Cell state · L2

SMC.activated

2,188 cells in the full atlas (not the displayed sample).

These are the cell-population annotations shown in the SCREATE Cell Browser.

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Marker genes

ADAMTS4, ATF3, ATP1B3, BTG2, CDKN1A, CREM, CRISPLD2, CYCS, DNAJB1, DNAJB9, EGR1, EIF4A3, FOS, FOSB, GLA, HSPA1A, HSPA1B, IGFBP5, IL6, JUN, MAT2A, MIR22HG, MT1A, NAMPT, RBKS, SNHG15, YBX3, ZNF331

Annotation genes

ADAMTS4, ATF3, CDKN1A, FOS, JUN

Annotation rationales

Immediate-early reprogramming (FOS/JUN/ATF3) and cell-cycle restraint (CDKN1A) accompany ECM protease ADAMTS4 and stress chaperones (HSPA/DNAJ), indicating phenotypic switching from contractile to synthetic/repair SMCs with cytokine output (IL6).

Functional implications

Executes vascular repair programs: migrates from media to intima, degrades/rebuilds matrix, secretes IL-6 and growth cues to recruit leukocytes and fibroblasts, forms neointima after injury, and restores wall integrity; temporarily sacrifices tone for plasticity, with potential to drive restenosis if unresolved.

Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.