Cell state · L2
T.CD8_Trm.cytotoxic
4,252 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ARL2, C12orf75, GZMB, GZMH, LGALS1, LITAF, LSP1, NKG7, PRF1
Annotation genes
GZMB, NKG7, PRF1
Annotation rationales
GZMB, PRF1, and NKG7 form the canonical cytotoxic machinery for perforin–granzyme–mediated killing, confirming potent CTL activity. LGALS1 (galectin-1) supports immune-synapse stabilization and co-stimulatory interactions, while LSP1/LITAF suggest activation-linked cytoskeletal remodeling and inflammatory signaling. This profile is distinct from circulating Tem because it combines full cytotoxic readiness with Trm hallmarks of tissue anchoring.
Functional implications
Represents fully armed resident cytotoxic Trm stationed at barrier sites (skin, gut, lung). Provides immediate, contact-dependent killing of infected or transformed cells without the need for recirculation. Acts as a first-line sentinel defense, delivering localized cytotoxicity within minutes of pathogen encounter, ensuring containment at the entry point.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.