Cell state · L2
OLG.regulatory_activated
2,602 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
SGK1
Annotation genes
SGK1
Annotation rationales
SGK1 is an immediate-early kinase activated by glucocorticoids and stress, regulating ion channels and survival pathways. In OLs it can adjust membrane excitability, osmotic balance, and anti-apoptotic programs during activity bursts or inflammatory cues.
Functional implications
Rapidly adapts OL physiology (ion/water handling, survival signaling) to fluctuating neuronal activity or stress, stabilizing myelin integrity and preparing the cell for either remodeling or return to baseline.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.