Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000010 · All tissues

Acne: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Acne

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	epithelial_cell	12.60	Significant	1.63e-41	1.15	Specific	24	47
2	schwann_cell	9.35	Significant	1.00	1.13	Relevant	10	57
3	endothelial_cell	7.49	Significant	1.31e-16	1.11	Other	373	974
4	adipose_stem_and_progenitor_cell	1.57	Nonsignificant	1.00	0.92	Other	327	954
5	astrocyte	1.16	Nonsignificant	1.00	0.99	Other	256	1,203
6	chondrocyte	1.10	Nonsignificant	1.00	0.88	Other	548	1,069
7	mesothelial_cell	1.09	Nonsignificant	1.00	0.94	Other	6	36
8	smooth_muscle_cell	1.08	Nonsignificant	1.00	0.90	Other	27	139
9	plasma_cell	0.79	Nonsignificant	1.00	0.88	Other	17	24
10	pericyte	0.72	Nonsignificant	1.00	0.89	Other	128	517
11	skeletal_muscle_cell	0.62	Nonsignificant	1.00	0.91	Other	944	2,600
12	hepatocyte	0.53	Nonsignificant	1.00	0.85	Other	1,515	3,822
13	fibroblast	0.47	Nonsignificant	1.00	0.82	Other	184	826
14	muscle_stem_cell	0.39	Nonsignificant	1.00	0.84	Other	7	27
15	platelet	0.17	Nonsignificant	—	0.02	Other	85	104
16	granulocyte	0.14	Nonsignificant	1.00	0.73	Other	5	6
17	dendritic_cell	0.13	Nonsignificant	1.00	0.77	Other	496	724
18	granulosa_cell	0.06	Nonsignificant	1.00	0.63	Other	293	670
19	thymocyte	0.05	Nonsignificant	1.00	0.62	Other	168	512
20	melanocyte	0.04	Nonsignificant	1.00	0.64	Other	97	309
21	T_cell	0.04	Nonsignificant	1.00	0.56	Other	470	959
22	monocyte	0.03	Nonsignificant	1.00	0.64	Other	2,176	3,871
23	induced_pluripotent_stem_cell	0.03	Nonsignificant	1.00	0.67	Other	0	0
24	macrophage	0.03	Nonsignificant	1.00	0.68	Other	813	1,732
25	B_cell	0.01	Nonsignificant	1.00	0.53	Other	356	694
26	cardiomyocyte	8.12e-03	Nonsignificant	1.00	0.46	Other	533	2,045
27	adipocyte	4.08e-03	Nonsignificant	1.00	0.69	Other	33	111
28	microglia	3.69e-03	Nonsignificant	1.00	0.49	Other	61	129
29	haematopoietic_progenitor_cell	2.76e-03	Nonsignificant	1.00	0.59	Other	262	502
30	neuron	1.39e-03	Nonsignificant	1.00	0.72	Other	330	1,328
31	oligodendrocyte_precursor_cell	1.38e-03	Nonsignificant	1.00	0.39	Other	461	1,454
32	oligodendrocyte	5.13e-04	Nonsignificant	1.00	0.75	Other	385	1,507
33	innate_lymphoid_cell_2	4.34e-04	Nonsignificant	1.00	0.37	Other	3	8
34	natural_killer_cell	2.99e-04	Nonsignificant	1.00	0.42	Other	1,204	2,052

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.thymic_cortical	98.68	Significant	1.56e-04	1.61	Specific	442	824
2	EPI.salivary_myoepithelial	76.72	Significant	6.74e-13	1.70	—	191	714
3	EPI.skin_sebaceous_duct_luminal	41.39	Significant	0.10	1.36	—	100	249
4	EPI.tracheal_suprabasal	36.31	Significant	0.24	1.42	Relevant	29	56
5	EPI.tracheal_basal	34.93	Significant	0.03	1.41	Specific	398	1,120
6	EPI.salivary_duct_excretory	34.14	Significant	0.10	1.35	—	85	180
7	EPI.skin_keratinocyte_basal	32.50	Significant	—	1.29	Relevant	13	26
8	EPI.skin_sweat_duct_keratinocyte	30.70	Significant	0.07	1.40	—	146	301
9	EPI.salivary_intercalated_defense	28.82	Significant	0.24	1.22	—	81	161
10	EPI.cervical_suprabasal	28.29	Significant	—	1.09	Relevant	14	50
11	EPI.skin_keratinocyte_proliferating	26.37	Significant	0.64	1.23	—	47	76
12	EPI.skin_keratinocyte_progenitor	23.39	Significant	—	0.87	Relevant	0	3
13	EPI.skin_appendage_keratinocyte	22.53	Significant	0.24	1.23	—	87	222
14	EPI.alveolar_type_2	22.06	Significant	0.06	1.25	—	813	1,853
15	EPI.skin_interfollicular_spinous	19.89	Significant	0.24	1.20	Relevant	260	563
16	EPI.skin_follicular_keratinizing	19.14	Significant	0.67	1.17	—	30	81
17	EPI.skin_hair_follicle_companion	18.65	Significant	—	0.80	—	8	12
18	EPI.ectocervical_granular	17.17	Significant	—	0.00	Other	11	23
19	EPI.thymic_medullary	15.27	Significant	0.72	1.11	Relevant	26	133
20	EPI.skin_hair_follicle_bulge	15.22	Significant	0.66	1.15	Relevant	51	178
21	EPI.endocervical_secretory	14.32	Significant	—	0.66	—	0	0
22	EPI.ileal_enterocyte_absorptive	12.40	Significant	1.00	0.98	—	118	338
23	EPI.colonocyte	11.37	Significant	1.00	0.92	Relevant	294	815
24	EC.capillary	11.07	Significant	8.68e-14	1.58	Specific	514	1,635
25	EPI.bile_duct_cholangiocyte	11.05	Significant	1.00	0.87	—	37	60
26	SCHWN.schwann_cell	9.35	Significant	—	—	Relevant	7	33
27	EC.venous	9.11	Significant	0.16	1.12	Specific	516	1,387
28	EPI.renal_distal_tubule	8.77	Significant	1.00	0.89	Relevant	133	361
29	EPI.esophageal_suprabasal	8.58	Significant	1.00	0.80	Relevant	158	404
30	EPI.alveolar_type_1	8.08	Significant	1.00	0.88	—	26	101
31	EC.arterial	6.33	Significant	1.00	0.80	Other	356	885
32	EPI.esophageal_basal	6.11	Significant	1.00	0.75	—	4	10
33	EPI.salivary_serous_acinar	5.97	Significant	1.00	0.70	—	233	531
34	EPI.lung_club_secretory	5.59	Significant	1.00	0.70	—	5	14
35	EPI.salivary_duct_ion_transport	5.38	Nominal	1.00	0.57	Other	5	11
36	EPI.salivary_mucous_acinar	4.91	Nominal	1.00	0.78	Other	639	1,189
37	EPI.ileal_enterocyte_crypt	4.76	Nominal	1.00	0.58	Other	67	113
38	EPI.extrahepatic_cholangiocyte	4.53	Nominal	—	0.00	Other	37	71
39	EPI.lung_multiciliated	3.37	Nominal	1.00	0.56	Other	16	49
40	EPI.intrahepatic_cholangiocyte_transport	3.05	Nominal	—	0.00	Other	12	42
41	EPI.pancreatic_ductal_progenitor	2.89	Nonsignificant	1.00	0.52	Other	234	873
42	EPI.pancreatic_ductal_mucinous	2.79	Nonsignificant	1.00	0.57	Other	219	430
43	EC.lymphatic	2.53	Nonsignificant	1.00	0.55	Other	630	998
44	EPI.tracheal_submucosal_gland	2.10	Nonsignificant	—	0.00	Other	0	0
45	EPI.renal_thick_ascending_limb	2.07	Nonsignificant	1.00	0.34	Other	453	1,153
46	EPI.renal_immature_ureteric_bud	1.93	Nonsignificant	1.00	0.34	Other	217	569
47	EPI.ileal_bile_transport	1.84	Nonsignificant	1.00	0.49	Other	61	93
48	EPI.gastric_foveolar	1.82	Nonsignificant	—	0.00	Other	0	0
49	ASPC.adipose_stem_and_progenitor_cell	1.57	Nonsignificant	—	—	Other	324	930
50	HEP.canalicular_transport	1.29	Nonsignificant	2.74e-45	1.58	Other	1,290	3,434
51	FIB.neurolectin_mucosa	1.27	Nonsignificant	0.06	1.31	Other	133	394
52	FIB.tracheal_subepithelial	1.17	Nonsignificant	—	1.15	Other	0	0
53	ASTRO.astrocyte	1.16	Nonsignificant	—	—	Other	228	1,111
54	CHOND.chondrocyte	1.10	Nonsignificant	—	—	Other	519	730
55	EPI.renal_proximal_tubule	1.09	Nonsignificant	1.00	0.42	Other	525	806
56	MESO.mesothelial_cell	1.09	Nonsignificant	—	—	Other	2	18
57	SMC.smooth_muscle_cell	1.08	Nonsignificant	—	—	Other	20	101
58	FIB.interstitial	1.00	Nonsignificant	1.90e-14	1.46	Other	288	940
59	EC.heart_remodeling	1.00	Nonsignificant	1.00	0.12	Other	569	1,594
60	MAC.microglia_like	0.99	Nonsignificant	0.31	1.19	Other	124	179
61	EPI.pancreatic_ductal_perivascular	0.88	Nonsignificant	1.00	0.20	Other	4	30
62	PC.IgA_muocsal	0.83	Nonsignificant	0.02	1.56	Other	18	31
63	EPI.pancreatic_ductal_bicarbonate	0.74	Nonsignificant	1.00	0.19	Other	131	548
64	SKM.type_1_slow	0.72	Nonsignificant	2.48e-06	2.52	Other	923	2,478
65	PERI.pericyte	0.72	Nonsignificant	—	—	Other	117	0
66	FIB.barrier_purinergic	0.64	Nonsignificant	—	0.51	Other	1	3
67	EPI.hepatic_ductular_cholangiocyte	0.63	Nonsignificant	1.00	0.20	Other	83	243
68	EPI.colonic_tuft	0.57	Nonsignificant	—	0.00	Other	7	24
69	SKM.type_2_fast	0.55	Nonsignificant	1.00	0.23	Other	972	2,639
70	FIB.reticular	0.49	Nonsignificant	1.00	0.92	Other	19	87
71	EPI.renal_principal_cell	0.47	Nonsignificant	1.00	0.10	Other	207	403
72	EPI.ileal_goblet	0.46	Nonsignificant	1.00	0.27	Other	181	432
73	FIB.perivascular_interface	0.46	Nonsignificant	1.00	0.89	Other	0	0
74	PC.IgG_systemic	0.44	Nonsignificant	0.89	0.71	Other	41	60
75	MUSC.muscle_stem_cell	0.39	Nonsignificant	—	—	Other	4	18
76	FIB.suburothelial	0.38	Nonsignificant	1.00	0.89	Other	122	432
77	FIB.barrier_secretory	0.37	Nonsignificant	1.00	0.79	Other	81	228
78	FIB.transitioning	0.35	Nonsignificant	1.00	0.97	Other	172	497
79	EPI.intrahepatic_cholangiocyte_defense	0.32	Nonsignificant	—	0.00	Other	8	13
80	FIB.lung_alveolar	0.32	Nonsignificant	—	0.32	Other	6	15
81	T.CD4_Th2	0.25	Nonsignificant	—	1.32	Other	1	2
82	DC.cDC1	0.24	Nonsignificant	0.60	1.04	Other	55	112
83	T.CD4_Trm	0.23	Nonsignificant	3.32e-03	1.20	Other	176	363
84	GRANU.neutrophil	0.21	Nonsignificant	0.27	1.46	Other	1,235	2,649
85	HEP.pericentral_lipoprotein	0.20	Nonsignificant	—	0.25	Other	0	0
86	T.CD4_Tfh	0.18	Nonsignificant	0.12	1.22	Other	47	45
87	PLAT.platelet	0.17	Nonsignificant	—	0.00	Other	38	53
88	HEP.periportal_metabolic	0.17	Nonsignificant	1.00	0.70	Other	1,750	4,427
