Evidence reports Cell populations ASPC.proliferative DE genes Static evidence for AI interpretation. These reports provide data for prompting AI and are not intended as a human-facing reading interface. Please visit the Cell Browser , Trait Browser and Genome Browser for interactive browsing. Have fun exploring SCREATE!Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.
ASPC.proliferative: DE genes
How association tiers are defined — cell–trait and gene–trait SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.
Cell–trait tiers Cell–trait links Identify cell types whose regulatory activity is associated with a trait’s genetic signal. Required for Specific or Relevant The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05. Specific (Tier 1) Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background. Relevant (Tier 2) Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types. Interpretation and report values CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance. Meta traits and individual traits Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier. Gene–trait priorities (variant–tCRE–gene evidence) Variant–tCRE–gene links Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model. Required genetic support The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2. Required cellular support The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority. High priority Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes. Medium priority Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score. Same-record evidence and aggregation Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule. Limits of interpretation A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields. Meta traits · Individual traits · Gene expression · DE genes DE log fold change is a different metric from mean expression and IC score. This is the complete available browser export, limited upstream to the top 1,000 genes per population; it is not an exhaustive genome-wide differential-expression result.
All 1,000 available exported DE genes
Browsers # Gene DE log fold change Meta traits (High Priority) Individual traits (High Priority)
1 LUM 10.56 5 20 2 CFD 10.05 32 76 3 DCN 9.66 5 30 4 DPT 9.41 0 1 5 IGFBP6 9.38 2 2 6 MGP 9.25 3 8 7 MFAP5 9.07 — — 8 THY1 9.02 8 20 9 APOD 8.80 0 0 10 PENK 8.48 3 13 11 SRPX 8.47 — — 12 PLAC9 8.44 19 33 13 CD248 8.37 2 3 14 MFAP4 8.35 1 6 15 CXCL14 8.35 0 0 16 COL3A1 8.26 3 5 17 SFRP4 8.18 12 39 18 ISLR 8.10 28 62 19 COL1A1 8.10 9 15 20 COL6A3 8.06 20 54 21 COL1A2 7.93 19 39 22 CXCL12 7.89 1 1 23 CLEC3B 7.83 5 5 24 LINC01048 7.82 0 0 25 EFEMP1 7.78 35 109 26 CCDC80 7.76 7 12 27 AADAC 7.73 1 4 28 SERPINF1 7.69 91 185 29 CAV1 7.63 15 135 30 SOD3 7.57 3 3 31 GPC3 7.57 — — 32 PLA2G2A 7.53 3 13 33 SPARC 7.45 1 2 34 TNFAIP6 7.44 2 12 35 IGFBP4 