Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

FING00000005 · All tissues

Abscess of anal and rectal regions: evidence report

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links: Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant: The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1): Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2): Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values: CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits: Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links: Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support: The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support: The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority: Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority: Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation: Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation: A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

ICE-CREAM (IC) is −log10(P) from a permutation test. An IC score of 3 corresponds to an unadjusted P value of 0.001; 5.5 is the multiple-testing-corrected significance threshold across all metacells. The Significance categories are Significant for IC > 5.5, Nominal for 3 ≤ IC ≤ 5.5, and Nonsignificant for IC < 3. These reports display mean IC scores across full-atlas populations, not the UMAP sample. The categories apply to the displayed scores: a cell-group mean or an average across individual traits is descriptive and is not itself a newly tested P value or a new multiple-testing correction. All scores are retained. Enrichment is not proof of causality or treatment efficacy.

Open this trait in Cell Browser →

Meta trait: Anal and rectal disorder

Interpret only the requested hierarchy level (L1, L1S or L2) and the exact cell identities listed for that level on the permanent reference page for the requested scope. Cell names link to their shared scope memberships. Membership is trait-independent and based on positive full-population overlap, not sampled points. A population can overlap several scopes. Cell-identity scopes include only the population itself and its ancestors, never its descendants: an L1 type does not list child L1S subtypes or L2 states. Tissue, system, lineage and theme scopes retain their full-population overlap memberships. These IC scores and cell counts remain full-atlas values: selecting a scope restricts which populations are interpreted; it does not recalculate tissue-specific averages. Do not interpret other levels or out-of-scope populations.

Scope reference: eligible cells by level · Cell-to-scope memberships

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states. Co-interpret eligible cell rankings with the associated-gene table below using both annotation-marker overlap and scope-pooled enriched-gene overlap, kept separate. Read each relevant cell's complete marker and enrichment lists through the linked reference. These support biological interpretation, not marker recaps, causal proof or a replacement for interpreting the ranking.

Type rankings — L1 (34)

Types ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	induced_pluripotent_stem_cell	14.21	Significant	1.11e-43	1.22	Relevant	0	0
2	muscle_stem_cell	7.91	Significant	0.19	1.13	Specific	7	27
3	adipose_stem_and_progenitor_cell	5.33	Nominal	7.47e-05	1.07	Other	327	954
4	thymocyte	4.63	Nominal	0.13	1.06	Other	168	512
5	chondrocyte	4.61	Nominal	1.00	0.98	Other	548	1,069
6	endothelial_cell	4.10	Nominal	0.02	1.04	Other	373	974
7	epithelial_cell	3.67	Nominal	0.17	1.02	Other	24	47
8	innate_lymphoid_cell_2	2.34	Nonsignificant	1.00	0.99	Other	3	8
9	fibroblast	2.32	Nonsignificant	1.00	1.01	Other	184	826
10	melanocyte	1.97	Nonsignificant	1.00	0.96	Other	97	309
11	smooth_muscle_cell	1.89	Nonsignificant	1.00	1.00	Other	27	139
12	pericyte	1.61	Nonsignificant	1.00	0.98	Other	128	517
13	haematopoietic_progenitor_cell	1.50	Nonsignificant	1.00	0.94	Other	262	502
14	schwann_cell	0.97	Nonsignificant	1.00	0.91	Other	10	57
15	dendritic_cell	0.73	Nonsignificant	1.00	0.86	Other	496	724
16	mesothelial_cell	0.65	Nonsignificant	1.00	0.93	Other	6	36
17	granulocyte	0.61	Nonsignificant	1.00	0.93	Other	5	6
18	T_cell	0.23	Nonsignificant	1.00	0.70	Other	470	959
19	natural_killer_cell	0.18	Nonsignificant	1.00	0.77	Other	1,204	2,052
20	microglia	0.12	Nonsignificant	1.00	0.58	Other	61	129
21	macrophage	0.11	Nonsignificant	1.00	0.62	Other	813	1,732
22	plasma_cell	0.10	Nonsignificant	1.00	0.54	Other	17	24
23	B_cell	0.07	Nonsignificant	1.00	0.48	Other	356	694
24	granulosa_cell	0.07	Nonsignificant	1.00	0.50	Other	293	670
25	neuron	0.07	Nonsignificant	1.00	0.50	Other	330	1,328
26	astrocyte	0.04	Nonsignificant	1.00	0.58	Other	256	1,203
27	monocyte	0.02	Nonsignificant	1.00	0.53	Other	2,176	3,871
28	oligodendrocyte_precursor_cell	0.01	Nonsignificant	1.00	0.33	Other	461	1,454
29	cardiomyocyte	0.01	Nonsignificant	1.00	0.29	Other	533	2,045
30	platelet	0.01	Nonsignificant	—	0.00	Other	85	104
31	skeletal_muscle_cell	6.47e-03	Nonsignificant	1.00	0.26	Other	944	2,600
32	oligodendrocyte	5.68e-03	Nonsignificant	1.00	0.22	Other	385	1,507
33	adipocyte	5.58e-03	Nonsignificant	1.00	0.45	Other	33	111
34	hepatocyte	2.74e-03	Nonsignificant	1.00	0.68	Other	1,515	3,822

Subtype rankings — L1S (152)