89	DC.cDC2	0.15	Nonsignificant	0.55	1.10	Other	1,189	1,793
90	T.CD4_transitional	0.15	Nonsignificant	0.12	1.18	Other	48	110
91	EPI.pancreatic_acinar	0.14	Nonsignificant	1.00	0.04	Other	429	1,475
92	EPI.renal_intercalated_cell_type_A	0.13	Nonsignificant	1.00	0.03	Other	67	142
93	GRANU.MAST	0.11	Nonsignificant	0.98	0.10	Other	5	6
94	DC.mig	0.10	Nonsignificant	—	0.43	Other	89	156
95	EPI.renal_intercalated_cell_type_B	0.08	Nonsignificant	—	0.00	Other	6	7
96	T.CD4_Treg	0.07	Nonsignificant	6.41e-03	1.25	Other	244	511
97	FIB.adventitial	0.07	Nonsignificant	1.00	0.08	Other	268	1,447
98	MONO.CD16	0.06	Nonsignificant	0.01	1.07	Other	1,304	1,835
99	GRNLSA.granulosa_cell	0.06	Nonsignificant	—	—	Other	257	0
100	THYMO.thymocyte	0.05	Nonsignificant	—	—	Other	163	495
101	T.CD8_Trm	0.04	Nonsignificant	1.00	0.95	Other	211	346
102	MEL.melanocyte	0.04	Nonsignificant	—	—	Other	79	242
103	FIB.skin_sheath	0.04	Nonsignificant	1.00	0.40	Other	49	118
104	MAC.resident_repair	0.04	Nonsignificant	1.00	1.03	Other	796	1,426
105	T.CD4_naive	0.04	Nonsignificant	1.00	0.95	Other	399	866
106	EPI.colonic_enteroendocrine	0.03	Nonsignificant	—	0.00	Other	1	1
107	IPSC.induced_pluripotent_stem_cell	0.03	Nonsignificant	—	—	Other	0	0
108	MONO.CD14	0.03	Nonsignificant	1.00	0.77	Other	2,294	4,139
109	FIB.skin_neurosecretory	0.03	Nonsignificant	—	0.00	Other	0	0
110	T.CD4_Tem	0.02	Nonsignificant	0.75	1.05	Other	365	697
111	MAC.resident_iron	0.02	Nonsignificant	1.00	1.00	Other	16	21
112	T.CD8_transitional	0.02	Nonsignificant	1.00	0.97	Other	497	932
113	T.CD4_Tcm	0.02	Nonsignificant	1.00	0.99	Other	494	988
114	T.CD8_naive	0.02	Nonsignificant	1.00	0.77	Other	317	708
115	T.CD4_Th17	0.02	Nonsignificant	1.00	0.82	Other	421	794
116	B.naive	0.02	Nonsignificant	1.31e-05	1.19	Other	307	595
117	T.CD8_Tcm	0.01	Nonsignificant	0.75	1.05	Other	460	926
118	EC.liver_sinusoidal	0.01	Nonsignificant	1.00	0.00	Other	1,083	1,925
119	T.MAIT	0.01	Nonsignificant	0.90	1.02	Other	469	855
120	FIB.hepatic_stellate_cell	0.01	Nonsignificant	—	0.00	Other	64	252
121	CM.cardiomyocyte	8.12e-03	Nonsignificant	—	—	Other	524	2,032
122	MAC.proliferating	7.55e-03	Nonsignificant	1.00	0.90	Other	87	253
123	MAC.LAM	6.52e-03	Nonsignificant	1.00	0.88	Other	914	2,064
124	B.memory	6.17e-03	Nonsignificant	1.00	0.89	Other	442	882
125	EPI.pancreatic_islet	5.68e-03	Nonsignificant	1.00	1.54e-03	Other	52	132
126	FIB.skin_tenogenic	5.49e-03	Nonsignificant	—	0.00	Other	108	227
127	ADIPO.adipocyte	4.08e-03	Nonsignificant	—	—	Other	20	62
128	MG.microglia	3.69e-03	Nonsignificant	—	—	Other	49	0
129	HPC.haematopoietic_progenitor_cell	2.76e-03	Nonsignificant	—	—	Other	211	370
130	B.age_associated	2.43e-03	Nonsignificant	1.00	0.95	Other	207	350
131	FIB.skin_papillary	2.31e-03	Nonsignificant	—	0.00	Other	0	0
132	MAC.MDM	2.30e-03	Nonsignificant	1.00	0.94	Other	623	986
133	NEU.EXC_SYT2	2.30e-03	Nonsignificant	—	0.63	Other	40	77
134	NEU.EXC_IT	2.25e-03	Nonsignificant	2.20e-04	1.05	Other	411	192
135	OPC.oligodendrocyte_precursor_cell	1.38e-03	Nonsignificant	—	—	Other	413	1,269
136	NEU.INH_VIP	9.48e-04	Nonsignificant	0.62	1.04	Other	241	366
137	OLG.oligodendrocyte	5.13e-04	Nonsignificant	—	—	Other	384	1,397
138	ILC2.innate_lymphoid_cell_2	4.34e-04	Nonsignificant	—	—	Other	2	0
139	T.gamma_delta	4.23e-04	Nonsignificant	1.00	0.51	Other	588	1,078
140	T.CD4_cytotoxic	3.82e-04	Nonsignificant	1.00	0.54	Other	855	1,493
141	T.CD8_Tem	3.01e-04	Nonsignificant	1.00	0.42	Other	1,083	1,857
142	NK.natural_killer_cell	2.99e-04	Nonsignificant	—	—	Other	1,204	2,045
143	HEP.acute_phase	2.49e-04	Nonsignificant	1.00	0.00	Other	1,441	3,641
144	MAC.kupffer	7.65e-05	Nonsignificant	1.00	0.64	Other	189	530
145	B.germinal_center	5.71e-05	Nonsignificant	1.00	0.25	Other	233	655
146	NEU.INH_PVALB	3.44e-05	Nonsignificant	1.00	0.94	Other	193	183
147	MAC.resident_cardiac	1.05e-05	Nonsignificant	1.00	0.38	Other	485	1,074
148	MAC.alveolar	5.88e-06	Nonsignificant	1.00	0.52	Other	1,432	3,122
149	NEU.INH_LAMP5	1.03e-07	Nonsignificant	1.00	0.88	Other	263	532
150	DC.pDC	2.59e-08	Nonsignificant	1.00	0.05	Other	496	1,028
151	NEU.EXC_CT	5.62e-10	Nonsignificant	1.00	0.53	Other	362	384
152	NEU.EXC_NTNG1	1.60e-12	Nonsignificant	—	0.00	Other	0	0

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.thymic_cortical.baseline	108.13	Significant	0.24	1.40	—	185	386
2	EPI.thymic_cortical.Notch_interface	105.07	Significant	—	0.03	Relevant	82	137
3	EPI.salivary_myoepithelial.activated	86.15	Significant	0.53	1.34	—	85	281
4	EPI.salivary_intercalated_defense.basal_EMT	84.71	Significant	—	2.00	—	0	0
5	EPI.salivary_myoepithelial.junctional_transport	83.06	Significant	0.53	1.16	—	66	121
6	EPI.thymic_cortical.secretory_remodeling	75.21	Significant	—	0.00	—	4	1
7	EPI.salivary_myoepithelial.baseline	70.98	Significant	0.93	0.37	—	42	141
8	EPI.tracheal_suprabasal.transitional_wound	50.96	Significant	—	0.60	—	16	1
9	EPI.skin_sebaceous_duct_luminal.immune_interface	50.60	Significant	—	0.67	—	0	0
10	EPI.skin_sebaceous_duct_luminal.detox_repair	49.70	Significant	0.16	1.72	—	137	94
11	EPI.salivary_myoepithelial.contractile_repair	45.89	Significant	—	0.00	—	3	9
12	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	43.06	Significant	—	1.15	Relevant	0	0
13	EPI.skin_keratinocyte_proliferating.detox_repair	42.95	Significant	—	1.13	—	0	0
14	EPI.salivary_duct_excretory.stress	41.25	Significant	0.57	1.06	—	33	68
15	EPI.skin_sweat_duct_keratinocyte.signal_gate	40.81	Significant	—	1.06	—	43	26
16	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	39.11	Significant	—	0.67	—	0	0
17	EPI.salivary_intercalated_defense.inflammatory	39.01	Significant	2.93e-03	1.92	—	152	360
18	EPI.skin_keratinocyte_basal.spinous_transition	38.40	Significant	—	0.97	—	0	0
19	EPI.skin_sweat_duct_keratinocyte.proliferative_S	38.04	Significant	—	0.76	—	0	0
20	EPI.tracheal_basal.homeostatic_progenitor	36.69	Significant	0.06	1.95	—	285	74
21	EPI.skin_keratinocyte_basal.transit_amplifying	36.57	Significant	—	0.00	Relevant	0	0
22	EPI.ectocervical_granular.proliferative_basal	35.31	Significant	—	1.15	—	0	0
23	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	33.84	Significant	—	0.00	—	0	0
24	EPI.skin_interfollicular_spinous.transition_basal	32.67	Significant	1.98e-04	2.51	—	100	127
25	EPI.tracheal_basal.activated_stress	32.27	Significant	0.70	0.73	—	32	0
26	EPI.cervical_suprabasal.secretory_vesicle	31.79	Significant	—	0.42	—	0	0
27	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	31.04	Significant	0.89	0.31	—	2	9
28	EPI.salivary_duct_excretory.baseline	30.96	Significant	0.57	0.91	—	23	57
29	EPI.skin_sweat_duct_keratinocyte.repair	27.79	Significant	—	0.00	—	0	0
30	EPI.skin_keratinocyte_basal.basement_anchoring	26.86	Significant	—	0.00	—	0	0
31	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	26.65	Significant	—	0.00	—	0	0
32	EPI.endocervical_secretory.squamous_barrier	26.20	Significant	—	0.67	—	0	0
33	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	26.15	Significant	0.08	1.76	—	33	34
34	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	25.68	Significant	—	0.00	—	0	0
35	EPI.alveolar_type_2.stress_response	25.13	Significant	0.10	1.73	—	675	1,562
36	EPI.cervical_suprabasal.inflammatory_repair	24.76	Significant	—	0.00	Relevant	0	0
37	EPI.skin_appendage_keratinocyte.transit_amplifying	24.49	Significant	—	0.57	—	109	358
38	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	24.34	Significant	—	0.00	—	39	82
39	EPI.skin_hair_follicle_companion.activated_migratory	23.40	Significant	—	0.97	—	0	0
40	EPI.skin_follicular_keratinizing.transit_amplifying	22.94	Significant	—	0.23	—	21	49
41	EPI.skin_interfollicular_spinous.proliferative	22.78	Significant	—	0.52	—	0	0
42	EPI.colonocyte.ionocyte_BEST4	22.58	Significant	0.02	2.09	—	103	188
43	EPI.colonocyte.distal_absorptive	22.07	Significant	—	1.26	—	0	0
44	EPI.skin_keratinocyte_proliferating.early_spinous_transition	21.49	Significant	—	0.00	—	135	290
45	EPI.skin_interfollicular_spinous.inflammatory	21.40	Significant	—	0.28	—	0	0
46	EPI.alveolar_type_2.injury_primed	21.32	Significant	0.97	0.66	—	434	245
47	EPI.thymic_medullary.proliferative_APC	21.26	Significant	—	1.26	—	0	0
48	EPI.skin_keratinocyte_proliferating.anchor_remodel	20.96	Significant	—	0.00	—	0	0
49	EPI.ileal_enterocyte_absorptive.brush_border	20.93	Significant	2.67e-08	2.09	—	580	1,717
