline	0.09	Nonsignificant	4.44e-04	1.47	Other	39	66
340	EC.lymphatic.valve	0.09	Nonsignificant	—	0.04	Other	0	0
341	EPI.thymic_cortical.baseline	0.09	Nonsignificant	0.64	0.91	Other	185	386
342	FIB.hepatic_stellate_cell.fibrogenic	0.09	Nonsignificant	—	0.73	Other	0	0
343	FIB.skin_papillary.baseline	0.09	Nonsignificant	—	0.00	Other	0	0
344	ILC2.activated	0.09	Nonsignificant	—	0.00	Other	0	0
345	EPI.ectocervical_granular.inflammatory	0.09	Nonsignificant	—	0.32	Other	0	0
346	EPI.thymic_medullary.stress_APC	0.09	Nonsignificant	0.93	0.48	Other	2	4
347	EPI.tracheal_suprabasal.transitional_wound	0.09	Nonsignificant	—	0.00	Other	16	1
348	EC.arterial.elastic	0.09	Nonsignificant	0.52	1.17	Other	22	45
349	FIB.interstitial.mesenchymal_regulator	0.09	Nonsignificant	0.62	1.11	Other	4	4
350	ASPC.adipocyte_capillary_interface	0.09	Nonsignificant	0.44	1.19	Other	21	54
351	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	0.09	Nonsignificant	0.10	1.38	Other	449	1,034
352	EPI.thymic_cortical.Notch_interface	0.09	Nonsignificant	—	0.00	Other	82	137
353	MAC.kupffer.tolerogenic	0.09	Nonsignificant	—	0.82	Other	45	49
354	EC.liver_sinusoidal.prostanoid	0.08	Nonsignificant	—	0.38	Other	11	64
355	THYMO.CD8aa_IELp	0.08	Nonsignificant	—	0.00	Other	1	7
356	MAC.MDM.complement_resolving	0.08	Nonsignificant	1.00	0.33	Other	440	860
357	FIB.skin_neurosecretory.baseline	0.08	Nonsignificant	—	0.00	Other	0	0
358	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	0.08	Nonsignificant	—	0.32	Other	0	0
359	FIB.skin_sheath.ECM_immune	0.08	Nonsignificant	—	0.00	Other	0	0
360	T.CD4_Th2.precursor	0.08	Nonsignificant	—	0.00	Other	0	0
361	GRNLSA.stress_metabolic	0.08	Nonsignificant	—	0.81	Other	1	2
362	PC.IgA_muocsal.baseline	0.08	Nonsignificant	0.10	1.23	Other	3	5
363	B.germinal_center.DZ_S_phase	0.07	Nonsignificant	—	0.00	Other	0	0
364	PC.IgA_muocsal.plasmablast	0.07	Nonsignificant	0.69	1.09	Other	5	4
365	FIB.skin_sheath.stress_chaperone	0.07	Nonsignificant	—	0.00	Other	0	0
366	MUSC.early_activation	0.07	Nonsignificant	0.94	0.77	Other	4	32
367	HEP.pericentral_lipoprotein.UPR_redox	0.07	Nonsignificant	—	0.67	Other	0	0
368	EC.arterial.metabolic	0.07	Nonsignificant	0.59	1.08	Other	195	159
369	MONO.CD14.platelet_bound	0.07	Nonsignificant	1.00	0.87	Other	964	176
370	DC.cDC2.lipid_metabolic	0.07	Nonsignificant	—	0.00	Other	0	0
371	EC.lymphatic.scavenger	0.07	Nonsignificant	1.00	0.52	Other	203	257
372	HEP.pericentral_lipoprotein.ApoB_coagulation	0.07	Nonsignificant	—	0.00	Other	0	0
373	MAC.resident_repair.stress_iron	0.07	Nonsignificant	0.86	0.90	Other	48	97
374	EC.arterial.inflammatory	0.07	Nonsignificant	0.59	1.05	Other	63	50
375	T.CD4_Treg.tissue_effector	0.07	Nonsignificant	0.33	1.22	Other	16	13
376	T.CD4_transitional.primed_cytotoxic	0.07	Nonsignificant	0.86	0.73	Other	28	30
377	PERI.inflammatory	0.06	Nonsignificant	0.26	1.19	Other	40	77
378	SMC.activated	0.06	Nonsignificant	1.00	0.16	Other	2	5
379	MAC.MDM.LAM_like	0.06	Nonsignificant	1.00	0.48	Other	12	14
380	FIB.adventitial.inflammatory_activated	0.06	Nonsignificant	0.15	1.12	Other	100	473
381	B.age_associated.naive_transitional	0.06	Nonsignificant	—	0.00	Other	0	0
382	T.CD8_transitional.Trm_primed	0.06	Nonsignificant	0.51	1.06	Other	108	15
383	MUSC.quiescent_reservoir	0.06	Nonsignificant	0.94	0.53	Other	2	8
384	T.CD4_transitional.primed_helper_effector	0.06	Nonsignificant	0.86	0.87	Other	19	43
385	EPI.thymic_medullary.hormone_xeno_barrier	0.06	Nonsignificant	—	0.00	Other	0	8
