Cell state · L2
T.CD8_Trm.dendritic_recruiter
1,227 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
CDKN1A, CRTAM, GZMK, HLA-DQA1, HLA-DRB1, HSPE1, MT2A, STMN1, TNFRSF9, XCL1, XCL2
Annotation genes
CRTAM, TNFRSF9, XCL1, XCL2
Annotation rationales
XCL1/2 chemokines are hallmarks of Trm that recruit cDC1s, bridging CD8 T cell activity to local antigen presentation. CRTAM enhances adhesion and communication with dendritic cells, while TNFRSF9 (4-1BB) provides co-stimulatory reinforcement. Low-level MHC-II (HLA-DQ/DR) suggests unconventional APC-like potential. CDKN1A and STMN1 indicate controlled proliferation under stress, while MT2A/HSPE1 highlight oxidative/proteotoxic stress adaptation.
Functional implications
Acts as a communication hub Trm, orchestrating local immunity by recruiting dendritic cells, enhancing antigen sampling, and sustaining T cell–APC interactions. Functions not only as killers but also as immune organizers, ensuring that antigen persistence in tissues triggers a broad, coordinated immune response while maintaining residency under stress conditions.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.