Cell state · L2
NK.adaptive_terminal_cytotoxic
2,878 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
CD5, CD6, FGFBP2, GNLY, KLRG1, SIT1, ZNF683
Annotation genes
FGFBP2, GNLY, KLRG1, ZNF683
Annotation rationales
Terminal maturation is defined by KLRG1, FGFBP2 (granule/exocytosis axis), GNLY (granulysin), and ZNF683 (Hobit) that imprints tissue-egress/cytotoxic residency traits.
Functional implications
Immediately cytotoxic NKs with maximal degranulation and tissue surveillance capability; clear virally infected or transformed cells swiftly and can egress or reside depending on cues, sustaining frontline antiviral/tumor control.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.