386	EC.liver_sinusoidal.hypoxia_metabolic	0.06	Nonsignificant	1.00	1.02	Other	183	107
387	EPI.renal_intercalated_cell_type_A.PC_transitional	0.05	Nonsignificant	—	0.00	Other	203	407
388	MONO.CD16.platelet_bound	0.05	Nonsignificant	0.25	1.29	Other	372	508
389	FIB.hepatic_stellate_cell.contractile	0.05	Nonsignificant	—	0.00	Other	0	0
390	EPI.ectocervical_granular.immune_interact	0.05	Nonsignificant	—	0.00	Other	0	0
391	THYMO.proliferative_S	0.05	Nonsignificant	0.99	0.71	Other	163	418
392	EC.venous.cardiac_structural	0.05	Nonsignificant	0.07	1.37	Other	102	229
393	PC.IgG_systemic.secretory	0.05	Nonsignificant	1.00	0.25	Other	0	0
394	FIB.hepatic_stellate_cell.inflammatory	0.05	Nonsignificant	—	0.00	Other	0	0
395	EPI.skin_interfollicular_spinous.stress_oxidative	0.05	Nonsignificant	—	0.00	Other	0	0
396	FIB.adventitial.adhesion_lipid	0.05	Nonsignificant	1.00	1.03	Other	58	209
397	HEP.canalicular_transport.secretory_ERAD_UPR	0.05	Nonsignificant	0.73	1.18	Other	232	28
398	MUSC.activated_migratory	0.04	Nonsignificant	0.94	0.24	Other	6	7
399	PC.IgA_muocsal.activated	0.04	Nonsignificant	0.97	0.91	Other	17	8
400	B.naive.activated	0.04	Nonsignificant	1.00	0.94	Other	77	127
401	EPI.tracheal_basal.homeostatic_progenitor	0.04	Nonsignificant	0.74	0.76	Other	285	74
402	HEP.acute_phase.hypoxia_lipid	0.04	Nonsignificant	—	0.00	Other	0	0
403	GRNLSA.cholesterol_mevalonate	0.04	Nonsignificant	0.70	1.14	Other	9	4
404	FIB.interstitial.immune_interact	0.04	Nonsignificant	0.62	1.06	Other	12	1
405	MONO.CD14.remodeling	0.04	Nonsignificant	1.00	0.81	Other	2,373	295
406	EPI.tracheal_basal.activated_stress	0.04	Nonsignificant	0.28	1.42	Other	32	0
407	EC.liver_sinusoidal.stress	0.04	Nonsignificant	—	0.00	Other	413	158
408	T.CD4_Tfh.effector_migratory	0.04	Nonsignificant	0.22	1.30	Other	122	57
409	T.CD8_Trm.homeostatic	0.04	Nonsignificant	0.92	0.99	Other	42	5
410	MAC.kupffer.inflammatory	0.04	Nonsignificant	—	0.00	Other	7	4
411	T.CD4_Trm.activated	0.04	Nonsignificant	0.66	1.06	Other	32	26
412	EPI.skin_hair_follicle_bulge.niche_crosstalk	0.04	Nonsignificant	—	0.86	Other	29	88
413	T.CD4_naive.gut_prone	0.04	Nonsignificant	0.74	1.30	Other	35	70
414	B.naive.antigen_presenting_ready	0.04	Nonsignificant	1.00	1.02	Other	48	73
415	ASPC.preadipocyte_lipid_primed	0.04	Nonsignificant	0.08	1.09	Other	331	129
416	EPI.lung_multiciliated.stress	0.04	Nonsignificant	—	0.00	Other	67	165
417	EC.heart_remodeling.angiocrine	0.04	Nonsignificant	0.48	1.17	Other	182	525
418	T.CD4_Tfh.suppression_exhaustion	0.04	Nonsignificant	0.82	1.07	Other	0	2
419	MAC.resident_iron.redox_metabolic	0.04	Nonsignificant	0.99	0.67	Other	4	4
420	NK.cytokine_tissue_resident	0.03	Nonsignificant	1.00	1.11	Other	74	82
421	PC.IgA_muocsal.migratory	0.03	Nonsignificant	0.97	0.76	Other	4	1
422	T.CD4_Th17.migratory	0.03	Nonsignificant	0.66	1.02	Other	13	23
423	T.CD4_Trm.metal_stress	0.03	Nonsignificant	0.63	1.18	Other	34	58
424	T.CD8_Trm.inflammatory	0.03	Nonsignificant	0.92	0.94	Other	124	176
425	EC.arterial.homeostatic	0.03	Nonsignificant	0.75	0.96	Other	24	3
426	B.memory.activated	0.03	Nonsignificant	0.54	1.05	Other	105	29
427	FIB.barrier_purinergic.stress_GF_binding	0.03	Nonsignificant	—	0.00	Other	0	0
428	T.CD4_Trm.baseline	0.03	Nonsignificant	0.63	1.06	Other	31	21
429	T.CD4_Tfh.canonical_GC_helper	0.03	Nonsignificant	0.82	0.94	Other	1	2
430	EPI.lung_multiciliated.baseline	0.03	Nonsignificant	—	0.00	Other	0	7