7.38 28 80 36 TIMP3 7.34 3 3 37 CTHRC1 7.34 0 0 38 POSTN 7.28 0 0 39 BGN 7.27 — — 40 C1R 7.24 2 4 41 ITIH5 7.23 4 4 42 LINC01050 7.19 0 0 43 PRG4 7.13 5 7 44 ECM1 7.13 60 158 45 WNT2 7.09 10 55 46 LINC01140 7.08 1 4 47 S100A16 7.05 5 8 48 FABP4 6.99 3 1 49 PCOLCE 6.96 19 63 50 CCL2 6.94 3 12 51 GSN 6.93 10 25 52 PDGFRL 6.86 28 59 53 C1S 6.85 1 3 54 PTGES 6.85 5 10 55 CRABP2 6.84 3 4 56 MXRA8 6.83 7 40 57 CAVIN3 6.82 0 0 58 APOE 6.79 351 1,543 59 MEDAG 6.78 0 0 60 SFRP2 6.77 1 4 61 IGFBP3 6.74 17 93 62 COL6A1 6.73 35 85 63 PRRX1 6.68 9 22 64 FGF7 6.67 5 15 65 OLFML3 6.64 72 147 66 TMEM119 6.62 11 22 67 COL6A2 6.61 34 82 68 MRGPRF 6.58 34 97 69 ANGPTL4 6.56 66 465 70 PRSS23 6.54 6 15 71 RBP5 6.53 0 0 72 CCL19 6.48 0 0 73 HSPB6 6.47 1 10 74 CTSK 6.43 91 236 75 CLU 6.43 11 28 76 ABI3BP 6.40 6 6 77 LINC01914 6.29 7 54 78 TWIST2 6.24 4 6 79 HTRA3 6.23 4 12 80 S100A3 6.22 0 0 81 NOVA1 6.22 0 0 82 FBLN1 6.21 4 8 83 MMP2 6.17 4 6 84 LINC01312 6.16 1 4 85 LINC02126 6.16 0 0 86 COL14A1 6.15 12 22 87 FBLN5 6.11 17 45 88 NNMT 6.09 19 24 89 ROR1-AS1 6.07 1 3 90 KDELR3 6.06 7 15 91 TNC 6.04 40 75 92 DCLK1 6.02 0 0 93 MYL9 6.01 7 17 94 CHRDL1 6.00 — — 95 TAGLN 6.00 25 92 96 TPPP3 5.95 25 66 97 AKR1C1 5.94 23 57 98 CILP 5.92 0 0 99 TIMP1 5.92 — — 100 MFAP2 5.91 25 65 101 RCN3 5.91 60 188 102 ADH1B 5.90 99 251 103 SPON2 5.90 23 69 104 IGFBP7 5.90 21 47 105 GGT5 5.89 4 5 106 FAP 5.86 0 0 107 PCOLCE2 5.86 7 20 108 LRRN4CL 5.85 0 0 109 C3 5.84 23 35 110 LOXL1 5.84 52 110 111 MGST1 5.83 2 1 112 NTRK2 5.82 7 9 113 CST3 5.80 — — 114 XG 5.80 — — 115 SERPING1 5.80 26 78 116 APOC1 5.76 301 1,434 117 CAVIN1 5.74 38 80 118 PODN 5.71 4 27 119 LGALS1 5.69 22 66 120 FBLN2 5.68 6 13 121 PPIC 5.68 5 11 122 ASPN 5.66 23 53 123 AKR1C2 5.66 12 28 124 PDGFRA 5.62 9 40 125 TPM2 5.61 29 79 126 LINC01133 5.61 6 11 127 SDC2 5.59 1 3 128 OLFML1 5.59 1 6 129 HTRA1 5.58 21 46 130 HSD3B7 5.57 46 104 131 PLTP 5.57 18 36 132 RAMP2 5.56 8 18 133 SERPINE1 5.56 25 41 134 RARRES2 5.52 22 42 135 COL5A2 5.52 17 35 136 EGFLAM 5.51 0 0 137 S100A13 5.50 8 14 138 ADIRF 5.49 5 6 139 LAMA4 5.49 10 12 140 LINC01179 5.49 0 0 141 TWIST1 5.45 1 1 142 FN1 5.45 29 100 143 F10 5.44 25 56 144 SERPINH1 5.40 22 57 145 GPNMB 5.38 2 6 146 SRPX2 5.38 — — 147 HSD11B1 5.38 16 46 148 TNNT3 5.37 24 72 149 OSR1 5.36 1 5 150 REM1 5.35 — — 151 LINC00519 5.35 0 0 152 CD34 5.34 24 109 153 TGFB1I1 5.33 6 16 154 GSTM5 5.32 4 7 155 KAZALD1 5.31 5 7 156 TMEM254 5.29 16 29 157 CPXM1 5.29 3 19 158 GPX8 5.27 8 21 159 ALDH1A3 5.27 1 4 160 LGALS3 5.26 7 33 161 IFI27 5.25 332 479 162 C11orf96 5.25 3 18 163 PDLIM4 5.25 171 263 164 FXYD1 5.24 76 148 165 PDGFRB 5.24 11 25 166 SLIT3 5.22 6 23 167 VIM 5.21 32 102 168 VCAN 5.21 11 255 169 GML 5.21 0 2 170 MT1M 5.21 29 70 171 MYOC 5.21 6 19 172 MEST 5.19 3 5 173 PRRX2 5.17 4 7 174 LOX 5.17 5 18 175 C1QTNF5 