50	EPI.skin_interfollicular_spinous.stress_oxidative	18.85	Significant	—	0.18	—	0	0
51	EPI.skin_hair_follicle_bulge.anagen_growth	18.44	Significant	—	0.67	Relevant	0	0
52	EPI.skin_interfollicular_spinous.early_differentiation	18.21	Significant	0.95	0.84	—	89	19
53	EPI.skin_hair_follicle_companion.gap_junction_contractile	17.87	Significant	—	0.00	—	0	0
54	EPI.thymic_medullary.hormone_xeno_barrier	17.49	Significant	—	0.43	Relevant	0	8
55	EPI.skin_follicular_keratinizing.upper_infundibulum	17.35	Significant	—	0.00	—	8	2
56	EPI.alveolar_type_2.baseline_surfactant	16.82	Significant	0.97	0.30	—	64	9
57	EPI.skin_follicular_keratinizing.root_infundibulum	16.69	Significant	—	0.00	—	0	0
58	EPI.tracheal_suprabasal.secretory_immune	16.20	Significant	—	0.00	Relevant	0	0
59	EPI.skin_hair_follicle_bulge.quiescent	16.10	Significant	0.54	0.93	—	56	69
60	EPI.skin_interfollicular_spinous.stress_UPR	15.87	Significant	—	0.00	—	0	0
61	SCHWN.reactive_inflammatory	15.81	Significant	—	1.27	—	0	0
62	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	15.79	Significant	1.00	8.56e-03	—	7	16
63	EPI.skin_interfollicular_spinous.baseline	15.72	Significant	0.95	0.31	—	35	3
64	EPI.skin_keratinocyte_progenitor.activated_stress	15.51	Significant	—	0.00	—	0	0
65	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	15.46	Significant	—	0.00	—	0	0
66	EPI.esophageal_suprabasal.proliferative_exit	15.42	Significant	—	1.61	—	0	0
67	EPI.thymic_medullary.stress_APC	15.30	Significant	0.94	0.95	Relevant	2	4
68	EPI.renal_distal_tubule.ion_transport	14.74	Significant	—	1.16	—	0	0
69	EPI.bile_duct_cholangiocyte.secretory_mucin	14.48	Significant	—	0.62	—	7	12
70	EPI.salivary_intercalated_defense.canonical_antimicrobial	14.00	Significant	1.00	0.00	—	11	22
71	EC.capillary.postcap_venule	13.96	Significant	0.03	1.85	—	355	261
72	EC.venous.adipose_lipid	13.03	Significant	0.44	1.25	—	254	476
73	EPI.colonocyte.junction_remodeling	12.94	Significant	0.34	1.43	—	218	305
74	EC.venous.remodeling_stalk	12.88	Significant	0.67	1.11	—	559	566
75	EC.venous.quiescent_homeostatic	12.64	Significant	0.24	1.39	—	456	360
76	EC.capillary.angiocrine	12.62	Significant	0.16	1.43	Relevant	250	630
77	EPI.thymic_medullary.canonical_alarmin	12.47	Significant	0.94	0.26	—	8	17
78	EPI.skin_sweat_duct_keratinocyte.barrier	12.33	Significant	—	0.00	—	0	0
79	EC.capillary.migratory	12.26	Significant	0.08	1.69	Relevant	181	509
80	EPI.renal_distal_tubule.immune_modulatory	11.94	Significant	—	0.71	Relevant	0	0
81	EC.capillary.stress	11.55	Significant	0.68	1.04	Relevant	44	36
82	EPI.skin_hair_follicle_bulge.niche_crosstalk	10.94	Significant	—	0.00	—	29	88
83	EC.capillary.baseline	10.63	Significant	1.00	0.77	Relevant	246	560
84	EC.arterial.metabolic	10.45	Significant	0.10	1.39	Relevant	195	159
85	EPI.esophageal_suprabasal.proliferative_G2M	10.14	Significant	—	0.51	—	0	0
86	EPI.esophageal_suprabasal.basal_transitional	10.12	Significant	0.89	1.07	—	44	67
87	EC.capillary.angiogenic_tip	9.89	Significant	0.27	1.39	Relevant	186	218
88	SCHWN.translation_boost	9.66	Significant	—	0.60	—	8	1
89	EPI.colonocyte.crypt_progenitor	9.56	Significant	0.96	0.46	—	115	265
90	EPI.colonocyte.secretory_boost	9.49	Significant	0.90	0.87	—	98	91
91	EPI.colonocyte.proximal_transport	9.20	Significant	0.90	0.77	—	24	12
92	EPI.alveolar_type_1.baseline	9.04	Significant	0.10	1.70	—	8	0
93	EPI.esophageal_suprabasal.proliferative_S	8.99	Significant	—	0.18	—	26	41
94	EC.arterial.inflammatory	8.82	Significant	0.10	1.43	Relevant	63	50
95	EC.venous.baseline	8.57	Significant	1.00	0.84	Relevant	346	807
96	EC.capillary.inflammatory	8.56	Significant	1.00	0.26	Relevant	27	51
97	EPI.endocervical_secretory.secretory_translocon	8.46	Significant	—	0.00	—	0	0
98	EPI.skin_interfollicular_spinous.upper_lipid	7.89	Significant	—	0.00	—	6	6
99	EPI.renal_distal_tubule.stress	7.89	Significant	—	0.00	—	0	0
100	EPI.bile_duct_cholangiocyte.inflammatory_APC	7.81	Significant	—	0.00	—	2	0
101	EC.venous.activated	7.77	Significant	1.00	0.79	Relevant	247	752
102	EPI.esophageal_suprabasal.differentiating_keratin	7.61	Significant	0.98	0.24	—	131	61
103	EC.arterial.mito_contact	7.44	Significant	0.97	1.02	Relevant	14	5
104	EPI.lung_club_secretory.ciliogenesis_axoneme	7.29	Significant	—	0.34	—	0	0
105	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	6.98	Significant	—	1.15	—	0	0
106	SCHWN.axon_contact_cardiac	6.97	Significant	1.00	0.00	Relevant	18	63
107	EC.capillary.activated	6.93	Significant	1.00	0.27	Relevant	2	5
108	EPI.esophageal_basal.junctional_barrier	6.90	Significant	—	0.69	—	0	0
109	EPI.ileal_enterocyte_crypt.baseline	6.51	Significant	0.02	1.85	—	11	6
110	EPI.salivary_serous_acinar.secretory_active	6.43	Significant	3.44e-06	2.61	—	242	69
111	EPI.lung_club_secretory.canonical_surfactant	6.31	Significant	—	0.39	—	74	104
112	EPI.colonocyte.goblet_interface	5.91	Significant	—	0.00	Relevant	11	21
113	EPI.esophageal_basal.activated_progenitor	5.85	Significant	0.69	0.63	—	1	0
114	EC.arterial.angiogenic_tip	5.82	Significant	—	0.00	Other	30	37
115	EC.arterial.arteriole_gas_exchange	5.81	Significant	0.97	0.78	Other	238	131
116	EPI.ileal_enterocyte_crypt.proliferative_S	5.59	Significant	0.27	1.42	Other	4	2
117	EC.arterial.arteriole_interface	5.53	Significant	0.97	0.87	Other	31	12
118	EPI.extrahepatic_cholangiocyte.barrier_interface	5.52	Significant	—	0.73	—	0	0
119	EPI.salivary_duct_ion_transport.baseline	5.38	Nominal	—	—	Other	0	0
120	EPI.renal_distal_tubule.repair	5.33	Nominal	—	0.00	Relevant	34	102
121	EPI.salivary_mucous_acinar.baseline	4.91	Nominal	—	—	Other	394	683
122	EPI.lung_club_secretory.inflammatory	4.89	Nominal	—	0.00	Other	0	0
123	EPI.renal_thick_ascending_limb.barrier_repair	4.50	Nominal	9.24e-04	1.84	Other	141	284
124	EC.arterial.elastic	4.47	Nominal	0.74	1.13	Other	22	45
125	EPI.ileal_enterocyte_crypt.proliferative_G2M	4.31	Nominal	—	0.00	Other	19	54
126	ASPC.activated	4.30	Nominal	1.48e-05	1.59	Other	164	162
127	EC.lymphatic.activated	4.10	Nominal	0.22	1.33	Other	47	73
128	EPI.lung_multiciliated.stress	3.92	Nominal	—	0.77	Other	67	165
129	EC.arterial.homeostatic	3.87	Nominal	0.97	0.89	Other	24	3
130	EPI.ileal_enterocyte_absorptive.villus_tip	3.79	Nominal	1.00	0.00	Other	4	3
131	EC.arterial.ion_pump	3.69	Nominal	0.97	0.45	Other	3	2
132	EPI.extrahepatic_cholangiocyte.mucin_secretory	3.59	Nominal	—	0.00	Other	0	0
133	EPI.renal_immature_ureteric_bud.defense_secretory	3.59	Nominal	5.88e-03	1.94	Other	45	76
134	ASTRO.A1_reactive	3.53	Nominal	0.40	1.16	Other	433	394
135	EPI.pancreatic_ductal_progenitor.ADM_like	3.48	Nominal	—	0.83	Other	0	0
136	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	3.48	Nominal	—	0.69	Other	0	0
137	EC.lymphatic.tip_migratory	3.42	Nominal	0.57	1.05	Other	23	37
138	EPI.ileal_enterocyte_crypt.bile_transport	3.40	Nominal	0.87	0.51	Other	2	0
139	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	3.31	Nominal	7.70e-03	2.27	Other	449	1,034
140	EPI.lung_multiciliated.baseline	3.06	Nominal	—	0.00	Other	0	7
141	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	2.86	Nonsignificant	—	0.00	Other	0	0
142	EPI.pancreatic_ductal_progenitor.baseline	2.85	Nonsignificant	0.75	0.67	Other	179	702
143	EPI.tracheal_submucosal_gland.ductal_luminal	2.83	Nonsignificant	—	0.73	Other	0	0
144	EPI.ileal_enterocyte_crypt.villus_transition	2.69	Nonsignificant	—	0.00	Other	7	10
145	EPI.ectocervical_granular.immune_interact	2.54	Nonsignificant	—	0.32	Other	0	0
146	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	2.50	Nonsignificant	—	0.00	Other	0	0
147	HEP.periportal_metabolic.stress_chaperone	2.48	Nonsignificant	—	0.88	Other	66	128
148	EPI.renal_distal_tubule.ciliated_remodelling	2.45	Nonsignificant	—	0.00	Other	0	0
149	EPI.renal_thick_ascending_limb.remodeling	2.40	Nonsignificant	0.46	1.25	Other	152	92
150	HEP.canalicular_transport.ductular_like_transition	2.33	Nonsignificant	1.40e-04	1.91	Other	400	87
151	EPI.pancreatic_ductal_progenitor.ciliated_transport	2.32	Nonsignificant	—	0.00	Other	105	368
152	ASTRO.stress_acute	2.30	Nonsignificant	1.00	0.96	Other	60	56
153	EPI.lung_club_secretory.ciliogenesis_primed	2.30	Nonsignificant	—	0.00	Other	0	0
154	EPI.ileal_enterocyte_crypt.secretory_precursor	2.29	Nonsignificant	—	0.00	Other	0	0
155	EC.lymphatic.baseline	2.29	Nonsignificant	0.57	1.07	Other	38	72
156	ASTRO.neuromodulatory	2.26	Nonsignificant	1.00	0.96	Other	34	172
