Cell state · L2
NK.adaptive_HLAE_tuned
6,358 cells in the full atlas (not the displayed sample).
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Marker genes
KLRC4
Annotation genes
KLRC4
Annotation rationales
KLRC4 (NKG2F/NKG2E family; co-expressed with CD94/KLRD1) denotes specialization toward HLA-E sensing—hallmark of educated, adaptive NK subsets with durable recall. This receptor bias complements intact cytotoxic machinery (e.g., PRF1/GZMB in the broader program).
Functional implications
HLA-E–educated killers that rapidly eliminate cells showing altered HLA-E peptide cargo (viral/self-stress) and maintain strong ADCC; robust recall responses characteristic of adaptive NK immunity.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.