5.16 8 19 176 VASN 5.16 28 75 177 OMD 5.15 22 51 178 FKBP10 5.15 15 19 179 SCARA5 5.15 17 28 180 CXCL9 5.14 6 5 181 LINC01116 5.14 6 23 182 DLX3 5.14 5 13 183 PMP22 5.13 4 13 184 AEBP1 5.13 4 12 185 ANGPTL2 5.12 6 16 186 CERCAM 5.09 0 0 187 PTGER3 5.09 0 0 188 S100A10 5.08 5 10 189 IGF2 5.07 43 132 190 LINC02458 5.07 12 19 191 CFH 5.07 68 103 192 COL12A1 5.05 1 1 193 CLEC11A 5.04 0 0 194 PDPN 5.03 1 9 195 FGF10-AS1 5.02 — — 196 CALD1 5.02 21 57 197 CYGB 5.01 7 7 198 LINC02424 5.01 — — 199 CPZ 5.01 11 38 200 LINC01060 5.00 1 1 201 HOXC10 4.99 0 0 202 HAS2 4.99 5 13 203 LINC01615 4.98 1 6 204 IGFBP5 4.97 6 11 205 FSTL1 4.97 1 1 206 S100A6 4.96 3 4 207 PI16 4.95 8 13 208 LHFPL6 4.94 1 3 209 MMP19 4.94 0 0 210 GAP43 4.94 0 0 211 ELN 4.93 15 47 212 C1QTNF2 4.92 0 0 213 SCARA3 4.92 16 40 214 ITGBL1 4.89 1 0 215 GDF10 4.89 0 0 216 EMP1 4.88 5 13 217 PRELP 4.88 6 11 218 HSPB2-C11orf52 4.87 11 30 219 HSPB2 4.87 11 30 220 GEM 4.86 7 10 221 LINC01436 4.86 0 1 222 GNG11 4.86 3 3 223 CITED1 4.85 — — 224 ANXA2 4.84 8 11 225 GPD1 4.84 1 0 226 CHI3L1 4.83 9 14 227 STEAP1 4.83 7 30 228 ASS1 4.82 1 2 229 NDN 4.82 — — 230 SELENOM 4.81 15 53 231 TUBB6 4.81 3 4 232 COX7A1 4.81 2 5 233 COL4A1 4.80 38 107 234 LINC01614 4.79 14 48 235 S100A4 4.78 2 2 236 RARRES1 4.78 2 7 237 LINC01886 4.77 0 0 238 EFEMP2 4.77 50 111 239 HAS1 4.77 37 49 240 VIT 4.76 2 2 241 SSPN 4.75 10 13 242 XPNPEP2 4.75 — — 243 ALPL 4.73 11 20 244 FGF16 4.73 — — 245 MOXD1 4.72 7 21 246 HRCT1 4.72 18 74 247 GPX3 4.71 9 17 248 LOXL2 4.71 13 42 249 IL11RA 4.71 0 0 250 RGS16 4.70 5 5 251 EMX2OS 4.69 4 10 252 NUPR1 4.68 22 50 253 COMP 4.68 6 12 254 HOXC9 4.68 6 8 255 PLAU 4.68 21 55 256 AKR1C3 4.67 59 224 257 FAM180B 4.67 — — 258 COL5A3 4.67 4 8 259 MAP1A 4.65 1 2 260 PPL 4.65 2 3 261 CIDEC 4.63 0 0 262 GFPT2 4.63 3 4 263 FMOD 4.63 9 18 264 LINC02202 4.61 10 13 265 RERG 4.60 5 14 266 MXRA5 4.60 — — 267 VCAM1 4.60 0 0 268 ANGPTL1 4.59 6 26 269 ADAMTS2 4.59 9 25 270 MAP1B 4.59 0 0 271 FNDC4 4.59 488 1,610 272 LINC02381 4.57 10 19 273 FAM151A 4.57 0 11 274 SGCE 4.56 2 4 275 FST 4.55 15 35 276 HAS2-AS1 4.55 5 13 277 RASL12 4.54 1 1 278 EMILIN1 4.54 14 23 279 LINC01426 4.51 7 17 280 LINC00857 4.50 16 29 281 BEND6 4.50 — — 282 LINC01915 4.50 1 1 283 KCNA1 4.49 0 0 284 KLF14 4.48 0 0 285 GP1BA 4.48 0 2 286 LMNA 4.46 18 37 287 CD9 4.46 2 6 288 SPARCL1 4.46 74 301 289 LMOD1 4.45 34 89 290 ACVRL1 4.45 18 37 291 TFPI 4.44 54 106 292 BDKRB1 4.44 0 0 293 MAP1LC3C 4.43 0 0 294 LPAR1 4.42 2 5 295 ANXA1 4.42 2 2 296 EHD2 4.42 3 8 297 IL33 4.40 1 2 298 GAL 4.39 6 12 299 RNASE4 4.37 5 7 300 ANG 4.37 5 7 301 TNXB 4.36 153 526 302 TRIM47 4.36 58 138 303 AHNAK2 4.35 2 1 304 FGFBP2 4.35 2 2 305 LARP6 4.33 3 2 306 IGF1 4.33 36 77 307 EMP2 4.32 14 22 308 AADACL2-AS1 4.32 1 5 309 FAM114A1 4.31 5 13 310 OGN 4.31 8 17 311 CLMP 4.30 3 5 312 