Subtypes ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.skin_appendage_keratinocyte	42.84	Significant	8.07e-04	1.32	Specific	87	222
2	EPI.thymic_medullary	42.72	Significant	8.07e-04	1.34	Specific	26	133
3	EPI.skin_follicular_keratinizing	22.82	Significant	0.41	1.23	Relevant	30	81
4	IPSC.induced_pluripotent_stem_cell	14.21	Significant	—	—	Relevant	0	0
5	EPI.skin_keratinocyte_proliferating	12.02	Significant	0.52	1.23	Relevant	47	76
6	EPI.tracheal_basal	11.42	Significant	0.18	1.19	Relevant	398	1,120
7	EPI.salivary_myoepithelial	10.08	Significant	0.05	1.20	Specific	191	714
8	EPI.colonocyte	9.37	Significant	0.05	1.15	Specific	294	815
9	EPI.skin_hair_follicle_companion	9.36	Significant	—	1.11	Relevant	8	12
10	EPI.skin_hair_follicle_bulge	8.48	Significant	1.00	1.05	Relevant	51	178
11	MUSC.muscle_stem_cell	7.91	Significant	—	—	Relevant	4	18
12	EPI.skin_sweat_duct_keratinocyte	7.70	Significant	0.13	1.23	Other	146	301
13	FIB.lung_alveolar	6.56	Significant	—	1.39	Relevant	6	15
14	EC.venous	6.37	Significant	1.61e-03	1.19	Other	516	1,387
15	EC.capillary	5.52	Significant	4.76e-13	1.39	Other	514	1,635
16	EPI.tracheal_suprabasal	5.47	Nominal	1.00	1.10	Other	29	56
17	ASPC.adipose_stem_and_progenitor_cell	5.33	Nominal	—	—	Other	324	930
18	FIB.neurolectin_mucosa	5.19	Nominal	0.62	1.14	Other	133	394
19	FIB.tracheal_subepithelial	4.81	Nominal	—	0.79	Other	0	0
20	FIB.interstitial	4.80	Nominal	3.87e-12	1.44	Other	288	940
21	THYMO.thymocyte	4.63	Nominal	—	—	Other	163	495
22	CHOND.chondrocyte	4.61	Nominal	—	—	Other	519	730
23	EPI.skin_keratinocyte_basal	3.62	Nominal	—	0.25	Other	13	26
24	FIB.skin_papillary	3.58	Nominal	—	0.52	Other	0	0
25	EPI.renal_immature_ureteric_bud	3.52	Nominal	1.00	0.91	Other	217	569
26	EPI.thymic_cortical	3.51	Nominal	1.00	1.03	Other	442	824
27	FIB.reticular	3.46	Nominal	1.00	0.92	Other	19	87
28	FIB.suburothelial	3.41	Nominal	1.00	0.99	Other	122	432
29	FIB.barrier_purinergic	3.39	Nominal	—	0.43	Other	1	3
30	EPI.skin_sebaceous_duct_luminal	3.38	Nominal	1.00	0.87	Other	100	249
31	EPI.renal_proximal_tubule	3.27	Nominal	1.00	1.06	Other	525	806
32	EPI.colonic_enteroendocrine	3.14	Nominal	—	0.50	Other	1	1
33	FIB.transitioning	3.07	Nominal	1.00	0.91	Other	172	497
34	FIB.skin_sheath	2.81	Nonsignificant	1.00	0.87	Other	49	118
35	EC.heart_remodeling	2.78	Nonsignificant	1.00	0.76	Other	569	1,594
36	DC.mig	2.56	Nonsignificant	—	1.48	Other	89	156
37	MAC.microglia_like	2.46	Nonsignificant	0.17	1.39	Other	124	179
38	ILC2.innate_lymphoid_cell_2	2.34	Nonsignificant	—	—	Other	2	0
39	EPI.esophageal_basal	2.21	Nonsignificant	1.00	0.88	Other	4	10
40	EPI.skin_keratinocyte_progenitor	2.06	Nonsignificant	—	0.58	Other	0	3
41	FIB.skin_neurosecretory	2.04	Nonsignificant	—	0.18	Other	0	0
42	MEL.melanocyte	1.97	Nonsignificant	—	—	Other	79	242
43	FIB.barrier_secretory	1.96	Nonsignificant	1.00	0.90	Other	81	228
44	FIB.perivascular_interface	1.96	Nonsignificant	1.00	0.77	Other	0	0
45	SMC.smooth_muscle_cell	1.89	Nonsignificant	—	—	Other	20	101
46	PERI.pericyte	1.61	Nonsignificant	—	—	Other	117	0
47	FIB.hepatic_stellate_cell	1.61	Nonsignificant	—	0.13	Other	64	252
48	B.germinal_center	1.56	Nonsignificant	0.01	1.53	Other	233	655
49	HPC.haematopoietic_progenitor_cell	1.50	Nonsignificant	—	—	Other	211	370
50	EPI.pancreatic_ductal_progenitor	1.49	Nonsignificant	1.00	0.84	Other	234	873
51	EPI.pancreatic_acinar	1.37	Nonsignificant	1.00	0.91	Other	429	1,475
52	EPI.lung_club_secretory	1.26	Nonsignificant	1.00	0.69	Other	5	14
53	EPI.alveolar_type_1	1.22	Nonsignificant	1.00	0.79	Other	26	101
54	EPI.colonic_tuft	1.21	Nonsignificant	—	0.38	Other	7	24
55	EC.arterial	1.16	Nonsignificant	1.00	0.59	Other	356	885
56	EPI.renal_intercalated_cell_type_B	0.98	Nonsignificant	—	0.32	Other	6	7
57	SCHWN.schwann_cell	0.97	Nonsignificant	—	—	Other	7	33
58	T.CD8_Trm	0.97	Nonsignificant	4.88e-20	1.62	Other	211	346
59	GRANU.MAST	0.96	Nonsignificant	9.43e-04	1.73	Other	5	6
60	FIB.skin_tenogenic	0.95	Nonsignificant	—	1.88e-03	Other	108	227
61	EPI.renal_thick_ascending_limb	0.88	Nonsignificant	1.00	0.69	Other	453	1,153
62	EPI.skin_interfollicular_spinous	0.84	Nonsignificant	1.00	0.86	Other	260	563
63	DC.cDC2	0.83	Nonsignificant	0.54	1.11	Other	1,189	1,793
64	MESO.mesothelial_cell	0.65	Nonsignificant	—	—	Other	2	18
65	EPI.renal_intercalated_cell_type_A	0.63	Nonsignificant	1.00	0.63	Other	67	142
66	T.CD4_Trm	0.60	Nonsignificant	7.05e-06	1.38	Other	176	363
67	EC.lymphatic	0.58	Nonsignificant	1.00	0.48	Other	630	998
68	DC.cDC1	0.58	Nonsignificant	1.00	0.92	Other	55	112
69	T.CD4_transitional	0.52	Nonsignificant	1.71e-03	1.38	Other	48	110
70	EPI.salivary_serous_acinar	0.50	Nonsignificant	1.00	0.69	Other	233	531
71	EPI.endocervical_secretory	0.45	Nonsignificant	—	0.10	Other	0	0
72	EPI.tracheal_submucosal_gland	0.33	Nonsignificant	—	0.04	Other	0	0
73	EPI.pancreatic_ductal_perivascular	0.31	Nonsignificant	1.00	0.53	Other	4	30
74	EPI.renal_principal_cell	0.31	Nonsignificant	1.00	0.52	Other	207	403
75	MAC.proliferating	0.29	Nonsignificant	0.61	1.18	Other	87	253
76	T.CD4_Tfh	0.27	Nonsignificant	0.99	1.01	Other	47	45
77	T.CD4_Tem	0.25	Nonsignificant	0.81	1.07	Other	365	697
78	EPI.ileal_enterocyte_crypt	0.25	Nonsignificant	1.00	0.65	Other	67	113
79	T.CD8_transitional	0.23	Nonsignificant	0.95	1.02	Other	497	932
80	EPI.pancreatic_islet	0.23	Nonsignificant	1.00	0.65	Other	52	132
81	EPI.lung_multiciliated	0.23	Nonsignificant	1.00	0.55	Other	16	49
82	T.CD4_naive	0.22	Nonsignificant	0.87	1.02	Other	399	866
83	PC.IgG_systemic	0.20	Nonsignificant	1.38e-03	1.50	Other	41	60
84	MAC.resident_iron	0.18	Nonsignificant	0.80	1.05	Other	16	21
85	NK.natural_killer_cell	0.18	Nonsignificant	—	—	Other	1,204	2,045
86	EPI.ileal_enterocyte_absorptive	0.18	Nonsignificant	1.00	0.46	Other	118	338
87	EPI.esophageal_suprabasal	0.17	Nonsignificant	1.00	0.44	Other	158	404
88	T.MAIT	0.17	Nonsignificant	1.00	0.70	Other	469	855
89	EPI.salivary_intercalated_defense	0.16	Nonsignificant	1.00	0.45	Other	81	161
90	EPI.ectocervical_granular	0.15	Nonsignificant	—	0.00	Other	11	23
91	HEP.pericentral_lipoprotein	0.14	Nonsignificant	—	2.64	Other	0	0
92	B.age_associated	0.14	Nonsignificant	0.45	1.21	Other	207	350
93	T.CD8_naive	0.14	Nonsignificant	1.00	0.66	Other	317	708
94	MAC.MDM	0.14	Nonsignificant	0.61	1.10	Other	623	986
95	FIB.adventitial	0.14	Nonsignificant	1.00	0.00	Other	268	1,447
96	MG.microglia	0.12	Nonsignificant	—	—	Other	49	0
97	T.gamma_delta	0.09	Nonsignificant	1.00	0.40	Other	588	1,078
98	NEU.INH_LAMP5	0.09	Nonsignificant	1.00	1.05	Other	263	532
99	T.CD4_cytotoxic	0.09	Nonsignificant	0.13	1.24	Other	855	1,493
100	T.CD8_Tcm	0.09	Nonsignificant	1.00	0.55	Other	460	926
101	NEU.EXC_IT	0.09	Nonsignificant	1.95e-04	1.32	Other	411	192
102	PC.IgA_muocsal	0.09	Nonsignificant	0.98	0.66	Other	18	31
103	EPI.salivary_duct_ion_transport	0.08	Nonsignificant	1.00	0.34	Other	5	11
104	T.CD4_Tcm	0.08	Nonsignificant	1.00	0.35	Other	494	988
105	T.CD4_Th2	0.08	Nonsignificant	—	0.00	Other	1	2
106	EPI.alveolar_type_2	0.07	Nonsignificant	1.00	0.33	Other	813	1,853
107	T.CD4_Th17	0.07	Nonsignificant	1.00	0.34	Other	421	794
108	T.CD4_Treg	0.07	Nonsignificant	1.00	0.53	Other	244	511
109	GRNLSA.granulosa_cell	0.07	Nonsignificant	—	—	Other	257	0
110	MAC.LAM	0.07	Nonsignificant	1.00	0.94	Other	914	2,064
111	MAC.resident_repair	0.06	Nonsignificant	1.00	0.89	Other	796	1,426
112	B.memory	0.06	Nonsignificant	1.00	0.87	Other	442	882
113	NEU.INH_VIP	0.05	Nonsignificant	1.00	0.87	Other	241	366
114	B.naive	0.05	Nonsignificant	1.00	0.81	Other	307	595
115	EC.liver_sinusoidal	0.05	Nonsignificant	1.00	0.10	Other	1,083	1,925
116	MAC.kupffer	0.04	Nonsignificant	0.84	1.02	Other	189	530
117	EPI.gastric_foveolar	0.04	Nonsignificant	—	0.00	Other	0	0
118	EPI.salivary_duct_excretory	0.04	Nonsignificant	1.00	0.26	Other	85	180
119	ASTRO.astrocyte	0.04	Nonsignificant	—	—	Other	228	1,111
120	NEU.INH_PVALB	0.03	Nonsignificant	1.00	0.65	Other	193	183
121	T.CD8_Tem	0.03	Nonsignificant	1.00	0.90	Other	1,083	1,857
122	NEU.EXC_SYT2	0.02	Nonsignificant	—	0.00	Other	40	77
123	EPI.ileal_bile_transport	0.02	Nonsignificant	1.00	0.27	Other	61	93
124	MONO.CD14	0.02	Nonsignificant	0.53	1.02	Other	2,294	4,139
125	OPC.oligodendrocyte_precursor_cell	0.01	Nonsignificant	—	—	Other	413	1,269
126	EPI.pancreatic_ductal_bicarbonate	0.01	Nonsignificant	1.00	0.14	Other	131	548
127	MONO.CD16	0.01	Nonsignificant	0.71	0.98	Other	1,304	1,835
128	CM.cardiomyocyte	0.01	Nonsignificant	—	—	Other	524	2,032
129	EPI.pancreatic_ductal_mucinous	0.01	Nonsignificant	1.00	0.15	Other	219	430
130	EPI.intrahepatic_cholangiocyte_defense	0.01	Nonsignificant	—	0.00	Other	8	13
131	EPI.cervical_suprabasal	0.01	Nonsignificant	—	0.00	Other	14	50
132	PLAT.platelet	0.01	Nonsignificant	—	0.00	Other	38	53
133	EPI.salivary_mucous_acinar	9.97e-03	Nonsignificant	1.00	0.14	Other	639	1,189
134	EPI.renal_distal_tubule	9.60e-03	Nonsignificant	1.00	0.12	Other	133	361
135	EPI.intrahepatic_cholangiocyte_transport	9.48e-03	Nonsignificant	—	0.00	Other	12	42
136	SKM.type_2_fast	7.22e-03	Nonsignificant	0.37	1.15	Other	972	2,639
137	HEP.periportal_metabolic	5.93e-03	Nonsignificant	0.99	1.02	Other	1,750	4,427
138	OLG.oligodendrocyte	5.68e-03	Nonsignificant	—	—	Other	384	1,397
139	ADIPO.adipocyte	5.58e-03	Nonsignificant	—	—	Other	20	62
140	SKM.type_1_slow	5.45e-03	Nonsignificant	0.78	0.85	Other	923	2,478
141	EPI.hepatic_ductular_cholangiocyte	5.07e-03	Nonsignificant	1.00	0.06	Other	83	243
142	MAC.resident_cardiac	4.42e-03	Nonsignificant	1.00	0.23	Other	485	1,074
143	EPI.extrahepatic_cholangiocyte	3.24e-03	Nonsignificant	—	0.00	Other	37	71
144	NEU.EXC_CT	3.14e-03	Nonsignificant	1.00	0.10	Other	362	384
145	NEU.EXC_NTNG1	2.97e-03	Nonsignificant	—	0.00	Other	0	0
146	EPI.bile_duct_cholangiocyte	2.56e-03	Nonsignificant	1.00	0.08	Other	37	60
147	EPI.ileal_goblet	2.52e-03	Nonsignificant	1.00	0.06	Other	181	432
148	GRANU.neutrophil	2.06e-03	Nonsignificant	1.00	0.00	Other	1,235	2,649
149	DC.pDC	1.79e-03	Nonsignificant	1.00	0.00	Other	496	1,028
150	MAC.alveolar	1.13e-04	Nonsignificant	1.00	0.15	Other	1,432	3,122
151	HEP.canalicular_transport	2.13e-05	Nonsignificant	0.99	0.89	Other	1,290	3,434
152	HEP.acute_phase	2.50e-06	Nonsignificant	0.99	0.86	Other	1,441	3,641

State rankings — L2 (688)

