Cell state · L2
T.CD4_Th2.tissue_adapted
127 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ADAM15, BACE2, CD7, CFH, CTSD, FCRL3, FSTL4, FXYD7, HPGDS, HTR1F, IRS2, ITGAM, KLRB1, LSR, MSRB3, NPDC1, PLAGL1, PTGDR2, RBPMS, RNF144A, TPMT, TRIB2, ZNF22, ZNF775
Annotation genes
HPGDS, KLRB1, PTGDR2
Annotation rationales
CRTH2/PTGDR2 with HPGDS confirms PGD₂ axis; KLRB1 marks human Th2 heterogeneity; HTR1F/MSRB3 suggest neuro-immune and oxidative-stress adaptation; adhesion/ECM genes (FSTL4, ADAM15 in markers) indicate tissue engagement.
Functional implications
PGD₂-responsive Th2 cells adapted to inflamed barriers: produce IL-4/IL-13, recruit eosinophils, and support epithelial repair; integrate neuromodulatory cues (HTR1F) and resist oxidative stress (MSRB3).
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.