Cell state · L2
T.CD8_Trm.homeostatic
4,250 cells in the full atlas (not the displayed sample).
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Marker genes
ANXA1, EZR, IL7R, LMNA, MYADM, RGCC
Annotation genes
EZR, IL7R, RGCC
Annotation rationales
IL7R expression ensures access to IL-7–mediated survival cues, a central feature of long-lived Trm. EZR and RGCC support cytoskeletal remodeling and cell-cycle restraint, compatible with tissue anchoring and quiescence. ANXA1, LMNA, MYADM stabilize plasma membrane and nuclear integrity, aligning with a maintenance phenotype rather than active effector function. Together, these markers define a quiescent Trm pool that persists in tissues awaiting reactivation.
Functional implications
Provides the homeostatic backbone of Trm populations, ensuring persistence for years at barrier sites. These cells maintain tissue residency through adhesion and survival pathways, consuming minimal resources while retaining readiness. On challenge, they can rapidly re-enter effector programs or proliferate locally, preserving tissue-protective immunity long after infection or vaccination.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.