Cell state · L2
OPC.homeostatic
1,964 cells in the full atlas (not the displayed sample).
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Marker genes
AFDN, AHI1, ANKRD36B, ARPP21, CACNA1A, CALD1, CAPN8, CCDC136, CCDC88A, CHD9, CMYA5, CPEB4, DDX46, EHMT1, GOLGA8A, GOLGA8B, LUC7L3, MACF1, MPHOSPH8, N4BP2L2, NPIPB12, NPIPB13, NPIPB3, NPIPB4, NPIPB5, PLEKHH2, SRRM2, TAOK3, ZNF532
Annotation genes
CACNA1A
Annotation rationales
CACNA1A (P/Q-type Ca²⁺ channel) appears at low levels in OPCs and likely reflects ambient neuronal transcripts or OPC Ca²⁺ signaling crosstalk; the broader profile (e.g., SRRM2, EHMT1, CPEB4) indicates RNA processing/chromatin regulation that maintains an undifferentiated, surveillance-ready OPC state. Lack of strong myelin genes fits premyelinating identity.
Functional implications
Preserve a proliferable OPC reservoir that monitors neurotransmitters/ionic cues, balances quiescence vs. entry into the cell cycle, and remains poised to respond to neuronal activity or injury with differentiation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.