Evidence reports Cell populations T.CD4_Treg.APC_interactive DE genes Static evidence for AI interpretation. These reports provide data for prompting AI and are not intended as a human-facing reading interface. Please visit the Cell Browser , Trait Browser and Genome Browser for interactive browsing. Have fun exploring SCREATE!Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.
T.CD4_Treg.APC_interactive: DE genes
How association tiers are defined — cell–trait and gene–trait SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.
Cell–trait tiers Cell–trait links Identify cell types whose regulatory activity is associated with a trait’s genetic signal. Required for Specific or Relevant The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05. Specific (Tier 1) Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background. Relevant (Tier 2) Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types. Interpretation and report values CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance. Meta traits and individual traits Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier. Gene–trait priorities (variant–tCRE–gene evidence) Variant–tCRE–gene links Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model. Required genetic support The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2. Required cellular support The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority. High priority Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes. Medium priority Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score. Same-record evidence and aggregation Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule. Limits of interpretation A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields. Meta traits · Individual traits · Gene expression · DE genes DE log fold change is a different metric from mean expression and IC score. This is the complete available browser export, limited upstream to the top 1,000 genes per population; it is not an exhaustive genome-wide differential-expression result.
All 1,000 available exported DE genes
Browsers # Gene DE log fold change Meta traits (High Priority) Individual traits (High Priority)
1 FOXP3 10.06 — — 2 CCR8 8.04 5 3 3 CTLA4 7.82 48 101 4 CCR4 7.43 7 16 5 LINC02195 7.36 0 0 6 CD177 7.32 2 3 7 PMCH 7.06 7 22 8 IL2RA 7.04 9 20 9 CCR10 6.89 17 35 10 LTB 6.81 127 281 11 TIGIT 6.80 1 1 12 CD3E 6.76 17 66 13 CD3D 6.69 18 62 14 IL32 6.66 3 5 15 RTKN2 6.32 21 42 16 CD27 6.22 20 36 17 CCR6 6.19 18 26 18 TNFRSF4 6.13 5 7 19 PTPRCAP 6.10 7 39 20 LINC02099 6.03 0 0 21 CD2 6.02 6 14 22 LCK 5.99 0 0 23 ICOS 5.98 0 2 24 LINC01727 5.97 1 1 25 CD3G 5.97 13 55 26 TNFRSF9 5.94 5 5 27 LINC01943 5.89 2 2 28 TNFRSF18 5.83 9 12 29 GBP5 5.82 2 2 30 FUT7 5.81 22 37 31 LAIR2 5.81 6 8 32 CD52 5.70 10 50 33 CXCR6 5.70 12 25 34 AHSP 5.68 0 0 35 CD28 5.68 12 25 36 