Cell state · L2
THYMO.SP_CD8_transitional
604 cells in the full atlas (not the displayed sample).
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Marker genes
CDH2, CR2, DANT2, HSP90B1, JAM3, MME, NUP155, SCN3A, SELENOI, TMEM131L
Annotation genes
CR2, MME
Annotation rationales
CR2 (CD21) and MME (CD10) define human ISP/RTE-like phenotypes; adhesion (CDH2/JAM3 in markers) supports thymic egress; slight CD8A with minimal CD8B/CD4 indicates CD8-leaning ISP transitioning to mature SP. The pair (CR2, MME) is characteristic of RTEs.
Functional implications
Mature toward full CD8⁺ phenotype while emigrating; calibrate responsiveness and tissue-homing cues for integration into the peripheral naïve pool.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.