LGALS3BP 4.29 5 5 313 SMOC2 4.29 3 11 314 SERPINE2 4.28 6 14 315 HOXD-AS2 4.25 12 47 316 TUBB3 4.24 13 31 317 TMEM176A 4.24 50 102 318 SVEP1 4.23 1 1 319 PROCR 4.23 39 86 320 A4GALT 4.23 8 37 321 EMX2 4.22 4 10 322 ALX4 4.22 0 1 323 ADAMTS5 4.21 12 23 324 NRN1 4.21 5 4 325 F3 4.21 0 0 326 BMPER 4.20 0 0 327 ECM2 4.20 27 58 328 TNFRSF12A 4.20 1 1 329 TSHZ2 4.19 6 14 330 CRIP1 4.19 2 11 331 SERPINA5 4.18 359 512 332 GPC1 4.18 5 8 333 PCSK1 4.16 0 1 334 GSC 4.15 336 487 335 OAF 4.15 9 18 336 C1QTNF7 4.15 3 9 337 FHL1 4.15 — — 338 TMEM98 4.13 2 2 339 FGF10 4.12 — — 340 CYP7B1 4.11 0 0 341 ADAMTS12 4.11 1 1 342 CYP19A1 4.11 1 0 343 SPOCD1 4.11 4 5 344 HOXC8 4.10 5 6 345 COL4A2 4.09 31 70 346 GPRC5A 4.09 3 6 347 DPYSL3 4.09 1 1 348 LINC00398 4.09 1 0 349 PCDH18 4.07 0 5 350 TMEM176B 4.07 39 71 351 C16orf89 4.07 0 0 352 CRYAB 4.06 20 64 353 CNRIP1 4.05 26 38 354 SNAI2 4.05 0 0 355 IFITM3 4.05 28 58 356 LGI2 4.05 12 28 357 EBF1 4.04 13 22 358 SRY 4.03 — — 359 MT1A 4.02 27 116 360 RASD1 4.02 20 56 361 NPB 4.01 0 0 362 HOXA10 4.01 9 12 363 ARC 4.00 5 4 364 LINC01605 4.00 0 0 365 CRNDE 4.00 0 0 366 ADAMTS16 3.99 0 0 367 MEG3 3.99 13 43 368 CTBP1-AS 3.99 12 46 369 RAB7B 3.99 3 5 370 CPE 3.99 1 1 371 TP53TG3 3.98 — — 372 LRRC17 3.98 1 1 373 PTGIS 3.97 2 4 374 VGLL3 3.97 5 8 375 CD36 3.97 101 134 376 CBR3 3.96 1 5 377 ADAM12 3.96 2 2 378 PYCR1 3.96 2 1 379 DAB2 3.96 39 81 380 RAB34 3.96 — — 381 CADM3 3.94 2 15 382 BIRC5 3.94 15 62 383 FAIM2 3.94 5 10 384 RAB13 3.93 8 20 385 TRIML2 3.92 0 1 386 FILIP1L 3.92 16 37 387 TBPL2 3.92 0 0 388 EXOC1L 3.91 0 0 389 KLK15 3.91 0 0 390 EPHX1 3.91 4 4 391 SPOCK1 3.91 0 0 392 FBN1 3.91 21 79 393 PLPP3 3.90 50 135 394 SSC5D 3.89 16 44 395 CDO1 3.89 5 17 396 SNCG 3.88 0 0 397 LINC02454 3.88 14 44 398 ANK2 3.88 0 0 399 TMEM233 3.88 0 0 400 CRIP2 3.88 0 0 401 OLFML2B 3.86 9 18 402 SNX21 3.86 10 26 403 EBF2 3.85 2 2 404 DBN1 3.85 18 31 405 CXCL10 3.85 8 10 406 SPHK1 3.85 1 6 407 GLT8D2 3.85 1 1 408 CD68 3.84 33 81 409 MT1E 3.84 20 37 410 S100A11 3.84 3 3 411 PTMS 3.84 15 37 412 TCF21 3.84 1 2 413 EFS 3.84 7 111 414 SEMA3C 3.84 69 90 415 DIO3 3.83 1 2 416 LINC00517 3.83 0 0 417 THBS2 3.83 7 38 418 RGS4 3.83 0 0 419 CCL26 3.83 1 5 420 ARHGAP36 3.83 — — 421 CD276 3.82 13 27 422 HOXC6 3.81 9 9 423 S1PR3 3.80 3 7 424 CTSL 3.80 2 3 425 PRR16 3.80 5 3 426 PTPRT 3.80 0 0 427 PHLDA3 3.79 16 23 428 AGTR1 3.79 9 10 429 MRC2 3.78 14 64 430 TSKU 3.78 9 19 431 ITM2A 3.77 — — 432 MMP28 3.77 4 4 433 FBXO43 3.76 0 0 434 GACAT2 3.76 0 0 435 AGAP2-AS1 3.75 7 23 436 GALNT16 3.75 5 8 437 TMEM45A 3.74 5 5 438 PBK 3.74 10 14 439 LRRC32 3.73 3 3 440 PTGFR 3.73 8 36 441 AK1 3.73 7 16 442 CHL1 3.72 0 0 443 MEOX1 3.72 40 209 444 C7 3.71 2 5 445 CFB 3.70 508 1,239 446 LINC01305 3.70 0 0 447 TK1 3.70 15 62 448 KCNK15 3.70 12 19 449 ZDHHC1 3.69 22 54 450 HSD11B2 3.69 