Cell state · L2
OLG.stress
7,400 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
HSPA1A, HSPA1B
Annotation genes
HSPA1A, HSPA1B
Annotation rationales
Annotation genes HSPA1A/HSPA1B (HSP70s) indicate an acute chaperone response that prevents aggregation of abundant myelin proteins (e.g., PLP1, MBP) and protects secretory/ER load. This is a canonical OL defense during fever, oxidative stress, or cytokine exposure.
Functional implications
Temporarily prioritize proteostasis to maintain sheath protein quality, avert UPR-driven apoptosis, and enable rapid recovery of myelin synthesis after stress subsides.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.