CCR3 5.68 11 25 37 CGA 5.60 0 0 38 CD5 5.50 23 80 39 SIT1 5.41 18 57 40 C4orf50 5.34 3 20 41 LINC02539 5.33 11 26 42 DUSP4 5.33 0 0 43 JAKMIP1 5.31 3 20 44 CXCR3 5.30 — — 45 SIRPG 5.30 5 7 46 GTSF1L 5.26 1 1 47 HPGD 5.25 0 0 48 IL2RG 5.25 — — 49 CD247 5.24 8 30 50 BATF 5.22 4 12 51 SKAP1 5.22 9 21 52 LAT 5.16 26 82 53 FCMR 5.09 23 28 54 NOBOX 5.06 0 0 55 CD7 5.04 7 24 56 RGS1 5.02 7 12 57 SPOCK2 5.01 16 24 58 SELPLG 4.99 13 26 59 LEF1 4.99 7 10 60 DIAPH2-AS1 4.98 — — 61 LINC00426 4.97 2 14 62 RAC2 4.95 7 38 63 TRBV11-2 4.95 — — 64 CST7 4.94 — — 65 CORO1A 4.92 14 39 66 IL2RB 4.92 15 52 67 SELL 4.90 26 113 68 ITK 4.89 18 59 69 PTPRC 4.86 14 91 70 ZAP70 4.84 — — 71 GATA3 4.83 12 44 72 XXYLT1-AS2 4.83 3 4 73 RHOH 4.82 1 2 74 LINC01281 4.81 — — 75 DOK2 4.79 20 88 76 TBC1D10C 4.79 11 36 77 CHRNA6 4.78 — — 78 SLAMF1 4.75 18 26 79 LINC00861 4.75 6 55 80 LIME1 4.74 58 137 81 TTC39C-AS1 4.73 19 15 82 CD70 4.71 9 14 83 TSHR 4.67 3 5 84 GNG8 4.64 16 22 85 CAMK4 4.64 0 0 86 NANOGNB 4.63 — — 87 ZC3H12D 4.63 3 3 88 TRAF3IP3 4.62 8 45 89 MAL 4.60 — — 90 S100A4 4.60 2 2 91 IL10RA 4.59 11 12 92 PI16 4.57 8 13 93 LINC00544 4.54 1 1 94 SUSD3 4.51 28 29 95 CD6 4.50 26 83 96 NCF4 4.49 7 38 97 SH2D2A 4.49 8 19 98 CD69 4.48 0 0 99 PYHIN1 4.47 14 29 100 ALOX5AP 4.47 1 0 101 S1PR4 4.46 13 44 102 TOX 4.44 1 2 103 IL7R 4.43 24 76 104 TNFRSF25 4.41 1 7 105 AQP3 4.41 1 1 106 FYB1 4.38 16 33 107 ZBTB32 4.36 0 0 108 CD4 4.36 17 28 109 HAPLN3 4.31 8 19 110 BCL11B 4.31 3 3 111 RASGRP1 4.31 3 7 112 PRDM1 4.30 2 2 113 PIM2 4.29 — — 114 P2RY10 4.27 — — 115 ISG20 4.27 7 21 116 FCRL3 4.24 26 32 117 ST8SIA6 4.24 4 27 118 ARHGDIB 4.22 3 8 119 MYO1G 4.22 19 74 120 F5 4.21 27 137 121 ETS1 4.21 60 88 122 CD37 4.19 8 15 123 HACD1 4.19 2 2 124 HCST 4.16 0 0 125 GPR183 4.11 11 28 126 CD53 4.11 9 18 127 RGL4 4.10 0 0 128 CEACAM21 4.10 5 5 129 ITGB7 4.10 3 7 130 LINC02273 4.09 2 2 131 TAGAP 4.08 41 93 132 IL12RB2 4.08 2 2 133 LAPTM5 4.08 16 38 134 BIN2 4.06 12 44 135 CYTIP 4.06 2 3 136 GPR15 4.06 1 1 137 BFSP2-AS1 4.05 0 0 138 SH2D1A 4.04 — — 139 WNT10A 4.04 13 85 140 ACAP1 4.04 107 149 141 PBXIP1 4.03 4 9 142 CD48 4.03 29 34 143 UBASH3A 4.03 17 49 144 ETV7 4.00 17 22 145 ARL4C 4.00 1 1 146 SAMSN1 3.99 11 22 147 CCDC141 3.99 15 143 148 HLA-DRB1 3.97 565 1,192 149 TNFRSF1B 3.97 10 16 150 LAYN 3.97 1 1 151 PRF1 3.97 6 16 152 SEMA3G 3.96 54 85 153 CXCR4 3.95 9 38 154 HLA-DRB5 3.95 364 756 155 NTSR1 3.94 2 2 156 KLF2 3.94 52 119 157 KLRB1 3.93 0 0 158 SYTL3 3.92 2 7 159 ACTG2 3.91 0 0 160 E2F2 3.87 8 74 161 SRGN 3.85 34 60 162 LFNG 3.84 5 9 163 LIMD2 3.84 7 34 164 SNX20 3.84 6 13 165 CARD16 3.83 2 2 166 HCLS1 3.82 18 46 167 LCP1 3.82 7 9 168 MIR3142HG 3.82 1 1 169 FBLN7 3.82 2 3 170 LCP2 3.82 2 6 171 LTA 3.81 226 418 172 ITGB2 3.81 45 135 173 SH3PXD2A-AS1 3.80 1 4 174 CD96 3.80 0 1 175 LSP1 3.79 41 132 176 PTTG1 3.79 0 0 177 GATA3-AS1 3.78 16 