24 69 451 OSR2 3.69 0 0 452 PCLAF 3.69 2 3 453 SERPINA3 3.69 330 480 454 GALNT13 3.69 0 0 455 MFGE8 3.68 17 46 456 TUSC3 3.68 10 10 457 PARVA 3.68 0 0 458 KCNIP4 3.68 0 1 459 TIMP4 3.68 52 199 460 LINC00702 3.68 3 3 461 EDNRB 3.67 14 41 462 IL12A-AS1 3.67 0 0 463 TP53TG3C 3.66 — — 464 WNT10B 3.66 4 7 465 TUBB2A 3.64 2 9 466 SELENOP 3.64 3 4 467 P4HA3 3.63 4 11 468 TPBG 3.63 0 0 469 LMO3 3.62 3 4 470 MSC 3.61 0 0 471 RTL3 3.61 — — 472 CNN3 3.60 2 3 473 CAV2 3.60 20 163 474 P4HA2 3.60 213 354 475 TCEAL9 3.59 — — 476 TSPAN4 3.58 20 57 477 ADORA2B 3.58 7 17 478 LINC01834 3.56 0 0 479 DIRC1 3.56 21 33 480 MUC12 3.56 14 29 481 CDC42EP5 3.55 1 1 482 COPZ2 3.54 25 92 483 FIBIN 3.54 1 9 484 COLCA1 3.54 16 45 485 TMEM54 3.54 0 1 486 INSRR 3.53 2 2 487 SHCBP1L 3.53 33 97 488 LINC01794 3.53 0 0 489 ANXA5 3.52 4 7 490 RCN1 3.52 5 11 491 CPA4 3.52 1 2 492 TSPAN15 3.52 35 53 493 SPIN2A 3.51 — — 494 UBE2C 3.51 9 25 495 SPRY1 3.51 2 3 496 KRT79 3.50 18 28 497 UCHL1 3.49 0 0 498 SELENBP1 3.48 16 25 499 PAMR1 3.48 1 2 500 HMCN1 3.48 5 7 501 DNM1 3.46 2 3 502 LINC01539 3.46 0 0 503 DIRAS3 3.46 1 1 504 TRERNA1 3.46 5 12 505 MMP14 3.46 28 53 506 CYB5R2 3.46 0 0 507 SIX1 3.45 0 0 508 NR0B1 3.45 — — 509 CDH11 3.44 1 5 510 BHLHE22 3.44 0 0 511 LSP1 3.44 41 132 512 ACTA2 3.44 5 5 513 DMRT3 3.43 8 27 514 ADAMTSL1 3.43 2 2 515 CCL13 3.42 2 11 516 CXCL11 3.42 6 5 517 ID4 3.42 6 17 518 GPC4 3.41 — — 519 GAS1RR 3.40 0 0 520 TNMD 3.40 — — 521 LMCD1 3.39 5 11 522 PDLIM3 3.39 2 4 523 HSPG2 3.39 47 92 524 BMP1 3.38 25 61 525 PLA2G5 3.38 3 12 526 TDRD12 3.37 2 2 527 FKBP7 3.37 0 0 528 CYBRD1 3.35 21 56 529 OLFM1 3.35 4 8 530 FMO1 3.35 4 2 531 OLFML2A 3.35 5 7 532 LAPTM4A 3.35 14 22 533 FBXO17 3.34 11 19 534 CCL8 3.33 5 14 535 ITGB3 3.33 15 38 536 CALHM2 3.33 7 15 537 HOXC5 3.32 5 3 538 CLIC2 3.32 — — 539 CAPG 3.32 33 98 540 TP53I3 3.32 5 43 541 EMP3 3.31 0 0 542 C1GALT1C1L 3.31 3 14 543 ITGA11 3.31 1 2 544 MSC-AS1 3.30 0 0 545 C2 3.30 61 83 546 COL5A1 3.30 4 10 547 CYP26B1 3.29 5 6 548 IL17B 3.29 0 0 549 EN1 3.29 13 14 550 POPDC2 3.29 2 2 551 GXYLT2 3.28 3 6 552 IFT22 3.28 15 24 553 SH3BGRL3 3.28 18 62 554 TUBB 3.28 165 310 555 PTGIR 3.28 17 25 556 TBX2-AS1 3.28 25 110 557 KLF4 3.27 0 0 558 HMGCLL1 3.27 0 0 559 CREB3L1 3.26 51 329 560 ZNF503 3.26 1 2 561 EPDR1 3.26 15 39 562 PABPC5 3.26 — — 563 APOL4 3.25 11 28 564 ELANE 3.25 31 86 565 PHLDA2 3.25 6 9 566 HSPB8 3.24 0 0 567 GSTM3 3.24 6 9 568 HOXC-AS1 3.24 4 7 569 IL17RE 3.24 2 2 570 DIO3OS 3.24 1 2 571 BHLHE41 3.23 16 23 572 LINC01204 3.23 — — 573 FKBP9 3.22 6 10 574 C1QTNF1 3.22 5 9 575 CCDC89 3.21 2 1 576 SHISA4 3.21 20 62 577 CLIP3 3.21 1 1 578 CD63 3.21 0 0 579 CD151 3.20 20 58 580 TMEM200B 3.19 1 3 581 FKBP14 3.19 2 5 582 LIMA1 3.19 22 63 583 DDR2 3.19 2 2 584 RGS17 3.18 0 1 585 BOC 3.18 4 6 586 FAM180A 3.18 0 0 587 PPARG 3.18 122 460 