Cell state · L2

THYMO.DP_early

4,945 cells in the full atlas (not the displayed sample).

These are the cell-population annotations shown in the SCREATE Cell Browser.

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Marker genes

ADAM10, BCL6, CD38, CD4, CD8A, CD8B, CYP2U1, LBR, NUP155, PTPRC, RAG1, SELENOI, SLC16A2

Annotation genes

ADAM10, CD4, CD8A, CD8B, RAG1

Annotation rationales

Co-expression of CD4/CD8 with RAG1 denotes early DP with ongoing rearrangement; ADAM10 participates in TCR selection signaling; CD38 marks activation/metabolic readiness. The subset (ADAM10, CD4, CD8A, CD8B, RAG1) sits at the onset of positive selection.

Functional implications

Execute TCRβ completion and initiate positive selection, preparing for lineage choice and negative selection.

Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.