59 178 NCR3 3.78 261 542 179 EVL 3.77 10 22 180 RCAN3 3.77 6 8 181 TMEM238 3.76 1 1 182 PRKCQ 3.76 3 4 183 TRAT1 3.75 4 9 184 CRIP1 3.75 2 11 185 ARHGAP30 3.75 13 25 186 LINC01801 3.74 52 101 187 CCR7 3.73 28 100 188 LINC02416 3.71 1 5 189 PTPN7 3.71 5 9 190 GZMM 3.71 2 2 191 FAM215A 3.70 5 12 192 LAX1 3.68 6 14 193 SAMD3 3.68 2 1 194 LINC00423 3.67 0 0 195 GMFG 3.67 1 1 196 TMC8 3.67 25 96 197 MAP4K1 3.66 14 38 198 CLEC2D 3.65 0 0 199 PDCD1 3.65 0 0 200 DEF6 3.64 23 105 201 PKIA 3.63 1 0 202 BIRC3 3.62 1 1 203 LINC02520 3.61 2 4 204 CDKL4 3.60 0 0 205 MEI1 3.60 31 94 206 PVRIG 3.60 11 39 207 LINC01891 3.58 0 0 208 CYTOR 3.58 2 2 209 GPR25 3.58 2 3 210 ANO9 3.57 2 6 211 PTPN22 3.56 73 148 212 IKZF1 3.56 58 153 213 TBC1D4 3.56 6 12 214 FLT3LG 3.56 72 222 215 HLA-DQA1 3.55 608 1,232 216 HS3ST3B1 3.55 5 14 217 LY9 3.54 39 62 218 CEP55 3.54 0 0 219 SASH3 3.52 — — 220 PMAIP1 3.52 2 4 221 UCP2 3.52 1 1 222 HLA-DQB1 3.52 703 1,314 223 GIMAP7 3.51 47 93 224 RASAL3 3.51 5 10 225 ZBP1 3.51 12 68 226 NLRC3 3.51 5 16 227 SYTL1 3.50 13 29 228 TOX2 3.50 10 31 229 ZNF831 3.50 20 88 230 GPR174 3.50 — — 231 PBX4 3.50 51 106 232 RBM38 3.49 8 67 233 TNFRSF13B 3.46 3 2 234 BFSP2 3.46 0 1 235 TTC39C 3.46 22 28 236 GPR55 3.45 3 2 237 EVI2B 3.45 — — 238 PCED1B 3.45 2 6 239 DUSP2 3.44 — — 240 ADAM8 3.44 6 7 241 ZFAT-AS1 3.44 — — 242 CARMIL2 3.44 17 56 243 POU3F1 3.44 2 14 244 PIK3R5 3.44 13 40 245 FBXL16 3.43 0 0 246 IL21R 3.43 13 27 247 IL16 3.43 6 11 248 SLFN12L 3.43 50 75 249 ICAM3 3.43 28 48 250 C12orf75 3.42 0 0 251 IL12RB1 3.42 47 133 252 LINC01227 3.40 0 0 253 SH3BP1 3.39 15 37 254 EMB 3.39 — — 255 ARHGAP45 3.39 43 188 256 FMNL1 3.37 18 39 257 RUNX3 3.37 86 173 258 NFE2L3 3.37 1 1 259 SLAMF6 3.36 14 14 260 NINJ2 3.36 15 54 261 MYO1F 3.35 66 278 262 CCR5 3.35 17 40 263 GCNT4 3.34 1 3 264 GRAP2 3.34 6 11 265 CDHR3 3.34 0 0 266 KCNA3 3.34 2 2 267 SPN 3.34 4 17 268 GPR68 3.34 0 2 269 CD101 3.34 6 22 270 MIR4435-2HG 3.33 13 33 271 RAB33A 3.33 — — 272 ARHGAP15 3.33 21 66 273 TGFB1 3.33 29 68 274 LBH 3.32 9 20 275 OOEP-AS1 3.31 — — 276 SLA 3.30 6 26 277 GIMAP4 3.30 44 105 278 GTSCR1 3.29 0 0 279 ARHGAP9 3.28 20 49 280 CENPM 3.27 29 65 281 SLA2 3.27 9 19 282 CORO2A 3.27 7 9 283 OCIAD2 3.27 0 0 284 CD79B 3.27 5 11 285 RIPOR2 3.26 11 46 286 COTL1 3.26 17 66 287 RAB37 3.26 13 58 288 SP140 3.25 8 23 289 AIM2 3.25 13 30 290 DENND1C 3.25 9 12 291 GLCCI1 3.25 7 7 292 WAS 3.24 — — 293 CD80 3.23 2 4 294 HLA-DPA1 3.22 287 545 295 TRAF1 3.21 13 34 296 FXYD5 3.21 87 178 297 SGPP2 3.21 0 0 298 KCNN4 3.20 27 66 299 IPCEF1 3.20 1 1 300 CD84 3.20 16 23 301 LINC00243 3.19 192 416 302 LINC00649 3.19 10 41 303 PRKCH 3.19 3 4 304 TESPA1 3.18 6 11 305 JAML 3.18 15 57 306 JAK3 3.17 6 8 307 LINC00239 3.17 0 0 308 FAS 3.17 5 7 309 RCSD1 3.16 7 20 310 TMEM154 3.16 0 0 311 ADORA2A 3.16 17 26 312 MAPK13 3.16 10 16 313 CDC25B 3.16 10 38 314 