588 XKR3 3.18 — — 589 DLC1 3.17 24 63 590 PFN2 3.17 0 0 591 TRIP10 3.16 8 26 592 SRGAP1 3.16 0 1 593 ADM 3.16 22 57 594 MSX1 3.16 0 0 595 NPR1 3.16 6 10 596 CYP1B1 3.15 4 15 597 SERPINB2 3.15 6 8 598 CDON 3.14 4 4 599 CDC42EP2 3.14 0 0 600 ACKR4 3.13 10 22 601 NOX4 3.13 9 56 602 STXBP6 3.13 3 2 603 CKAP2L 3.13 6 23 604 CDK15 3.13 0 0 605 IL15RA 3.12 0 0 606 ABCC2 3.12 37 70 607 CCDC74A 3.11 0 0 608 AKAP12 3.10 4 13 609 B3GNT9 3.09 16 33 610 FGFR1 3.09 15 23 611 PRRT3-AS1 3.09 0 0 612 MMP23B 3.09 2 14 613 ARHGAP20 3.08 0 0 614 LAMA2 3.08 1 0 615 CKAP4 3.07 3 6 616 LINC01169 3.07 26 89 617 CLIC1 3.07 159 256 618 ANGPTL5 3.07 3 6 619 CNTFR 3.07 0 0 620 LINC02319 3.07 2 5 621 LINC00640 3.07 0 0 622 FNDC1 3.07 26 48 623 MT2A 3.06 10 12 624 CCDC34 3.06 0 0 625 CCDC28B 3.06 1 1 626 CA12 3.05 7 15 627 C8orf48 3.05 7 28 628 BIRC7 3.05 7 8 629 ALDH1L2 3.05 0 0 630 CST4 3.05 — — 631 RTL8B 3.04 — — 632 ABCA8 3.04 83 140 633 ANPEP 3.04 13 24 634 PTGDS 3.03 3 2 635 PRRG3 3.03 — — 636 TCEAL7 3.02 — — 637 STMN3 3.02 62 155 638 STK32B 3.02 0 0 639 FKBP1A 3.01 5 6 640 KCTD11 3.01 20 39 641 KRBOX1 3.01 0 0 642 DBX2 3.01 0 0 643 PLBD1 3.00 4 7 644 MDK 3.00 57 347 645 ZFHX4-AS1 3.00 0 0 646 DDIT4L 3.00 7 16 647 TYMS 3.00 5 5 648 ARSI 3.00 9 21 649 ADAM33 3.00 20 42 650 ID1 3.00 — — 651 CDA 3.00 12 29 652 HCAR1 3.00 3 10 653 CSF1 2.99 5 9 654 CDC42EP1 2.99 12 29 655 LINC01531 2.99 61 105 656 PTCH2 2.99 0 0 657 IRX1 2.98 0 0 658 TUBA1B 2.98 0 0 659 HOXC4 2.98 5 3 660 CMBL 2.98 0 0 661 CDKN2C 2.98 0 0 662 OLFM2 2.98 2 4 663 SPAG17 2.98 2 10 664 LINC01638 2.98 1 2 665 GTSE1 2.98 0 2 666 RAB32 2.97 2 1 667 RAMP2-AS1 2.97 7 17 668 PTHLH 2.97 0 0 669 HGF 2.97 66 85 670 OXT 2.97 1 2 671 LY6E 2.97 0 0 672 SBSN 2.97 0 0 673 RUNX1T1 2.96 1 1 674 APOBEC3B 2.96 3 3 675 GAL3ST4 2.96 0 0 676 COLEC11 2.96 7 15 677 ACOT1 2.96 0 0 678 P3H3 2.96 12 24 679 RBPMS 2.95 31 78 680 TMEM225B 2.95 11 15 681 MYO1B 2.95 3 10 682 CDCA3 2.95 12 24 683 SLC12A8 2.95 17 32 684 P3H4 2.95 18 23 685 LINC01091 2.95 1 2 686 RMI2 2.95 9 16 687 FABP3 2.94 11 20 688 CYSTM1 2.94 11 14 689 FZD4 2.93 4 10 690 TRABD2A 2.93 1 1 691 LINC01971 2.93 11 15 692 COL16A1 2.93 6 12 693 C9orf50 2.92 0 0 694 SNX7 2.92 0 0 695 NQO1 2.92 2 4 696 FAM228A 2.92 4 31 697 SYCE2 2.91 3 3 698 IL17D 2.91 2 45 699 LINC02154 2.90 — — 700 LINC02261 2.90 0 0 701 SMIM10 2.90 — — 702 ACKR3 2.90 2 4 703 CCDC74B 2.90 0 0 704 SPR 2.89 0 0 705 PLSCR4 2.89 0 0 706 FAM110B 2.89 0 0 707 PLXDC1 2.89 1 3 708 BICC1 2.89 22 101 709 PDLIM7 2.88 15 30 710 AQP1 2.88 6 12 711 HOXD8 2.88 14 50 712 SLIT2 2.88 0 0 713 ENG 2.88 9 25 714 UBTD1 2.88 4 15 715 PLPP1 2.88 8 17 716 IER3 2.87 247 484 717 TRIL 2.87 3 4 718 COL8A1 2.87 4 14 719 DPCD 2.87 0 0 720 SPACA9 2.87 1 0 721 PLAUR 2.86 34 60 722 PRDX4 2.85 — — 723 MAGEE2 2.85 — — 724 LINC00322 2.84 0 0 725 PCDHGC3 2.84 0 