States ranked by mean IC score
#	Cell population	Mean IC score	Significance	CSEA FDR	CSEA NES	Tier	Meta traits (Specific)	Individual traits (Specific)
1	EPI.skin_appendage_keratinocyte.transit_amplifying	75.90	Significant	—	0.76	Specific	109	358
2	EPI.thymic_medullary.proliferative_APC	46.91	Significant	—	0.45	—	0	0
3	EPI.thymic_medullary.canonical_alarmin	43.56	Significant	0.69	0.92	Relevant	8	17
4	EPI.thymic_medullary.hormone_xeno_barrier	41.35	Significant	—	0.11	Specific	0	8
5	EPI.thymic_medullary.stress_APC	41.16	Significant	0.69	0.74	Relevant	2	4
6	EPI.skin_appendage_keratinocyte.ductal_barrier_detox	39.05	Significant	0.71	0.91	—	33	34
7	EPI.skin_appendage_keratinocyte.ductal_immune_interacting	37.35	Significant	0.71	0.72	Relevant	7	16
8	EPI.skin_appendage_keratinocyte.sebaceous_apocrine	27.59	Significant	—	0.00	—	39	82
9	EPI.skin_follicular_keratinizing.transit_amplifying	24.57	Significant	—	0.23	Relevant	21	49
10	EPI.skin_follicular_keratinizing.upper_infundibulum	24.06	Significant	—	0.13	—	8	2
11	EPI.skin_keratinocyte_proliferating.detox_repair	23.81	Significant	—	0.92	—	0	0
12	EPI.skin_sweat_duct_keratinocyte.proliferative_S	22.17	Significant	—	1.36	Relevant	0	0
13	EPI.skin_sweat_duct_keratinocyte.proliferative_G2M	21.75	Significant	—	0.96	Relevant	0	0
14	IPSC.mesenchymal_primed	21.65	Significant	2.14e-11	2.11	—	0	0
15	EPI.skin_keratinocyte_proliferating.anchor_remodel	20.18	Significant	—	0.40	—	0	0
16	IPSC.stress	18.34	Significant	0.92	1.12	Relevant	0	0
17	EPI.skin_follicular_keratinizing.root_infundibulum	17.63	Significant	—	0.00	—	0	0
18	EPI.skin_hair_follicle_companion.gap_junction_contractile	17.10	Significant	—	0.97	—	0	0
19	IPSC.stromal_primed	16.69	Significant	0.76	1.17	—	0	0
20	IPSC.proliferative	16.68	Significant	0.66	1.19	—	0	0
21	IPSC.midbrain_primed	15.56	Significant	1.00	0.89	Relevant	0	0
22	EPI.salivary_myoepithelial.contractile_repair	14.31	Significant	—	0.00	Relevant	3	9
23	IPSC.neural_primed	14.11	Significant	1.00	0.74	—	0	0
24	EC.venous.adipose_lipid	13.98	Significant	0.09	1.41	Relevant	254	476
25	EPI.skin_sebaceous_duct_luminal.immune_interface	13.70	Significant	—	1.80	Relevant	0	0
26	IPSC.mesendo_primed	13.50	Significant	1.00	0.82	—	0	0
27	EPI.colonocyte.crypt_progenitor	13.39	Significant	1.08e-03	1.90	Specific	115	265
28	IPSC.axial_identity_primed	12.57	Significant	1.00	0.73	—	0	0
29	EPI.skin_hair_follicle_bulge.niche_crosstalk	12.57	Significant	—	0.94	—	29	88
30	EPI.tracheal_basal.homeostatic_progenitor	12.35	Significant	0.03	2.22	—	285	74
31	ASPC.activated	11.20	Significant	7.27e-09	1.99	Specific	164	162
32	EPI.colonocyte.junction_remodeling	11.00	Significant	1.00	1.02	—	218	305
33	EPI.salivary_myoepithelial.junctional_transport	10.91	Significant	0.84	1.28	Relevant	66	121
34	THYMO.proliferative_G2M	10.73	Significant	—	1.86	Specific	164	413
35	CHOND.articular_collagen	10.47	Significant	2.19e-05	1.61	Specific	551	266
36	EPI.tracheal_basal.activated_stress	10.02	Significant	0.72	0.62	—	32	0
37	EPI.salivary_myoepithelial.activated	9.69	Significant	0.84	0.91	Relevant	85	281
38	EC.capillary.postcap_venule	9.54	Significant	0.04	1.39	Specific	355	261
39	EPI.salivary_myoepithelial.baseline	9.06	Significant	0.89	0.45	Relevant	42	141
40	MUSC.quiescent_reservoir	8.97	Significant	0.08	2.06	—	2	8
41	FIB.lung_alveolar.mito_secretory	8.55	Significant	—	0.48	—	0	0
42	EPI.skin_hair_follicle_companion.bulge_anchor_signaling	8.18	Significant	—	0.00	Relevant	0	0
43	EPI.skin_hair_follicle_bulge.quiescent	7.88	Significant	0.92	0.38	—	56	69
44	MUSC.baseline	7.82	Significant	0.78	0.70	—	0	0
45	EPI.colonic_enteroendocrine.progenitor	7.70	Significant	—	0.97	Relevant	0	0
46	EPI.skin_keratinocyte_basal.basement_anchoring	7.37	Significant	—	0.97	Relevant	0	0
47	MUSC.activated_migratory	7.23	Significant	0.78	0.63	—	6	7
48	MUSC.early_activation	7.18	Significant	0.78	0.61	Relevant	4	32
49	THYMO.proliferative_S	7.16	Significant	2.19e-03	2.16	Specific	163	418
50	EC.capillary.migratory	7.07	Significant	0.35	1.21	Relevant	181	509
51	EPI.tracheal_suprabasal.transitional_wound	6.99	Significant	—	0.60	Relevant	16	1
52	EPI.colonocyte.proximal_transport	6.93	Significant	1.00	0.46	—	24	12
53	EC.venous.quiescent_homeostatic	6.75	Significant	0.14	1.30	Other	456	360
54	FIB.interstitial.mesenchymal_APC	6.73	Significant	2.01e-03	1.87	Specific	81	33
55	EC.venous.activated	6.50	Significant	1.00	0.81	Other	247	752
56	FIB.neurolectin_mucosa.inflammatory	6.43	Significant	0.13	1.72	Relevant	52	110
57	EC.capillary.stress	6.39	Significant	0.67	1.02	Other	44	36
58	ASPC.preadipocyte_lipid_primed	6.35	Significant	4.21e-03	1.40	Specific	331	129
59	ASPC.baseline	6.19	Significant	0.30	1.16	Specific	363	170
60	EC.venous.baseline	6.13	Significant	0.76	1.04	Other	346	807
61	EC.capillary.angiocrine	6.01	Significant	0.67	0.99	Other	250	630
62	FIB.barrier_purinergic.stress_GF_binding	5.78	Significant	—	0.97	Relevant	0	0
63	THYMO.SP_CD4_naive	5.77	Significant	0.14	1.56	Relevant	65	75
64	EPI.colonocyte.goblet_interface	5.76	Significant	—	0.00	Other	11	21
65	FIB.neurolectin_mucosa.nerve_interface	5.66	Significant	—	0.26	Relevant	4	0
66	IPSC.mesodermal_primed	5.59	Significant	1.00	0.24	Other	0	0
67	FIB.interstitial.mesenchymal_regulator	5.54	Significant	0.79	1.07	Other	4	4
68	EPI.skin_sweat_duct_keratinocyte.signal_gate	5.40	Nominal	—	0.28	Other	43	26
69	THYMO.DP_early	5.31	Nominal	4.93e-03	1.80	Other	326	313
70	EC.heart_remodeling.remodeling_secretory	5.30	Nominal	0.02	1.58	Other	605	1,341
71	EC.capillary.baseline	5.26	Nominal	0.67	1.00	Other	246	560
72	EPI.thymic_cortical.secretory_remodeling	5.24	Nominal	—	0.27	Other	4	1
73	THYMO.DP_early_stress	5.13	Nominal	—	0.50	Other	0	0
74	FIB.neurolectin_mucosa.axon_responsive	4.95	Nominal	0.72	0.72	Other	10	10
75	EPI.colonocyte.secretory_boost	4.92	Nominal	1.00	0.17	Other	98	91
76	FIB.interstitial.immune_interact	4.81	Nominal	0.79	1.05	Other	12	1
77	FIB.tracheal_subepithelial.baseline	4.81	Nominal	—	0.00	Other	0	0
78	FIB.suburothelial.homeostasis_matrix	4.67	Nominal	0.02	2.25	Other	258	921
79	MAC.microglia_like.inflammatory_chemokine	4.64	Nominal	—	0.69	Other	20	32
80	FIB.interstitial.remodeling	4.44	Nominal	0.96	0.78	Other	31	9
81	FIB.transitioning.matrix_stress	4.32	Nominal	—	0.61	Other	47	138
82	EPI.skin_interfollicular_spinous.transition_basal	4.24	Nominal	0.05	1.22	Other	100	127
83	FIB.reticular.stress_metallothionein	4.24	Nominal	—	0.37	Other	3	32
84	EPI.lung_club_secretory.inflammatory	4.21	Nominal	—	1.47	Other	0	0
85	DC.cDC2.proliferative	4.12	Nominal	—	1.68	Other	39	71
86	IPSC.endoderm_primed	4.08	Nominal	1.00	0.09	Other	0	0
87	FIB.interstitial.stress_secretory	4.04	Nominal	0.79	0.97	Other	92	56
88	ILC2.migratory	3.95	Nominal	—	0.80	Other	0	0
89	EPI.renal_immature_ureteric_bud.defense_secretory	3.90	Nominal	0.44	1.30	Other	45	76
90	FIB.reticular.ECM_builder	3.86	Nominal	—	0.44	Other	0	0
91	FIB.lung_alveolar.stress_interacting	3.86	Nominal	—	0.00	Other	0	0
92	EPI.pancreatic_acinar.quiet_dedifferentiation	3.84	Nominal	0.27	1.15	Other	142	171
93	FIB.interstitial.lipid_matrix	3.84	Nominal	0.99	0.50	Other	258	191
94	EC.heart_remodeling.translation_boost	3.81	Nominal	—	0.81	Other	0	0
95	IPSC.neuroendocrine_primed	3.80	Nominal	—	0.00	Other	0	0
96	FIB.neurolectin_mucosa.remodeling_repair	3.79	Nominal	—	0.00	Other	4	2
97	PERI.inflammatory	3.79	Nominal	7.40e-03	1.25	Other	40	77
98	EC.heart_remodeling.remodeling_stalk	3.74	Nominal	0.47	1.28	Other	33	111
99	EPI.skin_hair_follicle_bulge.anagen_growth	3.70	Nominal	—	0.00	Other	0	0
100	ASPC.inflammatory	3.67	Nominal	1.00	0.81	Other	21	61
101	THYMO.CD8aa_IELp	3.66	Nominal	—	0.00	Other	1	7
102	NK.cytokine_lung_immediate_early	3.64	Nominal	0.53	1.22	Other	424	274
103	FIB.skin_sheath.ECM_immune	3.61	Nominal	—	0.44	Other	0	0
104	EPI.colonocyte.ionocyte_BEST4	3.58	Nominal	1.00	0.30	Other	103	188
105	FIB.skin_papillary.baseline	3.58	Nominal	—	0.00	Other	0	0
106	THYMO.DN_preTCR	3.52	Nominal	1.00	0.40	Other	41	71
107	FIB.reticular.immune_interface	3.49	Nominal	—	0.03	Other	1	6
108	THYMO.SP_CD8_naive	3.45	Nominal	1.00	0.12	Other	297	177
109	EC.capillary.angiogenic_tip	3.40	Nominal	0.35	1.21	Other	186	218
110	EPI.renal_immature_ureteric_bud.osmoprotective	3.39	Nominal	0.44	1.07	Other	126	44
111	EPI.tracheal_suprabasal.secretory_immune	3.39	Nominal	—	0.00	Other	0	0
112	HPC.MEP	3.38	Nominal	0.64	1.09	Other	599	1,195
113	FIB.perivascular_interface.lipid_shuttle	3.35	Nominal	—	0.97	Other	51	170
114	FIB.suburothelial.contractile_myofibroblast	3.34	Nominal	—	0.20	Other	9	0
115	ASPC.secretory	3.32	Nominal	1.00	0.36	Other	76	5
116	EPI.renal_proximal_tubule.detox_antioxidant	3.32	Nominal	0.52	1.14	Other	394	77
117	EPI.renal_proximal_tubule.onecarbon_peroxisome	3.21	Nominal	0.52	0.92	Other	58	89
118	PERI.baseline	3.17	Nominal	0.24	1.11	Other	39	66
119	FIB.transitioning.secretory_procollagen	3.14	Nominal	—	5.55e-17	Other	0	0
120	SCHWN.reactive_inflammatory	3.13	Nominal	—	1.14	Other	0	0
121	EC.heart_remodeling.capillary_metabolic	3.04	Nominal	0.47	1.29	Other	54	414
122	FIB.reticular.stromal_niche	3.02	Nominal	0.87	0.49	Other	0	0
123	EPI.thymic_cortical.baseline	3.01	Nominal	0.09	1.76	Other	185	386
124	EC.capillary.activated	2.95	Nonsignificant	1.00	0.71	Other	2	5
125	SMC.activated	2.93	Nonsignificant	4.67e-03	1.44	Other	2	5
126	EPI.skin_sebaceous_duct_luminal.ECM_remodelling	2.91	Nonsignificant	0.33	1.43	Other	2	9
127	THYMO.SP_CD8_transitional	2.89	Nonsignificant	1.00	0.15	Other	32	75
128	ILC2.activated	2.86	Nonsignificant	—	0.00	Other	0	0
129	ASPC.stem_like_progenitor	2.81	Nonsignificant	1.00	0.36	Other	300	842
130	FIB.skin_sheath.stress_chaperone	2.75	Nonsignificant	—	0.00	Other	0	0
131	FIB.suburothelial.urothelial_interface	2.66	Nonsignificant	0.96	0.14	Other	9	8
132	FIB.transitioning.motility_remodelling	2.65	Nonsignificant	—	0.00	Other	0	0
133	EPI.thymic_cortical.Notch_interface	2.59	Nonsignificant	—	0.00	Other	82	137
134	DC.mig.baseline	2.56	Nonsignificant	—	0.00	Other	1	0
135	ASPC.niche_keeping_progenitor	2.52	Nonsignificant	1.00	0.25	Other	52	219
136	HPC.MPP_IEG	2.51	Nonsignificant	0.64	1.18	Other	45	46
137	IPSC.canonical_pluripotent	2.48	Nonsignificant	1.00	0.01	Other	0	0
138	EC.capillary.inflammatory	2.48	Nonsignificant	1.00	0.58	Other	27	51
139	EPI.esophageal_basal.activated_progenitor	2.47	Nonsignificant	0.11	1.76	Other	1	0
140	FIB.suburothelial.inflammatory_prostanoid	2.46	Nonsignificant	—	0.00	Other	0	0
141	EPI.skin_hair_follicle_companion.activated_migratory	2.41	Nonsignificant	—	0.00	Other	0	0
142	MEL.dedifferentiated_migratory	2.40	Nonsignificant	—	0.61	Other	0	0