BICDL1 3.15 1 1 315 CASP8 3.14 24 62 316 SMPD3 3.14 4 20 317 GBP2 3.13 0 0 318 IKZF2 3.12 9 27 319 MAF 3.12 0 0 320 SNAI3 3.12 23 73 321 IRF4 3.11 37 94 322 MFNG 3.11 6 19 323 PSTPIP1 3.10 6 6 324 NDC80 3.10 0 0 325 SLFN5 3.09 3 5 326 FAM117A 3.09 4 16 327 MEOX1 3.09 40 209 328 ENTPD1 3.09 12 32 329 EIF4E3 3.08 2 2 330 ACP5 3.07 6 8 331 PAGE5 3.07 — — 332 RASSF5 3.06 13 29 333 GALM 3.05 1 10 334 CDCA7 3.04 1 3 335 IL23R 3.04 2 2 336 LINC00891 3.03 — — 337 PSG11 3.03 — — 338 HOXB2 3.03 27 81 339 CDKN2A 3.03 3 4 340 IKBKE 3.03 14 34 341 RNPEPL1 3.03 5 11 342 IFITM1 3.02 45 142 343 ITM2A 3.02 — — 344 NCKAP1L 3.02 5 11 345 STAM 3.01 0 1 346 OR2A1 3.01 — — 347 SAMHD1 3.01 9 18 348 ICAM2 3.00 18 29 349 ZBED2 2.99 0 1 350 EMP3 2.99 0 0 351 NCK2 2.99 2 7 352 IKZF3 2.99 83 204 353 IL7 2.99 0 0 354 B2M 2.99 0 0 355 ATP2A3 2.98 3 3 356 FGD3 2.98 23 23 357 GPSM3 2.98 358 590 358 HLA-A 2.98 281 510 359 ATG9B 2.98 14 20 360 GZMA 2.96 8 27 361 FERMT3 2.96 17 63 362 RGCC 2.96 1 4 363 CCDC88C 2.95 8 36 364 TNF 2.95 75 194 365 AGAP2 2.95 11 40 366 MPZL3 2.95 16 59 367 PPP1R16B 2.94 4 3 368 C2CD4D 2.93 0 0 369 GNG2 2.93 1 1 370 TNFAIP3 2.93 19 50 371 LRRC56 2.92 0 0 372 CD74 2.92 13 14 373 ATP8B2 2.91 33 81 374 ITGAL 2.91 25 90 375 CXCL13 2.91 0 0 376 LRRC32 2.91 3 3 377 IL17REL 2.89 12 13 378 LPAR2 2.89 15 30 379 CHST7 2.89 — — 380 ANXA2R 2.89 1 0 381 TNIP3 2.89 1 1 382 PIK3IP1 2.88 11 41 383 PSMB8-AS1 2.88 204 380 384 PPP1R18 2.88 153 285 385 CHST11 2.86 0 0 386 CSK 2.86 22 76 387 IGFLR1 2.85 1 1 388 MSC 2.85 0 0 389 FAM110A 2.85 2 2 390 S100A5 2.85 0 0 391 RGPD2 2.84 0 0 392 GNA15 2.83 9 20 393 CPNE2 2.83 17 39 394 RGS10 2.83 8 23 395 ZNF80 2.83 0 0 396 ZFYVE28 2.82 1 0 397 ARMS2 2.82 — — 398 HLA-DPB1 2.82 293 562 399 RASGRP2 2.82 5 11 400 PTPRJ-AS1 2.82 — — 401 LINC02361 2.81 11 17 402 APOBEC3H 2.81 11 23 403 EDARADD 2.81 1 1 404 EZR 2.80 6 21 405 LPO 2.80 0 0 406 CASP1 2.79 2 3 407 DAPP1 2.79 35 104 408 ABCD2 2.79 1 1 409 CENPK 2.79 0 0 410 CD226 2.79 16 42 411 RAB11FIP5 2.79 0 1 412 IQGAP2 2.79 26 84 413 SMAP2 2.78 5 17 414 GIMAP1 2.78 30 57 415 GIMAP1-GIMAP5 2.78 30 57 416 LINC00355 2.78 0 0 417 EPSTI1 2.77 0 0 418 PSMB9 2.77 227 422 419 TAP1 2.77 201 382 420 CARD11 2.77 11 26 421 SYT4 2.77 0 0 422 CASK 2.77 — — 423 STK17B 2.77 5 39 424 ZC2HC1A 2.77 0 0 425 C16orf54 2.77 2 2 426 TSC22D3 2.77 — — 427 ITGB2-AS1 2.76 42 129 428 KIF21B 2.76 0 1 429 PCSK1N 2.76 — — 430 ADTRP 2.76 9 23 431 IL27RA 2.75 10 37 432 CYTH4 2.75 4 21 433 ARHGAP25 2.75 17 54 434 ITPRIPL1 2.75 — — 435 HLA-B 2.74 493 836 436 OLFM2 2.74 2 4 437 SAMSN1-AS1 2.74 1 0 438 GRK6 2.74 51 66 439 CD82 2.74 4 13 440 CTSC 2.73 11 29 441 TCF7 2.73 12 36 442 FOXP1-AS1 2.73 — — 443 AKNA 2.73 49 78 444 INPP4B 2.72 1 1 445 CORO1B 2.72 11 38 446 LINC01550 2.72 1 1 447 TMEM244 2.72 0 0 448 HLA-DQA2 2.72 173 495 449 PPP1R3F 2.71 — — 450 OR2A1-AS1 2.71 2 6 