157	ASPC.preadipocyte_lipid_primed	2.24	Nonsignificant	2.85e-03	1.31	Other	331	129
158	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	2.23	Nonsignificant	0.34	1.39	Other	219	533
159	EPI.lung_multiciliated.mature_motile_cilia	1.96	Nonsignificant	—	0.00	Other	0	0
160	EPI.alveolar_type_1.activated	1.95	Nonsignificant	—	0.00	Other	0	0
161	MAC.microglia_like.phagocytic_redox	1.95	Nonsignificant	—	0.00	Other	0	0
162	EPI.ileal_bile_transport.absorptive_xenobiotic	1.90	Nonsignificant	0.23	1.50	Other	11	12
163	EC.heart_remodeling.perivascular	1.89	Nonsignificant	1.57e-03	1.64	Other	124	408
164	PERI.baseline	1.85	Nonsignificant	0.08	1.19	Other	39	66
165	FIB.interstitial.mesenchymal_APC	1.85	Nonsignificant	2.20e-03	1.70	Other	81	33
166	EPI.salivary_serous_acinar.quiescent	1.85	Nonsignificant	1.00	0.03	Other	178	493
167	FIB.neurolectin_mucosa.nerve_interface	1.84	Nonsignificant	—	0.72	Other	4	0
168	EPI.gastric_foveolar.baseline	1.82	Nonsignificant	—	0.00	Other	0	0
169	EC.heart_remodeling.translation_boost	1.81	Nonsignificant	—	0.85	Other	0	0
170	HEP.canalicular_transport.injury_stress	1.79	Nonsignificant	5.22e-03	1.67	Other	289	24
171	MESO.secretory_structural	1.77	Nonsignificant	—	0.00	Other	0	0
172	MESO.baseline	1.74	Nonsignificant	0.47	1.05	Other	0	6
173	EPI.ileal_bile_transport.detox_transcytosis	1.68	Nonsignificant	—	0.00	Other	0	1
174	EC.heart_remodeling.remodeling_stalk	1.55	Nonsignificant	0.32	1.29	Other	33	111
175	SMC.activated	1.52	Nonsignificant	0.04	1.48	Other	2	5
176	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	1.47	Nonsignificant	—	1.32	Other	6	9
177	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	1.44	Nonsignificant	—	0.00	Other	0	0
178	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	1.41	Nonsignificant	—	0.00	Other	0	0
179	FIB.neurolectin_mucosa.inflammatory	1.41	Nonsignificant	0.03	2.16	Other	52	110
180	EC.lymphatic.valve	1.40	Nonsignificant	—	0.04	Other	0	0
181	HEP.canalicular_transport.pericentral_like_hypoxia	1.40	Nonsignificant	0.64	1.11	Other	326	8
182	EPI.tracheal_submucosal_gland.acinar_serous	1.38	Nonsignificant	—	0.00	Other	0	0
183	ASPC.baseline	1.37	Nonsignificant	1.00	0.81	Other	363	170
184	EPI.renal_immature_ureteric_bud.osmoprotective	1.36	Nonsignificant	0.99	0.06	Other	126	44
185	CHOND.pro_inflammatory	1.35	Nonsignificant	0.39	1.30	Other	181	351
186	EPI.renal_principal_cell.inflammatory	1.32	Nonsignificant	0.59	1.41	Other	74	157
187	HEP.canalicular_transport.secretory_ERAD_UPR	1.29	Nonsignificant	0.91	0.93	Other	232	28
188	EPI.renal_thick_ascending_limb.canonical_salt_transporter	1.29	Nonsignificant	1.00	0.53	Other	322	317
189	PERI.inflammatory	1.22	Nonsignificant	0.08	1.20	Other	40	77
190	ASPC.inflammatory	1.20	Nonsignificant	1.00	1.05	Other	21	61
191	CHOND.articular_collagen	1.18	Nonsignificant	0.39	1.16	Other	551	266
192	FIB.tracheal_subepithelial.baseline	1.17	Nonsignificant	—	0.00	Other	0	0
193	EPI.ectocervical_granular.inflammatory	1.16	Nonsignificant	—	0.00	Other	0	0
194	EC.venous.cardiac_structural	1.16	Nonsignificant	1.00	0.02	Other	102	229
195	EPI.hepatic_ductular_cholangiocyte.stress	1.16	Nonsignificant	—	1.01	Other	0	0
196	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	1.15	Nonsignificant	—	1.09	Other	49	237
197	FIB.barrier_purinergic.stress_GF_binding	1.12	Nonsignificant	—	0.97	Other	0	0
198	EPI.renal_proximal_tubule.onecarbon_peroxisome	1.11	Nonsignificant	0.83	0.84	Other	58	89
199	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	1.11	Nonsignificant	—	0.00	Other	0	0
200	FIB.interstitial.mesenchymal_regulator	1.07	Nonsignificant	0.98	0.99	Other	4	4
201	FIB.neurolectin_mucosa.remodeling_repair	1.07	Nonsignificant	—	0.00	Other	4	2
202	EPI.renal_proximal_tubule.detox_antioxidant	1.07	Nonsignificant	0.83	0.41	Other	394	77
203	SMC.metabolic	1.07	Nonsignificant	0.98	0.81	Other	14	40
204	CHOND.activated_fibro_like	1.00	Nonsignificant	0.96	0.57	Other	531	188
205	EPI.renal_thick_ascending_limb.cation_flux	0.97	Nonsignificant	1.00	0.17	Other	57	95
206	HEP.canalicular_transport.baseline	0.96	Nonsignificant	0.91	0.79	Other	199	477
207	FIB.interstitial.immune_interact	0.95	Nonsignificant	0.98	1.01	Other	12	1
208	EPI.renal_thick_ascending_limb.salt_sensing	0.93	Nonsignificant	1.00	0.15	Other	73	103
209	ASTRO.hypoxia_angiogenic	0.93	Nonsignificant	0.48	1.23	Other	5	18
210	EC.heart_remodeling.remodeling_secretory	0.92	Nonsignificant	1.00	0.80	Other	605	1,341
211	EPI.pancreatic_ductal_perivascular.protective_antioxidant	0.92	Nonsignificant	—	0.22	Other	11	69
212	FIB.neurolectin_mucosa.axon_responsive	0.92	Nonsignificant	1.00	0.00	Other	10	10
213	EPI.ileal_goblet.immature	0.92	Nonsignificant	—	1.59	Other	0	0
214	PC.IgA_muocsal.migratory	0.89	Nonsignificant	0.68	1.20	Other	4	1
215	ASPC.secretory	0.87	Nonsignificant	1.00	0.54	Other	76	5
216	PC.IgA_muocsal.activated	0.87	Nonsignificant	0.78	0.97	Other	17	8
217	FIB.interstitial.lipid_matrix	0.86	Nonsignificant	0.98	0.78	Other	258	191
218	SKM.type_1_slow.oxidative	0.85	Nonsignificant	0.02	1.98	Other	802	251
219	EPI.pancreatic_ductal_perivascular.baseline	0.85	Nonsignificant	0.49	1.04	Other	1	5
220	MAC.microglia_like.inflammatory_chemokine	0.83	Nonsignificant	—	0.10	Other	20	32
221	FIB.reticular.stress_metallothionein	0.79	Nonsignificant	—	0.28	Other	3	32
222	PC.IgA_muocsal.baseline	0.78	Nonsignificant	0.78	0.87	Other	3	5
223	SMC.contractile	0.76	Nonsignificant	0.98	0.61	Other	80	588
224	MESO.antiviral	0.75	Nonsignificant	—	0.00	Other	3	8
225	FIB.perivascular_interface.lipid_shuttle	0.75	Nonsignificant	—	0.97	Other	51	170
226	PC.IgG_systemic.secretory	0.75	Nonsignificant	0.20	1.41	Other	0	0
227	ASPC.niche_keeping_progenitor	0.74	Nonsignificant	1.00	0.50	Other	52	219
228	SKM.type_1_slow.contractile	0.74	Nonsignificant	0.16	1.43	Other	596	8
229	EPI.renal_principal_cell.activated_acute	0.73	Nonsignificant	0.86	1.15	Other	29	59
230	FIB.interstitial.remodeling	0.72	Nonsignificant	0.98	0.59	Other	31	9
231	PC.IgG_systemic.stress	0.72	Nonsignificant	—	0.82	Other	1	5
232	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	0.71	Nonsignificant	—	0.41	Other	0	0
233	HEP.canalicular_transport.sterol_lipid_biosynthesis	0.70	Nonsignificant	—	0.00	Other	10	20
234	CHOND.remodeling	0.66	Nonsignificant	—	0.00	Other	5	0
235	EPI.ectocervical_granular.secretory_apocrine	0.65	Nonsignificant	—	0.00	Other	0	0
236	HEP.canalicular_transport.inflammatory	0.64	Nonsignificant	1.00	2.97e-03	Other	1,335	194
237	FIB.suburothelial.inflammatory_prostanoid	0.63	Nonsignificant	—	0.89	Other	0	0
238	EC.heart_remodeling.capillary_metabolic	0.62	Nonsignificant	1.00	0.92	Other	54	414
239	PERI.angiocrine	0.62	Nonsignificant	1.00	0.84	Other	93	102
240	MUSC.activated_migratory	0.61	Nonsignificant	0.03	2.11	Other	6	7
241	FIB.interstitial.stress_secretory	0.60	Nonsignificant	0.98	0.49	Other	92	56
242	EPI.colonic_tuft.activated	0.60	Nonsignificant	—	0.00	Other	0	0
243	PC.IgA_muocsal.plasmablast	0.59	Nonsignificant	0.78	0.77	Other	5	4
244	SKM.type_2_fast.oxidative_IIa	0.59	Nonsignificant	2.30e-03	2.25	Other	946	56
245	EC.lymphatic.scavenger	0.57	Nonsignificant	1.00	0.06	Other	203	257
246	FIB.suburothelial.homeostasis_matrix	0.56	Nonsignificant	0.58	1.21	Other	258	921
247	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.55	Nonsignificant	—	0.73	Other	0	0
248	FIB.reticular.immune_interface	0.55	Nonsignificant	—	0.29	Other	1	6
249	T.CD4_Th2.tissue_adapted	0.54	Nonsignificant	—	0.97	Other	0	0
250	EPI.colonic_tuft.homeostatic	0.54	Nonsignificant	—	0.00	Other	0	0
251	FIB.barrier_secretory.homeostasis	0.52	Nonsignificant	—	0.43	Other	0	0
252	T.CD4_Trm.helper_like	0.50	Nonsignificant	0.70	1.25	Other	84	147
253	MAC.microglia_like.patrolling_adhesive	0.49	Nonsignificant	—	0.00	Other	0	0
254	FIB.suburothelial.contractile_myofibroblast	0.49	Nonsignificant	—	0.41	Other	9	0
255	SKM.type_2_fast.glycolytic_IIx_IIb	0.49	Nonsignificant	0.97	0.37	Other	565	1,482
256	ASPC.adipocyte_capillary_interface	0.49	Nonsignificant	1.00	0.38	Other	21	54
257	SKM.type_1_slow.glycolytic	0.48	Nonsignificant	1.00	0.00	Other	362	647
258	ASPC.remodeling	0.48	Nonsignificant	1.00	0.64	Other	106	354
259	DC.cDC2.lipid_metabolic	0.47	Nonsignificant	—	1.03	Other	0	0
260	PLAT.megakaryocytic	0.47	Nonsignificant	—	0.97	Other	0	0
261	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.46	Nonsignificant	0.96	1.03	Other	14	32
