Cell state · L2
T.CD4_Trm.cytotoxic_effector
3,276 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CCL5, CD7, CD74, CST7, CXCR3, DUSP4, GZMA, GZMH, GZMK, HCST, HLA-DRB1, HLA-DRB5, IL32, LGALS1, MT2A, MYL6, NKG7
Annotation genes
CCL5, CXCR3, GZMA, GZMK
Annotation rationales
Strong granzyme load (GZMA/GZMK/GZMH), CCL5-mediated recruitment, and CXCR3-guided positioning define resident Th1-like effectors; CD74/HLA-DR suggest heightened antigen scanning.
Functional implications
Frontline Trm defenders against viral/bacterial re-infection: rapid cytotoxicity and IFN-γ-driven inflammation with local coordination via CCL5.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.