431	T.CD4_Th17.cytotoxic	0.03	Nonsignificant	0.66	1.02	Other	332	123
432	T.CD4_naive.neddylation_mitoprot	0.03	Nonsignificant	0.34	1.21	Other	93	56
433	EPI.renal_immature_ureteric_bud.osmoprotective	0.03	Nonsignificant	0.74	0.95	Other	126	44
434	EC.venous.baseline	0.03	Nonsignificant	2.74e-07	1.37	Other	346	807
435	T.CD4_naive.Treg_like	0.03	Nonsignificant	0.24	1.49	Other	121	72
436	T.CD4_Trm.stress_adaptive	0.03	Nonsignificant	0.32	1.23	Other	8	22
437	T.CD8_transitional.effector_primed	0.03	Nonsignificant	0.51	1.04	Other	435	151
438	T.CD8_naive.cytokine_dampened	0.03	Nonsignificant	0.47	1.19	Other	71	4
439	T.CD8_naive.splicing_enriched	0.03	Nonsignificant	0.47	1.20	Other	120	16
440	EPI.lung_club_secretory.ciliogenesis_axoneme	0.03	Nonsignificant	—	0.00	Other	0	0
441	T.CD8_naive.nfkb_related	0.03	Nonsignificant	0.47	1.29	Other	1	0
442	T.CD4_Th17.baseline	0.02	Nonsignificant	0.66	0.97	Other	51	5
443	EC.arterial.mito_contact	0.02	Nonsignificant	0.70	1.00	Other	14	5
444	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.02	Nonsignificant	—	0.83	Other	10	20
445	ASPC.remodeling	0.02	Nonsignificant	0.74	1.04	Other	106	354
446	EPI.skin_interfollicular_spinous.inflammatory	0.02	Nonsignificant	—	0.00	Other	0	0
447	EPI.renal_immature_ureteric_bud.defense_secretory	0.02	Nonsignificant	0.74	1.06	Other	45	76
448	MONO.CD14.APC_like	0.02	Nonsignificant	1.00	1.00	Other	1,686	2,493
449	EPI.skin_interfollicular_spinous.proliferative	0.02	Nonsignificant	—	0.00	Other	0	0
450	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	0.02	Nonsignificant	—	0.97	Other	0	0
451	B.naive.proteostasis	0.02	Nonsignificant	1.00	0.92	Other	49	69
452	DC.mig.baseline	0.02	Nonsignificant	—	0.00	Other	1	0
453	MAC.LAM.inflammatory_APC	0.02	Nonsignificant	1.47e-03	1.10	Other	872	165
454	EPI.skin_interfollicular_spinous.transition_basal	0.02	Nonsignificant	1.00	0.13	Other	100	127
455	CHOND.pro_inflammatory	0.02	Nonsignificant	1.00	0.27	Other	181	351
456	PERI.angiocrine	0.02	Nonsignificant	1.00	0.71	Other	93	102
457	HEP.canalicular_transport.ductular_like_transition	0.02	Nonsignificant	0.73	1.09	Other	400	87
458	FIB.interstitial.stress_secretory	0.02	Nonsignificant	0.62	1.18	Other	92	56
459	EC.arterial.arteriole_interface	0.02	Nonsignificant	0.59	1.04	Other	31	12
460	B.naive.metabolic	0.02	Nonsignificant	1.00	0.81	Other	50	79
461	T.CD4_Tcm.migratory_cilium	0.02	Nonsignificant	0.52	1.23	Other	5	10
462	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	0.02	Nonsignificant	—	0.00	Other	0	0
463	T.CD8_Trm.muscosal_Tc17	0.02	Nonsignificant	0.92	1.04	Other	19	38
464	EPI.ectocervical_granular.secretory_apocrine	0.02	Nonsignificant	—	0.00	Other	0	0
465	EPI.renal_intercalated_cell_type_A.acid_secretion	0.02	Nonsignificant	0.86	0.82	Other	12	6
466	PERI.cardiac_skeletal	0.02	Nonsignificant	1.00	0.27	Other	313	630
467	T.CD4_Treg.Tr1_like	0.01	Nonsignificant	—	0.35	Other	8	8
468	EC.capillary.inflammatory	0.01	Nonsignificant	0.27	1.25	Other	27	51
469	T.CD8_transitional.early	0.01	Nonsignificant	0.96	0.95	Other	327	55
470	NK.cytokine_lung_immediate_early	0.01	Nonsignificant	1.00	1.06	Other	424	274
471	ASPC.stem_like_progenitor	0.01	Nonsignificant	0.14	1.20	Other	300	842
472	T.CD4_Tem.long_term_memory	0.01	Nonsignificant	0.52	1.16	Other	314	587
473	FIB.interstitial.remodeling	0.01	Nonsignificant	1.00	0.96	Other	31	9
474	T.CD4_Treg.APC_interactive	0.01	Nonsignificant	0.99	0.87	Other	118	28
475	HEP.canalicular_transport.pericentral_like_hypoxia	0.01	Nonsignificant	0.96	0.93	Other	326	8
