Cell state · L2
T.CD8_Tcm.gut_homing
1,270 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CCR9, CD248, CLIC3, HOPX, IGFBP3, ITGA1, ITGA4, ITM2C, KLRB1, KLRC1, NT5E, PELO, TMIGD2
Annotation genes
CCR9, ITGA4, NT5E
Annotation rationales
CCR9 and ITGA4 drive small-intestine homing (CCL25/MAdCAM-1); NT5E (CD73) confers adenosine-mediated immunoregulation; low KLRB1 indicates mild tissue adaptation. The trio (CCR9, ITGA4, NT5E) fits mucosal surveillance with brake capacity.
Functional implications
Patrol gut-associated niches as regulatory-competent memory killers: rapid IL-2/IFN-γ on infection, tempered by adenosine production to protect epithelium.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.