Cell state · L2
OLG.regulatory
10,882 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ANK3, CALD1, CCDC88A, CD22, ENOSF1, ERBIN, FRMD4B, KCNH8, KNOP1, LCNL1, MPHOSPH8, NPIPB5, PAXBP1, SIK3, SPECC1, SRRM2
Annotation genes
ANK3, CALD1, CCDC88A, MPHOSPH8, SRRM2
Annotation rationales
The annotation genes indicate a “poising” program rather than overt myelination: SRRM2 (splicing), MPHOSPH8 (chromatin), ANK3 (membrane scaffolding at axon–glia contacts), CALD1 (caldesmon, actin regulation), and CCDC88A (cytoskeletal adaptor) coordinate RNA processing and cytoskeletal readiness. Absence of strong MBP/PLP1/MOG surges suggests regulatory OLs that modulate signaling and structure without executing full sheath assembly.
Functional implications
Calibrate OL transcript splicing and cytoskeletal architecture to fine-tune sheath thickness/length and responsiveness to neuronal activity. Likely gate transitions between stable maintenance and active remodeling, influencing activity-dependent plasticity of myelination.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.