Cell state · L2
THYMO.CD8aa_IELp
444 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CD27, CLEC2D, CNN2, COTL1, CST7, GNG4, HCST, ID3, IGFLR1, LCP2, LGALS1, NAB2, NFATC1, NMB, PPM1M, PRKCH, RTKN2, SH3BGRL3, TOX2
Annotation genes
CD27, CLEC2D, CST7, GNG4, HCST, ID3, LCP2, NFATC1, PRKCH
Annotation rationales
ID3/TOX2 support innate-like differentiation; NFATC1/PRKCH promote TCR signaling reprogramming; CLEC2D and HCST (DAP10) add NK-like receptors/adaptors; CST7 indicates early granule regulation; GNG4 highlights CD8αα IEL-precursor identity; LCP2 mediates proximal TCR signaling; CD27 marks survival/selection competence. This set (CD27, CLEC2D, CST7, GNG4, HCST, ID3, LCP2, NFATC1, PRKCH) fits the human CD8αα intraepithelial lymphocyte precursor that branches from DP.
Functional implications
Seed the CD8αα IEL lineage: acquire innate-like recognition, limited cytotoxic readiness, and epithelium-homing competence to enforce barrier surveillance in gut/skin post-export.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.