Cell state · L2
PERI.angiocrine
3,270 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CD55, CD69, EZR, FAM107B, FGL2, GABARAPL1, HOOK2, KCNN4, KLF3, LMNA, MCL1, METRNL, PNRC1, RAB11FIP1, S100A10, TNFSF12A, UBE2H, ZNF267
Annotation genes
CD69, FGL2, LMNA, MCL1
Annotation rationales
CD69 supports retention in survival niches, and FGL2 mediates immune–stromal interactions. MCL1 provides anti-apoptotic protection crucial for plasma cell longevity, while LMNA stabilizes nuclear architecture during high transcriptional activity. This represents a niche-adapted systemic IgG plasma cell population optimized for persistence.
Functional implications
Engage bone marrow or splenic stromal networks to achieve long-term persistence, relying on CD69- and FGL2-mediated cross-talk with niche cells. MCL1 safeguards them from apoptosis, enabling sustained IgG output for years. These cells form the backbone of durable humoral immunity, protecting against systemic reinfections and maintaining vaccine-induced antibody titers across an individual’s lifespan.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.