143	THYMO.SP_CD8_naive_stress	2.40	Nonsignificant	1.00	0.03	Other	1	1
144	MEL.mature_oxidative_traffic	2.36	Nonsignificant	0.10	1.68	Other	247	285
145	EC.heart_remodeling.perivascular	2.36	Nonsignificant	0.76	1.01	Other	124	408
146	EPI.skin_keratinocyte_progenitor.quiescent_stem_like	2.36	Nonsignificant	—	0.32	Other	0	0
147	EPI.renal_thick_ascending_limb.canonical_salt_transporter	2.35	Nonsignificant	2.63e-03	1.42	Other	322	317
148	B.germinal_center.LZ_memory_precursor	2.28	Nonsignificant	—	0.79	Other	0	0
149	MEL.neurotrophic_migratory	2.25	Nonsignificant	—	0.43	Other	0	0
150	EC.arterial.metabolic	2.25	Nonsignificant	0.23	1.18	Other	195	159
151	FIB.barrier_secretory.homeostasis	2.21	Nonsignificant	—	0.00	Other	0	0
152	B.germinal_center.DZ_S_phase	2.21	Nonsignificant	—	0.34	Other	0	0
153	NK.cytokine_tissue_activation	2.17	Nonsignificant	0.54	1.22	Other	267	450
154	CHOND.remodeling	2.11	Nonsignificant	—	0.00	Other	5	0
155	FIB.skin_sheath.neuro_vascular_interface	2.09	Nonsignificant	—	0.00	Other	0	0
156	FIB.transitioning.ISG_primed_interface	2.04	Nonsignificant	—	0.00	Other	17	80
157	FIB.skin_neurosecretory.baseline	2.04	Nonsignificant	—	0.00	Other	0	0
158	EPI.pancreatic_acinar.baseline	1.96	Nonsignificant	0.27	1.15	Other	274	163
159	NK.cytokine_tissue_resident	1.93	Nonsignificant	0.84	1.21	Other	74	82
160	EPI.skin_keratinocyte_progenitor.activated_stress	1.93	Nonsignificant	—	0.00	Other	0	0
161	FIB.hepatic_stellate_cell.inflammatory	1.84	Nonsignificant	—	1.15	Other	0	0
162	SMC.metabolic	1.82	Nonsignificant	0.87	0.97	Other	14	40
163	EPI.pancreatic_acinar.stress	1.80	Nonsignificant	0.59	1.03	Other	28	28
164	B.germinal_center.LZ_survival	1.79	Nonsignificant	—	0.37	Other	0	0
165	EPI.skin_sebaceous_duct_luminal.detox_repair	1.74	Nonsignificant	0.91	0.27	Other	137	94
166	CHOND.activated_fibro_like	1.73	Nonsignificant	1.00	0.41	Other	531	188
167	EC.arterial.inflammatory	1.71	Nonsignificant	0.32	1.16	Other	63	50
168	MEL.secretory_quiescent	1.70	Nonsignificant	0.96	0.44	Other	19	13
169	EPI.pancreatic_ductal_progenitor.baseline	1.64	Nonsignificant	0.03	1.92	Other	179	702
170	EC.venous.remodeling_stalk	1.63	Nonsignificant	1.00	0.65	Other	559	566
171	FIB.hepatic_stellate_cell.contractile	1.62	Nonsignificant	—	0.00	Other	0	0
172	FIB.barrier_secretory.remodeling	1.62	Nonsignificant	—	0.00	Other	0	0
173	DC.cDC2.lipid_metabolic	1.62	Nonsignificant	—	0.90	Other	0	0
174	EPI.colonic_enteroendocrine.Lcell_peptide	1.57	Nonsignificant	—	0.00	Other	0	0
175	ASPC.adipocyte_capillary_interface	1.57	Nonsignificant	1.00	0.72	Other	21	54
176	EPI.skin_sebaceous_duct_luminal.secretoglobin_neuro	1.52	Nonsignificant	—	0.00	Other	0	0
177	MEL.stress_glucocorticoid	1.49	Nonsignificant	0.96	0.29	Other	11	34
178	FIB.barrier_purinergic.lipid_secretory	1.48	Nonsignificant	—	0.00	Other	0	0
179	FIB.hepatic_stellate_cell.fibrogenic	1.47	Nonsignificant	—	0.00	Other	0	0
180	EPI.esophageal_basal.junctional_barrier	1.44	Nonsignificant	—	0.00	Other	0	0
181	EPI.pancreatic_ductal_progenitor.ciliated_transport	1.42	Nonsignificant	—	0.11	Other	105	368
182	DC.cDC2.tolerogenic_regulatory	1.38	Nonsignificant	0.90	1.21	Other	44	4
183	EPI.colonic_tuft.activated	1.38	Nonsignificant	—	0.42	Other	0	0
184	T.CD8_Trm.dendritic_recruiter	1.37	Nonsignificant	0.27	1.45	Other	47	85
185	EPI.alveolar_type_1.baseline	1.37	Nonsignificant	0.10	1.71	Other	8	0
186	T.CD4_Trm.metal_stress	1.36	Nonsignificant	0.27	1.35	Other	34	58
187	T.CD8_transitional.stress	1.29	Nonsignificant	—	1.82	Other	24	34
188	EPI.salivary_intercalated_defense.basal_EMT	1.29	Nonsignificant	—	2.00	Other	0	0
189	T.CD4_transitional.primed_cytotoxic	1.27	Nonsignificant	0.16	1.37	Other	28	30
190	ASPC.proliferative	1.24	Nonsignificant	1.00	0.71	Other	33	85
191	T.CD8_Trm.inflammatory	1.20	Nonsignificant	0.27	1.28	Other	124	176
192	SCHWN.translation_boost	1.20	Nonsignificant	—	0.55	Other	8	1
193	EPI.pancreatic_ductal_progenitor.ADM_like	1.18	Nonsignificant	—	0.00	Other	0	0
194	B.germinal_center.LZ_selection	1.17	Nonsignificant	—	0.00	Other	0	0
195	SMC.contractile	1.17	Nonsignificant	1.00	0.66	Other	80	588
196	EPI.pancreatic_acinar.inflammatory_regenerative	1.17	Nonsignificant	0.21	1.31	Other	25	113
197	EC.arterial.mito_contact	1.15	Nonsignificant	0.88	0.98	Other	14	5
198	EPI.skin_keratinocyte_proliferating.early_spinous_transition	1.15	Nonsignificant	—	0.00	Other	135	290
199	EPI.endocervical_secretory.squamous_barrier	1.14	Nonsignificant	—	0.67	Other	0	0
200	PERI.angiocrine	1.14	Nonsignificant	1.00	0.84	Other	93	102
201	DC.cDC1.proliferative	1.12	Nonsignificant	—	1.53	Other	0	0
202	EC.lymphatic.scavenger	1.11	Nonsignificant	0.31	1.16	Other	203	257
203	MESO.secretory_structural	1.11	Nonsignificant	—	0.44	Other	0	0
204	T.CD4_naive.gut_prone	1.10	Nonsignificant	0.01	1.77	Other	35	70
205	FIB.perivascular_interface.vasomotor_tone	1.08	Nonsignificant	—	0.00	Other	0	0
206	EC.arterial.elastic	1.08	Nonsignificant	0.99	0.92	Other	22	45
207	EC.arterial.homeostatic	1.06	Nonsignificant	0.88	0.99	Other	24	3
208	EPI.colonic_tuft.homeostatic	1.04	Nonsignificant	—	0.00	Other	0	0
209	T.CD4_Trm.stress_adaptive	1.02	Nonsignificant	2.25e-03	1.59	Other	8	22
210	GRANU.MAST.activated_repair	1.01	Nonsignificant	—	0.17	Other	0	1
211	FIB.perivascular_interface.vascular_BM_remodelling	1.01	Nonsignificant	—	0.00	Other	0	0
212	EC.heart_remodeling.angiocrine	0.98	Nonsignificant	1.00	0.03	Other	182	525
213	EPI.renal_intercalated_cell_type_B.baseline	0.98	Nonsignificant	—	0.00	Other	3	1
214	T.CD8_Trm.homeostatic	0.97	Nonsignificant	0.68	1.04	Other	42	5
215	FIB.skin_tenogenic.baseline	0.95	Nonsignificant	—	0.00	Other	0	2
216	GRANU.MAST.activated_acute	0.95	Nonsignificant	—	0.31	Other	0	0
217	DC.cDC2.antiviral	0.93	Nonsignificant	1.00	0.99	Other	100	37
218	T.CD8_Trm.cytotoxic	0.90	Nonsignificant	1.00	0.65	Other	165	85
219	GRANU.MAST.resting_granule	0.90	Nonsignificant	—	0.00	Other	0	0
220	CHOND.pro_inflammatory	0.87	Nonsignificant	1.00	0.52	Other	181	351
221	HPC.GMP_inflammatory	0.86	Nonsignificant	0.64	0.94	Other	20	10
222	DC.cDC1.activated	0.83	Nonsignificant	—	0.52	Other	0	0
223	EPI.pancreatic_ductal_progenitor.biliary_like_xenobiotic	0.81	Nonsignificant	—	0.00	Other	0	0
224	EC.arterial.arteriole_gas_exchange	0.81	Nonsignificant	0.99	0.88	Other	238	131
225	ASPC.mesothelial_like	0.80	Nonsignificant	1.00	0.96	Other	143	486
226	EPI.lung_club_secretory.ciliogenesis_axoneme	0.77	Nonsignificant	—	0.00	Other	0	0
227	EPI.ileal_enterocyte_crypt.proliferative_S	0.76	Nonsignificant	0.83	1.23	Other	4	2
228	MESO.activated_migratory	0.74	Nonsignificant	—	0.37	Other	0	0
229	EPI.renal_intercalated_cell_type_A.acid_secretion	0.73	Nonsignificant	0.35	1.12	Other	12	6
230	MESO.baseline	0.70	Nonsignificant	0.47	1.06	Other	0	6
231	DC.cDC1.cross_presenting	0.69	Nonsignificant	—	0.17	Other	0	0
232	T.CD4_transitional.tissue_enagement	0.67	Nonsignificant	0.49	1.23	Other	5	11
233	EPI.renal_principal_cell.canonical_vasopressin	0.66	Nonsignificant	0.48	1.34	Other	2	0
234	EPI.esophageal_suprabasal.basal_transitional	0.65	Nonsignificant	0.10	1.65	Other	44	67
235	EPI.renal_thick_ascending_limb.remodeling	0.65	Nonsignificant	1.00	0.88	Other	152	92
236	MAC.microglia_like.phagocytic_redox	0.64	Nonsignificant	—	0.00	Other	0	0
237	HPC.GMP_granulocytic	0.64	Nonsignificant	—	0.00	Other	3	3
238	MESO.antiviral	0.64	Nonsignificant	—	0.00	Other	3	8
239	EC.arterial.angiogenic_tip	0.64	Nonsignificant	—	0.00	Other	30	37
240	T.CD4_naive.proteostasis	0.63	Nonsignificant	1.21e-05	1.96	Other	14	9
241	EC.arterial.arteriole_interface	0.62	Nonsignificant	0.99	0.78	Other	31	12
242	T.CD4_Trm.cytotoxic_effector	0.61	Nonsignificant	0.62	1.11	Other	118	77
243	EPI.ileal_enterocyte_crypt.proliferative_G2M	0.61	Nonsignificant	—	0.80	Other	19	54
244	EC.lymphatic.baseline	0.60	Nonsignificant	0.31	1.11	Other	38	72
245	T.CD4_Trm.baseline	0.60	Nonsignificant	0.90	0.80	Other	31	21
246	MAC.resident_iron.stress_tolerogenic	0.59	Nonsignificant	—	0.90	Other	0	0
247	EC.arterial.ion_pump	0.58	Nonsignificant	0.73	1.11	Other	3	2
248	EC.heart_remodeling.activated_acute	0.58	Nonsignificant	1.00	0.11	Other	102	186
249	EPI.lung_club_secretory.ciliogenesis_primed	0.57	Nonsignificant	—	0.37	Other	0	0
250	EPI.salivary_serous_acinar.secretory_active	0.55	Nonsignificant	6.99e-13	2.43	Other	242	69
251	EPI.renal_principal_cell.activated_acute	0.54	Nonsignificant	0.48	1.25	Other	29	59
252	HPC.MPP_activated	0.54	Nonsignificant	—	0.00	Other	0	0
253	T.CD4_Trm.activated	0.52	Nonsignificant	0.90	0.87	Other	32	26
254	EPI.ectocervical_granular.secretory_apocrine	0.51	Nonsignificant	—	1.15	Other	0	0
255	T.CD4_naive.proteostasis_mitoprot	0.51	Nonsignificant	7.25e-03	1.71	Other	15	37
256	DC.cDC2.pro_inflammatory	0.50	Nonsignificant	1.00	0.93	Other	3	5
257	T.CD4_Tem.inflammatory	0.50	Nonsignificant	7.03e-03	1.43	Other	28	6
258	T.CD8_transitional.Trm_primed	0.49	Nonsignificant	5.56e-03	1.43	Other	108	15
259	T.MAIT.stress	0.48	Nonsignificant	—	0.50	Other	0	0
260	FIB.adventitial.adhesion_lipid	0.46	Nonsignificant	0.05	1.29	Other	58	209
261	T.CD4_Trm.helper_like	0.45	Nonsignificant	0.90	0.82	Other	84	147
262	ILC2.quiescent	0.45	Nonsignificant	—	0.00	Other	0	0
263	ASPC.remodeling	0.45	Nonsignificant	1.00	0.03	Other	106	354
264	EPI.tracheal_submucosal_gland.acinar_serous	0.45	Nonsignificant	—	0.73	Other	0	0
265	T.CD4_Tfh.effector_migratory	0.43	Nonsignificant	0.22	1.40	Other	122	57
266	T.CD4_transitional.baseline	0.41	Nonsignificant	0.99	0.84	Other	59	97
267	EPI.skin_keratinocyte_basal.transit_amplifying	0.41	Nonsignificant	—	0.00	Other	0	0
268	PC.IgG_systemic.stress	0.39	Nonsignificant	—	0.83	Other	1	5
269	HPC.LMPP	0.38	Nonsignificant	0.64	0.94	Other	65	31
270	EPI.lung_club_secretory.canonical_surfactant	0.37	Nonsignificant	—	0.00	Other	74	104
271	FIB.adventitial.activated_remodelling	0.37	Nonsignificant	—	0.59	Other	141	319
272	T.CD8_Trm.muscosal_Tc17	0.36	Nonsignificant	1.00	0.19	Other	19	38
273	DC.cDC2.adhesion_signaling	0.35	Nonsignificant	1.00	0.69	Other	35	9
274	EPI.renal_thick_ascending_limb.barrier_repair	0.35	Nonsignificant	1.00	0.69	Other	141	284
275	EC.lymphatic.valve	0.35	Nonsignificant	—	0.04	Other	0	0
276	EPI.lung_multiciliated.baseline	0.33	Nonsignificant	—	0.73	Other	0	7
277	EPI.renal_thick_ascending_limb.cation_flux	0.32	Nonsignificant	1.00	0.67	Other	57	95
278	MAC.proliferating.DNA_replication	0.32	Nonsignificant	0.52	0.99	Other	3	6
279	T.CD8_naive.lipid_synthesis	0.32	Nonsignificant	0.03	1.77	Other	6	4
280	EC.lymphatic.activated	0.32	Nonsignificant	0.31	1.11	Other	47	73
