SCREATE

Cell state · L2

T.CD8_Tem.TEMRA

4,728 cells in the full atlas (not the displayed sample).

These are the cell-population annotations shown in the SCREATE Cell Browser.

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Marker genes

CD63, CD7, GNLY, IFITM3, IKZF2, KIR2DL1, KIR2DL3, KIR3DL1, KIR3DL2, KLRC2, KLRC3, LAT2, NCR3, TXK, TYROBP

Annotation genes

KIR2DL1, KLRC2, NCR3

Annotation rationales

Expanded KIR/NKG2 (KIR2DL1, KLRC2) and NCR3 indicate NK-like licensing; GNLY/IFITM3 mark antiviral/lytic bias; IKZF2 supports terminal effector programs. The trio (KIR2DL1, KLRC2, NCR3) highlights innate-like recognition layered onto terminal cytotoxicity.

Functional implications

Terminal sentinels with powerful granule-mediated killing and innate-like targeting—rapidly eliminate stressed/infected cells, often with reduced proliferative reserve.

Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.