476	HEP.canalicular_transport.inflammatory	0.01	Nonsignificant	0.96	0.98	Other	1,335	194
477	EC.arterial.ion_pump	0.01	Nonsignificant	0.59	1.07	Other	3	2
478	EPI.skin_hair_follicle_companion.gap_junction_contractile	0.01	Nonsignificant	—	0.00	Other	0	0
479	ASPC.baseline	0.01	Nonsignificant	0.91	0.97	Other	363	170
480	EC.arterial.arteriole_gas_exchange	0.01	Nonsignificant	1.00	0.67	Other	238	131
481	EC.venous.adipose_lipid	0.01	Nonsignificant	0.97	1.01	Other	254	476
482	EPI.ileal_enterocyte_absorptive.brush_border	0.01	Nonsignificant	1.00	0.00	Other	580	1,717
483	ASPC.activated	0.01	Nonsignificant	0.89	0.98	Other	164	162
484	B.naive.baseline	0.01	Nonsignificant	0.95	1.10	Other	10	13
485	GRNLSA.chemokine_mechanosensory	0.01	Nonsignificant	0.87	0.75	Other	1	0
486	ASPC.inflammatory	0.01	Nonsignificant	0.44	1.17	Other	21	61
487	NK.immature_bridge	0.01	Nonsignificant	0.85	1.04	Other	117	122
488	T.CD8_naive.effector_transition	0.01	Nonsignificant	0.99	0.93	Other	35	62
489	T.CD4_Tcm.tissue_homing	0.01	Nonsignificant	0.52	1.17	Other	78	46
490	T.CD4_naive.survival_mitoprot	0.01	Nonsignificant	0.74	1.18	Other	13	7
491	T.CD4_cytotoxic.precursor	0.01	Nonsignificant	0.52	1.20	Other	156	67
492	T.CD4_Trm.central_like	9.57e-03	Nonsignificant	0.66	1.02	Other	38	31
493	B.naive.remodeling	9.42e-03	Nonsignificant	1.00	0.87	Other	135	230
494	EC.heart_remodeling.remodeling_secretory	9.38e-03	Nonsignificant	0.53	1.18	Other	605	1,341
495	T.CD8_naive.baseline	9.18e-03	Nonsignificant	0.99	0.84	Other	142	2
496	T.MAIT.migratory	9.02e-03	Nonsignificant	0.17	1.37	Other	10	1
497	MAC.resident_iron.heme_catabolism	8.55e-03	Nonsignificant	0.99	0.32	Other	30	51
498	ASPC.secretory	8.49e-03	Nonsignificant	0.91	0.90	Other	76	5
499	ASPC.niche_keeping_progenitor	8.10e-03	Nonsignificant	0.91	0.88	Other	52	219
500	MAC.proliferating.DNA_replication	8.08e-03	Nonsignificant	0.38	1.13	Other	3	6
501	B.germinal_center.DZ_M_phase	8.08e-03	Nonsignificant	—	0.00	Other	0	0
502	FIB.barrier_secretory.remodeling	7.86e-03	Nonsignificant	—	0.00	Other	0	0
503	T.CD4_naive.homeostatic	7.73e-03	Nonsignificant	0.99	0.95	Other	215	108
504	T.CD4_Tfh.precursor_migratory	7.52e-03	Nonsignificant	1.00	0.34	Other	72	27
505	T.CD4_Tcm.Th2_like	7.48e-03	Nonsignificant	0.88	1.10	Other	23	55
506	MAC.kupffer.stress	7.38e-03	Nonsignificant	0.97	0.46	Other	9	3
507	T.CD4_Tcm.Tfh_like	7.37e-03	Nonsignificant	0.70	1.11	Other	102	214
508	GRNLSA.secretory_remodeling	7.27e-03	Nonsignificant	0.87	0.83	Other	90	25
509	T.CD4_naive.mature_mitoprot	7.26e-03	Nonsignificant	0.99	0.95	Other	212	476
510	B.naive.purinergic	7.26e-03	Nonsignificant	1.00	0.74	Other	384	820
511	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	7.16e-03	Nonsignificant	0.43	1.16	Other	7	16
512	T.CD4_naive.mature	7.15e-03	Nonsignificant	0.99	0.95	Other	211	100
513	MONO.CD14.cord_tolerance	7.11e-03	Nonsignificant	1.00	0.77	Other	864	753
514	EC.capillary.angiogenic_tip	6.80e-03	Nonsignificant	0.91	1.11	Other	186	218
515	T.CD8_Trm.cytotoxic	6.69e-03	Nonsignificant	1.00	0.57	Other	165	85
516	EPI.alveolar_type_1.activated	6.66e-03	Nonsignificant	—	1.64	Other	0	0
517	T.CD8_naive.vesicle_secretory	6.54e-03	Nonsignificant	0.99	0.80	Other	42	0
518	T.CD8_naive.lipid_synthesis	6.26e-03	Nonsignificant	0.99	0.79	Other	6	4
519	EC.capillary.postcap_venule	6.12e-03	Nonsignificant	0.92	0.94	Other	355	261
520	EC.capillary.baseline	6.06e-03	Nonsignificant	0.92	1.00	Other	246	560