451 DUSP16 2.71 10 17 452 TNFAIP8L2 2.71 11 38 453 GDPD5 2.71 4 4 454 POU2F2 2.71 2 3 455 EPHB6 2.71 8 11 456 GPRIN3 2.70 5 10 457 ATP6V0E2 2.70 10 18 458 MCF2L2 2.69 3 9 459 IRF5 2.69 48 98 460 TRABD2A 2.68 1 1 461 HRH4 2.68 0 0 462 PARP15 2.67 6 21 463 CMTM7 2.67 2 2 464 HLA-E 2.67 193 384 465 RGS19 2.66 24 68 466 CMTM3 2.66 23 32 467 NEIL3 2.66 0 0 468 PAG1 2.66 2 3 469 TNFRSF10A 2.65 15 44 470 CD44 2.65 4 5 471 LRRC8C 2.65 2 6 472 CISH 2.65 23 66 473 TCAF2 2.65 6 10 474 UBALD2 2.64 3 4 475 HLA-C 2.64 738 1,070 476 TRIB2 2.64 3 4 477 LINC00332 2.64 0 0 478 TSPAN32 2.64 17 78 479 LINC02325 2.63 0 0 480 APOBEC3C 2.63 3 3 481 NETO2 2.63 1 1 482 ZNF101 2.63 2 8 483 TNFSF14 2.62 22 33 484 TMSB4X 2.62 — — 485 SH3BGRL3 2.62 18 62 486 GIMAP5 2.61 34 64 487 PRDM8 2.61 8 9 488 LOXL1-AS1 2.61 44 98 489 DGKA 2.60 0 0 490 FLI1 2.60 61 103 491 IKZF4 2.60 0 0 492 APOBEC3G 2.60 7 11 493 TNIK 2.60 61 202 494 CNN2 2.59 27 139 495 ORAI1 2.59 18 48 496 RPS6KA1 2.59 13 54 497 PLP2 2.59 — — 498 LINC00589 2.58 0 0 499 GZMK 2.58 8 21 500 SLC14A1 2.58 3 16 501 GRAPL 2.58 0 0 502 GIMAP6 2.58 42 95 503 TUBA4A 2.58 4 18 504 TSTD1 2.57 23 36 505 STAMBPL1 2.57 3 2 506 FAM107B 2.57 1 5 507 R3HDM4 2.57 28 78 508 GRAP 2.57 0 0 509 MFHAS1 2.57 51 225 510 JUNB 2.56 9 31 511 IL26 2.56 0 0 512 SLC35F3 2.56 0 0 513 DOCK2 2.56 1 1 514 PLCL1 2.55 0 0 515 OAS1 2.55 8 23 516 GPR171 2.55 0 0 517 CEP128 2.55 4 6 518 RASA3 2.55 9 52 519 SAMD10 2.54 16 34 520 LINC00885 2.54 8 49 521 FAAH2 2.54 — — 522 S1PR1 2.54 4 19 523 OASL 2.54 57 132 524 OAS2 2.54 8 25 525 EVI2A 2.53 — — 526 IL6R 2.53 65 111 527 EPB41 2.53 3 10 528 HLA-DRA 2.53 693 1,237 529 GPA33 2.52 4 4 530 C2CD4A 2.52 13 24 531 CCM2 2.52 18 75 532 CCL20 2.52 4 4 533 METTL27 2.51 35 78 534 TRIM59 2.51 0 0 535 OR5B12 2.51 — — 536 CBX4 2.51 3 3 537 GLIPR1 2.51 0 1 538 LY75 2.51 11 46 539 LY75-CD302 2.51 11 46 540 PLSCR3 2.50 8 11 541 LEPROTL1 2.50 0 3 542 STK10 2.50 21 35 543 APOBEC3D 2.49 3 3 544 SLC38A1 2.49 0 1 545 RORA 2.49 17 20 546 MIAT 2.49 1 1 547 LINC02090 2.49 14 30 548 TMC6 2.49 18 74 549 PIK3CD 2.49 5 45 550 RNF166 2.48 28 105 551 GLRX 2.48 5 11 552 ZNRF1 2.48 0 0 553 FAM78A 2.47 0 0 554 F8A3 2.47 — — 555 CCDC167 2.47 0 0 556 TMSB10 2.47 1 1 557 DUSP10 2.47 0 0 558 TRIM14 2.47 5 8 559 PTPN6 2.46 0 0 560 CALHM2 2.46 7 15 561 CRIP2 2.45 0 0 562 ASB2 2.45 151 215 563 INPP5D 2.45 15 58 564 ELK3 2.45 1 2 565 ACTA2 2.45 5 5 566 SEL1L3 2.45 8 10 567 ST8SIA4 2.45 1 1 568 SLC35F2 2.45 0 0 569 KCNAB2 2.45 7 165 570 PARVG 2.45 2 1 571 PKIA-AS1 2.45 0 0 572 LINC00161 2.44 0 0 573 PVT1 2.44 1 1 574 GPR132 2.43 2 2 575 THEM4 2.43 0 0 576 PSMB8 2.43 200 385 577 ARMC2-AS1 2.43 1 7 578 CD40LG 2.43 — — 579 GPR65 2.43 12 17 580 RNF125 2.43 5 4 581 SIX3 2.42 0 0 582 GBP4 2.42 2 2 583 CORO7 2.42 20 57 584 BTN3A2 2.42 124 241 585 TSPAN5 2.41 98 239 586 INSL3 2.41 4 6 587 ARPC1B 2.41 27 109 