281	EPI.pancreatic_ductal_perivascular.baseline	0.31	Nonsignificant	0.54	1.02	Other	1	5
282	T.CD4_naive.survival_neddylation	0.31	Nonsignificant	0.24	1.37	Other	26	38
283	EPI.lung_multiciliated.mature_motile_cilia	0.31	Nonsignificant	—	0.89	Other	0	0
284	EPI.pancreatic_ductal_perivascular.protective_antioxidant	0.31	Nonsignificant	—	0.18	Other	11	69
285	MAC.MDM.APC_dendritic	0.29	Nonsignificant	0.52	1.15	Other	48	15
286	EC.lymphatic.tip_migratory	0.29	Nonsignificant	0.88	0.80	Other	23	37
287	FIB.adventitial.inflammatory_activated	0.29	Nonsignificant	0.08	1.20	Other	100	473
288	EPI.alveolar_type_1.activated	0.29	Nonsignificant	—	0.00	Other	0	0
289	EPI.ileal_enterocyte_absorptive.brush_border	0.28	Nonsignificant	8.43e-04	1.69	Other	580	1,717
290	EPI.renal_intercalated_cell_type_A.PC_transitional	0.28	Nonsignificant	—	0.00	Other	203	407
291	EPI.renal_principal_cell.inflammatory	0.28	Nonsignificant	0.48	1.28	Other	74	157
292	NEU.EXC_IT.structural	0.28	Nonsignificant	0.08	1.24	Other	171	41
293	T.CD8_transitional.effector_primed	0.28	Nonsignificant	0.57	1.08	Other	435	151
294	PC.IgG_systemic.interacting	0.27	Nonsignificant	0.82	1.02	Other	0	0
295	MAC.kupffer.monocyte_like	0.27	Nonsignificant	—	1.65	Other	0	0
296	EPI.pancreatic_islet.alpha	0.27	Nonsignificant	—	0.26	Other	152	330
297	EPI.skin_interfollicular_spinous.proliferative	0.27	Nonsignificant	—	0.89	Other	0	0
298	T.CD4_cytotoxic.precursor	0.27	Nonsignificant	0.51	1.10	Other	156	67
299	HEP.periportal_metabolic.stress_chaperone	0.26	Nonsignificant	—	1.54	Other	66	128
300	T.CD4_Tfh.canonical_GC_helper	0.26	Nonsignificant	0.81	0.94	Other	1	2
301	T.CD4_Tfh.suppression_exhaustion	0.25	Nonsignificant	0.77	1.15	Other	0	2
302	EPI.pancreatic_islet.beta	0.25	Nonsignificant	0.20	1.28	Other	42	57
303	T.CD4_Trm.central_like	0.24	Nonsignificant	0.67	1.07	Other	38	31
304	T.CD4_naive.neddylation	0.24	Nonsignificant	1.00	1.04	Other	104	222
305	B.germinal_center.DZ_M_phase	0.24	Nonsignificant	—	0.00	Other	0	0
306	MAC.proliferating.stress	0.24	Nonsignificant	—	0.00	Other	87	136
307	T.CD4_transitional.primed_helper_effector	0.23	Nonsignificant	0.99	0.61	Other	19	43
308	T.CD4_naive.neddylation_mitoprot	0.22	Nonsignificant	1.00	0.88	Other	93	56
309	B.age_associated.activated	0.22	Nonsignificant	—	0.23	Other	18	22
310	PC.IgG_systemic.secretory	0.22	Nonsignificant	0.82	1.14	Other	0	0
311	T.CD4_Tem.cytotoxic_effector	0.22	Nonsignificant	0.97	1.02	Other	225	398
312	T.CD4_naive.resist_bystander	0.22	Nonsignificant	1.00	1.03	Other	40	25
313	MAC.resident_iron.APC_iron_sensing	0.22	Nonsignificant	0.79	1.16	Other	211	114
314	DC.cDC2.migratory	0.21	Nonsignificant	1.00	0.81	Other	185	39
315	EPI.tracheal_submucosal_gland.ductal_luminal	0.20	Nonsignificant	—	0.00	Other	0	0
316	T.CD8_Tcm.baseline	0.20	Nonsignificant	0.25	1.45	Other	90	89
317	T.CD4_naive.mature	0.20	Nonsignificant	1.00	0.78	Other	211	100
318	T.MAIT.quiescent	0.20	Nonsignificant	0.70	1.26	Other	100	5
319	T.CD4_Treg.tissue_effector	0.20	Nonsignificant	0.03	1.76	Other	16	13
320	MAC.microglia_like.patrolling_adhesive	0.20	Nonsignificant	—	0.00	Other	0	0
321	T.CD4_naive.mature_mitoprot	0.19	Nonsignificant	1.00	0.77	Other	212	476
322	MONO.CD14.cord_tolerance	0.19	Nonsignificant	0.34	1.16	Other	864	753
323	EPI.esophageal_suprabasal.proliferative_S	0.18	Nonsignificant	—	0.88	Other	26	41
324	EPI.colonic_enteroendocrine.enterochromaffin_serotonin	0.18	Nonsignificant	—	0.00	Other	0	0
325	T.MAIT.cytotoxic	0.18	Nonsignificant	0.70	1.14	Other	52	15
326	T.CD8_naive.splicing_enriched	0.18	Nonsignificant	0.50	1.18	Other	120	16
327	T.CD4_naive.purinergic	0.17	Nonsignificant	1.00	0.79	Other	49	1
328	T.MAIT.MAPK_brake	0.17	Nonsignificant	0.70	1.07	Other	44	66
329	T.CD8_naive.effector_transition	0.17	Nonsignificant	0.50	1.27	Other	35	62
330	HEP.pericentral_lipoprotein.ApoB_coagulation	0.17	Nonsignificant	—	0.67	Other	0	0
331	B.memory.activated	0.17	Nonsignificant	0.01	1.39	Other	105	29
332	DC.cDC1.homeostatic_inhibitory	0.17	Nonsignificant	—	0.00	Other	0	0
333	MG.phagocytic_APC	0.17	Nonsignificant	0.52	1.28	Other	25	8
334	NEU.INH_VIP.serotonergic	0.17	Nonsignificant	—	1.10	Other	9	2
335	T.CD4_Tfh.precursor_migratory	0.16	Nonsignificant	0.97	0.48	Other	72	27
336	T.CD4_naive.survival	0.16	Nonsignificant	1.00	0.85	Other	12	17
337	T.CD8_transitional.APC_like	0.16	Nonsignificant	1.00	0.73	Other	205	62
338	B.naive.activated	0.15	Nonsignificant	0.44	1.30	Other	77	127
339	MAC.LAM.anti_inflammatory	0.15	Nonsignificant	0.07	1.41	Other	86	132
340	GRNLSA.stress_metabolic	0.15	Nonsignificant	—	0.35	Other	1	2
341	T.CD4_naive.homeostatic	0.15	Nonsignificant	1.00	0.49	Other	215	108
342	T.CD4_Tem.transitional_CM	0.15	Nonsignificant	0.97	0.64	Other	31	20
343	MAC.resident_repair.antigen_presenting	0.15	Nonsignificant	0.26	1.23	Other	244	113
344	T.CD4_naive.survival_mitoprot	0.14	Nonsignificant	1.00	0.62	Other	13	7
345	T.CD4_transitional.APC_interacting	0.14	Nonsignificant	0.99	0.22	Other	10	14
346	MAC.LAM.perivascular_angiocrine	0.14	Nonsignificant	—	0.80	Other	53	138
347	GRNLSA.proliferative_migratory	0.14	Nonsignificant	0.67	1.11	Other	248	292
348	T.CD4_Tcm.imprinted_splicing	0.14	Nonsignificant	0.08	1.57	Other	6	17
349	T.MAIT.vesicle	0.14	Nonsignificant	0.70	1.06	Other	37	65
350	T.CD4_cytotoxic.NK_adapted	0.14	Nonsignificant	0.51	1.15	Other	82	33
351	EPI.lung_multiciliated.stress	0.13	Nonsignificant	—	0.00	Other	67	165
352	T.CD8_naive.vesicle_secretory	0.13	Nonsignificant	0.97	0.89	Other	42	0
353	MONO.CD14.platelet_bound	0.13	Nonsignificant	0.16	1.19	Other	964	176
354	T.MAIT.early_activation	0.13	Nonsignificant	0.71	0.93	Other	57	4
355	T.CD8_transitional.early	0.13	Nonsignificant	1.00	0.52	Other	327	55
356	NEU.INH_LAMP5.projecting	0.13	Nonsignificant	—	0.71	Other	0	0
357	B.age_associated.naive_transitional	0.12	Nonsignificant	—	0.35	Other	0	0
358	EPI.salivary_intercalated_defense.canonical_antimicrobial	0.12	Nonsignificant	0.94	0.98	Other	11	22
359	T.CD4_Tcm.migratory_cilium	0.12	Nonsignificant	0.33	1.36	Other	5	10
360	T.CD8_naive.baseline	0.12	Nonsignificant	0.97	0.69	Other	142	2
361	NEU.INH_LAMP5.exc_inh_balance	0.12	Nonsignificant	—	0.31	Other	46	2
362	T.CD4_Tcm.stress	0.12	Nonsignificant	0.50	1.24	Other	5	11
363	T.MAIT.migratory	0.12	Nonsignificant	0.91	0.51	Other	10	1
364	T.gamma_delta.early_effector	0.12	Nonsignificant	0.40	1.14	Other	89	0
365	HEP.pericentral_lipoprotein.UPR_redox	0.12	Nonsignificant	—	0.00	Other	0	0
366	T.CD8_naive.mito_proteostasis	0.12	Nonsignificant	0.50	1.21	Other	428	100
367	T.CD4_Tcm.DC_interact	0.12	Nonsignificant	0.50	1.20	Other	72	32
368	MG.baseline	0.12	Nonsignificant	0.73	1.00	Other	16	5
369	FIB.adventitial.complement_angiocrine	0.12	Nonsignificant	1.00	0.91	Other	153	684
370	DC.cDC2.monocyte_like	0.11	Nonsignificant	1.00	0.22	Other	1,285	791
371	EC.liver_sinusoidal.hypoxia_metabolic	0.11	Nonsignificant	0.16	1.33	Other	183	107
372	T.CD8_Tcm.effector_bias	0.11	Nonsignificant	0.73	1.20	Other	199	329
373	T.CD8_naive.nfkb_related	0.11	Nonsignificant	0.97	0.90	Other	1	0
374	T.CD4_Tem.long_term_memory	0.11	Nonsignificant	0.97	0.65	Other	314	587
375	SCHWN.axon_contact_cardiac	0.11	Nonsignificant	1.00	0.06	Other	18	63
376	T.CD4_Th17.cytotoxic	0.11	Nonsignificant	0.77	1.17	Other	332	123
377	NEU.EXC_IT.adhesion	0.11	Nonsignificant	0.91	0.98	Other	252	108
378	MAC.MDM.inflammatory_phagocytic	0.11	Nonsignificant	0.66	0.98	Other	199	52
379	T.gamma_delta.central_memory	0.11	Nonsignificant	0.40	1.14	Other	460	919
380	EPI.endocervical_secretory.secretory_translocon	0.10	Nonsignificant	—	0.00	Other	0	0
381	T.CD4_Th2.precursor	0.10	Nonsignificant	—	0.48	Other	0	0
382	T.CD4_cytotoxic.activated	0.10	Nonsignificant	0.51	1.11	Other	3	1
383	PC.IgA_muocsal.activated	0.10	Nonsignificant	0.34	1.13	Other	17	8
384	T.CD8_naive.cytokine_dampened	0.10	Nonsignificant	0.97	0.73	Other	71	4
385	T.CD4_naive.Treg_like	0.10	Nonsignificant	1.00	0.19	Other	121	72
386	PC.IgA_muocsal.plasmablast	0.10	Nonsignificant	0.34	1.29	Other	5	4
387	EPI.alveolar_type_2.stress_response	0.10	Nonsignificant	0.51	1.15	Other	675	1,562
388	T.CD4_Tcm.baseline	0.09	Nonsignificant	0.13	1.40	Other	61	31
389	NK.adaptive_adipose_stress	0.09	Nonsignificant	1.00	0.94	Other	374	39
390	EPI.skin_interfollicular_spinous.stress_oxidative	0.09	Nonsignificant	—	0.00	Other	0	0
391	ASTRO.A1_reactive	0.09	Nonsignificant	0.73	1.09	Other	433	394
392	B.age_associated.migratory	0.09	Nonsignificant	0.77	0.65	Other	2	2
393	T.CD4_Tcm.synapse_dynamics	0.09	Nonsignificant	0.50	1.24	Other	15	10
394	T.CD8_naive.innate_like	0.09	Nonsignificant	0.97	0.44	Other	10	1
395	PC.IgA_muocsal.baseline	0.09	Nonsignificant	0.70	0.99	Other	3	5
396	MAC.resident_iron.redox_metabolic	0.09	Nonsignificant	0.93	0.57	Other	4	4
397	HPC.CLP_B_primed	0.09	Nonsignificant	—	0.00	Other	0	0
398	MAC.MDM.LAM_like	0.08	Nonsignificant	0.52	1.15	Other	12	14
399	DC.cDC1.baseline	0.08	Nonsignificant	—	0.00	Other	0	0
400	EPI.salivary_intercalated_defense.inflammatory	0.08	Nonsignificant	0.94	0.33	Other	152	360
401	NEU.INH_VIP.develop_niche	0.08	Nonsignificant	—	1.08	Other	0	0
402	EPI.salivary_duct_ion_transport.baseline	0.08	Nonsignificant	—	—	Other	0	0
403	EPI.renal_principal_cell.injury_repair	0.08	Nonsignificant	1.00	0.38	Other	26	9
404	T.CD4_Tcm.secretory	0.08	Nonsignificant	1.00	1.04	Other	20	11
405	EPI.ileal_enterocyte_crypt.baseline	0.08	Nonsignificant	0.96	0.86	Other	11	6
406	T.CD4_cytotoxic.baseline	0.08	Nonsignificant	0.51	1.17	Other	0	0
407	CHOND.angiogenic	0.07	Nonsignificant	—	0.00	Other	0	0
408	NEU.INH_LAMP5.rosehip	0.07	Nonsignificant	—	0.00	Other	0	0
409	EPI.esophageal_suprabasal.differentiating_keratin	0.07	Nonsignificant	0.99	0.17	Other	131	61
410	GRNLSA.angiocrine_mechanosensory	0.07	Nonsignificant	—	0.63	Other	0	0
411	PC.IgA_muocsal.migratory	0.07	Nonsignificant	0.98	0.73	Other	4	1
412	T.CD4_Tcm.APC_mimicry	0.07	Nonsignificant	1.00	0.95	Other	54	43
413	T.CD4_Tcm.effector_like	0.07	Nonsignificant	1.00	1.00	Other	293	533
414	MAC.LAM.antimicrobial	0.07	Nonsignificant	0.98	0.96	Other	389	93
415	NEU.INH_VIP.cannabinoid	0.07	Nonsignificant	—	0.63	Other	0	0
416	GRNLSA.secretory_remodeling	0.07	Nonsignificant	0.53	1.27	Other	90	25
417	MAC.MDM.complement_resolving	0.07	Nonsignificant	0.66	0.95	Other	440	860
418	MAC.resident_iron.heme_catabolism	0.07	Nonsignificant	0.93	0.50	Other	30	51
419	EPI.ileal_enterocyte_absorptive.villus_tip	0.07	Nonsignificant	1.00	0.00	Other	4	3
420	MONO.CD14.inflammatory	0.07	Nonsignificant	0.34	1.32	Other	92	134
421	B.naive.metabolic	0.07	Nonsignificant	0.98	1.05	Other	50	79
422	EPI.alveolar_type_2.baseline_surfactant	0.07	Nonsignificant	0.51	1.14	Other	64	9