521	T.MAIT.early_activation	5.99e-03	Nonsignificant	0.27	1.31	Other	57	4
522	GRNLSA.proliferative_migratory	5.94e-03	Nonsignificant	0.87	0.75	Other	248	292
523	T.CD4_Tcm.crosstalk_myeloid	5.79e-03	Nonsignificant	0.88	1.10	Other	5	4
524	HEP.canalicular_transport.injury_stress	5.75e-03	Nonsignificant	0.96	0.74	Other	289	24
525	EC.capillary.angiocrine	5.70e-03	Nonsignificant	0.92	0.92	Other	250	630
526	EC.capillary.activated	5.68e-03	Nonsignificant	0.89	1.22	Other	2	5
527	MONO.CD16.inflammatory	5.50e-03	Nonsignificant	0.74	1.00	Other	1,640	168
528	T.CD8_naive.innate_like	5.38e-03	Nonsignificant	0.99	0.62	Other	10	1
529	NK.cytokine_tissue_activation	5.33e-03	Nonsignificant	1.00	1.05	Other	267	450
530	T.CD4_Trm.helper_like	5.31e-03	Nonsignificant	0.96	0.83	Other	84	147
531	T.CD4_Tcm.effector_like	5.26e-03	Nonsignificant	0.88	1.00	Other	293	533
532	MAC.resident_repair.lipid_phagocytic	5.10e-03	Nonsignificant	1.00	0.06	Other	228	604
533	T.CD4_Tcm.regulatory_poised	5.02e-03	Nonsignificant	0.89	0.98	Other	2	3
534	T.CD4_Tcm.imprinted_splicing	5.01e-03	Nonsignificant	0.52	1.23	Other	6	17
535	T.CD4_Trm.cytotoxic_effector	4.90e-03	Nonsignificant	0.96	0.82	Other	118	77
536	MONO.CD16.hepatic_mac_like	4.88e-03	Nonsignificant	0.74	1.00	Other	803	117
537	EC.venous.quiescent_homeostatic	4.78e-03	Nonsignificant	0.99	0.61	Other	456	360
538	GRNLSA.p53_damage	4.75e-03	Nonsignificant	—	0.00	Other	13	10
539	T.CD8_transitional.APC_like	4.72e-03	Nonsignificant	0.96	0.90	Other	205	62
540	T.CD4_Tcm.baseline	4.67e-03	Nonsignificant	0.55	1.15	Other	61	31
541	EPI.renal_intercalated_cell_type_B.baseline	4.63e-03	Nonsignificant	—	0.00	Other	3	1
542	FIB.adventitial.mechano_chemo_sensing	4.57e-03	Nonsignificant	1.00	0.94	Other	135	524
543	T.CD4_naive.resist_bystander	4.46e-03	Nonsignificant	0.99	1.01	Other	40	25
544	FIB.adventitial.baseline	3.93e-03	Nonsignificant	1.00	0.83	Other	157	278
545	EPI.skin_keratinocyte_proliferating.early_spinous_transition	3.73e-03	Nonsignificant	—	0.87	Other	135	290
546	T.CD4_Tcm.stress	3.68e-03	Nonsignificant	0.88	1.04	Other	5	11
547	EC.liver_sinusoidal.secretory_lipoprotein	3.66e-03	Nonsignificant	1.00	0.00	Other	120	70
548	T.CD4_Tcm.DC_interact	3.66e-03	Nonsignificant	0.88	1.05	Other	72	32
549	B.memory.baseline	3.59e-03	Nonsignificant	1.00	0.69	Other	472	99
550	EC.capillary.migratory	3.38e-03	Nonsignificant	0.92	0.82	Other	181	509
551	EPI.salivary_myoepithelial.contractile_repair	3.38e-03	Nonsignificant	—	1.80	Other	3	9
552	T.CD4_naive.neddylation	3.24e-03	Nonsignificant	0.99	0.74	Other	104	222
553	MONO.CD16.baseline	3.20e-03	Nonsignificant	0.74	1.07	Other	50	1
554	T.gamma_delta.central_memory	3.15e-03	Nonsignificant	0.93	0.83	Other	460	919
555	EC.capillary.stress	3.07e-03	Nonsignificant	0.96	0.70	Other	44	36
556	EC.venous.remodeling_stalk	2.71e-03	Nonsignificant	0.99	0.63	Other	559	566
557	T.CD8_Tcm.helper_like	2.61e-03	Nonsignificant	0.15	1.21	Other	81	159
558	T.CD4_naive.survival	2.60e-03	Nonsignificant	0.99	0.80	Other	12	17
559	T.CD8_Tem.baseline	2.60e-03	Nonsignificant	0.62	1.06	Other	458	356
560	EPI.skin_keratinocyte_progenitor.activated_stress	2.54e-03	Nonsignificant	—	0.11	Other	0	0
561	MAC.LAM.lipid_opsonization	2.49e-03	Nonsignificant	1.00	1.00	Other	45	14
562	B.memory.migratory	2.35e-03	Nonsignificant	1.00	0.75	Other	123	208
563	T.CD4_naive.proteostasis_mitoprot	2.35e-03	Nonsignificant	0.99	0.80	Other	15	37
564	EPI.skin_hair_follicle_bulge.anagen_growth	2.18e-03	Nonsignificant	—	0.67	Other	0	0