588 LGALS1 2.40 22 66 589 RHOG 2.40 9 22 590 ANKS1B 2.40 3 6 591 DOCK8 2.40 18 82 592 SLC16A10 2.40 0 2 593 GMIP 2.40 30 114 594 NUTM2B 2.40 — — 595 MAP3K1 2.39 8 14 596 CROCC2 2.39 4 6 597 JUND 2.39 32 94 598 SGTB 2.39 0 0 599 CSF2RB 2.39 17 45 600 HLA-F 2.39 205 352 601 CYFIP2 2.38 22 66 602 VAV1 2.37 11 25 603 RGS14 2.37 108 243 604 STAT4 2.37 2 3 605 SAMD9 2.37 0 0 606 MICB 2.37 294 633 607 PLCB2 2.37 4 13 608 NLRP1 2.37 3 4 609 APOLD1 2.36 1 5 610 DENND2D 2.36 4 12 611 PRR5 2.36 2 1 612 LINC00539 2.36 0 0 613 JRKL-AS1 2.36 0 0 614 S100A10 2.36 5 10 615 PFN1 2.36 6 35 616 BCL2 2.36 0 0 617 RUNX2 2.35 3 12 618 HECA 2.35 4 6 619 ITGA4 2.35 22 102 620 ROPN1L 2.35 0 0 621 MORN3 2.35 14 37 622 CYBA 2.35 28 69 623 TAP2 2.34 198 364 624 FAM89B 2.34 3 6 625 IL18R1 2.34 52 145 626 LINC00221 2.34 0 0 627 ZNRF2 2.34 2 5 628 PPM1M 2.33 86 217 629 TNFSF12-TNFSF13 2.32 32 67 630 LETM2 2.32 0 0 631 MAD1L1 2.32 16 35 632 MXD4 2.32 1 0 633 TBCC 2.32 6 26 634 SPATA13-AS1 2.31 2 4 635 TNFSF12 2.31 31 66 636 ZDHHC18 2.31 80 389 637 ZNF365 2.31 19 27 638 PGM2L1 2.30 3 6 639 ARID5B 2.29 29 74 640 LGALS3 2.29 7 33 641 KLHL34 2.29 — — 642 GLIPR2 2.29 2 2 643 NUSAP1 2.28 1 3 644 UMODL1 2.28 2 1 645 FOXO1 2.28 6 39 646 FAM124B 2.27 5 9 647 DMTN 2.27 20 53 648 TBX21 2.27 13 31 649 SH2D3A 2.27 16 37 650 PLEKHF1 2.27 0 0 651 PHF19 2.26 11 32 652 TMEM250 2.26 1 1 653 RHEBL1 2.25 12 24 654 LINC02391 2.25 4 18 655 CCND2 2.24 11 45 656 C20orf204 2.24 20 56 657 ISG15 2.24 7 10 658 KLHL6 2.23 2 8 659 NLRC5 2.22 54 163 660 GOLGA7B 2.22 2 1 661 BTN3A1 2.22 35 65 662 GBP1 2.22 1 2 663 HNRNPLL 2.22 1 10 664 LAMP3 2.22 2 3 665 TNFAIP8 2.22 21 107 666 HELB 2.22 3 6 667 DNLZ 2.21 58 218 668 LAG3 2.21 12 24 669 MAP3K5 2.21 3 6 670 FYN 2.21 3 7 671 KIAA2013 2.21 12 38 672 STK4 2.20 35 58 673 VAMP8 2.20 38 110 674 KRTAP16-1 2.20 0 0 675 OTUD1 2.20 1 1 676 ANXA6 2.20 13 39 677 AGMAT 2.20 3 6 678 OPTN 2.19 1 1 679 HACD4 2.19 1 0 680 LY6G5C 2.19 38 57 681 TRIM22 2.19 13 23 682 IER5 2.19 5 20 683 TLX2 2.19 0 0 684 SH3KBP1 2.19 — — 685 SOCS1 2.19 7 11 686 UNC13D 2.19 70 166 687 ANTXR2 2.19 8 13 688 RASSF3 2.18 9 29 689 TRAF5 2.18 0 0 690 LINC00299 2.18 6 15 691 PASK 2.18 3 8 692 LINC02265 2.18 9 12 693 LINC01678 2.18 2 2 694 MCUB 2.18 0 0 695 AGFG2 2.18 21 63 696 SLC2A3 2.18 6 6 697 TMEM169 2.18 0 0 698 PDE3B 2.17 9 39 699 PHLDA1 2.17 0 1 700 IL23A 2.17 0 1 701 ADCY3 2.17 25 66 702 CD58 2.17 3 4 703 DBP 2.17 3 4 704 CDKN2D 2.17 4 30 705 BTG1 2.17 4 19 706 BTN3A3 2.17 35 71 707 RFTN1 2.16 4 4 708 LINC00324 2.16 11 25 709 LINC02046 2.16 0 0 710 RNF44 2.16 1 1 711 SHMT2 2.16 35 201 712 GJB6 2.16 0 0 713 WIPF1 2.16 1 5 714 RASA4B 2.15 25 62 715 PPP2R2B 2.15 0 0 716 ARHGEF18 2.15 8 13 717 MBD2 2.14 1 0 718 ARHGEF6 2.14 — — 719 IL1R2 2.14 24 43 720 PREX1 2.14 9 40 721 VIM 2.14 32 102 722 PTGIR 2.13 17 25 723 DNPH1 2.13 6 35 724 THAP11 2.13 