Cell state · L2
T.CD4_Th2.precursor
192 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
ANXA2, CAMK4, CD2, CD3D, CD3E, CD3G, CD5, CD6, CD82, COTL1, FYB1, GSTK1, HPGDS, ISG20, LIME1, LITAF, MED15, PKM, PTGDR2, SIT1, TBC1D10C
Annotation genes
HPGDS, PTGDR2
Annotation rationales
PTGDR2 (CRTH2) with HPGDS anchors PGD₂-responsive Th2 bias; strong TCR/adaptor presence (CD3 chains, CAMK4, FYB1) indicates recent priming rather than tissue remodeling; absence of HTR1F/FSTL4/MSRB3 fits early circulating stage.
Functional implications
Primed CRTH2⁺ Th2 progenitors that rapidly produce IL-4/IL-13 and respond to PGD₂, initiating eosinophil recruitment and type-2 inflammation; feed into tissue Th2 effectors.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.