565	B.naive.receptor_recycle	2.10e-03	Nonsignificant	1.00	0.60	Other	51	0
566	HEP.canalicular_transport.baseline	1.98e-03	Nonsignificant	0.96	0.64	Other	199	477
567	T.CD4_naive.proteostasis	1.97e-03	Nonsignificant	0.99	0.70	Other	14	9
568	EC.venous.activated	1.97e-03	Nonsignificant	0.99	0.73	Other	247	752
569	T.CD4_Tem.transitional_CM	1.94e-03	Nonsignificant	0.99	0.66	Other	31	20
570	T.CD4_naive.survival_neddylation	1.93e-03	Nonsignificant	0.99	0.60	Other	26	38
571	T.CD4_Tem.cytotoxic_effector	1.90e-03	Nonsignificant	0.99	0.66	Other	225	398
572	T.CD4_Tcm.APC_mimicry	1.89e-03	Nonsignificant	0.95	0.87	Other	54	43
573	EPI.skin_appendage_keratinocyte.transit_amplifying	1.84e-03	Nonsignificant	—	0.00	Other	109	358
574	T.MAIT.MAPK_brake	1.82e-03	Nonsignificant	0.96	1.00	Other	44	66
575	T.CD4_Tcm.synapse_dynamics	1.77e-03	Nonsignificant	0.95	0.84	Other	15	10
576	T.CD4_Treg.central_naive_like	1.74e-03	Nonsignificant	0.99	0.53	Other	333	45
577	ADIPO.inflammatory	1.65e-03	Nonsignificant	—	1.59	Other	0	0
578	EPI.renal_distal_tubule.ciliated_remodelling	1.50e-03	Nonsignificant	—	0.39	Other	0	0
579	GRANU.neutrophil.antiviral_endotoxin	1.42e-03	Nonsignificant	—	0.90	Other	0	0
580	EC.heart_remodeling.capillary_metabolic	1.38e-03	Nonsignificant	0.64	1.07	Other	54	414
581	MESO.secretory_structural	1.38e-03	Nonsignificant	—	0.86	Other	0	0
582	T.CD8_naive.mito_proteostasis	1.37e-03	Nonsignificant	0.99	0.37	Other	428	100
583	T.CD4_naive.purinergic	1.37e-03	Nonsignificant	0.99	0.46	Other	49	1
584	EPI.colonocyte.crypt_progenitor	1.34e-03	Nonsignificant	1.00	0.30	Other	115	265
585	NK.cytokine_biosynthetic_primed	1.31e-03	Nonsignificant	0.85	1.06	Other	360	21
586	GRANU.neutrophil.primed_degranulation	1.19e-03	Nonsignificant	—	0.00	Other	0	0
587	MAC.kupffer.metabolic	1.18e-03	Nonsignificant	—	0.00	Other	25	36
588	T.CD4_Tcm.retro_ZNF117	1.07e-03	Nonsignificant	0.95	0.70	Other	5	9
589	ASPC.mesothelial_like	1.06e-03	Nonsignificant	0.74	1.11	Other	143	486
590	T.CD4_Tcm.RNA_control	9.75e-04	Nonsignificant	0.99	0.61	Other	96	4
591	T.CD4_cytotoxic.baseline	9.35e-04	Nonsignificant	0.52	1.22	Other	0	0
592	T.CD8_transitional.stress	9.35e-04	Nonsignificant	—	0.61	Other	24	34
593	EC.heart_remodeling.activated_acute	9.21e-04	Nonsignificant	0.48	1.35	Other	102	186
594	FIB.adventitial.mito_secretory	9.06e-04	Nonsignificant	1.00	0.73	Other	21	7
595	MONO.CD14.repair_M2_like	8.87e-04	Nonsignificant	1.00	0.35	Other	550	1,495
596	FIB.interstitial.mesenchymal_APC	8.71e-04	Nonsignificant	1.00	0.64	Other	81	33
597	MESO.baseline	8.11e-04	Nonsignificant	0.26	1.24	Other	0	6
598	T.CD4_Tcm.secretory	7.10e-04	Nonsignificant	0.95	0.74	Other	20	11
599	EPI.skin_hair_follicle_bulge.quiescent	7.09e-04	Nonsignificant	0.98	0.26	Other	56	69
600	MESO.antiviral	7.06e-04	Nonsignificant	—	0.09	Other	3	8
601	NK.cytokine_quiescent	6.84e-04	Nonsignificant	0.85	1.05	Other	623	1,062
602	FIB.adventitial.PI16_matrix	6.71e-04	Nonsignificant	1.00	0.66	Other	70	90
603	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	6.42e-04	Nonsignificant	—	0.00	Other	0	0
604	T.CD8_Tcm.baseline	6.27e-04	Nonsignificant	0.99	0.86	Other	90	89
605	T.MAIT.vesicle	6.19e-04	Nonsignificant	0.96	0.75	Other	37	65
606	FIB.adventitial.complement_angiocrine	6.16e-04	Nonsignificant	1.00	0.62	Other	153	684
607	B.memory.pDC_imprint	5.94e-04	Nonsignificant	1.00	0.73	Other	157	103
608	T.CD8_Tcm.NK_like	5.37e-04	Nonsignificant	0.99	1.03	Other	334	581
