Cell state · L2
NK.adaptive_biosynthetic_primed
1,326 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
AK6, AKR1C3, CD3E, HLA-DRB1, KLRC2, TAF9
Annotation genes
AK6, HLA-DRB1, KLRC2, TAF9
Annotation rationales
A biosynthetic ramp is evident from transcription/translation co-factors TAF9 and AK6, preparing for clonal-like bursts. Adaptive features persist via KLRC2 and HLA-DRB1 (class II upshift in antigen-experienced NKs).
Functional implications
Early-activation “gear-up” state that expands translational capacity to increase granule proteins and cytokines; rapidly transitions to high-output cytotoxicity/ADCC upon pathogen re-encounter while retaining adaptive calibration through KLRC2.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.