Cell state · L2
THYMO.DP_early_stress
127 cells in the full atlas (not the displayed sample).
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Marker genes
ATP2C1, BAG3, CHORDC1, DNAJA4, DNAJB1, DNAJB4, DUSP1, FAM13A, HSPA1A, HSPA1B, HSPA6, HSPD1, HSPH1, MXD1, SERPINH1, TAGAP, TNFAIP3, TSPYL2, TXNIP, USPL1
Annotation genes
DNAJB1, DNAJB4, DUSP1, HSPA1A, HSPA1B, HSPA6, HSPH1, SERPINH1, TNFAIP3, TXNIP
Annotation rationales
Heat shock (HSPA1A/HSPH1) and co-chaperones (DNAJB1/4, SERPINH1) buffer proteotoxic load during rearrangement; DUSP1 and TNFAIP3 restrain MAPK/NF-κB; TXNIP couples redox/glucose stress. The set conveys DP cells under selection stress but protected from apoptosis.
Functional implications
Survive the proteostasis and signaling stress of recombination/selection, enabling proper maturation instead of attrition.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.