423	NEU.EXC_IT.transitional	0.07	Nonsignificant	0.70	1.12	Other	237	142
424	T.CD4_Tcm.Tfh_like	0.07	Nonsignificant	1.00	0.80	Other	102	214
425	FIB.adventitial.PI16_matrix	0.06	Nonsignificant	1.00	0.73	Other	70	90
426	EPI.ectocervical_granular.proliferative_basal	0.06	Nonsignificant	—	0.32	Other	0	0
427	EC.liver_sinusoidal.stress	0.06	Nonsignificant	—	0.10	Other	413	158
428	B.memory.migratory	0.06	Nonsignificant	0.76	1.11	Other	123	208
429	T.CD4_Treg.central_naive_like	0.06	Nonsignificant	0.43	1.20	Other	333	45
430	T.gamma_delta.cytotoxic_effector	0.06	Nonsignificant	0.97	0.57	Other	349	109
431	NEU.INH_PVALB.chandelier	0.06	Nonsignificant	0.22	1.40	Other	19	16
432	MAC.LAM.inflammatory_APC	0.06	Nonsignificant	0.98	0.97	Other	872	165
433	T.CD4_Th17.migratory	0.06	Nonsignificant	0.77	0.85	Other	13	23
434	MAC.resident_repair.chemokine_angiocrine	0.06	Nonsignificant	0.87	0.95	Other	87	138
435	T.CD4_Tcm.RNA_control	0.06	Nonsignificant	1.00	0.64	Other	96	4
436	T.CD4_Tcm.tissue_homing	0.06	Nonsignificant	1.00	0.59	Other	78	46
437	T.CD4_Th17.baseline	0.06	Nonsignificant	0.77	0.84	Other	51	5
438	EPI.esophageal_suprabasal.proliferative_exit	0.06	Nonsignificant	—	0.00	Other	0	0
439	NK.adaptive_axis_baseline	0.06	Nonsignificant	1.00	1.01	Other	1,008	153
440	NK.adaptive_biosynthetic_primed	0.06	Nonsignificant	1.00	0.97	Other	244	405
441	NEU.INH_VIP.nuclear_reg	0.05	Nonsignificant	—	0.34	Other	20	4
442	MONO.CD16.platelet_bound	0.05	Nonsignificant	0.13	1.38	Other	372	508
443	GRNLSA.lipid_hypoxia	0.05	Nonsignificant	0.53	1.21	Other	28	0
444	NK.immature_bridge	0.05	Nonsignificant	1.00	0.87	Other	117	122
445	T.CD4_Tcm.retro_ZNF117	0.05	Nonsignificant	1.00	0.60	Other	5	9
446	NEU.INH_VIP.LAMP5_hybrid	0.05	Nonsignificant	—	0.55	Other	1	9
447	B.naive.baseline	0.05	Nonsignificant	0.98	1.01	Other	10	13
448	NK.cytokine_axis_baseline	0.05	Nonsignificant	1.00	0.82	Other	1,172	116
449	ASTRO.stress_acute	0.05	Nonsignificant	0.92	1.06	Other	60	56
450	GRNLSA.EMT_insulin_signaling	0.05	Nonsignificant	0.93	0.76	Other	47	84
451	B.naive.antigen_presenting_ready	0.05	Nonsignificant	0.98	1.00	Other	48	73
452	B.naive.receptor_recycle	0.05	Nonsignificant	0.98	0.92	Other	51	0
453	B.naive.purinergic	0.05	Nonsignificant	0.98	0.92	Other	384	820
454	EPI.alveolar_type_2.injury_primed	0.05	Nonsignificant	0.81	0.76	Other	434	245
455	ASTRO.immature_lipid	0.05	Nonsignificant	0.34	1.23	Other	23	113
456	EC.venous.cardiac_structural	0.05	Nonsignificant	1.00	8.57e-03	Other	102	229
457	T.CD4_Tcm.regulatory_poised	0.05	Nonsignificant	1.00	0.75	Other	2	3
458	T.CD4_Treg.APC_interactive	0.05	Nonsignificant	0.95	0.53	Other	118	28
459	EPI.skin_keratinocyte_basal.spinous_transition	0.05	Nonsignificant	—	0.00	Other	0	0
460	T.CD8_Tem.baseline	0.05	Nonsignificant	0.40	1.11	Other	458	356
461	NK.cytokine_repair_primed	0.05	Nonsignificant	1.00	1.10	Other	266	11
462	T.CD4_Tcm.crosstalk_myeloid	0.04	Nonsignificant	1.00	0.58	Other	5	4
463	NEU.INH_VIP.canonical_disinhibitory	0.04	Nonsignificant	0.56	0.93	Other	59	38
464	T.CD8_Tcm.gut_homing	0.04	Nonsignificant	0.92	0.53	Other	380	112
465	MG.expanding	0.04	Nonsignificant	0.73	0.79	Other	2	1
466	T.CD8_Tcm.helper_like	0.04	Nonsignificant	0.92	0.64	Other	81	159
467	MONO.CD16.hepatic_mac_like	0.04	Nonsignificant	0.03	1.33	Other	803	117
468	NEU.EXC_IT.neuromodulated	0.04	Nonsignificant	0.91	1.01	Other	176	116
469	NEU.INH_VIP.enkephalinergic	0.04	Nonsignificant	—	0.12	Other	0	0
470	PC.IgG_systemic.metabolic	0.04	Nonsignificant	1.00	0.06	Other	46	63
471	T.CD4_Treg.Tr1_like	0.04	Nonsignificant	—	0.20	Other	8	8
472	PERI.cardiac_skeletal	0.04	Nonsignificant	1.00	0.00	Other	313	630
473	EPI.gastric_foveolar.baseline	0.04	Nonsignificant	—	0.00	Other	0	0
474	T.CD8_Tem.early_helper_like	0.04	Nonsignificant	0.85	1.05	Other	445	755
475	B.memory.baseline	0.04	Nonsignificant	1.00	0.72	Other	472	99
476	ASTRO.A2_reactive	0.04	Nonsignificant	0.92	1.05	Other	10	37
477	EPI.skin_interfollicular_spinous.inflammatory	0.04	Nonsignificant	—	0.38	Other	0	0
478	NK.cytokine_biosynthetic_primed	0.04	Nonsignificant	1.00	0.95	Other	360	21
479	MAC.resident_iron.heme_recycling	0.04	Nonsignificant	—	0.00	Other	30	37
480	MONO.CD14.APC_like	0.04	Nonsignificant	0.16	1.11	Other	1,686	2,493
481	EPI.ileal_enterocyte_crypt.secretory_precursor	0.04	Nonsignificant	—	0.12	Other	0	0
482	B.naive.remodeling	0.04	Nonsignificant	0.98	0.92	Other	135	230
483	EPI.salivary_duct_excretory.baseline	0.04	Nonsignificant	0.66	0.86	Other	23	57
484	EPI.renal_principal_cell.intercalated_like	0.04	Nonsignificant	1.00	0.00	Other	63	66
485	T.CD4_Th2.tissue_adapted	0.04	Nonsignificant	—	0.00	Other	0	0
486	ASTRO.hypoxia_angiogenic	0.04	Nonsignificant	0.73	1.23	Other	5	18
487	EPI.renal_thick_ascending_limb.salt_sensing	0.04	Nonsignificant	1.00	0.15	Other	73	103
488	NEU.INH_PVALB.nuclear_reg	0.04	Nonsignificant	0.50	1.05	Other	25	12
489	NEU.INH_VIP.regulatory_remodeling	0.04	Nonsignificant	—	0.00	Other	6	1
490	T.CD4_Tcm.Th2_like	0.03	Nonsignificant	1.00	0.28	Other	23	55
491	MAC.LAM.lipid_phagocytosis	0.03	Nonsignificant	0.98	0.60	Other	369	328
492	EPI.salivary_duct_excretory.stress	0.03	Nonsignificant	0.66	0.89	Other	33	68
493	NEU.EXC_SYT2.synaptic	0.03	Nonsignificant	—	0.00	Other	0	0
494	EPI.colonocyte.distal_absorptive	0.03	Nonsignificant	—	0.00	Other	0	0
495	NEU.INH_VIP.opioid	0.03	Nonsignificant	—	0.00	Other	50	9
496	T.CD8_Tcm.NK_like	0.03	Nonsignificant	0.92	0.47	Other	334	581
497	EPI.hepatic_ductular_cholangiocyte.acute_phase_complement	0.03	Nonsignificant	—	0.00	Other	0	0
498	GRNLSA.cholesterol_mevalonate	0.03	Nonsignificant	0.93	0.56	Other	9	4
499	MAC.LAM.lipid_opsonization	0.03	Nonsignificant	0.98	0.77	Other	45	14
500	EPI.pancreatic_acinar.metabolic_onecarbon	0.03	Nonsignificant	1.00	0.33	Other	287	328
501	CM.contractile_oxphos	0.03	Nonsignificant	0.58	1.27	Other	6	19
502	ASTRO.neuromodulatory	0.03	Nonsignificant	0.96	0.93	Other	34	172
503	NEU.INH_LAMP5.glial_interface	0.03	Nonsignificant	—	0.00	Other	0	0
504	EPI.renal_distal_tubule.ciliated_remodelling	0.03	Nonsignificant	—	1.04	Other	0	0
505	NK.adaptive_terminal_cytotoxic	0.03	Nonsignificant	1.00	0.78	Other	485	802
506	EPI.pancreatic_ductal_bicarbonate.inflammatory	0.03	Nonsignificant	0.52	1.41	Other	14	32
507	MAC.resident_repair.stress_iron	0.02	Nonsignificant	0.87	0.99	Other	48	97
508	EPI.ileal_bile_transport.detox_transcytosis	0.02	Nonsignificant	—	0.61	Other	0	1
509	FIB.adventitial.baseline	0.02	Nonsignificant	1.00	0.34	Other	157	278
510	EPI.skin_sweat_duct_keratinocyte.repair	0.02	Nonsignificant	—	0.00	Other	0	0
511	FIB.adventitial.mechano_chemo_sensing	0.02	Nonsignificant	1.00	0.47	Other	135	524
512	NK.cytokine_vascular_patrolling	0.02	Nonsignificant	1.00	0.77	Other	863	94
513	T.CD8_Tem.stress_adapted	0.02	Nonsignificant	0.96	0.98	Other	607	520
514	EPI.ileal_enterocyte_crypt.bile_transport	0.02	Nonsignificant	0.96	0.29	Other	2	0
515	FIB.adventitial.mito_secretory	0.02	Nonsignificant	1.00	0.51	Other	21	7
516	GRNLSA.chemokine_mechanosensory	0.02	Nonsignificant	0.93	0.54	Other	1	0
517	NEU.EXC_IT.callosal	0.02	Nonsignificant	1.00	0.65	Other	286	119
518	EPI.renal_distal_tubule.repair	0.02	Nonsignificant	—	0.55	Other	34	102
519	NEU.INH_PVALB.metabotropic	0.02	Nonsignificant	—	6.94e-17	Other	0	0
520	NEU.INH_VIP.excitatory_coupled	0.02	Nonsignificant	—	0.00	Other	13	0
521	CM.inflammatory	0.02	Nonsignificant	—	1.26	Other	0	0
522	EPI.intrahepatic_cholangiocyte_transport.protease_shield_hippo	0.02	Nonsignificant	—	0.73	Other	0	0
523	T.CD8_Tem.TEMRA	0.02	Nonsignificant	0.85	1.05	Other	920	1,088
524	EPI.pancreatic_ductal_bicarbonate.baseline	0.02	Nonsignificant	0.52	1.20	Other	11	42
525	CM.anti_inflammatory	0.02	Nonsignificant	0.58	1.26	Other	424	1,503
526	MAC.kupffer.metabolic	0.02	Nonsignificant	—	0.68	Other	25	36
527	EPI.pancreatic_ductal_bicarbonate.barrier_mucin	0.02	Nonsignificant	0.52	1.17	Other	219	533
528	MONO.CD14.repair_M2_like	0.02	Nonsignificant	0.59	1.07	Other	550	1,495
529	EPI.pancreatic_islet.delta	0.02	Nonsignificant	—	0.00	Other	0	0
530	OPC.homeostatic	0.02	Nonsignificant	0.19	1.38	Other	394	160
531	CM.baseline	0.02	Nonsignificant	0.77	1.12	Other	393	0
532	EPI.cervical_suprabasal.secretory_vesicle	0.02	Nonsignificant	—	0.73	Other	0	0
533	B.naive.proteostasis	0.02	Nonsignificant	0.99	0.61	Other	49	69
534	NK.cytokine_quiescent	0.02	Nonsignificant	1.00	0.82	Other	623	1,062
535	B.memory.preactivated	0.02	Nonsignificant	1.00	0.84	Other	173	174
536	EPI.ileal_bile_transport.absorptive_xenobiotic	0.02	Nonsignificant	0.80	0.54	Other	11	12
537	ASTRO.synaptic_interaction	0.02	Nonsignificant	0.96	0.88	Other	76	334
538	EPI.salivary_serous_acinar.quiescent	0.02	Nonsignificant	1.00	0.00	Other	178	493
539	B.naive.restrained	0.02	Nonsignificant	0.99	0.67	Other	183	353
540	EPI.salivary_serous_acinar.seromucous_like	0.02	Nonsignificant	—	0.00	Other	0	0
541	T.CD4_cytotoxic.terminal_effector	0.02	Nonsignificant	0.91	0.84	Other	286	21
542	NEU.INH_PVALB.neuromodulatory	0.02	Nonsignificant	—	0.00	Other	0	0
543	ADIPO.hypoxia_remodelling	0.02	Nonsignificant	—	0.32	Other	29	105
544	MAC.resident_repair.ECM_stromal_crosstalk	0.01	Nonsignificant	0.98	0.52	Other	95	158
545	MESO.activated_stress	0.01	Nonsignificant	—	0.00	Other	0	0
546	EC.liver_sinusoidal.secretory_lipoprotein	0.01	Nonsignificant	0.88	0.62	Other	120	70
547	PLAT.megakaryocytic	0.01	Nonsignificant	—	0.97	Other	0	0
548	NEU.INH_VIP.matrix	0.01	Nonsignificant	—	0.00	Other	24	77
549	EPI.pancreatic_ductal_mucinous.mucin_rich_barrier	0.01	Nonsignificant	0.25	1.31	Other	449	1,034
550	EC.liver_sinusoidal.prostanoid	0.01	Nonsignificant	—	0.00	Other	11	64
551	GRNLSA.p53_damage	0.01	Nonsignificant	—	0.00	Other	13	10
552	EPI.esophageal_suprabasal.proliferative_G2M	0.01	Nonsignificant	—	0.00	Other	0	0
553	EPI.pancreatic_ductal_mucinous.proliferative_gastric_like	0.01	Nonsignificant	—	0.46	Other	0	0
554	EPI.ileal_enterocyte_crypt.villus_transition	0.01	Nonsignificant	—	0.00	Other	7	10
555	EPI.ectocervical_granular.inflammatory	0.01	Nonsignificant	—	0.00	Other	0	0
556	EPI.intrahepatic_cholangiocyte_defense.secretory_barrier	0.01	Nonsignificant	—	0.00	Other	0	0
557	OPC.premyelinating	0.01	Nonsignificant	0.79	0.80	Other	185	12
558	MAC.resident_repair.lipid_phagocytic	0.01	Nonsignificant	0.87	1.08	Other	228	604
559	MAC.kupffer.inflammatory	0.01	Nonsignificant	—	0.19	Other	7	4
560	OPC.proliferative_immune_interact	0.01	Nonsignificant	0.79	0.77	Other	180	373
561	OLG.stress	0.01	Nonsignificant	0.08	1.39	Other	232	8
562	EPI.pancreatic_ductal_mucinous.remodeling_channel_rich	0.01	Nonsignificant	—	0.10	Other	0	0
