Cell state · L2
T.CD8_Tcm.effector_bias
1,604 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ADRB2, CCL4, CCL5, CD74, CST7, DUSP2, EFHD2, GZMA, GZMH, GZMK, GZMM, KLRG1, LAG3, NKG7, PLEK, PRF1, S1PR5, ZEB2
Annotation genes
GZMA, KLRG1, LAG3, PRF1
Annotation rationales
PRF1/NKG7/Granzymes indicate strong lytic capacity; ZEB2/KLRG1 drive terminal effector polarization; LAG3 suggests checkpoint tempering; S1PR5 biases egress toward peripheral tissues. The quartet (GZMA, KLRG1, LAG3, PRF1) defines a memory cell tipping toward effector fate.
Functional implications
Bridge Tcm→Tem: poised for rapid tissue redeployment and direct killing while preserving some central-memory logistics and checkpoint control.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.