Cell state · L2
NK.immature_bridge
4,184 cells in the full atlas (not the displayed sample).
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Marker genes
CCR7, GZMK, IGFBP4, IL7R, SELL, TCF7
Annotation genes
CCR7, GZMK, IL7R, SELL, TCF7
Annotation rationales
A developmental/intermediate state: lymphoid homing CCR7/SELL, cytokine dependence IL7R, transcriptional priming TCF7, and early effector GZMK (with low GZMB) define a bridge between CD56^bright-like cytokine NKs and mature cytotoxic NKs.
Functional implications
Migrates through lymphoid niches to proliferate and differentiate under IL-7/IL-15; seeds both helper-like and cytotoxic NK lineages, ensuring renewal of the effector pool and adaptability of the NK compartment during infections or vaccination.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.