262	FIB.reticular.stromal_niche	0.46	Nonsignificant	0.60	0.96	Other	0	0
263	FIB.transitioning.motility_remodelling	0.44	Nonsignificant	—	0.17	Other	0	0
264	EPI.ileal_goblet.inflammatory_mucin	0.43	Nonsignificant	0.62	0.96	Other	6	9
265	EPI.pancreatic_ductal_bicarbonate.baseline	0.43	Nonsignificant	0.96	0.71	Other	11	42
266	EC.heart_remodeling.angiocrine	0.43	Nonsignificant	1.00	0.23	Other	182	525
267	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	0.42	Nonsignificant	0.96	0.86	Other	40	191
268	DC.cDC1.baseline	0.42	Nonsignificant	—	1.53	Other	0	0
269	MESO.activated_stress	0.42	Nonsignificant	—	0.28	Other	0	0
270	FIB.lung_alveolar.stress_interacting	0.42	Nonsignificant	—	0.97	Other	0	0
271	EPI.ileal_goblet.baseline	0.41	Nonsignificant	0.62	0.85	Other	16	2
272	MUSC.baseline	0.41	Nonsignificant	0.88	0.79	Other	0	0
273	T.CD4_Treg.tissue_effector	0.41	Nonsignificant	0.17	1.16	Other	16	13
274	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.40	Nonsignificant	—	0.00	Other	0	0
275	ASTRO.immature_lipid	0.39	Nonsignificant	1.00	0.93	Other	23	113
276	FIB.transitioning.ISG_primed_interface	0.38	Nonsignificant	—	0.00	Other	17	80
277	EPI.hepatic_ductular_cholangiocyte.polarity	0.38	Nonsignificant	—	0.00	Other	0	0
278	EC.heart_remodeling.activated_acute	0.38	Nonsignificant	1.00	0.32	Other	102	186
279	EPI.salivary_serous_acinar.seromucous_like	0.37	Nonsignificant	—	0.00	Other	0	0
280	EPI.renal_intercalated_cell_type_A.PC_transitional	0.37	Nonsignificant	—	0.90	Other	203	407
281	EPI.ileal_goblet.stress_metallothionein	0.37	Nonsignificant	—	0.00	Other	4	11
282	FIB.transitioning.secretory_procollagen	0.37	Nonsignificant	—	0.00	Other	0	0
283	CHOND.angiogenic	0.36	Nonsignificant	—	0.00	Other	0	0
284	T.CD8_transitional.stress	0.33	Nonsignificant	—	2.06	Other	24	34
285	DC.cDC2.adhesion_signaling	0.32	Nonsignificant	0.14	1.23	Other	35	9
286	T.CD4_transitional.primed_cytotoxic	0.32	Nonsignificant	0.57	1.12	Other	28	30
287	THYMO.DP_early_stress	0.31	Nonsignificant	—	2.16	Other	0	0
288	T.CD4_Trm.cytotoxic_effector	0.31	Nonsignificant	0.70	1.06	Other	118	77
289	ASPC.mesothelial_like	0.31	Nonsignificant	1.00	0.25	Other	143	486
290	ASPC.proliferative	0.31	Nonsignificant	1.00	0.38	Other	33	85
291	ASPC.stem_like_progenitor	0.30	Nonsignificant	1.00	0.26	Other	300	842
292	MUSC.early_activation	0.30	Nonsignificant	0.88	0.50	Other	4	32
293	T.CD4_Trm.metal_stress	0.30	Nonsignificant	0.70	1.26	Other	34	58
294	T.CD4_Tfh.effector_migratory	0.28	Nonsignificant	0.47	1.12	Other	122	57
295	EPI.hepatic_ductular_cholangiocyte.ion_transport	0.28	Nonsignificant	—	0.00	Other	0	0
296	DC.cDC2.monocyte_like	0.28	Nonsignificant	0.14	1.19	Other	1,285	791
297	MUSC.quiescent_reservoir	0.27	Nonsignificant	0.88	0.70	Other	2	8
298	T.CD4_Tfh.suppression_exhaustion	0.27	Nonsignificant	0.57	1.05	Other	0	2
299	FIB.perivascular_interface.vasomotor_tone	0.27	Nonsignificant	—	0.00	Other	0	0
300	FIB.perivascular_interface.vascular_BM_remodelling	0.27	Nonsignificant	—	0.00	Other	0	0
301	PC.IgG_systemic.interacting	0.26	Nonsignificant	1.00	0.58	Other	0	0
302	FIB.transitioning.matrix_stress	0.26	Nonsignificant	—	0.15	Other	47	138
303	DC.cDC1.homeostatic_inhibitory	0.26	Nonsignificant	—	0.36	Other	0	0
304	FIB.lung_alveolar.mito_secretory	0.26	Nonsignificant	—	0.00	Other	0	0
305	FIB.barrier_purinergic.lipid_secretory	0.24	Nonsignificant	—	0.00	Other	0	0
306	GRANU.neutrophil.antiviral_endotoxin	0.24	Nonsignificant	—	0.00	Other	0	0
307	MESO.activated_migratory	0.24	Nonsignificant	—	0.00	Other	0	0
308	T.CD4_Trm.baseline	0.24	Nonsignificant	0.70	1.10	Other	31	21
309	T.CD4_Tfh.canonical_GC_helper	0.23	Nonsignificant	0.47	1.16	Other	1	2
310	DC.cDC1.activated	0.22	Nonsignificant	—	0.00	Other	0	0
311	EPI.hepatic_ductular_cholangiocyte.secretory_transport	0.22	Nonsignificant	—	0.00	Other	0	0
312	GRANU.MAST.activated_acute	0.22	Nonsignificant	—	1.09	Other	0	0
313	MONO.CD14.repair_M2_like	0.22	Nonsignificant	0.30	1.09	Other	550	1,495
314	EPI.pancreatic_acinar.stress	0.21	Nonsignificant	0.33	1.33	Other	28	28
315	HEP.pericentral_lipoprotein.UPR_redox	0.20	Nonsignificant	—	0.67	Other	0	0
316	GRANU.neutrophil.tissue_patrolling	0.20	Nonsignificant	—	0.52	Other	0	0
317	T.CD4_transitional.tissue_enagement	0.20	Nonsignificant	0.57	1.19	Other	5	11
318	HEP.periportal_metabolic.xenobiotic_detox	0.20	Nonsignificant	0.69	1.33	Other	1,440	139
319	IPSC.canonical_pluripotent	0.20	Nonsignificant	3.49e-04	1.13	Other	0	0
320	THYMO.SP_CD8_naive_stress	0.20	Nonsignificant	0.16	1.34	Other	1	1
321	HEP.pericentral_lipoprotein.ApoB_coagulation	0.19	Nonsignificant	—	0.00	Other	0	0
322	EPI.pancreatic_ductal_bicarbonate.activated	0.19	Nonsignificant	0.96	0.49	Other	10	7
323	EPI.pancreatic_acinar.adhesion_remodeling	0.19	Nonsignificant	0.41	1.23	Other	210	784
324	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	0.19	Nonsignificant	—	0.00	Other	5	3
325	DC.cDC1.cross_presenting	0.18	Nonsignificant	—	0.00	Other	0	0
326	EPI.pancreatic_acinar.metabolic_onecarbon	0.18	Nonsignificant	0.29	1.38	Other	287	328
327	HEP.periportal_metabolic.inflammatory_activated	0.18	Nonsignificant	0.69	1.22	Other	712	1,610
328	THYMO.DN_preTCR	0.17	Nonsignificant	0.05	1.38	Other	41	71
329	GRANU.neutrophil.primed_degranulation	0.17	Nonsignificant	—	0.00	Other	0	0
330	MONO.CD14.APC_like	0.17	Nonsignificant	0.11	1.09	Other	1,686	2,493
331	FIB.barrier_secretory.remodeling	0.17	Nonsignificant	—	0.00	Other	0	0
332	IPSC.endoderm_primed	0.16	Nonsignificant	1.00	1.13	Other	0	0
333	EPI.pancreatic_acinar.inflammatory_regenerative	0.16	Nonsignificant	0.73	1.01	Other	25	113
334	EPI.renal_principal_cell.canonical_vasopressin	0.16	Nonsignificant	0.94	0.66	Other	2	0
335	THYMO.SP_CD8_transitional	0.14	Nonsignificant	0.16	1.36	Other	32	75
336	GRNLSA.cholesterol_mevalonate	0.14	Nonsignificant	0.43	1.27	Other	9	4
337	EPI.renal_principal_cell.intercalated_like	0.14	Nonsignificant	0.86	1.05	Other	63	66
338	MONO.CD16.platelet_bound	0.14	Nonsignificant	0.58	1.14	Other	372	508
339	MONO.CD16.inflammatory	0.13	Nonsignificant	0.01	1.24	Other	1,640	168
340	HEP.periportal_metabolic.apolipoprotein_secretory	0.13	Nonsignificant	0.97	1.01	Other	43	110
341	DC.cDC2.migratory	0.12	Nonsignificant	0.99	0.99	Other	185	39
342	FIB.reticular.ECM_builder	0.12	Nonsignificant	—	0.00	Other	0	0
343	T.CD4_transitional.baseline	0.12	Nonsignificant	0.75	0.98	Other	59	97
344	DC.cDC1.proliferative	0.12	Nonsignificant	—	0.00	Other	0	0
345	DC.cDC2.antiviral	0.12	Nonsignificant	0.99	0.94	Other	100	37
346	EPI.renal_principal_cell.injury_repair	0.12	Nonsignificant	0.94	0.38	Other	26	9
347	THYMO.CD8aa_IELp	0.12	Nonsignificant	—	1.07	Other	1	7
348	FIB.adventitial.PI16_matrix	0.11	Nonsignificant	0.10	1.31	Other	70	90
349	GRANU.MAST.activated_repair	0.11	Nonsignificant	—	0.17	Other	0	1
350	GRNLSA.chemokine_mechanosensory	0.11	Nonsignificant	0.43	1.23	Other	1	0
351	T.MAIT.stress	0.11	Nonsignificant	—	1.16	Other	0	0
352	EPI.pancreatic_acinar.quiet_dedifferentiation	0.11	Nonsignificant	1.00	0.62	Other	142	171
353	FIB.suburothelial.urothelial_interface	0.10	Nonsignificant	1.00	0.00	Other	9	8
354	CM.inflammatory	0.10	Nonsignificant	—	2.32	Other	0	0
355	HEP.periportal_metabolic.urea_onecarbon_secretory	0.10	Nonsignificant	0.97	0.80	Other	1,332	3,053
356	DC.mig.baseline	0.10	Nonsignificant	—	0.00	Other	1	0
357	FIB.adventitial.complement_angiocrine	0.09	Nonsignificant	0.63	1.06	Other	153	684
358	MONO.CD16.baseline	0.09	Nonsignificant	1.00	0.96	Other	50	1
359	T.CD4_Trm.central_like	0.08	Nonsignificant	1.00	0.52	Other	38	31
360	T.CD8_Trm.muscosal_Tc17	0.08	Nonsignificant	0.04	1.36	Other	19	38
361	FIB.adventitial.mechano_chemo_sensing	0.08	Nonsignificant	0.63	1.09	Other	135	524
362	EPI.renal_intercalated_cell_type_B.baseline	0.08	Nonsignificant	—	0.00	Other	3	1
363	MEL.neurotrophic_migratory	0.08	Nonsignificant	—	1.13	Other	0	0
364	PC.IgG_systemic.metabolic	0.08	Nonsignificant	1.00	3.01e-03	Other	46	63
365	HEP.periportal_metabolic.stress_checkpoint	0.07	Nonsignificant	0.97	0.59	Other	234	786
366	T.CD4_naive.gut_prone	0.07	Nonsignificant	0.90	1.27	Other	35	70
367	FIB.adventitial.mito_secretory	0.07	Nonsignificant	0.83	0.94	Other	21	7
368	T.CD4_transitional.APC_interacting	0.07	Nonsignificant	0.57	1.12	Other	10	14
369	FIB.adventitial.adhesion_lipid	0.07	Nonsignificant	0.08	1.45	Other	58	209