0 0 725 CDKN1B 2.13 4 21 726 CSF1 2.12 5 9 727 CCDC69 2.12 18 43 728 MAP4K2 2.12 5 8 729 C3AR1 2.12 4 4 730 ABHD17A 2.12 10 24 731 RAB19 2.11 0 0 732 RPS29 2.11 1 1 733 CCDC65 2.11 2 3 734 TMEM156 2.11 8 15 735 CREG2 2.10 1 1 736 PDE4B 2.10 5 3 737 GTSF1 2.10 3 8 738 TET2-AS1 2.10 29 52 739 NSMCE3 2.10 1 0 740 SLC2A4RG 2.10 47 130 741 LINC00402 2.10 5 10 742 GYPC 2.10 3 4 743 ABRACL 2.10 5 13 744 CHIA 2.10 4 12 745 CCNG2 2.09 1 1 746 PTPRJ 2.09 — — 747 INE2 2.09 — — 748 LMNB1 2.09 2 5 749 PPP1CA 2.09 6 27 750 HOXB4 2.08 18 52 751 PPP6R1 2.08 2 5 752 SCML4 2.08 3 19 753 RELL2 2.08 5 7 754 PSD4 2.08 45 133 755 DCK 2.08 0 1 756 P2RX5-TAX1BP3 2.08 2 2 757 TXK 2.08 13 24 758 GCHFR 2.08 9 9 759 LDHB 2.07 18 32 760 NBEAL2 2.07 74 146 761 RPL39L 2.07 2 2 762 LINC00519 2.07 0 0 763 DGUOK-AS1 2.07 0 0 764 DOCK10 2.07 6 33 765 ARHGEF1 2.07 4 10 766 MAPKAPK2 2.07 19 20 767 GRK2 2.06 1 7 768 GNAI2 2.06 15 53 769 LINC02320 2.06 1 1 770 JMY 2.06 27 80 771 MKNK2 2.06 2 5 772 SLC38A5 2.06 — — 773 CCDC144NL-AS1 2.05 1 1 774 SLC7A5 2.05 17 47 775 ANKRD44 2.05 10 64 776 FLNA 2.05 — — 777 LINC01934 2.05 11 42 778 UPP2 2.05 0 0 779 SYNE2 2.04 7 21 780 MAT2B 2.04 0 0 781 STAT5A 2.04 25 56 782 HABP4 2.04 13 14 783 STX11 2.04 1 2 784 MZT2A 2.04 0 0 785 HPCAL4 2.04 7 28 786 MYB 2.03 0 0 787 DPEP2 2.03 25 58 788 MDS2 2.03 0 0 789 LGALS9 2.03 — — 790 TRAF3 2.02 13 26 791 CABP5 2.02 0 0 792 HLA-DMA 2.02 226 330 793 KIAA0040 2.02 7 24 794 TNFSF8 2.02 41 70 795 TAGLN2 2.02 13 26 796 JARID2-AS1 2.02 5 25 797 CNTNAP1 2.02 8 21 798 HERC5 2.01 6 16 799 PIM1 2.01 34 81 800 ATP8B3 2.01 6 8 801 GIMAP2 2.01 37 96 802 RINL 2.01 12 21 803 SLC16A6 2.01 4 10 804 CHRM3-AS2 2.01 2 1 805 XKRX 2.01 — — 806 TNFRSF14 2.00 20 50 807 VSIR 2.00 47 94 808 PACS1 2.00 14 42 809 STXBP2 1.99 9 10 810 TMEM63A 1.99 3 4 811 UBASH3B 1.99 11 47 812 RAB11FIP1 1.99 1 1 813 ST8SIA1 1.99 3 4 814 NAALADL1 1.99 0 0 815 TFPT 1.99 9 13 816 PHTF2 1.98 6 27 817 P2RX5 1.98 2 2 818 CENPB 1.98 10 31 819 SIDT1 1.98 2 2 820 HOXB-AS1 1.98 33 90 821 ALG1L2 1.97 0 0 822 MICAL1 1.97 23 131 823 SYT11 1.97 0 0 824 SLC35D2 1.96 12 13 825 RIPK3 1.96 13 23 826 YPEL3 1.95 29 111 827 QPRT 1.95 5 18 828 ZC3HAV1 1.95 8 52 829 ERAP2 1.95 31 57 830 BTBD6 1.95 0 0 831 PITPNM1 1.95 4 14 832 EFHD2 1.94 6 5 833 BAK1 1.94 19 57 834 RHOF 1.94 39 108 835 HPSE 1.94 0 0 836 PRKD2 1.94 18 24 837 FAM83G 1.94 0 0 838 USP20 1.94 6 10 839 ADPRH 1.93 2 6 840 LPAR6 1.93 0 0 841 RNASET2 1.92 29 62 842 ADCY7 1.92 5 10 843 HTATIP2 1.92 0 0 844 THEM5 1.92 0 0 845 LYL1 1.92 18 63 846 RPS27 1.92 11 53 847 TRERF1 1.92 13 56 848 CCNI2 1.92 1 1 849 CERK 1.92 1 0 850 ZDBF2 1.91 1 0 851 CKLF-CMTM1 1.91 14 14 852 STX1A 1.91 202 1,091 853 CALM3 1.91 6 12 854 LMNA 1.91 18 37 855 TJP3 1.90 1 2 856 STN1 1.90 1 9 857 LINC00954 1.90 14 23 858 ZNF331 1.89 1 1 859 UXS1 1.89 0 0 860 CKLF 1.89 7 8 861 SNED1 1.89 3 5 862 