Cell state · L2
PLAT.adhesion
232 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CD151, CD9, CDK2AP1, CFL1, CST3, FHL1, FKBP8, FLNA, GSN, ITGB1, MYL9, PARVB, PPDPF, PSAP, SH3BGRL, TRAPPC1, TUBA1B
Annotation genes
CD9, CFL1, FLNA, ITGB1, MYL9
Annotation rationales
Strong enrichment of cytoskeletal effectors: CFL1 (cofilin) and MYL9 (myosin light chain) control actin remodeling and contractility, while FLNA and TUBA1B maintain platelet shape and stability. Integrin β1 (ITGB1) and tetraspanin CD9, together with CD151, provide adhesion and signaling scaffolds at sites of vascular injury. This transcriptomic signature points to a mature platelet cluster specialized for structural remodeling and integrin-mediated adhesion.
Functional implications
Executes rapid adhesion to exposed subendothelial matrix at vascular injury sites, spreading across collagen/vWF surfaces and engaging ITGB1/CD9-driven signaling to stabilize thrombi. Beyond hemostasis, these adhesion-primed platelets facilitate immune surveillance by providing a scaffold for leukocyte recruitment, releasing chemokines upon contact, and directly interacting with neutrophils and monocytes to propagate inflammatory responses.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.