Cell state · L2
SKM.type_1_slow.contractile
3,511 cells in the full atlas (not the displayed sample).
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Marker genes
ABRA, BTG2, LGR5, LMOD2, PPP1R27, TXNIP, XIRP2
Annotation genes
ABRA, LMOD2, XIRP2
Annotation rationales
LMOD2, XIRP2, and ABRA coordinate thin-filament nucleation/elongation and Z-disc/actin–costamere coupling in slow fibers, sustaining orderly sarcomeres during repetitive low-frequency firing; TXNIP couples redox tone to glucose uptake, buffering oxidative load typical of tonic activity.
Functional implications
Delivers tonic, low-amplitude force with exceptional fatigue resistance for posture and anti-gravity tasks; preserves sarcomere alignment under continuous load, minimizes Ca²⁺ cycling cost, and maintains redox–substrate balance to protect mitochondria during prolonged contractions (e.g., spinal extensors, soleus).
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.