TSPAN17 1.89 1 1 863 ZG16B 1.89 3 3 864 TMEM102 1.89 16 26 865 ZNF792 1.89 68 122 866 ACSL5 1.89 52 149 867 LDLRAP1 1.89 6 7 868 DGKZ 1.89 61 373 869 RASSF7 1.89 10 24 870 PTGER2 1.89 1 1 871 RPL28 1.88 3 3 872 KNL1 1.88 7 7 873 FAM184A 1.88 8 11 874 VAMP5 1.88 32 95 875 CARD8-AS1 1.88 8 9 876 HELLS 1.88 4 6 877 NCAPG 1.88 1 1 878 NELFB 1.88 3 5 879 CYLD 1.88 5 10 880 ANXA2 1.87 8 11 881 DNAI2 1.87 13 34 882 RFFL 1.87 1 0 883 CKAP2 1.87 1 4 884 PFKP 1.87 1 1 885 CCL28 1.86 2 3 886 GRPEL2 1.86 0 0 887 PLEKHN1 1.86 2 4 888 SAMD9L 1.86 1 1 889 LY6E 1.86 0 0 890 RTP4 1.86 4 7 891 LPXN 1.86 7 17 892 SLC25A42 1.86 28 89 893 HTR2B 1.85 9 13 894 SGPP1 1.85 0 0 895 GCH1 1.85 8 47 896 VAV3 1.85 7 11 897 PAFAH1B3 1.85 0 0 898 MKI67 1.85 0 0 899 SLC9A9 1.85 5 17 900 CRACR2A 1.85 2 5 901 ARF6 1.85 0 0 902 MX1 1.85 11 14 903 NAP1L2 1.85 — — 904 ZBTB7B 1.85 17 28 905 CUL9 1.84 5 8 906 HEXIM1 1.84 14 31 907 RILPL2 1.84 24 92 908 CCDC116 1.84 0 0 909 MAP3K14-AS1 1.84 18 35 910 JPT1 1.84 10 22 911 KANSL1-AS1 1.84 57 211 912 DCP1B 1.83 6 13 913 RAP1A 1.83 2 11 914 LPCAT4 1.83 0 1 915 TTC22 1.83 9 32 916 SEMA4D 1.83 4 15 917 ZYX 1.83 6 10 918 ARHGAP11A 1.83 0 0 919 HSH2D 1.83 4 12 920 MYD88 1.83 2 1 921 MIR181A1HG 1.83 13 57 922 SESN3 1.82 0 0 923 TRIM32 1.82 8 26 924 ATP1A3 1.82 1 2 925 CFL1 1.82 24 101 926 FCHO1 1.81 18 35 927 GGT1 1.81 14 23 928 AKTIP 1.81 9 18 929 SLC25A38 1.81 4 5 930 GSTK1 1.81 6 11 931 FBXO45 1.81 1 1 932 NMT2 1.81 0 0 933 S1PR2 1.81 16 50 934 SHKBP1 1.81 38 102 935 ELF4 1.81 — — 936 RAB29 1.80 9 14 937 CHD3 1.80 21 35 938 KCTD17 1.80 16 62 939 CDC42SE2 1.80 9 9 940 NRROS 1.80 9 29 941 PTGER4 1.80 7 24 942 ITGB1 1.80 2 3 943 LRRC61 1.80 21 31 944 ACOT4 1.79 0 2 945 SMN1 1.79 0 0 946 TSHZ2 1.79 6 14 947 SUN2 1.79 17 55 948 PIP4K2A 1.79 1 0 949 ANXA11 1.79 24 45 950 NABP1 1.79 2 2 951 NAAA 1.79 5 6 952 PCYOX1L 1.78 0 0 953 FAM53B 1.78 5 21 954 UBE2S 1.78 1 1 955 GIPC1 1.78 9 45 956 EHD1 1.78 8 21 957 RAB39B 1.78 — — 958 HPRT1 1.78 — — 959 PROK2 1.78 1 1 960 PLCG1 1.77 21 43 961 CDC14A 1.77 2 7 962 TRIM62 1.77 5 8 963 LRP10 1.77 22 46 964 PARP8 1.77 — — 965 CD200R1 1.77 11 28 966 RPL41 1.77 2 2 967 MCM5 1.77 3 9 968 CCDC71L 1.77 1 13 969 VIM-AS1 1.77 32 101 970 SOCS3 1.77 33 147 971 S100A6 1.77 3 4 972 TNFAIP8L1 1.77 7 22 973 ITPR3 1.77 9 32 974 ACTB 1.77 14 51 975 DYRK2 1.76 0 0 976 GPR146 1.76 19 73 977 RHNO1 1.76 2 20 978 ZBTB7A 1.76 23 74 979 TTC9 1.76 1 1 980 FAM50B 1.76 2 12 981 PCSK7 1.76 13 41 982 CTSS 1.76 129 340 983 ATXN7L1 1.76 0 0 984 PARD6A 1.76 17 56 985 WDR76 1.76 4 5 986 APOL6 1.76 5 13 987 FLOT2 1.76 — — 988 ITPKB 1.75 4 9 989 TRG-AS1 1.75 3 4 990 NHLRC4 1.75 7 15 991 MT1F 1.75 0 2 992 DOK1 1.75 3 11 993 GIT1 1.75 — — 994 LINC00957 1.75 5 11 995 CHN1 1.74 1 5 996 ARL6IP5 1.74 0 0 997 DLGAP1-AS1 1.74 0 3 998 PATL2 1.74 1 1 999 ATP2B1-AS1 1.74 10 25 1000 FOXD2-AS1 1.74 — —