Cell state · L2
OLG.reactive_repair
3,037 cells in the full atlas (not the displayed sample).
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Marker genes
TUBA1B, PEA15, TUBA1A, TUBB2B, DHCR24, TNFRSF21, S100A1, MARCKSL1, TUBB, SCCPDH, PLIN3, UCHL1, KIF1A, S100B, LGALS1, RHOB, MAP1B
Annotation genes
TUBA1A, TUBA1B, TUBB2B, TUBB, MAP1B, KIF1A, RHOB, S100A1, S100B, LGALS1, PEA15, MARCKSL1, DHCR24
Annotation rationales
The annotation genes highlight an OL cytoskeletal remodeling and stress-response program: microtubule components (TUBA1A, TUBA1B, TUBB2B, TUBB) and transport (KIF1A) remodel processes; RHOB, MARCKSL1 alter actin/membrane curvature; S100A1/S100B and LGALS1 reflect glial activation; PEA15 modulates survival/ERK signaling. DHCR24 preserves cholesterol synthesis essential for myelin lipids, indicating lineage fidelity during repair.
Functional implications
Detach/reshape processes in demyelinated or damaged zones, phagocytose debris in collaboration with microglia/astrocytes, and prepare for remyelination. Maintain lipid supply for new wraps while resisting apoptosis—thus bridging from damage control to restorative myelin formation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.