0 726 RSPO3 2.84 29 81 727 NEGR1 2.84 5 12 728 NUDT11 2.84 — — 729 PTX3 2.83 4 8 730 FSTL3 2.83 6 5 731 VAT1 2.83 9 12 732 FERMT2 2.83 11 62 733 EMCN 2.82 10 11 734 DKK1 2.82 0 0 735 PDK4 2.82 5 8 736 CENPW 2.81 17 39 737 ETNK2 2.81 8 22 738 HSPA6 2.81 198 266 739 SNHG18 2.81 0 0 740 COL15A1 2.79 10 38 741 PHYHD1 2.79 15 29 742 KCNE4 2.79 2 2 743 ALDH1B1 2.79 3 3 744 BIN1 2.78 9 15 745 C6orf132 2.78 24 122 746 C14orf132 2.78 0 0 747 RASSF8-AS1 2.77 2 3 748 OSCP1 2.77 5 29 749 LINC00968 2.77 4 14 750 VKORC1 2.77 51 133 751 LIMS2 2.77 11 14 752 C1QTNF6 2.77 16 43 753 ZRANB2-AS1 2.76 0 0 754 SP9 2.76 0 0 755 LINC00668 2.76 0 0 756 KLK1 2.76 3 7 757 RHOC 2.75 29 113 758 GCSH 2.75 1 4 759 HNMT 2.75 2 2 760 NT5E 2.75 0 0 761 FAM20A 2.75 34 62 762 TAX1BP3 2.75 2 2 763 GNG12 2.74 13 26 764 BNC2 2.74 7 23 765 INAFM1 2.74 2 7 766 SPC25 2.74 13 44 767 CMKLR1 2.73 2 12 768 SFTA1P 2.73 1 1 769 CHPF 2.73 4 15 770 PDLIM1 2.73 19 37 771 NME1 2.73 0 0 772 NME1-NME2 2.73 0 0 773 LPAR4 2.73 — — 774 MYOF 2.72 4 6 775 PCOLCE-AS1 2.72 17 61 776 PDLIM2 2.71 29 58 777 PHGDH 2.71 0 0 778 ADH1C 2.71 133 303 779 TNFSF13B 2.71 1 0 780 C1orf220 2.71 7 22 781 EGR1 2.71 1 1 782 SUCNR1 2.71 1 4 783 ADAMTS3 2.71 17 49 784 PKMYT1 2.71 0 1 785 SDC4 2.70 36 95 786 FOS 2.70 3 3 787 LINC02351 2.70 0 0 788 C17orf58 2.70 20 50 789 FHL3 2.70 2 15 790 EGFR 2.70 10 11 791 CYB5R3 2.70 13 44 792 CD59 2.70 5 8 793 CCDC8 2.69 12 37 794 C10orf55 2.69 6 20 795 CENPF 2.69 0 1 796 LINC02076 2.69 23 42 797 NEXN 2.68 21 71 798 TYMP 2.68 15 62 799 HP 2.68 120 301 800 RNF24 2.68 2 2 801 PLAT 2.67 — — 802 APOL1 2.67 8 21 803 DBNDD2 2.67 30 88 804 MSRB3 2.67 0 0 805 C20orf144 2.67 1 1 806 LINC01117 2.66 12 46 807 CD302 2.66 13 43 808 PKDCC 2.66 23 83 809 LRP1 2.66 53 254 810 TEAD2 2.66 1 2 811 EFHD1 2.66 2 7 812 STAR 2.65 0 0 813 ATF3 2.65 8 26 814 BDKRB2 2.65 1 10 815 KCNJ15 2.64 18 18 816 GAS6 2.64 6 25 817 PAPLN 2.64 5 7 818 PKIG 2.64 10 20 819 FGL2 2.64 2 2 820 PGRMC1 2.64 — — 821 C1orf54 2.64 7 10 822 HOXA5 2.63 17 40 823 LINC01239 2.63 3 4 824 KLK14 2.63 1 1 825 SH3PXD2B 2.63 2 10 826 LINC01929 2.63 0 0 827 ASPA 2.62 1 1 828 GJB2 2.62 2 2 829 MATN2 2.62 6 10 830 TRIP6 2.61 16 52 831 HSPA1A 2.61 81 205 832 HCFC1R1 2.61 0 0 833 SEMA3E 2.61 2 3 834 KIF20A 2.61 0 0 835 FSCN1 2.61 0 0 836 PINLYP 2.60 30 52 837 HES1 2.60 0 0 838 CKS1B 2.60 5 10 839 DHRS9 2.60 21 60 840 COCH 2.59 1 1 841 GPR176 2.59 10 21 842 TUBA1C 2.59 0 0 843 DLGAP5 2.59 4 27 844 FOSL1 2.59 26 51 845 MAGEA8-AS1 2.59 — — 846 SPC24 2.59 93 836 847 CMTM3 2.59 23 32 848 AXL 2.59 13 25 849 C1QTNF4 2.59 — — 850 BASP1 2.59 0 0 851 ATL1 2.58 2 11 852 HOXB7 2.58 1 2 853 FAM162B 2.58 1 6 854 LAMC1 2.58 60 136 855 ZNRF3-AS1 2.58 3 5 856 ID3 2.58 4 9 857 MME 2.58 2 2 858 NPM3 2.58 0 0 859 SUSD2 2.57 2 2 860 EVA1B 2.57 16 55 861 WNT11 2.57 1 1 862 TP53TG3D 