Cell state · L2
THYMO.DN_preTCR
1,593 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
ABHD14B, ALKBH7, ANXA1, APRT, BIK, BST2, CD7, CEP70, CLIP3, DNAJC4, EEF2, EVL, FRMD4A, FXYD2, GLIPR1, HES4, ID1, JCHAIN, KCTD9, KLF3, LINC01819, LITAF, LY6H, MAL, MAPK3, MEST, MFAP4, NACA, NCF4, NOP53, NR3C1, PCBP4, PFKFB2, PIGZ, PLIN3, PTCRA, RACK1, RGS1, RPL10, RPL12, RPL35A, RSL1D1, SMIM24, SMIM3, SNHG7, SOCS2, SPON2, YBX3
Annotation genes
PTCRA
Annotation rationales
PTCRA encodes pre-Tα and defines the β-selection checkpoint; strong MAPK3/ID1/ANXA1 suggest survival signaling; MAL indicates pre-TCR membrane trafficking; SOCS2 restrains cytokine noise. PTCRA alone captures the decisive lineage-defining step.
Functional implications
Enforce β-selection: test for productive TCRβ, deliver survival/proliferation signals, and progress toward DP while repressing alternative fates.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.