Cell state · L2
NK.adaptive_immature_precursor
2,418 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CD160, CD27, GZMK, HLA-DQA1, HLA-DRB1, KLRC2, TCF7, TIGIT
Annotation genes
CD27, GZMK, KLRC2, TCF7
Annotation rationales
A precursor-like, cytokine-responsive profile: CD27/TCF7 denote less-differentiated NK poised for expansion; GZMK (with low GZMB) marks early effector bias; KLRC2 and HLA-DQA1/HLA-DRB1 tie to adaptive imprinting potential; TIGIT tempers activation thresholds.
Functional implications
Lymphoid-homing precursors that seed the mature cytotoxic pool; proliferate in response to IL-7/IL-15 and differentiate into KLRC2⁺ memory-like NKs, providing a renewable source of effectors during infection or vaccination.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.