2.57 — — 863 HAND2 2.57 2 5 864 TSPAN8 2.56 4 5 865 HEBP1 2.56 2 5 866 ADAMTS8 2.56 10 17 867 NENF 2.56 14 43 868 AIFM2 2.56 0 1 869 DENND6B 2.56 6 13 870 CD109 2.56 0 0 871 KIF25-AS1 2.55 1 1 872 CDC42EP4 2.55 2 4 873 FLG 2.55 0 0 874 LTBR 2.55 21 43 875 CCNB2 2.55 15 22 876 MARVELD1 2.55 3 9 877 BBOX1-AS1 2.55 0 0 878 LINC01785 2.54 — — 879 TFPI2 2.54 13 15 880 GLIPR2 2.54 2 2 881 CR1L 2.54 23 45 882 PLPP7 2.54 1 1 883 DOK5 2.54 — — 884 LINC01705 2.54 0 0 885 CCND1 2.54 44 94 886 MYC 2.54 0 0 887 COX4I2 2.53 — — 888 CLSTN3 2.53 0 0 889 CYTOR 2.53 2 2 890 CYP4F12 2.53 1 2 891 GPX4 2.53 30 119 892 CNPY4 2.53 0 0 893 HOXA9 2.53 13 44 894 PTGR1 2.52 5 8 895 RND3 2.52 0 5 896 MAFB 2.51 4 11 897 ARHGAP28 2.51 0 0 898 DEPDC1 2.51 0 0 899 GSTM1 2.51 1 1 900 HPDL 2.50 0 0 901 GPX7 2.50 6 10 902 MKI67 2.50 0 0 903 THBS4 2.50 5 20 904 GLI3 2.50 0 0 905 TMSB10 2.50 1 1 906 ERRFI1 2.49 3 6 907 TMED3 2.49 0 0 908 GLI1 2.49 16 42 909 RFX8 2.49 2 3 910 LDB2 2.49 2 2 911 SULF1 2.48 2 3 912 WSCD2 2.48 0 0 913 THBS1 2.48 7 22 914 CRISPLD2 2.47 18 52 915 ACE 2.47 11 44 916 SPRYD3 2.47 1 1 917 LMO4 2.47 0 0 918 ADGRD1 2.47 2 3 919 RTL8C 2.46 — — 920 G6PC3 2.46 0 0 921 ST3GAL4 2.46 37 47 922 NXPH3 2.46 3 9 923 RAB3IL1 2.46 25 205 924 DNM3OS 2.46 0 0 925 HIC1 2.46 36 105 926 CLCF1 2.46 3 8 927 LRRC73 2.45 0 0 928 BAIAP2L2 2.45 39 179 929 PLIN3 2.45 9 12 930 IKBIP 2.44 4 5 931 ROBO1 2.44 0 0 932 LTBP4 2.44 57 146 933 PLEKHA4 2.44 32 66 934 DNASE1L3 2.44 28 45 935 COL6A6 2.44 0 0 936 NAV1 2.44 12 34 937 MIR4435-2HG 2.44 13 33 938 PTPRD-AS1 2.43 1 0 939 PDE1B 2.43 1 4 940 BST1 2.43 2 2 941 UGDH 2.43 14 26 942 MORN2 2.43 1 1 943 NPDC1 2.42 19 47 944 CPXM2 2.42 1 1 945 LY96 2.42 3 3 946 UBE2Q1-AS1 2.42 — — 947 DCAF12L2 2.42 — — 948 TROAP 2.42 0 1 949 ANXA4 2.42 2 3 950 RHOD 2.42 10 15 951 ALX1 2.41 0 0 952 DDAH2 2.41 146 231 953 TNFRSF1A 2.41 22 43 954 UBE2E1-AS1 2.41 1 1 955 LINC02550 2.41 0 0 956 VASH2 2.41 0 0 957 CTSF 2.41 9 19 958 KDELR2 2.41 25 30 959 SYNC 2.41 5 12 960 AKR1B15 2.41 3 6 961 WNT1 2.40 4 7 962 TRIP13 2.40 1 1 963 PLP2 2.40 — — 964 SLC35G2 2.40 46 105 965 CRTAP 2.40 7 16 966 TUSC1 2.40 0 0 967 SOCS3 2.40 33 147 968 CDC6 2.40 12 41 969 HOXA7 2.39 11 15 970 COTL1 2.39 17 66 971 BACE2 2.39 17 18 972 CALU 2.39 14 34 973 PROS1 2.39 0 0 974 TDO2 2.39 2 2 975 MNS1 2.39 0 0 976 PID1 2.39 8 10 977 CRYBA2 2.39 2 11 978 PPIB 2.38 3 8 979 RXRG 2.38 0 0 980 CGREF1 2.38 7 15 981 CD44 2.38 4 5 982 TSPAN3 2.38 14 27 983 TBX3 2.38 11 38 984 HSPB1 2.38 1 0 985 IGSF10 2.38 3 11 986 EXOC3L4 2.37 38 45 987 BEX3 2.37 — — 988 NME2 2.37 0 1 989 CAMK1 2.37 0 0 990 LAMB2 2.37 16 40 991 GPR156 2.36 20 37 992 IL17RC 2.36 1 1 993 ADAMTS4 2.36 15 24 994 BAD 2.36 10 22 995 ARHGAP6 2.35 — — 996 LINC01894 2.35 1 1 997 RBMS3 2.35 1 3 998 IL6 2.35 13 38 999 MARCKS 2.35 1 2 1000 LINC01257 2.34 0 2