Cell state · L2
T.CD4_Trm.metal_stress
821 cells in the full atlas (not the displayed sample).
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Marker genes
FKBP4, HLA-DQA1, HLA-DQA2, HSP90AB4, HSPA1A, HSPE1, MT1E, MT1F, MT1G, MT1X, MT2A, SERPINH1, SLC30A1, ZFAND2A
Annotation genes
MT1E, MT2A, HSPA1A, HSPE1, SLC30A1
Annotation rationales
Metallothioneins (MT1E/MT2A) buffer Zn²⁺/Cu⁺ and scavenge ROS; HSPA1A/HSPE1 provide acute and mitochondrial chaperoning; SLC30A1 handles zinc export/storage. This stress-armored profile equips resident cells to endure oxidative and metal stress in inflamed epithelium.
Functional implications
Cytoprotective Trm subset that persists in harsh microenvironments (gut, skin), preserving barrier immunity by surviving oxidative bursts and metal flux while remaining capable of rapid recall.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.