Cell state · L2
PERI.inflammatory
4,294 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
BAG3, DNAJA1, DUSP1, GADD45B, HSPA6, HSPB1, HSPD1, HSPH1, IER5, TECR, UBE2S, ZFAND2A
Annotation genes
GADD45B, HSPA6, HSPB1, HSPD1
Annotation rationales
HSPB1, HSPA6, HSPD1 fortify protein folding and protect against aggregation, while DNAJA1/HSPH1 (from marker set) extend the chaperone network. GADD45B orchestrates transcriptional responses to DNA and oxidative stress, and DUSP1 restrains MAPK activity to limit excessive signaling. This reflects plasma cells under secretory strain that remain resistant to apoptosis.
Functional implications
Protect IgG secretion under hostile conditions such as fever, oxidative bursts, or hypoxia. By engaging robust chaperone and stress-response networks, these cells maintain ER proteostasis and avoid apoptosis. Their persistence during stress ensures continuity of systemic antibody coverage even when the host is experiencing inflammation or infection-induced metabolic strain.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.