563	EPI.intrahepatic_cholangiocyte_defense.raft_maturation	0.01	Nonsignificant	—	0.00	Other	0	0
564	SKM.type_1_slow.glycolytic	0.01	Nonsignificant	0.07	1.55	Other	362	647
565	EPI.skin_interfollicular_spinous.early_differentiation	0.01	Nonsignificant	0.97	0.72	Other	89	19
566	EPI.skin_interfollicular_spinous.baseline	0.01	Nonsignificant	0.97	0.76	Other	35	3
567	EPI.salivary_mucous_acinar.baseline	9.97e-03	Nonsignificant	—	—	Other	394	683
568	MONO.CD16.patrolling	9.82e-03	Nonsignificant	0.76	1.03	Other	797	216
569	EPI.hepatic_ductular_cholangiocyte.stress	9.72e-03	Nonsignificant	—	1.32	Other	0	0
570	EPI.pancreatic_ductal_bicarbonate.stress	9.64e-03	Nonsignificant	—	0.00	Other	12	33
571	NK.adaptive_HLAE_tuned	9.30e-03	Nonsignificant	1.00	0.74	Other	1,124	189
572	NEU.EXC_IT.guidance	8.94e-03	Nonsignificant	1.00	0.35	Other	274	63
573	EPI.skin_sweat_duct_keratinocyte.barrier	8.32e-03	Nonsignificant	—	0.00	Other	0	0
574	CM.mechano_activated	8.28e-03	Nonsignificant	0.87	1.00	Other	205	134
575	SKM.type_2_fast.oxidative_IIa	8.23e-03	Nonsignificant	0.14	1.28	Other	946	56
576	ASPC.signal_integrator	7.80e-03	Nonsignificant	—	0.00	Other	0	0
577	MAC.resident_cardiac.inflammatory_reparative	7.79e-03	Nonsignificant	0.52	1.27	Other	31	96
578	PLAT.adhesion	7.71e-03	Nonsignificant	—	0.00	Other	0	0
579	B.memory.pDC_imprint	7.50e-03	Nonsignificant	1.00	0.26	Other	157	103
580	OLG.regulatory_activated	7.34e-03	Nonsignificant	0.50	1.14	Other	196	614
581	OLG.reactive_repair	7.04e-03	Nonsignificant	0.50	1.21	Other	385	385
582	EPI.pancreatic_ductal_bicarbonate.activated	6.89e-03	Nonsignificant	0.94	0.45	Other	10	7
583	CM.oxidative_phospho	6.48e-03	Nonsignificant	0.87	0.97	Other	266	792
584	OLG.regulatory	6.47e-03	Nonsignificant	0.50	1.10	Other	353	73
585	EPI.ileal_goblet.immature	6.34e-03	Nonsignificant	—	0.64	Other	0	0
586	EC.liver_sinusoidal.remodeling_lipotoxicity	6.17e-03	Nonsignificant	—	0.00	Other	90	58
587	EPI.pancreatic_ductal_bicarbonate.repair_actin_junction	5.92e-03	Nonsignificant	—	0.00	Other	0	0
588	EPI.pancreatic_ductal_bicarbonate.junctional_remodel	5.71e-03	Nonsignificant	—	0.00	Other	49	237
589	EPI.pancreatic_acinar.adhesion_remodeling	5.69e-03	Nonsignificant	1.00	0.45	Other	210	784
590	NEU.INH_PVALB.serotonergic	5.64e-03	Nonsignificant	—	0.00	Other	0	0
591	MONO.CD14.remodeling	5.53e-03	Nonsignificant	0.79	0.99	Other	2,373	295
592	SKM.type_2_fast.glycolytic_IIx_IIb	5.51e-03	Nonsignificant	0.52	1.02	Other	565	1,482
593	CM.osmoprotection	5.45e-03	Nonsignificant	0.87	0.97	Other	34	57
594	HEP.periportal_metabolic.apolipoprotein_secretory	5.42e-03	Nonsignificant	0.66	1.23	Other	43	110
595	EPI.cervical_suprabasal.inflammatory_repair	5.27e-03	Nonsignificant	—	0.00	Other	0	0
596	CM.mito_proteostasis	5.25e-03	Nonsignificant	0.87	0.88	Other	329	29
597	EPI.pancreatic_ductal_bicarbonate.renewal_ion_pump	5.19e-03	Nonsignificant	0.71	0.95	Other	40	191
598	NK.adaptive_classII_inhibitory	5.19e-03	Nonsignificant	1.00	0.67	Other	880	154
599	EPI.renal_distal_tubule.immune_modulatory	5.10e-03	Nonsignificant	—	0.13	Other	0	0
600	CM.sarcomere_actin_interface	4.96e-03	Nonsignificant	0.87	0.86	Other	450	78
601	NEU.INH_PVALB.fastspike	4.94e-03	Nonsignificant	—	0.00	Other	24	22
602	SKM.type_1_slow.oxidative	4.60e-03	Nonsignificant	0.10	1.38	Other	802	251
603	EPI.extrahepatic_cholangiocyte.barrier_interface	4.40e-03	Nonsignificant	—	0.00	Other	0	0
604	DC.pDC.immature_metabolic	4.32e-03	Nonsignificant	0.84	1.42	Other	78	124
605	MAC.resident_cardiac.phagocytic_homeostasis	4.28e-03	Nonsignificant	0.72	0.88	Other	564	1,221
606	NEU.EXC_CT.projector	4.16e-03	Nonsignificant	0.47	1.11	Other	87	26
607	EPI.bile_duct_cholangiocyte.secretory_mucin	4.05e-03	Nonsignificant	—	0.46	Other	7	12
608	MAC.kupffer.stress	3.94e-03	Nonsignificant	0.91	0.48	Other	9	3
609	EPI.hepatic_ductular_cholangiocyte.ion_transport	3.92e-03	Nonsignificant	—	0.78	Other	0	0
610	MONO.CD14.baseline	3.82e-03	Nonsignificant	1.00	0.82	Other	2,268	76
611	CM.translation_boost_RPL	3.70e-03	Nonsignificant	0.87	0.79	Other	129	1
612	MONO.CD16.baseline	3.58e-03	Nonsignificant	0.85	0.89	Other	50	1
613	NEU.EXC_SYT2.nuclear_reg	3.46e-03	Nonsignificant	—	0.00	Other	0	0
614	OLG.myelinating_mature	3.37e-03	Nonsignificant	1.00	0.80	Other	363	94
615	SKM.type_1_slow.contractile	3.34e-03	Nonsignificant	0.88	0.68	Other	596	8
616	CM.translation_boost_RPS	3.18e-03	Nonsignificant	0.87	0.74	Other	69	16
617	NEU.EXC_NTNG1.nuclear_reg	3.13e-03	Nonsignificant	—	0.67	Other	0	0
618	T.CD4_naive.activated_stress	3.08e-03	Nonsignificant	1.00	0.00	Other	339	429
619	MAC.kupffer.fibrogenic	3.06e-03	Nonsignificant	—	0.00	Other	0	0
620	MAC.resident_cardiac.antigen_presenting	3.04e-03	Nonsignificant	0.72	0.87	Other	52	27
621	EPI.intrahepatic_cholangiocyte_transport.mechanosensing_remodelling	3.00e-03	Nonsignificant	—	0.00	Other	0	0
622	NEU.EXC_CT.remodeling	2.91e-03	Nonsignificant	—	0.00	Other	23	1
623	EPI.hepatic_ductular_cholangiocyte.barrier_chemokine	2.88e-03	Nonsignificant	—	0.66	Other	6	9
624	NEU.EXC_NTNG1.synaptic	2.79e-03	Nonsignificant	—	0.00	Other	0	0
625	GRANU.neutrophil.antiviral_endotoxin	2.72e-03	Nonsignificant	—	0.64	Other	0	0
626	T.CD8_Tem.motility_primed	2.62e-03	Nonsignificant	0.96	0.65	Other	269	4
627	EPI.ileal_goblet.inflammatory_mucin	2.58e-03	Nonsignificant	0.72	0.99	Other	6	9
628	NEU.EXC_CT.Ca2_sensor	2.51e-03	Nonsignificant	—	0.00	Other	0	0
629	EPI.pancreatic_ductal_mucinous.xenobiotic_ERexit	2.46e-03	Nonsignificant	—	0.00	Other	0	0
630	ADIPO.inflammatory	2.41e-03	Nonsignificant	—	0.59	Other	0	0
631	T.CD8_Tem.signaling_turnover	2.24e-03	Nonsignificant	0.96	0.72	Other	425	683
632	GRANU.neutrophil.primed_degranulation	2.23e-03	Nonsignificant	—	0.00	Other	0	0
633	EPI.extrahepatic_cholangiocyte.mucin_secretory	2.14e-03	Nonsignificant	—	0.00	Other	0	0
634	NK.adaptive_immature_precursor	2.11e-03	Nonsignificant	1.00	0.42	Other	358	111
635	EPI.renal_distal_tubule.stress	2.00e-03	Nonsignificant	—	0.00	Other	0	0
636	EPI.skin_interfollicular_spinous.upper_lipid	1.96e-03	Nonsignificant	—	0.00	Other	6	6
637	EPI.ileal_goblet.baseline	1.88e-03	Nonsignificant	0.72	0.74	Other	16	2
638	EPI.skin_interfollicular_spinous.stress_UPR	1.86e-03	Nonsignificant	—	0.07	Other	0	0
639	MAC.kupffer.tolerogenic	1.84e-03	Nonsignificant	—	0.00	Other	45	49
640	OLG.myelinating_stress	1.80e-03	Nonsignificant	1.00	0.51	Other	232	62
641	EPI.ileal_goblet.stress_metallothionein	1.75e-03	Nonsignificant	—	0.00	Other	4	11
642	OLG.vesicle_trafficking	1.58e-03	Nonsignificant	1.00	0.29	Other	124	10
643	ASTRO.stress_mito	1.53e-03	Nonsignificant	0.96	0.79	Other	47	110
644	NEU.EXC_CT.Ca2_signaling	1.49e-03	Nonsignificant	—	0.00	Other	68	17
645	EPI.hepatic_ductular_cholangiocyte.polarity	1.21e-03	Nonsignificant	—	0.08	Other	0	0
646	EPI.bile_duct_cholangiocyte.inflammatory_APC	1.16e-03	Nonsignificant	—	0.00	Other	2	0
647	GRANU.neutrophil.tissue_patrolling	1.06e-03	Nonsignificant	—	0.00	Other	0	0
648	EPI.intrahepatic_cholangiocyte_transport.mucin_secretory	8.40e-04	Nonsignificant	—	0.00	Other	0	0
649	EC.liver_sinusoidal.inflammatory	8.16e-04	Nonsignificant	—	0.00	Other	223	154
650	MONO.CD16.inflammatory	7.99e-04	Nonsignificant	1.00	0.37	Other	1,640	168
651	ADIPO.immature	6.73e-04	Nonsignificant	—	0.00	Other	24	40
652	DC.pDC.baseline	6.57e-04	Nonsignificant	0.84	0.85	Other	88	123
653	MAC.alveolar.stress_metabolic	6.45e-04	Nonsignificant	0.01	1.20	Other	116	148
654	EPI.hepatic_ductular_cholangiocyte.secretory_transport	5.28e-04	Nonsignificant	—	0.00	Other	0	0
655	EPI.renal_distal_tubule.ion_transport	4.87e-04	Nonsignificant	—	0.00	Other	0	0
656	EPI.ectocervical_granular.immune_interact	4.75e-04	Nonsignificant	—	0.00	Other	0	0
657	HEP.periportal_metabolic.inflammatory_activated	4.68e-04	Nonsignificant	0.75	1.08	Other	712	1,610
658	ASTRO.homeostatic	4.38e-04	Nonsignificant	1.00	0.24	Other	200	431
659	EPI.hepatic_ductular_cholangiocyte.lipid_mevalonate	4.09e-04	Nonsignificant	—	0.00	Other	0	0
660	EPI.hepatic_ductular_cholangiocyte.mechanosense_adhesion	3.84e-04	Nonsignificant	—	0.00	Other	5	3
661	ADIPO.thermogenic	3.00e-04	Nonsignificant	—	0.00	Other	0	0
662	DC.pDC.poised_migratory	2.20e-04	Nonsignificant	0.99	0.23	Other	54	95
663	EPI.skin_sweat_duct_keratinocyte.cornifying_acrosyringeal	1.90e-04	Nonsignificant	—	0.00	Other	0	0
664	HEP.periportal_metabolic.stress_checkpoint	1.48e-04	Nonsignificant	0.75	1.10	Other	234	786
665	HEP.canalicular_transport.inflammatory	4.56e-05	Nonsignificant	0.54	1.05	Other	1,335	194
666	HEP.acute_phase.proliferative	3.20e-05	Nonsignificant	—	0.77	Other	4	6
667	EPI.skin_sweat_duct_keratinocyte.suprabasal_hypoxic	2.61e-05	Nonsignificant	—	0.00	Other	0	0
668	HEP.canalicular_transport.injury_stress	2.41e-05	Nonsignificant	0.54	1.09	Other	289	24
669	MAC.alveolar.capillary_interacting	1.33e-05	Nonsignificant	0.82	1.14	Other	113	181
670	HEP.acute_phase.stress_secretory	1.32e-05	Nonsignificant	0.35	1.24	Other	26	3
671	HEP.periportal_metabolic.acute_phase_barrier	1.14e-05	Nonsignificant	1.00	0.99	Other	533	138
672	HEP.periportal_metabolic.xenobiotic_detox	1.07e-05	Nonsignificant	1.00	0.83	Other	1,440	139
673	HEP.periportal_metabolic.canonical_urea_cycle	8.13e-06	Nonsignificant	1.00	0.77	Other	1,464	269
674	HEP.canalicular_transport.secretory_ERAD_UPR	3.38e-06	Nonsignificant	0.54	1.09	Other	232	28
675	HEP.acute_phase.baseline	2.95e-06	Nonsignificant	0.96	0.99	Other	946	19
676	HEP.periportal_metabolic.urea_onecarbon_secretory	2.06e-06	Nonsignificant	1.00	0.56	Other	1,332	3,053
677	HEP.acute_phase.complement_antiviral	1.77e-06	Nonsignificant	0.96	1.04	Other	377	751
678	MAC.alveolar.biosynthetic_sterol_heme	1.58e-06	Nonsignificant	0.84	1.02	Other	347	40
679	HEP.canalicular_transport.ductular_like_transition	1.42e-06	Nonsignificant	0.54	1.05	Other	400	87
680	HEP.canalicular_transport.sterol_lipid_biosynthesis	8.50e-07	Nonsignificant	—	0.64	Other	10	20
681	HEP.canalicular_transport.pericentral_like_hypoxia	3.91e-07	Nonsignificant	1.00	0.87	Other	326	8
682	HEP.acute_phase.complement_metabolic	1.00e-07	Nonsignificant	0.96	0.93	Other	1,423	3,464
683	MAC.alveolar.lipid_autophagy	5.52e-08	Nonsignificant	—	0.10	Other	35	44
684	MAC.alveolar.scavenging_endocytic	3.16e-08	Nonsignificant	—	0.00	Other	140	283
685	MAC.alveolar.inflammatory	2.99e-08	Nonsignificant	0.93	0.70	Other	208	312
686	HEP.acute_phase.hypoxia_lipid	2.14e-09	Nonsignificant	—	0.60	Other	0	0
687	HEP.acute_phase.inflammatory	1.15e-09	Nonsignificant	0.96	0.73	Other	382	649
688	HEP.canalicular_transport.baseline	1.17e-10	Nonsignificant	1.00	0.11	Other	199	477

