Cell state · L2
SKM.type_2_fast.glycolytic_IIx_IIb
3,990 cells in the full atlas (not the displayed sample).
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Marker genes
ACTN3, ALDOA, IL32, MYBPC2, MYH1, MYHAS, MYLK2, MYLK4, PRKAG3
Annotation genes
ACTN3, ALDOA, MYH1
Annotation rationales
MYH1 (IIx) and ACTN3 confer high shortening velocity and power; ALDOA and PRKAG3 tune glycolytic throughput and AMPK sensing; MYLK2/4 and MYBPC2 optimize cross-bridge cycling under rapid firing.
Functional implications
Generates explosive force for sprints and jumps: fast Ca²⁺ transients, rapid cross-bridge turnover, and heavy reliance on anaerobic glycolysis; builds intramuscular lactate quickly yet tolerates acidosis transiently; ideal for short, maximal efforts with quick fatigue.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.