Cell state · L2
THYMO.SP_CD8_naive_stress
697 cells in the full atlas (not the displayed sample).
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Marker genes
CACYBP, DNAJB1, DNAJB4, FKBP4, GADD45B, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA6, HSPB1, HSPE1, HSPH1, SERPINH1, TAGAP, ZFAND2A
Annotation genes
DNAJB1, DNAJB4, GADD45B, HSP90AA1, HSP90AB1, HSPA1A, HSPA6, HSPB1, HSPE1, HSPH1, ZFAND2A
Annotation rationales
Extensive heat-shock/co-chaperone upregulation (HSP90AA1/HSPA1A/HSPE1) plus GADD45B signals DNA damage/stress responses as cells finalize selection and egress. The set indicates newly minted SP CD8s under transient proteotoxic/oxidative load.
Functional implications
Protect nascent SP CD8 cells as they leave the thymus, preserving viability and TCR repertoire integrity during the transition to circulation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.