Associated genes: best evidence per gene

One row per gene, using its best association: priority ascending (01 before 02), then gene credibility score descending. G-tier and C-tier are the source genetic and cellular tiers from that same winning association. Score is the gene_credibility_score, not an IC score, expression measurement or new P-value. The marker column lists exact matches to the supplied annotation marker lists, with hierarchy levels. The separate scope-pooled enriched column lists exact matches to the union of up to 100 Enriched-tier genes per population from every valid published scope. Genes first require expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2, then are ranked by descending log2 fold change using full-population cells. Fewer than 100 qualifying genes are retained without lower-tier backfill. Each population appears only once per gene; larger match lists use a compact link to their complete named-cell list. This is a candidate pool, not enrichment in every scope. Both columns match gene symbols case-insensitively, without aliases or inheritance. Enriched genes are not automatically annotation markers or specific to one cell type. A blank match in either column does not prove absence of expression. Use only matches belonging to the requested scope and level from both columns. Read the linked cell-gene reference for the supporting scope, rank, enrichment detection percentage and comparison-cell counts. Prioritize the requested scope and level; Overview is broader context, and enrichment found only in another scope is not local evidence. IC means remain full-atlas values. Marker and enrichment overlap are distinct supporting context, not proof of causality or treatment efficacy. The linked cell-gene reference provides every marker and scope-specific top-100 score.

Complete annotation marker lists · Complete markers and scope-aware enriched-gene evidence for all cell types, subtypes and states

0 unique genes. Showing 0–0. The complete list is available through the ordinary gene-table page links; no genes are omitted.

Best gene associations, ordered by priority then score
Browsers	Gene	Priority	Score	MAGMA −log10(P)	G-tier	C-tier	Marker of cell types/states	Enriched in trait related cells	Scope-pooled enriched in cell types/states	Meta traits (High Priority)	Individual traits (High Priority)

Each hierarchy level is ranked separately. Rows are sorted by score descending; ties use name/identifier order. Measurements are displayed to two decimal places; original values are retained for sorting. Counts and ranks remain whole numbers.

MAGMA −log10(P) describes gene-level association, not the ICE-CREAM cell enrichment score. Individual traits use the minimum available raw MAGMA P value for each gene. Meta traits show the strongest available individual trait evidence among their current children (maximum −log10(P), not the separately aggregated meta-trait P value). The retained top-100 MAGMA export supplements missing gene/individual-trait pairs where identity is unambiguous; its scores are rounded and capped at 350. Full original MAGMA results are unavailable, so child coverage may be incomplete; unavailable values do not mean no association. A raw P recorded as zero is displayed using the existing export convention of 350, not as an exact P value. Positive raw P values are not capped.

Enriched in trait related cells intersects each gene’s membership in the union of up to 100 Enriched-tier genes for each cell population across all available scopes with the Specific and Relevant cells associated with this trait. Gene eligibility requires expression > 0.01 in at least 5% of finite-valued cells and log2 fold change > 2; eligible genes are ranked by descending log2 fold change within each cell/scope, with no lower-tier backfill. The displayed tiers are the authored trait–cell association tiers, not IC-score significance labels. Meta traits use their own aggregate tiers, not a union of child-trait tiers. Marker membership alone does not qualify a cell for this column. A dash means no qualifying intersection in the available evidence.

CSEA (cell set enrichment analysis) is analogous to GSEA: it asks whether a cell set is enriched along a ranked list of ICE-CREAM scores. CSEA FDR is distinct from the existing IC-score Significance category and from the authored trait–cell Tier. CSEA NES is the normalized enrichment score, not a log fold change. Missing evidence is shown as a dash, not zero. Existing IC scores, Significance categories and ranking order are unchanged. For an individual trait, CSEA FDR is the source-adjusted p-value and CSEA NES is the source normalized enrichment score.