Cell state · L2
NK.adaptive_adipose_stress
2,316 cells in the full atlas (not the displayed sample).
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Marker genes
CD3E, CREM, DNAJB6, FAM177A1, HSPE1, JMJD6, KLRC2, LDHA, MT1E, MT1X, MT2A, RGS2, TUBA4A, TUBB2A
Annotation genes
CREM, HSPE1, KLRC2, LDHA, MT1E, MT1X, MT2A
Annotation rationales
The adaptive/“memory-like” axis is indicated by KLRC2 (NKG2C), which is enriched after CMV imprinting and supports heightened recall cytotoxicity. Adipose stress biology is reflected by metallothioneins (MT1E/MT1X/MT2A) that buffer Zn²⁺/ROS, and HSPE1 (chaperonin) that sustains proteostasis. LDHA suggests glycolytic fueling of killing. Transcriptional tuning via CREM adapts responses in lipotoxic niches.
Functional implications
Maintains potent, recallable killing and ADCC in oxidative, lipid-rich adipose tissue while limiting bystander damage: metallothionein-driven ROS control sustains degranulation; KLRC2-imprinted signaling supports rapid responses to stressed adipocytes or infected cells and modulates adipose inflammation–insulin sensitivity cross-talk.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.