Cell state · L2
PERI.cardiac_skeletal
8,729 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ARPC2, BTF3, CYBA, DERL1, ERGIC3, ETFB, FAU, GRN, IFI30, ITM2C, NDUFAF4, NDUFC2, PRDX4, PSME2, RACK1, REEP5, RPL10, RPL11, RPL21, RPL23A, RPL26, RPL3, RPL30, RPL32, RPL8, RPN2, RPS15, RPS15A, RPS18, RPS21, RPS27, RPS27A, TNFRSF17, TXNDC15, UBA52, UBE2J1
Annotation genes
TNFRSF17
Annotation rationales
Expanded ribosomal gene expression and ER-trafficking machinery (RPN2, ERGIC3, REEP5) reflect massive translational throughput. DERL1/UBE2J1 mediate ER-associated degradation to handle misfolded proteins, while oxidoreductases (PRDX4, TXNDC15) stabilize disulfide bonds. TNFRSF17 (BCMA) secures survival signaling from APRIL/BAFF. This defines a state of maximal IgG secretion.
Functional implications
Function as true antibody factories, each cell producing thousands of IgG molecules per second. ER-associated degradation prevents toxic buildup of misfolded proteins, while BCMA signaling maintains viability. These plasma cells dominate long-term systemic antibody protection, ensuring rapid neutralization of blood-borne pathogens and persistent humoral immunity after vaccination or infection.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.