370	FIB.skin_sheath.ECM_immune	0.07	Nonsignificant	—	0.59	Other	0	0
371	GRNLSA.stress_metabolic	0.07	Nonsignificant	—	0.15	Other	1	2
372	GRNLSA.EMT_insulin_signaling	0.07	Nonsignificant	0.04	1.53	Other	47	84
373	HEP.periportal_metabolic.acute_phase_barrier	0.07	Nonsignificant	0.97	0.54	Other	533	138
374	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.07	Nonsignificant	—	0.00	Other	0	0
375	T.CD8_Tcm.gut_homing	0.07	Nonsignificant	0.02	1.27	Other	380	112
376	T.CD4_transitional.primed_helper_effector	0.06	Nonsignificant	0.83	0.81	Other	19	43
377	MAC.resident_repair.chemokine_angiocrine	0.06	Nonsignificant	0.34	1.17	Other	87	138
378	DC.cDC2.proliferative	0.06	Nonsignificant	—	0.00	Other	39	71
379	EPI.renal_intercalated_cell_type_A.acid_secretion	0.06	Nonsignificant	0.99	0.41	Other	12	6
380	MEL.dedifferentiated_migratory	0.06	Nonsignificant	—	0.59	Other	0	0
381	T.CD4_Th2.precursor	0.06	Nonsignificant	—	0.00	Other	0	0
382	T.CD8_naive.nfkb_related	0.06	Nonsignificant	0.03	1.52	Other	1	0
383	MEL.secretory_quiescent	0.06	Nonsignificant	0.10	1.61	Other	19	13
384	T.CD4_Tcm.DC_interact	0.06	Nonsignificant	0.72	1.14	Other	72	32
385	EPI.colonic_enteroendocrine.progenitor	0.06	Nonsignificant	—	0.97	Other	0	0
386	EPI.pancreatic_acinar.baseline	0.05	Nonsignificant	1.00	0.09	Other	274	163
387	HEP.periportal_metabolic.canonical_urea_cycle	0.05	Nonsignificant	0.97	0.67	Other	1,464	269
388	MAC.resident_repair.stress_iron	0.05	Nonsignificant	0.34	1.26	Other	48	97
389	T.CD8_Trm.cytotoxic	0.05	Nonsignificant	0.77	1.02	Other	165	85
390	T.CD4_Tcm.baseline	0.05	Nonsignificant	0.72	1.16	Other	61	31
391	MAC.resident_iron.stress_tolerogenic	0.05	Nonsignificant	—	0.89	Other	0	0
392	T.CD8_Trm.inflammatory	0.05	Nonsignificant	0.77	1.06	Other	124	176
393	T.CD4_naive.homeostatic	0.05	Nonsignificant	0.90	1.14	Other	215	108
394	EPI.pancreatic_ductal_bicarbonate.stress	0.05	Nonsignificant	—	0.00	Other	12	33
395	EC.liver_sinusoidal.secretory_lipoprotein	0.05	Nonsignificant	0.35	1.18	Other	120	70
396	T.CD4_naive.mature	0.05	Nonsignificant	0.90	1.06	Other	211	100
397	T.CD4_Tcm.Th2_like	0.04	Nonsignificant	0.72	1.22	Other	23	55
398	MONO.CD16.hepatic_mac_like	0.04	Nonsignificant	1.00	0.88	Other	803	117
399	T.CD4_Tem.inflammatory	0.04	Nonsignificant	0.44	1.10	Other	28	6
400	FIB.adventitial.baseline	0.04	Nonsignificant	1.00	0.52	Other	157	278
401	T.MAIT.migratory	0.04	Nonsignificant	0.94	1.18	Other	10	1
402	GRANU.MAST.resting_granule	0.04	Nonsignificant	—	0.00	Other	0	0
403	T.CD4_Th17.migratory	0.04	Nonsignificant	0.64	1.05	Other	13	23
404	ASTRO.stress_mito	0.04	Nonsignificant	1.00	0.79	Other	47	110
405	T.CD4_Tfh.precursor_migratory	0.04	Nonsignificant	1.00	0.45	Other	72	27
406	T.CD8_transitional.Trm_primed	0.04	Nonsignificant	0.76	1.04	Other	108	15
407	GRNLSA.proliferative_migratory	0.04	Nonsignificant	0.99	0.68	Other	248	292
408	T.CD4_naive.neddylation_mitoprot	0.03	Nonsignificant	0.90	0.98	Other	93	56
409	MEL.stress_glucocorticoid	0.03	Nonsignificant	1.00	0.55	Other	11	34
410	T.CD4_naive.proteostasis_mitoprot	0.03	Nonsignificant	0.90	1.16	Other	15	37
411	GRNLSA.secretory_remodeling	0.03	Nonsignificant	0.99	0.88	Other	90	25
412	T.CD4_naive.proteostasis	0.03	Nonsignificant	0.90	1.01	Other	14	9
413	B.naive.baseline	0.03	Nonsignificant	0.62	1.16	Other	10	13
414	MAC.LAM.lipid_opsonization	0.03	Nonsignificant	0.27	1.21	Other	45	14
415	T.CD8_naive.effector_transition	0.03	Nonsignificant	0.23	1.26	Other	35	62
416	MAC.LAM.perivascular_angiocrine	0.03	Nonsignificant	—	1.55	Other	53	138
417	T.CD4_Treg.central_naive_like	0.03	Nonsignificant	0.99	0.95	Other	333	45
418	T.CD8_Trm.homeostatic	0.03	Nonsignificant	1.00	0.72	Other	42	5
419	T.CD4_naive.mature_mitoprot	0.03	Nonsignificant	1.00	0.83	Other	212	476
420	MAC.resident_iron.heme_catabolism	0.03	Nonsignificant	2.18e-03	1.33	Other	30	51
421	FIB.skin_sheath.stress_chaperone	0.03	Nonsignificant	—	0.00	Other	0	0
422	B.naive.activated	0.03	Nonsignificant	0.62	1.12	Other	77	127
423	MAC.resident_iron.redox_metabolic	0.03	Nonsignificant	0.86	1.00	Other	4	4
424	THYMO.SP_CD4_naive	0.03	Nonsignificant	0.98	0.90	Other	65	75
425	DC.cDC2.tolerogenic_regulatory	0.03	Nonsignificant	0.99	0.70	Other	44	4
426	T.CD4_naive.survival	0.03	Nonsignificant	0.90	1.10	Other	12	17
427	T.CD4_Trm.activated	0.03	Nonsignificant	1.00	0.20	Other	32	26
428	T.CD4_naive.resist_bystander	0.03	Nonsignificant	0.90	0.98	Other	40	25
429	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	0.03	Nonsignificant	—	0.00	Other	0	0
430	T.CD4_Tem.long_term_memory	0.03	Nonsignificant	0.89	1.02	Other	314	587
431	T.CD4_naive.survival_neddylation	0.03	Nonsignificant	0.90	0.96	Other	26	38
432	T.CD8_naive.splicing_enriched	0.03	Nonsignificant	0.12	1.26	Other	120	16
433	MAC.resident_repair.antigen_presenting	0.03	Nonsignificant	0.79	0.91	Other	244	113
434	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.03	Nonsignificant	—	0.00	Other	0	0
435	B.naive.proteostasis	0.03	Nonsignificant	0.62	1.15	Other	49	69
436	FIB.skin_neurosecretory.baseline	0.03	Nonsignificant	—	0.00	Other	0	0
437	THYMO.SP_CD8_naive	0.02	Nonsignificant	0.98	0.82	Other	297	177
438	T.CD4_naive.neddylation	0.02	Nonsignificant	1.00	0.86	Other	104	222
439	T.CD4_naive.purinergic	0.02	Nonsignificant	0.90	1.05	Other	49	1
440	IPSC.stress	0.02	Nonsignificant	1.00	0.98	Other	0	0
441	T.CD4_Tcm.tissue_homing	0.02	Nonsignificant	0.85	1.12	Other	78	46
442	T.CD4_Trm.stress_adaptive	0.02	Nonsignificant	1.00	0.20	Other	8	22
443	T.CD4_Tcm.effector_like	0.02	Nonsignificant	0.85	1.10	Other	293	533
444	MEL.mature_oxidative_traffic	0.02	Nonsignificant	1.00	0.00	Other	247	285
445	B.memory.preactivated	0.02	Nonsignificant	0.18	1.21	Other	173	174
446	B.naive.receptor_recycle	0.02	Nonsignificant	0.62	1.11	Other	51	0
447	ASTRO.A2_reactive	0.02	Nonsignificant	1.00	0.74	Other	10	37
448	T.CD8_naive.lipid_synthesis	0.02	Nonsignificant	0.98	1.01	Other	6	4
449	T.CD4_naive.survival_mitoprot	0.02	Nonsignificant	0.96	0.89	Other	13	7
450	NEU.INH_VIP.enkephalinergic	0.02	Nonsignificant	—	2.15	Other	0	0
451	HPC.GMP_granulocytic	0.02	Nonsignificant	—	0.88	Other	3	3
452	T.CD8_transitional.early	0.02	Nonsignificant	0.92	0.97	Other	327	55
453	MAC.resident_repair.ECM_stromal_crosstalk	0.02	Nonsignificant	0.79	0.89	Other	95	158
454	DC.cDC2.pro_inflammatory	0.02	Nonsignificant	0.99	0.55	Other	3	5
455	T.CD4_Tcm.regulatory_poised	0.02	Nonsignificant	0.85	1.09	Other	2	3
456	T.CD4_Tcm.imprinted_splicing	0.02	Nonsignificant	0.85	1.00	Other	6	17
457	EC.liver_sinusoidal.inflammatory	0.02	Nonsignificant	—	0.27	Other	223	154
458	B.naive.metabolic	0.02	Nonsignificant	0.90	0.93	Other	50	79
459	T.CD8_Tcm.NK_like	0.02	Nonsignificant	0.44	1.17	Other	334	581
460	T.CD4_Tcm.Tfh_like	0.01	Nonsignificant	0.85	1.02	Other	102	214
461	CM.contractile_oxphos	0.01	Nonsignificant	0.96	1.21	Other	6	19
462	MAC.resident_iron.APC_iron_sensing	0.01	Nonsignificant	0.86	0.86	Other	211	114
463	MONO.CD14.platelet_bound	0.01	Nonsignificant	0.30	1.09	Other	964	176
464	B.naive.antigen_presenting_ready	0.01	Nonsignificant	0.90	0.91	Other	48	73
465	THYMO.DP_early	0.01	Nonsignificant	0.98	0.85	Other	326	313
466	T.CD4_Th17.baseline	0.01	Nonsignificant	0.64	0.98	Other	51	5
467	T.CD8_naive.baseline	0.01	Nonsignificant	0.98	0.82	Other	142	2
468	B.naive.remodeling	0.01	Nonsignificant	0.90	0.86	Other	135	230
469	T.CD4_Treg.APC_interactive	0.01	Nonsignificant	0.99	0.84	Other	118	28
470	T.CD4_Tem.transitional_CM	0.01	Nonsignificant	0.96	0.95	Other	31	20
471	T.CD4_Tcm.stress	0.01	Nonsignificant	0.85	1.03	Other	5	11
472	T.CD8_naive.cytokine_dampened	0.01	Nonsignificant	0.98	0.71	Other	71	4
473	GRNLSA.lipid_hypoxia	0.01	Nonsignificant	0.99	0.36	Other	28	0
474	IPSC.midbrain_primed	0.01	Nonsignificant	1.00	0.90	Other	0	0
475	FIB.hepatic_stellate_cell.fibrogenic	0.01	Nonsignificant	—	0.42	Other	0	0
476	T.CD8_naive.vesicle_secretory	0.01	Nonsignificant	0.98	0.76	Other	42	0
477	CM.mechano_activated	0.01	Nonsignificant	0.96	1.15	Other	205	134
478	CM.baseline	0.01	Nonsignificant	0.16	1.20	Other	393	0
479	ADIPO.hypoxia_remodelling	0.01	Nonsignificant	—	0.66	Other	29	105
480	B.naive.purinergic	0.01	Nonsignificant	0.90	0.91	Other	384	820
481	FIB.hepatic_stellate_cell.inflammatory	0.01	Nonsignificant	—	0.32	Other	0	0
482	T.MAIT.quiescent	0.01	Nonsignificant	0.94	1.05	Other	100	5
483	NEU.EXC_IT.structural	0.01	Nonsignificant	0.63	1.09	Other	171	41