609	FIB.interstitial.lipid_matrix	5.21e-04	Nonsignificant	1.00	0.61	Other	258	191
610	T.MAIT.cytotoxic	4.75e-04	Nonsignificant	0.96	0.61	Other	52	15
611	EC.arterial.angiogenic_tip	4.52e-04	Nonsignificant	—	0.00	Other	30	37
612	EPI.alveolar_type_1.baseline	4.41e-04	Nonsignificant	1.00	0.00	Other	8	0
613	NK.cytokine_axis_baseline	4.40e-04	Nonsignificant	1.00	0.95	Other	1,172	116
614	T.MAIT.quiescent	4.28e-04	Nonsignificant	0.96	0.47	Other	100	5
615	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	4.10e-04	Nonsignificant	—	0.00	Other	0	0
616	EPI.skin_keratinocyte_basal.spinous_transition	3.92e-04	Nonsignificant	—	0.97	Other	0	0
617	MAC.LAM.anti_inflammatory	3.23e-04	Nonsignificant	1.00	0.88	Other	86	132
618	EPI.salivary_myoepithelial.baseline	3.16e-04	Nonsignificant	0.97	0.97	Other	42	141
619	EPI.renal_distal_tubule.ion_transport	3.16e-04	Nonsignificant	—	0.00	Other	0	0
620	MESO.activated_migratory	2.82e-04	Nonsignificant	—	0.00	Other	0	0
621	GRANU.neutrophil.tissue_patrolling	2.61e-04	Nonsignificant	—	0.00	Other	0	0
622	MESO.activated_stress	2.61e-04	Nonsignificant	—	0.00	Other	0	0
623	MONO.CD16.patrolling	2.53e-04	Nonsignificant	1.00	0.46	Other	797	216
624	EPI.lung_club_secretory.inflammatory	2.38e-04	Nonsignificant	—	0.00	Other	0	0
625	T.CD8_Tcm.effector_bias	2.33e-04	Nonsignificant	0.99	0.68	Other	199	329
626	EPI.skin_sebaceous_duct_luminal.detox_repair	2.30e-04	Nonsignificant	0.50	1.20	Other	137	94
627	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	2.27e-04	Nonsignificant	—	0.28	Other	0	0
628	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	2.25e-04	Nonsignificant	0.50	1.04	Other	2	9
629	EPI.skin_hair_follicle_companion.activated_migratory	2.24e-04	Nonsignificant	—	0.00	Other	0	0
630	EPI.skin_follicular_keratinizing.upper_infundibulum	2.21e-04	Nonsignificant	—	0.36	Other	8	2
631	EC.heart_remodeling.perivascular	2.16e-04	Nonsignificant	0.99	0.72	Other	124	408
632	EPI.skin_follicular_keratinizing.root_infundibulum	1.90e-04	Nonsignificant	—	0.14	Other	0	0
633	EPI.colonocyte.junction_remodeling	1.79e-04	Nonsignificant	1.00	0.20	Other	218	305
634	NK.adaptive_immature_precursor	1.78e-04	Nonsignificant	1.00	0.97	Other	358	111
635	T.CD8_Tem.signaling_turnover	1.68e-04	Nonsignificant	0.93	1.07	Other	425	683
636	EPI.skin_follicular_keratinizing.transit_amplifying	1.52e-04	Nonsignificant	—	0.00	Other	21	49
637	NK.adaptive_axis_baseline	1.44e-04	Nonsignificant	1.00	0.96	Other	1,008	153
638	EPI.salivary_myoepithelial.junctional_transport	1.35e-04	Nonsignificant	0.97	0.86	Other	66	121
639	EPI.salivary_myoepithelial.activated	1.09e-04	Nonsignificant	0.97	0.61	Other	85	281
640	EC.heart_remodeling.remodeling_stalk	9.57e-05	Nonsignificant	0.99	0.58	Other	33	111
641	T.CD4_cytotoxic.activated	9.40e-05	Nonsignificant	0.96	0.98	Other	3	1
642	NK.cytokine_vascular_patrolling	9.20e-05	Nonsignificant	1.00	0.96	Other	863	94
643	T.CD8_Tem.TEMRA	8.98e-05	Nonsignificant	0.93	0.97	Other	920	1,088
644	EPI.skin_keratinocyte_basal.transit_amplifying	7.05e-05	Nonsignificant	—	0.00	Other	0	0
645	T.CD8_Tcm.gut_homing	6.57e-05	Nonsignificant	0.99	0.50	Other	380	112
646	GRNLSA.angiocrine_mechanosensory	5.95e-05	Nonsignificant	—	0.00	Other	0	0
647	T.CD8_Tem.stress_adapted	5.45e-05	Nonsignificant	0.93	0.94	Other	607	520
648	FIB.adventitial.activated_remodelling	3.89e-05	Nonsignificant	—	0.00	Other	141	319
649	ADIPO.thermogenic	3.80e-05	Nonsignificant	—	0.29	Other	0	0
