Cell state · L2
T.CD8_Tcm.helper_like
2,398 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ANXA1, C1orf162, CAPG, CCR4, CD40LG, CRIP1, CRIP2, GATA3, GLIPR1, ITGB1, LGALS1, LPAR6, PLP2, S100A11
Annotation genes
CCR4, GATA3, LGALS1
Annotation rationales
GATA3/CCR4 bias a Th2-like transcriptional program within CD8 memory; LGALS1 supports survival/synapse tuning; CD40LG (in markers) implies helper crosstalk with B cells/APCs—an atypical but described CD8 feature.
Functional implications
Provide non-classical helper outputs (costimulation/cytokines) to B cells/stroma while retaining CD8 memory traits—useful in type-2–skewed barrier responses.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.