Cell state · L2
NK.cytokine_tissue_activation
1,152 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CCL3, CCL4, CCL4L2, CD69, DUSP2, FCER1G, NFKBIA, XCL1, XCL2
Annotation genes
CCL3, CCL4, CCL4L2, CD69, FCER1G, NFKBIA, XCL1, XCL2
Annotation rationales
Tissue activation marker CD69 with XCL1/XCL2 (cDC1-recruiting chemokines) and CCL3/4 (broad leukocyte chemoattractants) defines a resident cytokine hub; NFKBIA/DUSP2 temper NF-κB to avoid overdrive; FCER1G keeps cytokine coupling high.
Functional implications
Coordinates local immune cell influx—especially cDC1 via XCL1/2—and sets an NK–DC axis that accelerates antigen presentation while restraining excessive inflammation through built-in NF-κB brakes.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.