Cell state · L2
T.CD8_transitional.early
8,799 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CCR7, CD55, FTH1, IL7R, PABPC1, YPEL5
Annotation genes
CCR7, IL7R
Annotation rationales
IL7R and CCR7 mark classic Tcm-like identity, enabling LN homing and IL-7–dependent survival. CD55 contributes complement regulation, protecting cells in lymphoid tissues. PABPC1/YPEL5 reflect high RNA-binding and biosynthetic capacity, supporting readiness for clonal expansion. This constellation suggests early transitional cells retaining memory-like homing while ramping up metabolic/biosynthetic support in preparation for effector polarization.
Functional implications
Serves as the proliferative reservoir of transitional CD8 T cells: survives long-term via IL-7 signals, patrols secondary lymphoid organs via CCR7, and maintains clonal flexibility. Functionally, these cells provide the pool that can either persist as central memory or differentiate toward effector lineages upon antigen re-encounter. They safeguard immune durability while enabling adaptive plasticity—key to balancing longevity with rapid deployment.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.