Cell state · L2
NEU.INH_VIP.opioid
394 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CDH8, CLSTN2, CNTNAP5, CRH, CRHR2, LCP2, MIR4435-2HG, OPRK1, OPRM1, PLCE1, RXRG, TRH, TRPC6
Annotation genes
CRH, CRHR2, OPRK1, OPRM1
Annotation rationales
OPRM1/OPRK1 confer μ/κ-opioid sensitivity; CRH/CRHR2 connect VIP output to stress-axis neuromodulation; adhesion CNTNAP5/CDH8/CLSTN2 refine synaptic partnerships.
Functional implications
Adjusts disinhibition according to stress and opioid tone, modulating sensory gating, anxiety, and reward valuation by reweighting VIP→SST/PV pathways.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.