Cell state · L2

T.CD4_Trm.activated

781 cells in the full atlas (not the displayed sample).

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Marker genes

BRD2, BTG2, CD69, CITED2, DUSP1, EGR1, FOS, FOSB, GADD45B, IER3, JUN, KLF6, NFKBIA, PPP1R15A, RASD1, SERTAD1, TNF, TNFAIP3, ZFP36L1

Annotation genes

CD69, EGR1, FOS, JUN, TNF

Annotation rationales

CD69 blocks S1PR1 egress and anchors residency; IEGs (FOS/JUN/EGR1) indicate immediate re-activation; TNF marks first-wave cytokine output; NFKBIA/TNFAIP3 (in markers) buffer NF-κB to avoid tissue damage.

Functional implications

First-responding Trm that detonates a rapid cytokine burst (TNF/IFN-γ/IL-2) and chemokine recruitment upon re-challenge, then self-limits to preserve tissue integrity.

Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.