484	T.CD4_Tcm.migratory_cilium	0.01	Nonsignificant	0.85	1.04	Other	5	10
485	EPI.pancreatic_islet.beta	0.01	Nonsignificant	0.30	1.26	Other	42	57
486	MONO.CD14.cord_tolerance	0.01	Nonsignificant	1.00	0.89	Other	864	753
487	FIB.adventitial.inflammatory_activated	0.01	Nonsignificant	1.00	0.19	Other	100	473
488	MAC.LAM.anti_inflammatory	0.01	Nonsignificant	0.84	1.04	Other	86	132
489	T.CD8_transitional.effector_primed	0.01	Nonsignificant	0.76	1.04	Other	435	151
490	MAC.proliferating.DNA_replication	0.01	Nonsignificant	0.15	1.27	Other	3	6
491	T.CD8_Trm.dendritic_recruiter	0.01	Nonsignificant	1.00	0.35	Other	47	85
492	PERI.cardiac_skeletal	0.01	Nonsignificant	1.00	0.02	Other	313	630
493	T.CD8_naive.innate_like	0.01	Nonsignificant	0.98	0.69	Other	10	1
494	THYMO.proliferative_S	0.01	Nonsignificant	0.98	0.56	Other	163	418
495	GRNLSA.p53_damage	9.89e-03	Nonsignificant	—	0.00	Other	13	10
496	FIB.skin_sheath.neuro_vascular_interface	9.83e-03	Nonsignificant	—	0.00	Other	0	0
497	MONO.CD14.inflammatory	9.56e-03	Nonsignificant	1.00	0.94	Other	92	134
498	T.CD8_transitional.APC_like	9.54e-03	Nonsignificant	0.92	0.90	Other	205	62
499	MG.phagocytic_APC	9.43e-03	Nonsignificant	0.11	1.23	Other	25	8
500	T.CD4_Tcm.synapse_dynamics	8.99e-03	Nonsignificant	0.85	1.04	Other	15	10
501	MONO.CD14.remodeling	8.93e-03	Nonsignificant	1.00	0.90	Other	2,373	295
502	HEP.acute_phase.hypoxia_lipid	8.45e-03	Nonsignificant	—	2.25	Other	0	0
503	MONO.CD16.patrolling	7.70e-03	Nonsignificant	1.00	0.34	Other	797	216
504	FIB.hepatic_stellate_cell.contractile	7.47e-03	Nonsignificant	—	0.00	Other	0	0
505	CM.osmoprotection	6.80e-03	Nonsignificant	0.99	0.92	Other	34	57
506	T.CD8_naive.mito_proteostasis	6.34e-03	Nonsignificant	0.98	0.56	Other	428	100
507	T.CD4_Treg.Tr1_like	5.94e-03	Nonsignificant	—	0.00	Other	8	8
508	B.naive.restrained	5.87e-03	Nonsignificant	0.90	0.86	Other	183	353
509	T.CD8_Tcm.effector_bias	5.58e-03	Nonsignificant	0.44	1.15	Other	199	329
510	FIB.skin_tenogenic.baseline	5.49e-03	Nonsignificant	—	0.00	Other	0	2
511	B.memory.migratory	5.33e-03	Nonsignificant	0.87	1.01	Other	123	208
512	IPSC.neuroendocrine_primed	5.22e-03	Nonsignificant	—	0.89	Other	0	0
513	MONO.CD14.baseline	5.00e-03	Nonsignificant	1.00	0.67	Other	2,268	76
514	T.MAIT.early_activation	4.93e-03	Nonsignificant	0.94	0.97	Other	57	4
515	B.memory.baseline	4.85e-03	Nonsignificant	0.95	0.94	Other	472	99
516	T.CD4_naive.Treg_like	4.78e-03	Nonsignificant	1.00	0.44	Other	121	72
517	MAC.MDM.inflammatory_phagocytic	4.75e-03	Nonsignificant	0.69	1.08	Other	199	52
518	CM.sarcomere_actin_interface	4.53e-03	Nonsignificant	0.99	0.68	Other	450	78
519	B.memory.activated	4.49e-03	Nonsignificant	0.87	1.00	Other	105	29
520	B.age_associated.migratory	4.40e-03	Nonsignificant	0.27	1.22	Other	2	2
521	MAC.resident_repair.lipid_phagocytic	4.37e-03	Nonsignificant	0.79	0.85	Other	228	604
522	EC.liver_sinusoidal.stress	4.27e-03	Nonsignificant	—	0.29	Other	413	158
523	HPC.GMP_inflammatory	4.24e-03	Nonsignificant	0.85	1.14	Other	20	10
524	IPSC.stromal_primed	4.18e-03	Nonsignificant	1.00	0.84	Other	0	0
525	IPSC.mesenchymal_primed	4.17e-03	Nonsignificant	1.00	0.83	Other	0	0
526	IPSC.axial_identity_primed	3.95e-03	Nonsignificant	1.00	0.86	Other	0	0
527	T.CD4_Tcm.retro_ZNF117	3.93e-03	Nonsignificant	0.92	0.91	Other	5	9
528	CM.mito_proteostasis	3.86e-03	Nonsignificant	0.99	0.80	Other	329	29
529	T.CD8_Tcm.baseline	3.76e-03	Nonsignificant	0.44	1.10	Other	90	89
530	T.CD4_Tcm.secretory	3.74e-03	Nonsignificant	0.98	0.73	Other	20	11
531	NEU.EXC_SYT2.synaptic	3.73e-03	Nonsignificant	—	0.48	Other	0	0
532	T.CD4_Th17.cytotoxic	3.70e-03	Nonsignificant	0.64	0.91	Other	332	123
533	CM.oxidative_phospho	3.66e-03	Nonsignificant	0.99	0.74	Other	266	792
534	CM.anti_inflammatory	3.62e-03	Nonsignificant	0.99	0.61	Other	424	1,503
535	OPC.premyelinating	3.47e-03	Nonsignificant	0.03	1.23	Other	185	12
536	MAC.LAM.inflammatory_APC	3.37e-03	Nonsignificant	0.84	1.01	Other	872	165
537	OLG.stress	2.92e-03	Nonsignificant	0.57	1.09	Other	232	8
538	CM.translation_boost_RPS	2.86e-03	Nonsignificant	0.99	0.76	Other	69	16
539	CM.translation_boost_RPL	2.83e-03	Nonsignificant	0.99	0.50	Other	129	1
540	NEU.INH_VIP.LAMP5_hybrid	2.79e-03	Nonsignificant	—	1.19	Other	1	9
541	NEU.INH_VIP.develop_niche	2.76e-03	Nonsignificant	—	1.23	Other	0	0
542	MAC.resident_iron.heme_recycling	2.71e-03	Nonsignificant	—	0.00	Other	30	37
543	T.CD4_cytotoxic.precursor	2.59e-03	Nonsignificant	0.17	1.26	Other	156	67
544	FIB.adventitial.activated_remodelling	2.44e-03	Nonsignificant	—	0.00	Other	141	319
545	MAC.LAM.lipid_phagocytosis	2.41e-03	Nonsignificant	0.93	0.87	Other	369	328
546	NK.cytokine_repair_primed	2.35e-03	Nonsignificant	0.14	1.15	Other	266	11
547	FIB.skin_papillary.baseline	2.31e-03	Nonsignificant	—	0.00	Other	0	0
548	T.CD4_Tcm.crosstalk_myeloid	2.05e-03	Nonsignificant	0.98	0.58	Other	5	4
549	T.CD4_Tem.cytotoxic_effector	2.02e-03	Nonsignificant	1.00	0.59	Other	225	398
550	PLAT.adhesion	1.99e-03	Nonsignificant	—	0.00	Other	0	0
551	ASTRO.synaptic_interaction	1.96e-03	Nonsignificant	1.00	0.55	Other	76	334
552	NK.adaptive_classII_inhibitory	1.94e-03	Nonsignificant	0.40	1.08	Other	880	154
553	T.MAIT.cytotoxic	1.92e-03	Nonsignificant	0.94	0.82	Other	52	15
554	EPI.pancreatic_islet.delta	1.82e-03	Nonsignificant	—	0.67	Other	0	0
555	T.CD4_Tcm.RNA_control	1.81e-03	Nonsignificant	0.98	0.69	Other	96	4
556	THYMO.proliferative_G2M	1.79e-03	Nonsignificant	—	0.00	Other	164	413
557	T.CD4_Tcm.APC_mimicry	1.78e-03	Nonsignificant	0.98	0.64	Other	54	43
558	EPI.colonic_enteroendocrine.Lcell_peptide	1.69e-03	Nonsignificant	—	0.00	Other	0	0
559	MAC.MDM.complement_resolving	1.64e-03	Nonsignificant	0.69	0.99	Other	440	860
560	B.age_associated.naive_transitional	1.62e-03	Nonsignificant	—	0.73	Other	0	0
561	NK.cytokine_lung_immediate_early	1.55e-03	Nonsignificant	0.69	1.13	Other	424	274
562	MG.baseline	1.50e-03	Nonsignificant	0.94	0.78	Other	16	5
563	NEU.INH_VIP.regulatory_remodeling	1.45e-03	Nonsignificant	—	0.07	Other	6	1
564	T.CD8_Tcm.helper_like	1.45e-03	Nonsignificant	0.90	0.81	Other	81	159
565	T.MAIT.MAPK_brake	1.30e-03	Nonsignificant	0.94	0.84	Other	44	66
566	EC.liver_sinusoidal.hypoxia_metabolic	1.19e-03	Nonsignificant	0.96	0.63	Other	183	107
567	MAC.MDM.APC_dendritic	1.15e-03	Nonsignificant	0.69	1.09	Other	48	15
568	HPC.CLP_B_primed	1.11e-03	Nonsignificant	—	0.99	Other	0	0
569	HEP.acute_phase.stress_secretory	1.04e-03	Nonsignificant	0.27	1.28	Other	26	3
570	HEP.acute_phase.inflammatory	9.99e-04	Nonsignificant	0.41	1.12	Other	382	649
571	ILC2.migratory	9.36e-04	Nonsignificant	—	0.59	Other	0	0
572	T.CD8_Tem.baseline	7.39e-04	Nonsignificant	0.71	1.04	Other	458	356
573	EC.liver_sinusoidal.prostanoid	6.98e-04	Nonsignificant	—	0.00	Other	11	64
574	IPSC.neural_primed	6.75e-04	Nonsignificant	1.00	0.70	Other	0	0
575	MAC.proliferating.stress	6.66e-04	Nonsignificant	—	0.00	Other	87	136
576	IPSC.mesodermal_primed	6.54e-04	Nonsignificant	1.00	0.76	Other	0	0
577	T.MAIT.vesicle	6.17e-04	Nonsignificant	0.94	0.60	Other	37	65
578	T.gamma_delta.central_memory	6.02e-04	Nonsignificant	0.36	1.12	Other	460	919
579	NK.adaptive_HLAE_tuned	4.98e-04	Nonsignificant	0.14	1.06	Other	1,124	189
580	OPC.proliferative_immune_interact	4.91e-04	Nonsignificant	1.00	0.84	Other	180	373
581	T.CD4_naive.activated_stress	4.75e-04	Nonsignificant	1.00	0.14	Other	339	429
582	B.age_associated.activated	4.21e-04	Nonsignificant	—	0.00	Other	18	22
583	T.gamma_delta.early_effector	3.65e-04	Nonsignificant	0.36	1.12	Other	89	0
584	MG.expanding	3.64e-04	Nonsignificant	0.94	0.81	Other	2	1
585	ADIPO.thermogenic	3.56e-04	Nonsignificant	—	0.44	Other	0	0
586	HPC.MEP	3.38e-04	Nonsignificant	0.97	0.93	Other	599	1,195
587	NK.adaptive_immature_precursor	3.08e-04	Nonsignificant	0.77	1.07	Other	358	111
588	T.gamma_delta.cytotoxic_effector	2.99e-04	Nonsignificant	0.71	0.98	Other	349	109
589	HPC.MPP_IEG	2.49e-04	Nonsignificant	0.97	1.02	Other	45	46
590	NK.immature_bridge	2.47e-04	Nonsignificant	0.78	1.02	Other	117	122
591	T.CD8_Tem.early_helper_like	2.44e-04	Nonsignificant	0.71	1.05	Other	445	755
592	MAC.LAM.antimicrobial	2.36e-04	Nonsignificant	0.93	0.83	Other	389	93
593	IPSC.proliferative	2.23e-04	Nonsignificant	1.00	0.71	Other	0	0
594	ILC2.activated	2.18e-04	Nonsignificant	—	0.00	Other	0	0
595	ILC2.quiescent	1.90e-04	Nonsignificant	—	0.00	Other	0	0