650	T.MAIT.stress	3.70e-05	Nonsignificant	—	0.00	Other	0	0
651	EPI.skin_keratinocyte_basal.basement_anchoring	3.36e-05	Nonsignificant	—	0.00	Other	0	0
652	MAC.alveolar.inflammatory	3.02e-05	Nonsignificant	0.43	1.11	Other	208	312
653	T.CD4_cytotoxic.NK_adapted	2.90e-05	Nonsignificant	0.96	0.77	Other	82	33
654	EPI.skin_sebaceous_duct_luminal.immune_interface	2.47e-05	Nonsignificant	—	0.00	Other	0	0
655	T.CD8_Tem.early_helper_like	2.47e-05	Nonsignificant	0.93	0.88	Other	445	755
656	EPI.renal_distal_tubule.stress	2.35e-05	Nonsignificant	—	0.00	Other	0	0
657	EC.heart_remodeling.translation_boost	2.29e-05	Nonsignificant	—	0.00	Other	0	0
658	ADIPO.immature	2.20e-05	Nonsignificant	—	0.00	Other	24	40
659	NK.adaptive_adipose_stress	2.15e-05	Nonsignificant	1.00	0.83	Other	374	39
660	NK.adaptive_classII_inhibitory	1.94e-05	Nonsignificant	1.00	0.88	Other	880	154
661	T.CD4_cytotoxic.terminal_effector	1.75e-05	Nonsignificant	0.96	0.75	Other	286	21
662	ADIPO.hypoxia_remodelling	1.58e-05	Nonsignificant	—	0.00	Other	29	105
663	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	1.50e-05	Nonsignificant	0.97	0.37	Other	33	34
664	NK.adaptive_biosynthetic_primed	1.04e-05	Nonsignificant	1.00	0.82	Other	244	405
665	NK.cytokine_repair_primed	9.05e-06	Nonsignificant	1.00	0.84	Other	266	11
666	NK.adaptive_HLAE_tuned	6.23e-06	Nonsignificant	1.00	0.79	Other	1,124	189
667	EPI.skin_keratinocyte_proliferating.anchor_remodel	6.22e-06	Nonsignificant	—	0.00	Other	0	0
668	NK.adaptive_terminal_cytotoxic	6.02e-06	Nonsignificant	1.00	0.75	Other	485	802
669	MAC.LAM.lipid_phagocytosis	3.66e-06	Nonsignificant	1.00	0.62	Other	369	328
670	MAC.LAM.antimicrobial	3.61e-06	Nonsignificant	1.00	0.39	Other	389	93
671	T.CD8_Tem.motility_primed	3.56e-06	Nonsignificant	0.93	0.84	Other	269	4
672	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	3.05e-06	Nonsignificant	—	0.00	Other	39	82
673	EPI.skin_sweat_duct_keratinocyte.repair	2.52e-06	Nonsignificant	—	0.42	Other	0	0
674	EPI.renal_distal_tubule.immune_modulatory	1.77e-06	Nonsignificant	—	0.00	Other	0	0
675	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	9.31e-07	Nonsignificant	—	0.57	Other	0	0
676	ASPC.signal_integrator	7.97e-07	Nonsignificant	—	0.00	Other	0	0
677	MAC.alveolar.lipid_autophagy	7.59e-07	Nonsignificant	—	0.00	Other	35	44
678	MAC.alveolar.capillary_interacting	7.13e-07	Nonsignificant	0.94	1.09	Other	113	181
679	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	3.80e-07	Nonsignificant	—	0.27	Other	0	0
680	MAC.proliferating.stress	2.07e-07	Nonsignificant	—	0.00	Other	87	136
681	MAC.LAM.perivascular_angiocrine	6.39e-08	Nonsignificant	—	0.00	Other	53	138
682	EPI.skin_sweat_duct_keratinocyte.signal_gate	5.75e-08	Nonsignificant	—	0.00	Other	43	26
683	MAC.alveolar.scavenging_endocytic	3.40e-08	Nonsignificant	—	0.42	Other	140	283
684	MAC.alveolar.stress_metabolic	2.88e-08	Nonsignificant	0.96	0.90	Other	116	148
685	MAC.alveolar.biosynthetic_sterol_heme	1.71e-09	Nonsignificant	0.96	0.63	Other	347	40
686	EPI.skin_keratinocyte_proliferating.detox_repair	1.31e-09	Nonsignificant	—	0.00	Other	0	0
687	EPI.skin_sweat_duct_keratinocyte.proliferative_S	2.28e-10	Nonsignificant	—	0.00	Other	0	0
688	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	6.00e-12	Nonsignificant	—	0.00	Other	0	0

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

0 unique genes. Showing 0–0. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Browsers	Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.