Cell state · L2
PERI.baseline
3,780 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ACADVL, ANKRD36B, ATXN2L, CDK14, CREBZF, CROCC, EDEM3, GAB1, GOLGA8B, LINC00412, MALAT1, NEAT1, PHKB, RAPGEF1, RBM6, SENP2, SIAH2-AS1, SLC38A2, STAT2, XIST, ZBTB20
Annotation genes
ACADVL, MALAT1, NEAT1, STAT2
Annotation rationales
ACADVL enables fatty acid β-oxidation, fueling energy-intensive Ig synthesis, while PHKB (in marker set) mobilizes glycogen stores. SLC38A2 ensures amino acid supply, and nuclear lncRNAs MALAT1 and NEAT1 optimize RNA processing and nuclear body function. STAT2 flags interferon sensitivity, aligning antibody production with systemic antiviral defense. This profile highlights a metabolically flexible state.
Functional implications
These cells dynamically rewire energy metabolism to sustain high antibody production even under nutrient stress. By flexibly switching between glycolysis, glycogenolysis, and fatty acid oxidation, they ensure uninterrupted IgG synthesis. Integration of interferon signaling (STAT2) aligns systemic antibody production with antiviral states, ensuring that these plasma cells can survive during infection and reinforce host defense with tailored antibody output.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.