Cell state · L2
NK.cytokine_axis_baseline
17,915 cells in the full atlas (not the displayed sample).
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Marker genes
CLIC3, FCER1G, KLRB1
Annotation genes
FCER1G, KLRB1
Annotation rationales
A helper-like axis is indicated by KLRB1 (CD161) and FCER1G, typical of CD56^bright-analog NKs that excel at cytokine sensing and secretion rather than pure cytotoxicity.
Functional implications
High-sensitivity cytokine sentinels that produce IFN-γ/TNF and chemokines upon IL-12/IL-18/IL-15 priming; recruit/activate DCs and T cells and orchestrate early antiviral settings before full cytotoxic waves arrive.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.