596	T.CD8_Tem.stress_adapted	1.88e-04	Nonsignificant	0.71	1.00	Other	607	520
597	MAC.kupffer.inflammatory	1.80e-04	Nonsignificant	—	0.35	Other	7	4
598	T.CD8_Tem.signaling_turnover	1.77e-04	Nonsignificant	0.71	1.05	Other	425	683
599	NK.adaptive_terminal_cytotoxic	1.73e-04	Nonsignificant	0.78	1.02	Other	485	802
600	OLG.myelinating_mature	1.38e-04	Nonsignificant	0.86	1.04	Other	363	94
601	T.CD4_cytotoxic.baseline	1.37e-04	Nonsignificant	0.95	1.16	Other	0	0
602	IPSC.mesendo_primed	1.32e-04	Nonsignificant	1.00	0.69	Other	0	0
603	B.memory.pDC_imprint	1.32e-04	Nonsignificant	0.95	0.57	Other	157	103
604	B.germinal_center.LZ_selection	1.16e-04	Nonsignificant	—	0.92	Other	0	0
605	GRNLSA.angiocrine_mechanosensory	1.10e-04	Nonsignificant	—	0.00	Other	0	0
606	NEU.INH_PVALB.chandelier	1.04e-04	Nonsignificant	0.76	1.13	Other	19	16
607	NEU.INH_VIP.matrix	9.54e-05	Nonsignificant	—	0.08	Other	24	77
608	T.CD4_cytotoxic.terminal_effector	9.24e-05	Nonsignificant	0.96	0.95	Other	286	21
609	T.CD8_Tem.TEMRA	8.97e-05	Nonsignificant	0.71	1.01	Other	920	1,088
610	MAC.kupffer.stress	8.76e-05	Nonsignificant	0.29	1.12	Other	9	3
611	EPI.pancreatic_islet.alpha	7.61e-05	Nonsignificant	—	0.00	Other	152	330
612	MAC.kupffer.tolerogenic	7.30e-05	Nonsignificant	—	0.15	Other	45	49
613	B.germinal_center.DZ_S_phase	7.04e-05	Nonsignificant	—	0.00	Other	0	0
614	NEU.INH_VIP.nuclear_reg	5.99e-05	Nonsignificant	—	0.00	Other	20	4
615	MAC.MDM.LAM_like	5.80e-05	Nonsignificant	0.69	0.98	Other	12	14
616	MAC.kupffer.metabolic	5.41e-05	Nonsignificant	—	0.00	Other	25	36
617	NK.adaptive_axis_baseline	5.02e-05	Nonsignificant	0.60	1.05	Other	1,008	153
618	B.germinal_center.LZ_memory_precursor	4.72e-05	Nonsignificant	—	0.00	Other	0	0
619	HEP.acute_phase.baseline	4.53e-05	Nonsignificant	0.99	0.93	Other	946	19
620	OPC.homeostatic	4.34e-05	Nonsignificant	1.00	0.24	Other	394	160
621	NEU.INH_VIP.canonical_disinhibitory	3.83e-05	Nonsignificant	0.81	0.83	Other	59	38
622	NK.cytokine_axis_baseline	3.73e-05	Nonsignificant	0.92	0.97	Other	1,172	116
623	ADIPO.immature	3.73e-05	Nonsignificant	—	0.00	Other	24	40
624	NK.cytokine_biosynthetic_primed	3.19e-05	Nonsignificant	0.78	1.06	Other	360	21
625	MAC.alveolar.capillary_interacting	3.09e-05	Nonsignificant	0.37	1.23	Other	113	181
626	NEU.INH_PVALB.fastspike	2.85e-05	Nonsignificant	—	0.00	Other	24	22
627	MAC.resident_cardiac.inflammatory_reparative	2.36e-05	Nonsignificant	0.29	1.26	Other	31	96
628	NK.cytokine_tissue_resident	2.18e-05	Nonsignificant	0.77	1.12	Other	74	82
629	NK.cytokine_quiescent	2.12e-05	Nonsignificant	0.78	1.02	Other	623	1,062
630	ASTRO.homeostatic	1.82e-05	Nonsignificant	1.00	0.20	Other	200	431
631	HEP.acute_phase.complement_antiviral	1.80e-05	Nonsignificant	0.99	0.83	Other	377	751
632	MAC.kupffer.monocyte_like	1.64e-05	Nonsignificant	—	0.00	Other	0	0
633	NK.cytokine_vascular_patrolling	1.32e-05	Nonsignificant	0.78	1.01	Other	863	94
634	HEP.acute_phase.proliferative	1.19e-05	Nonsignificant	—	0.25	Other	4	6
635	NEU.INH_VIP.serotonergic	9.56e-06	Nonsignificant	—	0.00	Other	9	2
636	MAC.resident_cardiac.antigen_presenting	9.31e-06	Nonsignificant	0.35	1.13	Other	52	27
637	MAC.resident_cardiac.phagocytic_homeostasis	9.02e-06	Nonsignificant	0.48	1.02	Other	564	1,221
638	ASPC.signal_integrator	7.78e-06	Nonsignificant	—	0.00	Other	0	0
639	NEU.INH_PVALB.metabotropic	7.61e-06	Nonsignificant	—	0.45	Other	0	0
640	HEP.acute_phase.complement_metabolic	6.65e-06	Nonsignificant	0.99	0.76	Other	1,423	3,464
641	NEU.INH_VIP.excitatory_coupled	5.76e-06	Nonsignificant	—	0.00	Other	13	0
642	NEU.INH_VIP.cannabinoid	5.67e-06	Nonsignificant	—	0.00	Other	0	0
643	MAC.alveolar.inflammatory	4.95e-06	Nonsignificant	0.86	1.04	Other	208	312
644	T.CD8_Tem.motility_primed	4.31e-06	Nonsignificant	0.86	0.83	Other	269	4
645	NEU.EXC_IT.adhesion	3.85e-06	Nonsignificant	0.63	1.09	Other	252	108
646	HPC.LMPP	3.05e-06	Nonsignificant	0.98	0.67	Other	65	31
647	B.germinal_center.LZ_survival	2.94e-06	Nonsignificant	—	0.00	Other	0	0
648	NEU.INH_VIP.opioid	2.70e-06	Nonsignificant	—	0.00	Other	50	9
649	NEU.INH_PVALB.nuclear_reg	2.13e-06	Nonsignificant	0.91	0.64	Other	25	12
650	EC.liver_sinusoidal.remodeling_lipotoxicity	2.02e-06	Nonsignificant	—	0.00	Other	90	58
651	MAC.kupffer.fibrogenic	1.83e-06	Nonsignificant	—	0.00	Other	0	0
652	MAC.alveolar.lipid_autophagy	1.59e-06	Nonsignificant	—	0.00	Other	35	44
653	NK.cytokine_tissue_activation	1.37e-06	Nonsignificant	0.90	0.91	Other	267	450
654	T.CD4_cytotoxic.NK_adapted	1.33e-06	Nonsignificant	0.96	0.75	Other	82	33
655	B.germinal_center.DZ_M_phase	1.15e-06	Nonsignificant	—	0.00	Other	0	0
656	T.CD4_cytotoxic.activated	1.13e-06	Nonsignificant	0.96	0.58	Other	3	1
657	OLG.regulatory_activated	9.98e-07	Nonsignificant	0.86	1.02	Other	196	614
658	NK.adaptive_adipose_stress	7.24e-07	Nonsignificant	0.92	0.81	Other	374	39
659	OLG.myelinating_stress	5.71e-07	Nonsignificant	0.92	0.96	Other	232	62
660	OLG.reactive_repair	4.84e-07	Nonsignificant	0.86	1.04	Other	385	385
661	NK.adaptive_biosynthetic_primed	2.60e-07	Nonsignificant	0.90	0.88	Other	244	405
662	NEU.INH_LAMP5.projecting	2.53e-07	Nonsignificant	—	1.16	Other	0	0
663	OLG.regulatory	1.61e-07	Nonsignificant	0.99	0.80	Other	353	73
664	NEU.INH_PVALB.neuromodulatory	1.44e-07	Nonsignificant	—	0.00	Other	0	0
665	NEU.INH_LAMP5.exc_inh_balance	1.25e-07	Nonsignificant	—	0.00	Other	46	2
666	MAC.alveolar.stress_metabolic	9.78e-08	Nonsignificant	0.90	0.93	Other	116	148
667	OLG.vesicle_trafficking	9.13e-08	Nonsignificant	0.99	0.85	Other	124	10
668	HPC.MPP_activated	7.16e-08	Nonsignificant	—	0.00	Other	0	0
669	NEU.EXC_IT.neuromodulated	6.68e-08	Nonsignificant	0.82	1.06	Other	176	116
670	DC.pDC.immature_metabolic	3.82e-08	Nonsignificant	0.37	1.23	Other	78	124
671	NEU.INH_PVALB.serotonergic	2.84e-08	Nonsignificant	—	0.00	Other	0	0
672	DC.pDC.baseline	2.37e-08	Nonsignificant	0.52	1.08	Other	88	123
673	DC.pDC.poised_migratory	1.46e-08	Nonsignificant	0.52	1.12	Other	54	95
674	NEU.EXC_IT.transitional	8.10e-09	Nonsignificant	1.00	0.97	Other	237	142
675	MAC.alveolar.scavenging_endocytic	1.43e-09	Nonsignificant	—	0.00	Other	140	283
676	NEU.EXC_CT.projector	1.25e-09	Nonsignificant	0.03	1.28	Other	87	26
677	MAC.alveolar.biosynthetic_sterol_heme	4.80e-10	Nonsignificant	0.90	0.77	Other	347	40
678	NEU.INH_LAMP5.rosehip	4.67e-10	Nonsignificant	—	0.00	Other	0	0
679	NEU.INH_LAMP5.glial_interface	3.50e-10	Nonsignificant	—	0.00	Other	0	0
680	ADIPO.inflammatory	1.29e-10	Nonsignificant	—	0.00	Other	0	0
681	NEU.EXC_CT.Ca2_sensor	3.46e-11	Nonsignificant	—	0.00	Other	0	0
682	NEU.EXC_CT.Ca2_signaling	3.45e-11	Nonsignificant	—	0.00	Other	68	17
683	NEU.EXC_CT.remodeling	2.02e-11	Nonsignificant	—	0.00	Other	23	1
684	NEU.EXC_IT.guidance	5.11e-12	Nonsignificant	1.00	0.57	Other	274	63
685	NEU.EXC_SYT2.nuclear_reg	3.09e-12	Nonsignificant	—	0.00	Other	0	0
686	NEU.EXC_NTNG1.synaptic	2.67e-12	Nonsignificant	—	0.67	Other	0	0
687	NEU.EXC_NTNG1.nuclear_reg	6.59e-13	Nonsignificant	—	0.00	Other	0	0
688	NEU.EXC_IT.callosal	2.25e-13	Nonsignificant	1.00	0.34	Other	286	119

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

11 unique genes. Showing 1–11. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)
RASSF10-DT	01-High	0.51	1.97	G1	C1	—	—	—	1	2
RASSF10	01-High	0.48	2.58	G1	C1	—	EC.venous (Tier: specific) EPI.tracheal_basal (Tier: specific) EPI.colonocyte (Tier: relevant) EPI.esophageal_suprabasal (Tier: relevant) EPI.skin_keratinocyte_progenitor (Tier: relevant) EPI.thymic_medullary (Tier: relevant) EC.arterial.mito_contact (Tier: relevant) EC.capillary.migratory (Tier: relevant) EPI.skin_keratinocyte_progenitor.quiescent_stem_like (Tier: relevant)	47 cells — complete matches	2	3
SEMA4B	02-Medium	0.40	7.69	G2	C2	—	—	25 cells — complete matches	13	18
ENSG00000277007	02-Medium	0.36	10.58	G2	C2	—	—	—	4	14
ENSG00000307248	02-Medium	0.31	12.43	G2	C1	—	—	—	4	11
ENSG00000296119	02-Medium	0.31	12.89	G2	C2	—	—	—	0	0
LYPLAL1	02-Medium	0.30	11.25	G2	C2	B.memory.migratory (L2)	—	B.germinal_center.LZ_survival (L2), B.memory.migratory (L2), EPI.cervical_suprabasal.secretory_vesicle (L2)	4	12
ENSG00000287676	02-Medium	0.24	10.01	G2	C2	—	—	—	0	3
LYPLAL1-DT	02-Medium	0.22	10.24	G2	C2	—	—	—	4	11
ENSG00000305547	02-Medium	0.21	12.24	G2	C2	—	—	—	1	7
LYPLAL1-AS1	02-Medium	0.19	10.59	G2	C2	—	—	—	1	1

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.